Mus musculus

197 known processes

Brca1

breast cancer 1

Brca1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 1.000
dna repair GO:0006281 107 1.000
Human
dna recombination GO:0006310 92 1.000
Human
cellular response to dna damage stimulus GO:0006974 207 1.000
meiotic cell cycle GO:0051321 122 1.000
meiotic cell cycle process GO:1903046 77 1.000
regulation of cell cycle g2 m phase transition GO:1902749 10 1.000
double strand break repair GO:0006302 48 0.999
Human
response to ionizing radiation GO:0010212 42 0.999
Human
negative regulation of cell cycle phase transition GO:1901988 48 0.999
recombinational repair GO:0000725 21 0.999
Human
meiosis i GO:0007127 60 0.998
male meiosis i GO:0007141 16 0.997
cell cycle checkpoint GO:0000075 47 0.996
Human
cellular response to gamma radiation GO:0071480 4 0.996
meiotic chromosome segregation GO:0045132 19 0.996
double strand break repair via homologous recombination GO:0000724 21 0.996
Human
reciprocal dna recombination GO:0035825 16 0.995
negative regulation of cell cycle GO:0045786 123 0.994
Human
regulation of cell cycle GO:0051726 281 0.993
Human
meiotic nuclear division GO:0007126 115 0.993
mitotic cell cycle process GO:1903047 159 0.991
mitotic cell cycle GO:0000278 195 0.990
regulation of cell division GO:0051302 76 0.989
nuclear division GO:0000280 158 0.988
response to radiation GO:0009314 165 0.985
Human
female meiosis chromosome segregation GO:0016321 1 0.983
organelle fission GO:0048285 170 0.982
reciprocal meiotic recombination GO:0007131 16 0.982
regulation of mitotic cell cycle phase transition GO:1901990 73 0.978
spermatogenesis GO:0007283 284 0.976
negative regulation of dna replication GO:0008156 4 0.975
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.974
dna replication GO:0006260 52 0.973
apoptotic signaling pathway GO:0097190 306 0.965
Human
negative regulation of mitotic cell cycle GO:0045930 58 0.964
mitotic g2 dna damage checkpoint GO:0007095 8 0.964
signal transduction by p53 class mediator GO:0072331 51 0.964
cellular response to ionizing radiation GO:0071479 11 0.964
dna conformation change GO:0071103 37 0.960
regionalization GO:0003002 337 0.959
telomere maintenance GO:0000723 19 0.958
cell division GO:0051301 120 0.951
centrosome cycle GO:0007098 23 0.951
positive regulation of chromatin modification GO:1903310 28 0.947
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.943
Human
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.937
histone acetylation GO:0016573 41 0.937
positive regulation of cell cycle GO:0045787 92 0.930
Human
cell aging GO:0007569 35 0.928
cell cycle arrest GO:0007050 37 0.927
Human
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.925
regulation of mitotic cell cycle GO:0007346 126 0.925
male meiosis GO:0007140 37 0.923
regulation of mitosis GO:0007088 29 0.918
dna integrity checkpoint GO:0031570 28 0.917
Human
negative regulation of cell cycle process GO:0010948 69 0.914
chromosome segregation GO:0007059 48 0.913
Human
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.912
regulation of organelle organization GO:0033043 289 0.905
intrinsic apoptotic signaling pathway GO:0097193 132 0.904
Human
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.901
microtubule organizing center organization GO:0031023 28 0.898
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.896
blastocyst growth GO:0001832 23 0.896
chromatin organization GO:0006325 206 0.895
regulation of cell cycle phase transition GO:1901987 77 0.891
centrosome organization GO:0051297 26 0.887
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 3 0.884
signal transduction involved in dna damage checkpoint GO:0072422 3 0.883
response to light stimulus GO:0009416 135 0.882
protein autophosphorylation GO:0046777 61 0.875
mitotic sister chromatid cohesion GO:0007064 1 0.872
response to uv GO:0009411 44 0.862
