Mus musculus

197 known processes

Brca1

breast cancer 1

Brca1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 1.000
dna repair GO:0006281 107 1.000
Human
dna recombination GO:0006310 92 1.000
Human
cellular response to dna damage stimulus GO:0006974 207 1.000
meiotic cell cycle GO:0051321 122 1.000
meiotic cell cycle process GO:1903046 77 1.000
regulation of cell cycle g2 m phase transition GO:1902749 10 1.000
double strand break repair GO:0006302 48 0.999
Human
response to ionizing radiation GO:0010212 42 0.999
Human
negative regulation of cell cycle phase transition GO:1901988 48 0.999
recombinational repair GO:0000725 21 0.999
Human
meiosis i GO:0007127 60 0.998
male meiosis i GO:0007141 16 0.997
cell cycle checkpoint GO:0000075 47 0.996
Human
cellular response to gamma radiation GO:0071480 4 0.996
meiotic chromosome segregation GO:0045132 19 0.996
double strand break repair via homologous recombination GO:0000724 21 0.996
Human
reciprocal dna recombination GO:0035825 16 0.995
negative regulation of cell cycle GO:0045786 123 0.994
Human
regulation of cell cycle GO:0051726 281 0.993
Human
meiotic nuclear division GO:0007126 115 0.993
mitotic cell cycle process GO:1903047 159 0.991
mitotic cell cycle GO:0000278 195 0.990
regulation of cell division GO:0051302 76 0.989
nuclear division GO:0000280 158 0.988
response to radiation GO:0009314 165 0.985
Human
female meiosis chromosome segregation GO:0016321 1 0.983
organelle fission GO:0048285 170 0.982
reciprocal meiotic recombination GO:0007131 16 0.982
regulation of mitotic cell cycle phase transition GO:1901990 73 0.978
spermatogenesis GO:0007283 284 0.976
negative regulation of dna replication GO:0008156 4 0.975
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.974
dna replication GO:0006260 52 0.973
apoptotic signaling pathway GO:0097190 306 0.965
Human
negative regulation of mitotic cell cycle GO:0045930 58 0.964
mitotic g2 dna damage checkpoint GO:0007095 8 0.964
signal transduction by p53 class mediator GO:0072331 51 0.964
cellular response to ionizing radiation GO:0071479 11 0.964
dna conformation change GO:0071103 37 0.960
regionalization GO:0003002 337 0.959
telomere maintenance GO:0000723 19 0.958
cell division GO:0051301 120 0.951
centrosome cycle GO:0007098 23 0.951
positive regulation of chromatin modification GO:1903310 28 0.947
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.943
Human
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.937
histone acetylation GO:0016573 41 0.937
positive regulation of cell cycle GO:0045787 92 0.930
Human
cell aging GO:0007569 35 0.928
cell cycle arrest GO:0007050 37 0.927
Human
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.925
regulation of mitotic cell cycle GO:0007346 126 0.925
male meiosis GO:0007140 37 0.923
regulation of mitosis GO:0007088 29 0.918
dna integrity checkpoint GO:0031570 28 0.917
Human
negative regulation of cell cycle process GO:0010948 69 0.914
chromosome segregation GO:0007059 48 0.913
Human
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.912
regulation of organelle organization GO:0033043 289 0.905
intrinsic apoptotic signaling pathway GO:0097193 132 0.904
Human
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.901
microtubule organizing center organization GO:0031023 28 0.898
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.896
blastocyst growth GO:0001832 23 0.896
chromatin organization GO:0006325 206 0.895
regulation of cell cycle phase transition GO:1901987 77 0.891
centrosome organization GO:0051297 26 0.887
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 3 0.884
signal transduction involved in dna damage checkpoint GO:0072422 3 0.883
response to light stimulus GO:0009416 135 0.882
protein autophosphorylation GO:0046777 61 0.875
mitotic sister chromatid cohesion GO:0007064 1 0.872
response to uv GO:0009411 44 0.862
