Mus musculus

78 known processes

Casp4

caspase 4, apoptosis-related cysteine peptidase

(Aliases: Casp11,Caspl,ich-3)

Casp4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of necroptotic process GO:0060546 9 1.000
Mouse
defense response to other organism GO:0098542 197 1.000
cellular response to molecule of bacterial origin GO:0071219 83 1.000
cellular response to lipopolysaccharide GO:0071222 77 1.000
cellular response to biotic stimulus GO:0071216 92 1.000
regulation of defense response to bacterium GO:1900424 3 1.000
activation of innate immune response GO:0002218 56 1.000
positive regulation of cytokine production GO:0001819 174 1.000
positive regulation of defense response GO:0031349 124 0.999
regulation of defense response GO:0031347 233 0.999
Mouse
cellular response to interferon beta GO:0035458 21 0.999
response to molecule of bacterial origin GO:0002237 143 0.999
Mouse
i kappab kinase nf kappab signaling GO:0007249 85 0.999
Mouse
inflammatory response GO:0006954 244 0.999
Mouse
antibacterial peptide production GO:0002778 2 0.999
antibacterial peptide biosynthetic process GO:0002780 2 0.999
cellular response to cytokine stimulus GO:0071345 189 0.999
positive regulation of innate immune response GO:0045089 80 0.999
necroptotic process GO:0070266 21 0.999
Mouse
response to lipopolysaccharide GO:0032496 128 0.998
Mouse
response to atp GO:0033198 8 0.998
Mouse
positive regulation of peptidase activity GO:0010952 49 0.998
Mouse Fly
positive regulation of interleukin 8 production GO:0032757 2 0.998
regulation of necroptotic process GO:0060544 10 0.998
Mouse
antibacterial humoral response GO:0019731 8 0.998
positive regulation of antimicrobial peptide production GO:0002225 1 0.998
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.997
negative regulation of cytokine production GO:0001818 84 0.997
defense response to virus GO:0051607 68 0.997
regulation of cytokine production GO:0001817 266 0.997
positive regulation of interleukin 1 secretion GO:0050716 14 0.997
regulation of defense response to virus GO:0050688 18 0.997
regulation of innate immune response GO:0045088 91 0.997
regulation of response to biotic stimulus GO:0002831 38 0.997
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.997
regulation of protein import into nucleus GO:0042306 52 0.997
cytokine production GO:0001816 319 0.996
regulation of necrotic cell death GO:0010939 13 0.996
Mouse
regulation of protein transport GO:0051223 163 0.996
regulation of interleukin 1 production GO:0032652 26 0.995
defense response to gram positive bacterium GO:0050830 50 0.995
regulation of protein targeting GO:1903533 61 0.995
interspecies interaction between organisms GO:0044419 83 0.995
antimicrobial peptide production GO:0002775 2 0.995
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.995
Mouse Fly
positive regulation of interleukin 1 beta production GO:0032731 16 0.994
regulation of antibacterial peptide production GO:0002786 1 0.994
regulation of defense response to virus by host GO:0050691 8 0.994
positive regulation of cytokine secretion GO:0050715 41 0.993
interleukin 1 beta production GO:0032611 30 0.993
regulation of establishment of protein localization GO:0070201 181 0.993
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.992
defense response to bacterium GO:0042742 119 0.991
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.991
interleukin 1 production GO:0032612 31 0.991
regulation of inflammatory response GO:0050727 147 0.989
Mouse
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.988
regulation of multi organism process GO:0043900 111 0.988
immune effector process GO:0002252 321 0.988
pyroptosis GO:0070269 8 0.987
chemokine production GO:0032602 34 0.986
activation of immune response GO:0002253 138 0.986
regulation of circadian sleep wake cycle non rem sleep GO:0045188 1 0.985
regulation of interferon gamma production GO:0032649 57 0.985
antimicrobial peptide biosynthetic process GO:0002777 2 0.984
interleukin 8 production GO:0032637 4 0.983
regulation of lymphocyte proliferation GO:0050670 117 0.983