response to caffeine GO:0031000 6 0.861
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.856
negative regulation of mammary gland epithelial cell proliferation GO:0033600 3 0.848
g2 dna damage checkpoint GO:0031572 8 0.848
Human
negative regulation of cell proliferation GO:0008285 296 0.840
histone h3 acetylation GO:0043966 14 0.837
cellular response to radiation GO:0071478 28 0.825
organic cyclic compound catabolic process GO:1901361 295 0.823
cell cycle g2 m phase transition GO:0044839 20 0.821
response to x ray GO:0010165 11 0.816
female meiotic division GO:0007143 21 0.814
regulation of response to dna damage stimulus GO:2001020 34 0.814
Human
chromatin modification GO:0016568 187 0.806
macromolecule catabolic process GO:0009057 281 0.801
replication fork protection GO:0048478 1 0.794
dna catabolic process exonucleolytic GO:0000738 3 0.788
cellular macromolecule catabolic process GO:0044265 206 0.778
anatomical structure homeostasis GO:0060249 145 0.771
negative regulation of organelle organization GO:0010639 90 0.763
dna catabolic process GO:0006308 19 0.763
dna packaging GO:0006323 30 0.761
peptidyl lysine acetylation GO:0018394 45 0.758
negative regulation of cellular protein metabolic process GO:0032269 247 0.747
protein catabolic process GO:0030163 221 0.737
negative regulation of epithelial cell proliferation GO:0050680 64 0.730
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.726
non recombinational repair GO:0000726 10 0.719
mitotic cell cycle checkpoint GO:0007093 31 0.713
cellular nitrogen compound catabolic process GO:0044270 280 0.711
regulation of cellular response to stress GO:0080135 159 0.706
Human
negative regulation of cellular component organization GO:0051129 194 0.703
heterocycle catabolic process GO:0046700 280 0.695
regulation of cell cycle process GO:0010564 160 0.694
Human
oocyte differentiation GO:0009994 35 0.689
protein acylation GO:0043543 64 0.683
microtubule cytoskeleton organization GO:0000226 157 0.665
regulation of dna replication GO:0006275 17 0.662
mitotic sister chromatid segregation GO:0000070 14 0.658
regulation of chromosome organization GO:0033044 83 0.655
cytokinesis GO:0000910 17 0.651
regulation of cytokinesis GO:0032465 5 0.651
germ cell development GO:0007281 185 0.648
female gamete generation GO:0007292 74 0.645
male gamete generation GO:0048232 285 0.641
epithelial cell proliferation GO:0050673 174 0.634
positive regulation of histone methylation GO:0031062 16 0.633
peptidyl amino acid modification GO:0018193 336 0.618
dna dependent dna replication GO:0006261 24 0.618
proteasomal protein catabolic process GO:0010498 98 0.603
mitochondrial dna repair GO:0043504 3 0.582
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.566
g2 m transition of mitotic cell cycle GO:0000086 20 0.557
centrosome duplication GO:0051298 16 0.553
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.553
oocyte development GO:0048599 33 0.551
translesion synthesis GO:0019985 1 0.549
mammary gland epithelial cell proliferation GO:0033598 24 0.542
negative regulation of nuclear division GO:0051784 19 0.536
dna damage checkpoint GO:0000077 26 0.534
Human
regulation of epithelial cell proliferation GO:0050678 141 0.533
histone methylation GO:0016571 71 0.525
telomere capping GO:0016233 4 0.524
protein methylation GO:0006479 81 0.523
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.521
mitotic spindle assembly checkpoint GO:0007094 7 0.521
oogenesis GO:0048477 56 0.511
negative regulation of gene expression epigenetic GO:0045814 15 0.508
positive regulation of cell cycle phase transition GO:1901989 17 0.502
microtubule based process GO:0007017 236 0.498
replicative senescence GO:0090399 2 0.497
purine containing compound metabolic process GO:0072521 311 0.492
response to alkaloid GO:0043279 34 0.492
cellular response to abiotic stimulus GO:0071214 56 0.488