response to caffeine GO:0031000 6 0.861
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.856
negative regulation of mammary gland epithelial cell proliferation GO:0033600 3 0.848
g2 dna damage checkpoint GO:0031572 8 0.848
Human
negative regulation of cell proliferation GO:0008285 296 0.840
histone h3 acetylation GO:0043966 14 0.837
cellular response to radiation GO:0071478 28 0.825
organic cyclic compound catabolic process GO:1901361 295 0.823
cell cycle g2 m phase transition GO:0044839 20 0.821
response to x ray GO:0010165 11 0.816
female meiotic division GO:0007143 21 0.814
regulation of response to dna damage stimulus GO:2001020 34 0.814
Human
chromatin modification GO:0016568 187 0.806
macromolecule catabolic process GO:0009057 281 0.801
replication fork protection GO:0048478 1 0.794
dna catabolic process exonucleolytic GO:0000738 3 0.788
cellular macromolecule catabolic process GO:0044265 206 0.778
anatomical structure homeostasis GO:0060249 145 0.771
negative regulation of organelle organization GO:0010639 90 0.763
dna catabolic process GO:0006308 19 0.763
dna packaging GO:0006323 30 0.761
peptidyl lysine acetylation GO:0018394 45 0.758
negative regulation of cellular protein metabolic process GO:0032269 247 0.747
protein catabolic process GO:0030163 221 0.737
negative regulation of epithelial cell proliferation GO:0050680 64 0.730
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.726
non recombinational repair GO:0000726 10 0.719
mitotic cell cycle checkpoint GO:0007093 31 0.713
cellular nitrogen compound catabolic process GO:0044270 280 0.711
regulation of cellular response to stress GO:0080135 159 0.706
Human
negative regulation of cellular component organization GO:0051129 194 0.703
heterocycle catabolic process GO:0046700 280 0.695
regulation of cell cycle process GO:0010564 160 0.694
Human
oocyte differentiation GO:0009994 35 0.689
protein acylation GO:0043543 64 0.683
microtubule cytoskeleton organization GO:0000226 157 0.665
regulation of dna replication GO:0006275 17 0.662
mitotic sister chromatid segregation GO:0000070 14 0.658
regulation of chromosome organization GO:0033044 83 0.655
cytokinesis GO:0000910 17 0.651
regulation of cytokinesis GO:0032465 5 0.651
germ cell development GO:0007281 185 0.648
female gamete generation GO:0007292 74 0.645
male gamete generation GO:0048232 285 0.641
epithelial cell proliferation GO:0050673 174 0.634
positive regulation of histone methylation GO:0031062 16 0.633
peptidyl amino acid modification GO:0018193 336 0.618
dna dependent dna replication GO:0006261 24 0.618
proteasomal protein catabolic process GO:0010498 98 0.603
mitochondrial dna repair GO:0043504 3 0.582
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.566
g2 m transition of mitotic cell cycle GO:0000086 20 0.557
centrosome duplication GO:0051298 16 0.553
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.553
oocyte development GO:0048599 33 0.551
translesion synthesis GO:0019985 1 0.549
mammary gland epithelial cell proliferation GO:0033598 24 0.542
negative regulation of nuclear division GO:0051784 19 0.536
dna damage checkpoint GO:0000077 26 0.534
Human
regulation of epithelial cell proliferation GO:0050678 141 0.533
histone methylation GO:0016571 71 0.525
telomere capping GO:0016233 4 0.524
protein methylation GO:0006479 81 0.523
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.521
mitotic spindle assembly checkpoint GO:0007094 7 0.521
oogenesis GO:0048477 56 0.511
negative regulation of gene expression epigenetic GO:0045814 15 0.508
positive regulation of cell cycle phase transition GO:1901989 17 0.502
microtubule based process GO:0007017 236 0.498
replicative senescence GO:0090399 2 0.497
purine containing compound metabolic process GO:0072521 311 0.492
response to alkaloid GO:0043279 34 0.492