Mouse
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.982
innate immune response GO:0045087 157 0.982
Fly
adaptive immune response GO:0002250 155 0.982
positive regulation of defense response to bacterium GO:1900426 1 0.981
positive regulation of interleukin 1 alpha production GO:0032730 4 0.981
Mouse
regulation of antimicrobial humoral response GO:0002759 3 0.979
regulation of antimicrobial peptide production GO:0002784 1 0.978
immune response regulating signaling pathway GO:0002764 125 0.977
regulation of interleukin 6 production GO:0032675 55 0.977
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.976
Mouse Fly
positive regulation of secretion by cell GO:1903532 114 0.975
t cell proliferation GO:0042098 120 0.974
Mouse
interleukin 1 beta secretion GO:0050702 16 0.973
regulation of apoptotic dna fragmentation GO:1902510 5 0.972
Mouse
interleukin 1 secretion GO:0050701 16 0.972
positive regulation of interleukin 1 beta secretion GO:0050718 14 0.972
regulation of circadian sleep wake cycle GO:0042749 3 0.972
interleukin 1 alpha secretion GO:0050703 3 0.971
Mouse
regulation of protein localization GO:0032880 231 0.970
dna catabolic process endonucleolytic GO:0000737 15 0.969
Mouse
positive regulation of antimicrobial humoral response GO:0002760 2 0.969
regulation of protein localization to nucleus GO:1900180 60 0.969
establishment of protein localization to organelle GO:0072594 118 0.968
protein localization to organelle GO:0033365 185 0.968
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.967
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.966
Mouse
nuclear import GO:0051170 95 0.966
positive regulation of interleukin 1 alpha secretion GO:0050717 3 0.965
Mouse
inflammatory response to wounding GO:0090594 4 0.965
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.965
regulation of endopeptidase activity GO:0052548 89 0.965
Mouse Fly
apoptotic mitochondrial changes GO:0008637 48 0.965
Mouse
pattern recognition receptor signaling pathway GO:0002221 47 0.964
positive regulation of protein secretion GO:0050714 52 0.964
protein secretion GO:0009306 111 0.964
regulation of intracellular protein transport GO:0033157 82 0.964
regulation of proteolysis GO:0030162 164 0.963
Mouse Fly
cellular response to glucocorticoid stimulus GO:0071385 13 0.962
Mouse
defense response to protozoan GO:0042832 25 0.959
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 4 0.959
Fly
positive regulation of proteolysis GO:0045862 85 0.958
Mouse Fly
response to endoplasmic reticulum stress GO:0034976 53 0.957
Mouse
positive regulation of programmed cell death GO:0043068 218 0.956
Mouse Fly
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.956
single organism nuclear import GO:1902593 95 0.954
regulation of response to wounding GO:1903034 189 0.953
Mouse
leukocyte activation involved in immune response GO:0002366 126 0.950
positive regulation of apoptotic process GO:0043065 217 0.950
Mouse Fly
production of molecular mediator of immune response GO:0002440 103 0.949
membrane hyperpolarization GO:0060081 21 0.943
Mouse
regulation of nucleocytoplasmic transport GO:0046822 73 0.942
positive regulation of protein transport GO:0051222 93 0.940
negative regulation of phosphorus metabolic process GO:0010563 184 0.940
Mouse
regulation of execution phase of apoptosis GO:1900117 9 0.937
Mouse
regulation of leukocyte proliferation GO:0070663 121 0.934
Mouse
regulation of t cell activation GO:0050863 170 0.933
Mouse
t cell activation GO:0042110 289 0.931
Mouse
positive regulation of interleukin 1 production GO:0032732 17 0.931
regulation of reactive oxygen species metabolic process GO:2000377 40 0.929
wound healing involved in inflammatory response GO:0002246 4 0.925
regulation of stress activated mapk cascade GO:0032872 69 0.923
defense response to gram negative bacterium GO:0050829 28 0.920
protein localization to nucleus GO:0034504 121 0.920
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.919
regulation of peptidase activity GO:0052547 96 0.919