histone h4 acetylation GO:0043967 10 0.477
blastocyst development GO:0001824 80 0.468
glycosyl compound catabolic process GO:1901658 206 0.467
response to purine containing compound GO:0014074 28 0.458
mammary gland epithelium development GO:0061180 65 0.457
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 3 0.455
chromosome condensation GO:0030261 10 0.454
chromosome organization involved in meiosis GO:0070192 39 0.446
development of primary sexual characteristics GO:0045137 143 0.444
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.441
positive regulation of mitotic cell cycle GO:0045931 41 0.432
response to gamma radiation GO:0010332 22 0.431
development of primary female sexual characteristics GO:0046545 73 0.431
intra s dna damage checkpoint GO:0031573 4 0.428
somatic diversification of immune receptors GO:0002200 53 0.426
purine ribonucleotide metabolic process GO:0009150 290 0.413
positive regulation of apoptotic process GO:0043065 217 0.412
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.412
ribonucleoside catabolic process GO:0042454 206 0.409
regulation of lymphocyte proliferation GO:0050670 117 0.400
regulation of g2 m transition of mitotic cell cycle GO:0010389 10 0.398
oocyte maturation GO:0001556 18 0.396
lymphocyte proliferation GO:0046651 164 0.396
negative regulation of dna dependent dna replication GO:2000104 1 0.391
regulation of mitotic sister chromatid segregation GO:0033047 12 0.388
purine nucleoside catabolic process GO:0006152 205 0.387
digestive tract development GO:0048565 190 0.386
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.383
mitotic recombination GO:0006312 3 0.379
regulation of cell cycle g1 s phase transition GO:1902806 35 0.372
organelle assembly GO:0070925 177 0.365
sister chromatid segregation GO:0000819 20 0.362
nucleoside triphosphate metabolic process GO:0009141 230 0.359
internal peptidyl lysine acetylation GO:0018393 42 0.358
inner cell mass cell proliferation GO:0001833 15 0.357
axonogenesis GO:0007409 274 0.356
response to organic cyclic compound GO:0014070 198 0.349
Human Rat
dna biosynthetic process GO:0071897 22 0.349
aromatic compound catabolic process GO:0019439 286 0.348
dna damage response signal transduction resulting in transcription GO:0042772 2 0.345
attachment of spindle microtubules to kinetochore GO:0008608 4 0.345
protein modification by small protein conjugation or removal GO:0070647 207 0.337
Human
metaphase plate congression GO:0051310 2 0.336
regulation of metaphase anaphase transition of cell cycle GO:1902099 9 0.334
cellular response to light stimulus GO:0071482 19 0.330
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.315
regulation of cellular amine metabolic process GO:0033238 20 0.314
mitotic nuclear division GO:0007067 48 0.313
peptidyl serine modification GO:0018209 83 0.308
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.304
peptidyl lysine modification GO:0018205 77 0.299
cohesin localization to chromatin GO:0071921 1 0.295
histone lysine methylation GO:0034968 50 0.291
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.289
negative regulation of cell division GO:0051782 24 0.283
production of molecular mediator of immune response GO:0002440 103 0.282
somatic cell dna recombination GO:0016444 51 0.281
modification dependent protein catabolic process GO:0019941 133 0.278
positive regulation of histone modification GO:0031058 28 0.275
ubiquitin dependent protein catabolic process GO:0006511 129 0.275
regulation of chromosome segregation GO:0051983 21 0.275
regulation of nuclear division GO:0051783 56 0.274
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.272
gene silencing GO:0016458 38 0.270
digestive tract morphogenesis GO:0048546 147 0.262
dna duplex unwinding GO:0032508 7 0.260
g1 s transition of mitotic cell cycle GO:0000082 57 0.260