cellular response to abiotic stimulus GO:0071214 56 0.488
histone h4 acetylation GO:0043967 10 0.477
blastocyst development GO:0001824 80 0.468
glycosyl compound catabolic process GO:1901658 206 0.467
response to purine containing compound GO:0014074 28 0.458
mammary gland epithelium development GO:0061180 65 0.457
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 3 0.455
chromosome condensation GO:0030261 10 0.454
chromosome organization involved in meiosis GO:0070192 39 0.446
development of primary sexual characteristics GO:0045137 143 0.444
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.441
positive regulation of mitotic cell cycle GO:0045931 41 0.432
response to gamma radiation GO:0010332 22 0.431
development of primary female sexual characteristics GO:0046545 73 0.431
intra s dna damage checkpoint GO:0031573 4 0.428
somatic diversification of immune receptors GO:0002200 53 0.426
purine ribonucleotide metabolic process GO:0009150 290 0.413
positive regulation of apoptotic process GO:0043065 217 0.412
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.412
ribonucleoside catabolic process GO:0042454 206 0.409
regulation of lymphocyte proliferation GO:0050670 117 0.400
regulation of g2 m transition of mitotic cell cycle GO:0010389 10 0.398
oocyte maturation GO:0001556 18 0.396
lymphocyte proliferation GO:0046651 164 0.396
negative regulation of dna dependent dna replication GO:2000104 1 0.391
regulation of mitotic sister chromatid segregation GO:0033047 12 0.388
purine nucleoside catabolic process GO:0006152 205 0.387
digestive tract development GO:0048565 190 0.386
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.383
mitotic recombination GO:0006312 3 0.379
regulation of cell cycle g1 s phase transition GO:1902806 35 0.372
organelle assembly GO:0070925 177 0.365
sister chromatid segregation GO:0000819 20 0.362
nucleoside triphosphate metabolic process GO:0009141 230 0.359
internal peptidyl lysine acetylation GO:0018393 42 0.358
inner cell mass cell proliferation GO:0001833 15 0.357
axonogenesis GO:0007409 274 0.356
response to organic cyclic compound GO:0014070 198 0.349
Human Rat
dna biosynthetic process GO:0071897 22 0.349
aromatic compound catabolic process GO:0019439 286 0.348
dna damage response signal transduction resulting in transcription GO:0042772 2 0.345
attachment of spindle microtubules to kinetochore GO:0008608 4 0.345
protein modification by small protein conjugation or removal GO:0070647 207 0.337
Human
metaphase plate congression GO:0051310 2 0.336
regulation of metaphase anaphase transition of cell cycle GO:1902099 9 0.334
cellular response to light stimulus GO:0071482 19 0.330
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.315
regulation of cellular amine metabolic process GO:0033238 20 0.314
mitotic nuclear division GO:0007067 48 0.313
peptidyl serine modification GO:0018209 83 0.308
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.304
peptidyl lysine modification GO:0018205 77 0.299
cohesin localization to chromatin GO:0071921 1 0.295
histone lysine methylation GO:0034968 50 0.291
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.289
negative regulation of cell division GO:0051782 24 0.283
production of molecular mediator of immune response GO:0002440 103 0.282
somatic cell dna recombination GO:0016444 51 0.281
modification dependent protein catabolic process GO:0019941 133 0.278
positive regulation of histone modification GO:0031058 28 0.275
ubiquitin dependent protein catabolic process GO:0006511 129 0.275
regulation of chromosome segregation GO:0051983 21 0.275
regulation of nuclear division GO:0051783 56 0.274
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.272
gene silencing GO:0016458 38 0.270
digestive tract morphogenesis GO:0048546 147 0.262
dna duplex unwinding GO:0032508 7 0.260
g1 s transition of mitotic cell cycle GO:0000082 57 0.260