Mouse Fly
zymogen activation GO:0031638 41 0.917
Mouse Fly
regulation of type i interferon production GO:0032479 22 0.916
regulation of lymphocyte apoptotic process GO:0070228 41 0.915
Mouse
jnk cascade GO:0007254 72 0.915
regulation of cell activation GO:0050865 289 0.911
Mouse
regulation of chemokine production GO:0032642 30 0.906
positive regulation of endopeptidase activity GO:0010950 43 0.905
Mouse Fly
regulation of adaptive immune response GO:0002819 90 0.905
nucleocytoplasmic transport GO:0006913 139 0.903
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 3 0.900
Fly
cell activation involved in immune response GO:0002263 126 0.899
regulation of t cell proliferation GO:0042129 92 0.896
Mouse
regulation of cytokine secretion GO:0050707 61 0.896
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.895
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.895
Mouse Fly
membrane depolarization GO:0051899 64 0.895
Mouse
toll like receptor signaling pathway GO:0002224 38 0.893
regulation of cysteine type endopeptidase activity GO:2000116 65 0.892
Mouse Fly
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.891
Mouse
positive regulation of defense response to virus by host GO:0002230 6 0.891
circadian behavior GO:0048512 13 0.891
positive regulation of secretion GO:0051047 130 0.884
interleukin 6 production GO:0032635 58 0.882
regulation of interferon alpha production GO:0032647 5 0.881
type i interferon production GO:0032606 29 0.880
regulation of interleukin 1 secretion GO:0050704 15 0.878
tumor necrosis factor production GO:0032640 50 0.878
regulation of leukocyte apoptotic process GO:2000106 56 0.877
Mouse
regulation of jnk cascade GO:0046328 62 0.876
intrinsic apoptotic signaling pathway GO:0097193 132 0.872
Mouse
regulation of hydrolase activity GO:0051336 246 0.871
Mouse Fly
intracellular protein transport GO:0006886 204 0.868
activation of cysteine type endopeptidase activity GO:0097202 27 0.867
Mouse Fly
cytoplasmic transport GO:0016482 234 0.866
apoptotic dna fragmentation GO:0006309 7 0.865
Mouse
positive regulation of immune effector process GO:0002699 107 0.864
glial cell apoptotic process GO:0034349 3 0.863
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.863
Mouse
connective tissue replacement involved in inflammatory response wound healing GO:0002248 3 0.861
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.860
immune response activating signal transduction GO:0002757 116 0.858
peptide biosynthetic process GO:0043043 11 0.857
extrinsic apoptotic signaling pathway GO:0097191 126 0.856
Mouse
sperm individualization GO:0007291 1 0.856
Fly
lymphocyte proliferation GO:0046651 164 0.855
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.854
Mouse
positive regulation of interleukin 6 production GO:0032755 37 0.849
cellular response to interferon gamma GO:0071346 25 0.849
cellular amide metabolic process GO:0043603 58 0.843
positive regulation of interferon gamma production GO:0032729 39 0.843
phagocytosis GO:0006909 66 0.843
Worm
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.843
Mouse
cellular component disassembly involved in execution phase of apoptosis GO:0006921 9 0.841
Mouse
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.840
Mouse
regulation of interleukin 1 alpha production GO:0032650 4 0.839
Mouse
positive regulation of chemokine production GO:0032722 22 0.837
interferon beta biosynthetic process GO:0045350 4 0.836
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.835
keratinocyte differentiation GO:0030216 48 0.834
Mouse
regulation of defense response to fungus GO:1900150 1 0.833
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.833
Mouse Fly
protein import into nucleus GO:0006606 95 0.832
protein targeting GO:0006605 143 0.831
negative regulation of immune system process GO:0002683 209 0.830
Mouse
cellular response to dna damage stimulus GO:0006974 207 0.829
Mouse
cellular response to lipid GO:0071396 145 0.829
Mouse
positive regulation of cell death GO:0010942 224 0.828
Mouse Fly