dna geometric change GO:0032392 7 0.258
macromolecule methylation GO:0043414 120 0.257
mitotic sister chromatid separation GO:0051306 9 0.257
regulation of protein localization GO:0032880 231 0.256
regulation of cohesin localization to chromatin GO:0071922 1 0.254
positive regulation of protein modification process GO:0031401 299 0.253
purine nucleotide metabolic process GO:0006163 302 0.252
maintenance of location GO:0051235 89 0.251
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.249
covalent chromatin modification GO:0016569 163 0.247
glycosyl compound metabolic process GO:1901657 246 0.247
regulation of dna dependent dna replication GO:0090329 8 0.241
regulation of microtubule based process GO:0032886 52 0.240
ribonucleotide metabolic process GO:0009259 291 0.239
regulation of binding GO:0051098 111 0.238
regulation of mammary gland epithelial cell proliferation GO:0033599 12 0.238
double strand break repair via nonhomologous end joining GO:0006303 10 0.232
chromatin silencing GO:0006342 15 0.227
mitotic g1 dna damage checkpoint GO:0031571 4 0.227
regulation of transferase activity GO:0051338 263 0.227
b cell activation GO:0042113 161 0.222
intracellular mrna localization GO:0008298 4 0.222
peptidyl serine phosphorylation GO:0018105 74 0.221
negative regulation of cell cycle arrest GO:0071157 1 0.220
positive regulation of g2 m transition of mitotic cell cycle GO:0010971 5 0.216
b cell proliferation GO:0042100 53 0.208
positive regulation of programmed cell death GO:0043068 218 0.206
atp catabolic process GO:0006200 55 0.203
gland development GO:0048732 330 0.202
signal transduction in response to dna damage GO:0042770 21 0.201
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 18 0.200
female gonad development GO:0008585 71 0.200
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.195
regulation of protein stability GO:0031647 52 0.192
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.192
gonad development GO:0008406 141 0.192
response to organonitrogen compound GO:0010243 246 0.191
Human
t cell receptor v d j recombination GO:0033153 5 0.188
leukocyte proliferation GO:0070661 172 0.187
neuron migration GO:0001764 122 0.186
histone h3 k9 methylation GO:0051567 17 0.185
cellular amino acid metabolic process GO:0006520 103 0.184
protein oligomerization GO:0051259 67 0.184
regulation of chromatin modification GO:1903308 57 0.183
nucleoside monophosphate catabolic process GO:0009125 59 0.182
regulation of mitotic metaphase anaphase transition GO:0030071 8 0.180
nucleoside phosphate catabolic process GO:1901292 222 0.178
cellular ketone metabolic process GO:0042180 84 0.176
Human
nucleoside monophosphate metabolic process GO:0009123 85 0.176
purine nucleoside triphosphate metabolic process GO:0009144 226 0.175
nucleobase containing small molecule metabolic process GO:0055086 352 0.174
histone modification GO:0016570 159 0.173
mitotic cytokinesis GO:0000281 4 0.173
response to metal ion GO:0010038 47 0.167
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.166
protein localization to chromatin GO:0071168 3 0.165
t cell activation GO:0042110 289 0.162
leukocyte mediated immunity GO:0002443 174 0.162
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.161
negative regulation of protein modification process GO:0031400 163 0.159
positive regulation of cell development GO:0010720 237 0.158
response to uv c GO:0010225 3 0.157
regulation of chromatin organization GO:1902275 57 0.155
negative regulation of mitotic sister chromatid segregation GO:0033048 7 0.155
dna endoreduplication GO:0042023 4 0.154
organophosphate catabolic process GO:0046434 232 0.151
protein ubiquitination GO:0016567 171 0.149
Human
regulation of sister chromatid cohesion GO:0007063 5 0.149
actin filament organization GO:0007015 113 0.149
cellular protein catabolic process GO:0044257 155 0.146