dna geometric change GO:0032392 7 0.258
macromolecule methylation GO:0043414 120 0.257
mitotic sister chromatid separation GO:0051306 9 0.257
regulation of protein localization GO:0032880 231 0.256
regulation of cohesin localization to chromatin GO:0071922 1 0.254
positive regulation of protein modification process GO:0031401 299 0.253
purine nucleotide metabolic process GO:0006163 302 0.252
maintenance of location GO:0051235 89 0.251
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.249
covalent chromatin modification GO:0016569 163 0.247
glycosyl compound metabolic process GO:1901657 246 0.247
regulation of dna dependent dna replication GO:0090329 8 0.241
regulation of microtubule based process GO:0032886 52 0.240
ribonucleotide metabolic process GO:0009259 291 0.239
regulation of binding GO:0051098 111 0.238
regulation of mammary gland epithelial cell proliferation GO:0033599 12 0.238
double strand break repair via nonhomologous end joining GO:0006303 10 0.232
chromatin silencing GO:0006342 15 0.227
mitotic g1 dna damage checkpoint GO:0031571 4 0.227
regulation of transferase activity GO:0051338 263 0.227
b cell activation GO:0042113 161 0.222
intracellular mrna localization GO:0008298 4 0.222
peptidyl serine phosphorylation GO:0018105 74 0.221
negative regulation of cell cycle arrest GO:0071157 1 0.220
positive regulation of g2 m transition of mitotic cell cycle GO:0010971 5 0.216
b cell proliferation GO:0042100 53 0.208
positive regulation of programmed cell death GO:0043068 218 0.206
atp catabolic process GO:0006200 55 0.203
gland development GO:0048732 330 0.202
signal transduction in response to dna damage GO:0042770 21 0.201
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 18 0.200
female gonad development GO:0008585 71 0.200
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.195
regulation of protein stability GO:0031647 52 0.192
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.192
gonad development GO:0008406 141 0.192
response to organonitrogen compound GO:0010243 246 0.191
Human
t cell receptor v d j recombination GO:0033153 5 0.188
leukocyte proliferation GO:0070661 172 0.187
neuron migration GO:0001764 122 0.186
histone h3 k9 methylation GO:0051567 17 0.185
cellular amino acid metabolic process GO:0006520 103 0.184
protein oligomerization GO:0051259 67 0.184
regulation of chromatin modification GO:1903308 57 0.183
nucleoside monophosphate catabolic process GO:0009125 59 0.182
regulation of mitotic metaphase anaphase transition GO:0030071 8 0.180
nucleoside phosphate catabolic process GO:1901292 222 0.178
cellular ketone metabolic process GO:0042180 84 0.176
Human
nucleoside monophosphate metabolic process GO:0009123 85 0.176
purine nucleoside triphosphate metabolic process GO:0009144 226 0.175
nucleobase containing small molecule metabolic process GO:0055086 352 0.174
histone modification GO:0016570 159 0.173
mitotic cytokinesis GO:0000281 4 0.173
response to metal ion GO:0010038 47 0.167
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.166
protein localization to chromatin GO:0071168 3 0.165
t cell activation GO:0042110 289 0.162
leukocyte mediated immunity GO:0002443 174 0.162
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.161
negative regulation of protein modification process GO:0031400 163 0.159
positive regulation of cell development GO:0010720 237 0.158
response to uv c GO:0010225 3 0.157
regulation of chromatin organization GO:1902275 57 0.155
negative regulation of mitotic sister chromatid segregation GO:0033048 7 0.155
dna endoreduplication GO:0042023 4 0.154
organophosphate catabolic process GO:0046434 232 0.151
protein ubiquitination GO:0016567 171 0.149
Human
regulation of sister chromatid cohesion GO:0007063 5 0.149
actin filament organization GO:0007015 113 0.149
cellular protein catabolic process GO:0044257 155 0.146