homeostasis of number of cells GO:0048872 210 0.826
Mouse
compound eye development GO:0048749 1 0.825
Fly
stress activated protein kinase signaling cascade GO:0031098 81 0.824
positive regulation of adaptive immune response GO:0002821 61 0.824
b cell mediated immunity GO:0019724 71 0.824
positive regulation of hydrolase activity GO:0051345 148 0.822
Mouse Fly
protein ubiquitination GO:0016567 171 0.822
regulation of intracellular transport GO:0032386 159 0.819
regulation of interleukin 10 secretion GO:2001179 4 0.819
leukocyte proliferation GO:0070661 172 0.815
Mouse
immunoglobulin mediated immune response GO:0016064 69 0.807
positive regulation of response to biotic stimulus GO:0002833 15 0.805
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.804
positive regulation of interleukin 6 secretion GO:2000778 1 0.803
regulation of secretion GO:0051046 274 0.797
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.793
Mouse Fly
regulation of lymphocyte activation GO:0051249 240 0.792
Mouse
apoptotic signaling pathway GO:0097190 306 0.787
Mouse Fly
cellular response to organic cyclic compound GO:0071407 87 0.787
Mouse
cellular response to peptidoglycan GO:0071224 4 0.785
innate immune response activating signal transduction GO:0002758 50 0.784
cytokine secretion GO:0050663 72 0.780
mitochondrion organization GO:0007005 134 0.779
Mouse
autophagy GO:0006914 45 0.777
Mouse Fly
regulation of acute inflammatory response GO:0002673 27 0.774
positive regulation of neutrophil mediated killing of symbiont cell GO:0070961 1 0.772
response to interleukin 1 GO:0070555 11 0.772
positive regulation of chemokine secretion GO:0090197 4 0.771
cellularization GO:0007349 1 0.771
Fly
leukocyte differentiation GO:0002521 342 0.770
Mouse
detection of molecule of bacterial origin GO:0032490 2 0.769
peptide transport GO:0015833 133 0.767
thymocyte apoptotic process GO:0070242 19 0.766
Mouse
positive regulation of jnk cascade GO:0046330 46 0.765
regulation of tumor necrosis factor production GO:0032680 49 0.764
negative regulation of protein transport GO:0051224 46 0.753
lymphocyte apoptotic process GO:0070227 54 0.752
Mouse
positive regulation of interleukin 8 secretion GO:2000484 1 0.751
negative regulation of phosphate metabolic process GO:0045936 184 0.751
Mouse
regulation of production of molecular mediator of immune response GO:0002700 65 0.748
stress activated mapk cascade GO:0051403 80 0.748
negative regulation of protein phosphorylation GO:0001933 126 0.747
Mouse
negative regulation of leukocyte proliferation GO:0070664 46 0.744
Mouse
negative regulation of phosphorylation GO:0042326 166 0.744
Mouse
response to dexamethasone GO:0071548 8 0.743
Mouse
mitochondrial depolarization GO:0051882 6 0.739
Mouse
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.736
regulation of thymocyte apoptotic process GO:0070243 14 0.735
Mouse
protein maturation GO:0051604 176 0.732
Mouse Worm Fly
negative regulation of activated t cell proliferation GO:0046007 7 0.731
Mouse
regulation of secretion by cell GO:1903530 249 0.731
cellular response to corticosteroid stimulus GO:0071384 13 0.726
Mouse
regulation of transcription factor import into nucleus GO:0042990 24 0.724
b cell proliferation GO:0042100 53 0.716
Mouse
negative regulation of t cell activation GO:0050868 65 0.716
Mouse
regulation of interleukin 1 beta secretion GO:0050706 15 0.708
positive regulation of lymphocyte activation GO:0051251 140 0.705
regulation of interleukin 18 production GO:0032661 3 0.704
neutrophil mediated killing of gram negative bacterium GO:0070945 4 0.702
regulation of protein secretion GO:0050708 82 0.702
regulation of protein serine threonine kinase activity GO:0071900 157 0.701
Mouse
protein autoprocessing GO:0016540 2 0.700
Worm Fly
release of cytochrome c from mitochondria GO:0001836 23 0.699
Mouse
positive regulation of protein import into nucleus GO:0042307 26 0.683
engulfment of apoptotic cell GO:0043652 3 0.682
Worm
cytokine mediated signaling pathway GO:0019221 115 0.676
syncytium formation by plasma membrane fusion GO:0000768 42 0.672