dendrite development GO:0016358 115 0.145
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.145
regulation of histone methylation GO:0031060 30 0.144
nucleoside phosphate metabolic process GO:0006753 338 0.143
purine ribonucleoside catabolic process GO:0046130 205 0.143
positive regulation of cell cycle process GO:0090068 61 0.143
Human
positive regulation of apoptotic signaling pathway GO:2001235 95 0.143
isotype switching GO:0045190 36 0.143
female sex differentiation GO:0046660 84 0.142
positive regulation of response to dna damage stimulus GO:2001022 14 0.142
Human
spindle assembly involved in mitosis GO:0090307 4 0.140
negative regulation of cellular senescence GO:2000773 3 0.140
lymphocyte differentiation GO:0030098 242 0.139
negative regulation of mitotic metaphase anaphase transition GO:0045841 7 0.138
homeostasis of number of cells GO:0048872 210 0.136
ribonucleoside triphosphate metabolic process GO:0009199 220 0.135
regulation of dna templated transcription in response to stress GO:0043620 9 0.135
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 24 0.134
dna catabolic process endonucleolytic GO:0000737 15 0.133
positive regulation of chromosome segregation GO:0051984 4 0.132
nucleoside metabolic process GO:0009116 246 0.131
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.130
positive regulation of protein autophosphorylation GO:0031954 4 0.130
negative regulation of phosphate metabolic process GO:0045936 184 0.130
regulation of cellular protein catabolic process GO:1903362 61 0.130
amine metabolic process GO:0009308 45 0.128
cellular response to inorganic substance GO:0071241 37 0.128
leukocyte activation involved in immune response GO:0002366 126 0.126
cellular response to growth factor stimulus GO:0071363 197 0.126
regulation of protein kinase activity GO:0045859 232 0.123
negative regulation of chromosome organization GO:2001251 30 0.122
regulation of histone modification GO:0031056 56 0.121
synapsis GO:0007129 34 0.119
negative regulation of protein depolymerization GO:1901880 21 0.119
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.117
spindle checkpoint GO:0031577 12 0.115
regulation of apoptotic signaling pathway GO:2001233 197 0.114
Human
negative regulation of cellular catabolic process GO:0031330 47 0.112
positive regulation of transferase activity GO:0051347 167 0.111
negative regulation of cell cycle g1 s phase transition GO:1902807 18 0.111
digestive system development GO:0055123 200 0.109
mitotic cell cycle arrest GO:0071850 4 0.109
b cell lineage commitment GO:0002326 4 0.109
erythrocyte differentiation GO:0030218 88 0.109
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.106
positive regulation of cell death GO:0010942 224 0.106
stem cell development GO:0048864 219 0.105
spindle organization GO:0007051 28 0.103
positive regulation of nervous system development GO:0051962 221 0.101
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.101
neuron apoptotic process GO:0051402 142 0.101
cell fate commitment GO:0045165 210 0.101
regulation of cellular ketone metabolic process GO:0010565 66 0.101
Human
dna ligation GO:0006266 3 0.100
regulation of cytoskeleton organization GO:0051493 122 0.098
negative regulation of protein metabolic process GO:0051248 282 0.098
pole plasm assembly GO:0007315 2 0.097
posttranscriptional regulation of gene expression GO:0010608 155 0.097
t cell proliferation GO:0042098 120 0.095
establishment of organelle localization GO:0051656 122 0.094
nucleoside triphosphate catabolic process GO:0009143 205 0.094
regulation of sister chromatid segregation GO:0033045 13 0.093
regulation of proteasomal protein catabolic process GO:0061136 46 0.092
positive regulation of cellular amine metabolic process GO:0033240 5 0.092
negative regulation of mitotic sister chromatid separation GO:2000816 7 0.091