dendrite development GO:0016358 115 0.145
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.145
regulation of histone methylation GO:0031060 30 0.144
nucleoside phosphate metabolic process GO:0006753 338 0.143
purine ribonucleoside catabolic process GO:0046130 205 0.143
positive regulation of cell cycle process GO:0090068 61 0.143
Human
positive regulation of apoptotic signaling pathway GO:2001235 95 0.143
isotype switching GO:0045190 36 0.143
female sex differentiation GO:0046660 84 0.142
positive regulation of response to dna damage stimulus GO:2001022 14 0.142
Human
spindle assembly involved in mitosis GO:0090307 4 0.140
negative regulation of cellular senescence GO:2000773 3 0.140
lymphocyte differentiation GO:0030098 242 0.139
negative regulation of mitotic metaphase anaphase transition GO:0045841 7 0.138
homeostasis of number of cells GO:0048872 210 0.136
ribonucleoside triphosphate metabolic process GO:0009199 220 0.135
regulation of dna templated transcription in response to stress GO:0043620 9 0.135
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 24 0.134
dna catabolic process endonucleolytic GO:0000737 15 0.133
positive regulation of chromosome segregation GO:0051984 4 0.132
nucleoside metabolic process GO:0009116 246 0.131
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.130
positive regulation of protein autophosphorylation GO:0031954 4 0.130
negative regulation of phosphate metabolic process GO:0045936 184 0.130
regulation of cellular protein catabolic process GO:1903362 61 0.130
amine metabolic process GO:0009308 45 0.128
cellular response to inorganic substance GO:0071241 37 0.128
leukocyte activation involved in immune response GO:0002366 126 0.126
cellular response to growth factor stimulus GO:0071363 197 0.126
regulation of protein kinase activity GO:0045859 232 0.123
negative regulation of chromosome organization GO:2001251 30 0.122
regulation of histone modification GO:0031056 56 0.121
synapsis GO:0007129 34 0.119
negative regulation of protein depolymerization GO:1901880 21 0.119
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.117
spindle checkpoint GO:0031577 12 0.115
regulation of apoptotic signaling pathway GO:2001233 197 0.114
Human
negative regulation of cellular catabolic process GO:0031330 47 0.112
positive regulation of transferase activity GO:0051347 167 0.111
negative regulation of cell cycle g1 s phase transition GO:1902807 18 0.111
digestive system development GO:0055123 200 0.109
mitotic cell cycle arrest GO:0071850 4 0.109
b cell lineage commitment GO:0002326 4 0.109
erythrocyte differentiation GO:0030218 88 0.109
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.106
positive regulation of cell death GO:0010942 224 0.106
stem cell development GO:0048864 219 0.105
spindle organization GO:0007051 28 0.103
positive regulation of nervous system development GO:0051962 221 0.101
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.101
neuron apoptotic process GO:0051402 142 0.101
cell fate commitment GO:0045165 210 0.101
regulation of cellular ketone metabolic process GO:0010565 66 0.101
Human
dna ligation GO:0006266 3 0.100
regulation of cytoskeleton organization GO:0051493 122 0.098
negative regulation of protein metabolic process GO:0051248 282 0.098
pole plasm assembly GO:0007315 2 0.097
posttranscriptional regulation of gene expression GO:0010608 155 0.097
t cell proliferation GO:0042098 120 0.095
establishment of organelle localization GO:0051656 122 0.094
nucleoside triphosphate catabolic process GO:0009143 205 0.094
regulation of sister chromatid segregation GO:0033045 13 0.093
regulation of proteasomal protein catabolic process GO:0061136 46 0.092
positive regulation of cellular amine metabolic process GO:0033240 5 0.092
negative regulation of mitotic sister chromatid separation GO:2000816 7 0.091