regulation of cytoplasmic transport GO:1903649 112 0.088
atp metabolic process GO:0046034 75 0.088
purine containing compound catabolic process GO:0072523 213 0.088
cellular response to organonitrogen compound GO:0071417 145 0.087
Human
cell growth GO:0016049 130 0.087
regulation of intracellular protein transport GO:0033157 82 0.087
nucleotide excision repair GO:0006289 13 0.087
purine ribonucleoside metabolic process GO:0046128 241 0.086
regulation of lymphocyte activation GO:0051249 240 0.085
regulation of mitotic sister chromatid separation GO:0010965 12 0.085
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.083
mitotic chromosome condensation GO:0007076 1 0.083
regulation of leukocyte proliferation GO:0070663 121 0.083
positive regulation of keratinocyte proliferation GO:0010838 4 0.081
negative regulation of lipid kinase activity GO:0090219 1 0.081
ribonucleoside metabolic process GO:0009119 245 0.080
purine nucleoside metabolic process GO:0042278 241 0.079
regulation of proteolysis GO:0030162 164 0.079
developmental maturation GO:0021700 193 0.079
negative regulation of sister chromatid segregation GO:0033046 7 0.076
purine ribonucleotide catabolic process GO:0009154 208 0.076
negative regulation of kinase activity GO:0033673 81 0.075
glial cell apoptotic process GO:0034349 3 0.074
b cell activation involved in immune response GO:0002312 50 0.074
methylation GO:0032259 134 0.074
negative regulation of protein phosphorylation GO:0001933 126 0.073
branching morphogenesis of an epithelial tube GO:0048754 159 0.073
stem cell differentiation GO:0048863 268 0.073
adaptive immune response GO:0002250 155 0.072
rna localization GO:0006403 23 0.071
peptidyl tyrosine phosphorylation GO:0018108 143 0.071
negative regulation of mitosis GO:0045839 10 0.070
sister chromatid cohesion GO:0007062 12 0.070
negative regulation of growth GO:0045926 99 0.070
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.070
cellular lipid metabolic process GO:0044255 323 0.070
Human
histone threonine phosphorylation GO:0035405 1 0.069
regulation of neuron differentiation GO:0045664 281 0.069
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.069
regulation of meiosis i GO:0060631 7 0.069
positive regulation of neuron differentiation GO:0045666 141 0.068
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 6 0.068
regulation of protein targeting GO:1903533 61 0.068
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.067
membrane organization GO:0061024 245 0.067
organonitrogen compound catabolic process GO:1901565 264 0.067
ribonucleoside monophosphate metabolic process GO:0009161 80 0.067
cellular amine metabolic process GO:0044106 44 0.067
positive regulation of chromosome organization GO:2001252 33 0.067
positive regulation of growth GO:0045927 104 0.066
negative regulation of lymphocyte proliferation GO:0050672 45 0.066
base excision repair GO:0006284 9 0.066
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.065
multicellular organism growth GO:0035264 161 0.065
negative regulation of proteolysis GO:0045861 74 0.064
centriole assembly GO:0098534 6 0.064
regulation of histone acetylation GO:0035065 19 0.063
spindle assembly involved in female meiosis GO:0007056 3 0.063
internal protein amino acid acetylation GO:0006475 42 0.062
chromatin assembly GO:0031497 13 0.062
positive regulation of organelle organization GO:0010638 128 0.062
negative regulation of phosphorylation GO:0042326 166 0.061
negative regulation of b cell activation GO:0050869 27 0.061
cerebrospinal fluid secretion GO:0033326 4 0.061
cellular protein complex assembly GO:0043623 116 0.061
spindle assembly GO:0051225 13 0.061
astral microtubule organization GO:0030953 3 0.060
mitotic spindle organization GO:0007052 10 0.060
histone mrna metabolic process GO:0008334 3 0.060
negative regulation of cell activation GO:0050866 111 0.060
t cell differentiation GO:0030217 174 0.060
negative regulation of leukocyte proliferation GO:0070664 46 0.060
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 8 0.060
skeletal muscle organ development GO:0060538 163 0.060
regulation of microtubule depolymerization GO:0031114 13 0.060
t cell differentiation in thymus GO:0033077 77 0.059
traversing start control point of mitotic cell cycle GO:0007089 2 0.058
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.058
myeloid cell differentiation GO:0030099 233 0.058
regulation of protein depolymerization GO:1901879 26 0.058
leukocyte differentiation GO:0002521 342 0.057
dna hypermethylation GO:0044026 3 0.057
negative regulation of protein catabolic process GO:0042177 36 0.057
embryonic organ morphogenesis GO:0048562 276 0.056
ribose phosphate metabolic process GO:0019693 291 0.056
regulation of cellular amino acid metabolic process GO:0006521 5 0.056
regulation of cell activation GO:0050865 289 0.056
negative regulation of phosphorus metabolic process GO:0010563 184 0.056
dna replication checkpoint GO:0000076 2 0.055
establishment or maintenance of cell polarity GO:0007163 86 0.055
mitochondrion organization GO:0007005 134 0.055
nucleotide metabolic process GO:0009117 332 0.055
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.055
somatic diversification of t cell receptor genes GO:0002568 5 0.054
positive regulation of histone h3 k27 methylation GO:0061087 4 0.054
immune effector process GO:0002252 321 0.053
regulation of protein maturation GO:1903317 96 0.052
organelle localization GO:0051640 179 0.052
protein modification by small protein conjugation GO:0032446 187 0.052
Human
positive regulation of kinase activity GO:0033674 155 0.052
positive regulation of transcription by galactose GO:0000411 1 0.051
regulation of neuron death GO:1901214 134 0.050
regulation of microtubule cytoskeleton organization GO:0070507 37 0.050
negative regulation of immature t cell proliferation GO:0033087 3 0.050
modification dependent macromolecule catabolic process GO:0043632 133 0.050
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.049
purine nucleoside triphosphate catabolic process GO:0009146 203 0.049
regulation of meiotic cell cycle GO:0051445 34 0.049
regulation of protein binding GO:0043393 60 0.048
regulation of innate immune response GO:0045088 91 0.048
muscle cell differentiation GO:0042692 261 0.048
regulation of hydrolase activity GO:0051336 246 0.047
photoreceptor cell differentiation GO:0046530 52 0.047
small gtpase mediated signal transduction GO:0007264 97 0.047

Brca1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
organ system cancer DOID:0050686 0 0.999
Human
cancer DOID:162 0 0.999
Human
disease of cellular proliferation DOID:14566 0 0.999
Human
endocrine gland cancer DOID:170 0 0.992
Human
disease of anatomical entity DOID:7 0 0.991
bone marrow disease DOID:4961 0 0.991
immune system disease DOID:2914 0 0.991
hematopoietic system disease DOID:74 0 0.991
aplastic anemia DOID:12449 0 0.991
anemia DOID:2355 0 0.991
thoracic cancer DOID:5093 0 0.989
congenital hypoplastic anemia DOID:1342 0 0.989
fanconi s anemia DOID:13636 0 0.981
breast cancer DOID:1612 0 0.913
urinary system cancer DOID:3996 0 0.626
kidney cancer DOID:263 0 0.626
pancreatic cancer DOID:1793 0 0.608
Human
prostate cancer DOID:10283 0 0.533
male reproductive organ cancer DOID:3856 0 0.533
reproductive organ cancer DOID:193 0 0.533
immune system cancer DOID:0060083 0 0.361
hematologic cancer DOID:2531 0 0.361
large intestine cancer DOID:5672 0 0.164
colon cancer DOID:219 0 0.164
colorectal cancer DOID:9256 0 0.164
intestinal cancer DOID:10155 0 0.164
gastrointestinal system cancer DOID:3119 0 0.164
nervous system cancer DOID:3093 0 0.055
central nervous system cancer DOID:3620 0 0.055
renal cell carcinoma DOID:4450 0 0.054
renal carcinoma DOID:4451 0 0.054