regulation of cytoplasmic transport GO:1903649 112 0.088
atp metabolic process GO:0046034 75 0.088
purine containing compound catabolic process GO:0072523 213 0.088
cellular response to organonitrogen compound GO:0071417 145 0.087
Human
cell growth GO:0016049 130 0.087
regulation of intracellular protein transport GO:0033157 82 0.087
nucleotide excision repair GO:0006289 13 0.087
purine ribonucleoside metabolic process GO:0046128 241 0.086
regulation of lymphocyte activation GO:0051249 240 0.085
regulation of mitotic sister chromatid separation GO:0010965 12 0.085
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.083
mitotic chromosome condensation GO:0007076 1 0.083
regulation of leukocyte proliferation GO:0070663 121 0.083
positive regulation of keratinocyte proliferation GO:0010838 4 0.081
negative regulation of lipid kinase activity GO:0090219 1 0.081
ribonucleoside metabolic process GO:0009119 245 0.080
purine nucleoside metabolic process GO:0042278 241 0.079
regulation of proteolysis GO:0030162 164 0.079
developmental maturation GO:0021700 193 0.079
negative regulation of sister chromatid segregation GO:0033046 7 0.076
purine ribonucleotide catabolic process GO:0009154 208 0.076
negative regulation of kinase activity GO:0033673 81 0.075
glial cell apoptotic process GO:0034349 3 0.074
b cell activation involved in immune response GO:0002312 50 0.074
methylation GO:0032259 134 0.074
negative regulation of protein phosphorylation GO:0001933 126 0.073
branching morphogenesis of an epithelial tube GO:0048754 159 0.073
stem cell differentiation GO:0048863 268 0.073
adaptive immune response GO:0002250 155 0.072
rna localization GO:0006403 23 0.071
peptidyl tyrosine phosphorylation GO:0018108 143 0.071
negative regulation of mitosis GO:0045839 10 0.070
sister chromatid cohesion GO:0007062 12 0.070
negative regulation of growth GO:0045926 99 0.070
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.070
cellular lipid metabolic process GO:0044255 323 0.070
Human
histone threonine phosphorylation GO:0035405 1 0.069
regulation of neuron differentiation GO:0045664 281 0.069
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.069
regulation of meiosis i GO:0060631 7 0.069
positive regulation of neuron differentiation GO:0045666 141 0.068
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 6 0.068
regulation of protein targeting GO:1903533 61 0.068
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.067
membrane organization GO:0061024 245 0.067
organonitrogen compound catabolic process GO:1901565 264 0.067
ribonucleoside monophosphate metabolic process GO:0009161 80 0.067
cellular amine metabolic process GO:0044106 44 0.067
positive regulation of chromosome organization GO:2001252 33 0.067
positive regulation of growth GO:0045927 104 0.066
negative regulation of lymphocyte proliferation GO:0050672 45 0.066
base excision repair GO:0006284 9 0.066
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.065
multicellular organism growth GO:0035264 161 0.065
negative regulation of proteolysis GO:0045861 74 0.064
centriole assembly GO:0098534 6 0.064
regulation of histone acetylation GO:0035065 19 0.063
spindle assembly involved in female meiosis GO:0007056 3 0.063
internal protein amino acid acetylation GO:0006475 42 0.062
chromatin assembly GO:0031497 13 0.062
positive regulation of organelle organization GO:0010638 128 0.062
negative regulation of phosphorylation GO:0042326 166 0.061
negative regulation of b cell activation GO:0050869 27 0.061
cerebrospinal fluid secretion GO:0033326 4 0.061
cellular protein complex assembly GO:0043623 116 0.061
spindle assembly GO:0051225 13 0.061
astral microtubule organization GO:0030953 3 0.060
mitotic spindle organization GO:0007052 10 0.060
histone mrna metabolic process GO:0008334 3 0.060
negative regulation of cell activation GO:0050866 111 0.060
t cell differentiation GO:0030217 174 0.060
negative regulation of leukocyte proliferation GO:0070664 46 0.060
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 8 0.060
skeletal muscle organ development GO:0060538 163 0.060
regulation of microtubule depolymerization GO:0031114 13 0.060
t cell differentiation in thymus GO:0033077 77 0.059
traversing start control point of mitotic cell cycle GO:0007089 2 0.058
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.058
myeloid cell differentiation GO:0030099 233 0.058
regulation of protein depolymerization GO:1901879 26 0.058
leukocyte differentiation GO:0002521 342 0.057
dna hypermethylation GO:0044026 3 0.057
negative regulation of protein catabolic process GO:0042177 36 0.057
embryonic organ morphogenesis GO:0048562 276 0.056
ribose phosphate metabolic process GO:0019693 291 0.056
regulation of cellular amino acid metabolic process GO:0006521 5 0.056
regulation of cell activation GO:0050865 289 0.056
negative regulation of phosphorus metabolic process GO:0010563 184 0.056
dna replication checkpoint GO:0000076 2 0.055
establishment or maintenance of cell polarity GO:0007163 86 0.055
mitochondrion organization GO:0007005 134 0.055
nucleotide metabolic process GO:0009117 332 0.055
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.055
somatic diversification of t cell receptor genes GO:0002568 5 0.054
positive regulation of histone h3 k27 methylation GO:0061087 4 0.054
immune effector process GO:0002252 321 0.053
regulation of protein maturation GO:1903317 96 0.052
organelle localization GO:0051640 179 0.052
protein modification by small protein conjugation GO:0032446 187 0.052
Human
positive regulation of kinase activity GO:0033674 155 0.052
positive regulation of transcription by galactose GO:0000411 1 0.051
regulation of neuron death GO:1901214 134 0.050
regulation of microtubule cytoskeleton organization GO:0070507 37 0.050
negative regulation of immature t cell proliferation GO:0033087 3 0.050
modification dependent macromolecule catabolic process GO:0043632 133 0.050
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.049
purine nucleoside triphosphate catabolic process GO:0009146 203 0.049
regulation of meiotic cell cycle GO:0051445 34 0.049
regulation of protein binding GO:0043393 60 0.048
regulation of innate immune response GO:0045088 91 0.048
muscle cell differentiation GO:0042692 261 0.048
regulation of hydrolase activity GO:0051336 246 0.047
photoreceptor cell differentiation GO:0046530 52 0.047
small gtpase mediated signal transduction GO:0007264 97 0.047

Brca1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.999
Human
disease of cellular proliferation DOID:14566 0 0.999
Human
organ system cancer DOID:0050686 0 0.999
Human
endocrine gland cancer DOID:170 0 0.992
Human
immune system disease DOID:2914 0 0.991
aplastic anemia DOID:12449 0 0.991
disease of anatomical entity DOID:7 0 0.991
bone marrow disease DOID:4961 0 0.991
anemia DOID:2355 0 0.991
hematopoietic system disease DOID:74 0 0.991
thoracic cancer DOID:5093 0 0.989
congenital hypoplastic anemia DOID:1342 0 0.989
fanconi s anemia DOID:13636 0 0.981
breast cancer DOID:1612 0 0.913
kidney cancer DOID:263 0 0.626
urinary system cancer DOID:3996 0 0.626
pancreatic cancer DOID:1793 0 0.608
Human
prostate cancer DOID:10283 0 0.533
male reproductive organ cancer DOID:3856 0 0.533
reproductive organ cancer DOID:193 0 0.533
immune system cancer DOID:0060083 0 0.361
hematologic cancer DOID:2531 0 0.361
large intestine cancer DOID:5672 0 0.164
colon cancer DOID:219 0 0.164
gastrointestinal system cancer DOID:3119 0 0.164
intestinal cancer DOID:10155 0 0.164
colorectal cancer DOID:9256 0 0.164
nervous system cancer DOID:3093 0 0.055
central nervous system cancer DOID:3620 0 0.055
renal cell carcinoma DOID:4450 0 0.054
renal carcinoma DOID:4451 0 0.054