positive regulation of organelle organization GO:0010638 128 0.671
lymphocyte activation involved in immune response GO:0002285 93 0.667
mapk cascade GO:0000165 281 0.666
protein import GO:0017038 101 0.665
regulation of interleukin 1 beta production GO:0032651 25 0.664
response to organophosphorus GO:0046683 22 0.663
Mouse
interferon beta production GO:0032608 16 0.661
response to interferon beta GO:0035456 22 0.645
positive regulation of lymphocyte proliferation GO:0050671 70 0.641
organonitrogen compound biosynthetic process GO:1901566 192 0.641
leukocyte apoptotic process GO:0071887 71 0.640
Mouse
regulation of neutrophil mediated killing of gram negative bacterium GO:0070951 1 0.640
hepatocyte apoptotic process GO:0097284 11 0.634
Mouse
t cell apoptotic process GO:0070231 39 0.629
Mouse
pigment metabolic process GO:0042440 32 0.628
Fly
b cell activation GO:0042113 161 0.618
Mouse
regulation of b cell activation GO:0050864 81 0.617
Mouse
negative regulation of lymphocyte proliferation GO:0050672 45 0.612
Mouse
secondary metabolic process GO:0019748 18 0.611
Fly
negative regulation of protein modification process GO:0031400 163 0.607
Mouse
positive regulation of leukocyte proliferation GO:0070665 73 0.604
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.603
positive regulation of stress activated mapk cascade GO:0032874 48 0.600
protein processing GO:0016485 163 0.598
Mouse Worm Fly
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.596
Mouse
negative regulation of interleukin 6 production GO:0032715 17 0.596
positive regulation of transcription factor import into nucleus GO:0042993 8 0.594
response to organic cyclic compound GO:0014070 198 0.594
Mouse
regulation of growth of symbiont in host GO:0044126 19 0.589
er nucleus signaling pathway GO:0006984 27 0.585
Mouse
peptide metabolic process GO:0006518 46 0.583
cellular nitrogen compound catabolic process GO:0044270 280 0.577
Mouse
fat soluble vitamin biosynthetic process GO:0042362 4 0.570
response to tumor necrosis factor GO:0034612 26 0.570
circadian sleep wake cycle GO:0042745 5 0.559
regulation of vitamin d biosynthetic process GO:0060556 1 0.556
positive regulation of apoptotic signaling pathway GO:2001235 95 0.556
Mouse Fly
macromolecule catabolic process GO:0009057 281 0.555
Mouse Worm
negative regulation of cell proliferation GO:0008285 296 0.554
Mouse Fly
positive regulation of phagocytosis GO:0050766 26 0.553
negative regulation of t cell proliferation GO:0042130 38 0.553
Mouse
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.551
Mouse
regulation of nucleotide binding oligomerization domain containing signaling pathway GO:0070424 3 0.551
positive regulation of neutrophil mediated cytotoxicity GO:0070960 1 0.547
activation of mapk activity involved in innate immune response GO:0035419 2 0.547
regulation of interleukin 10 production GO:0032653 21 0.544
macrophage differentiation GO:0030225 20 0.543
Mouse
acute inflammatory response GO:0002526 41 0.536
dna metabolic process GO:0006259 303 0.536
Mouse
interleukin 18 mediated signaling pathway GO:0035655 2 0.535
regulation of autophagy GO:0010506 30 0.534
Mouse Fly
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.534
reactive nitrogen species metabolic process GO:2001057 0 0.533
cytokine metabolic process GO:0042107 71 0.532
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.530
myeloid leukocyte activation GO:0002274 83 0.530
positive regulation of interleukin 10 secretion GO:2001181 1 0.530
myeloid cell differentiation GO:0030099 233 0.529
Mouse
cellular response to hormone stimulus GO:0032870 150 0.526
Mouse
regulation of interleukin 8 secretion GO:2000482 2 0.525
regulation of chemokine secretion GO:0090196 4 0.524
positive regulation of neuron death GO:1901216 28 0.518
Mouse
midgut development GO:0007494 4 0.516
cell fate commitment GO:0045165 210 0.516
Mouse
aromatic compound catabolic process GO:0019439 286 0.514
Mouse
regulation of kinase activity GO:0043549 249 0.514
Mouse
response to protozoan GO:0001562 28 0.513
positive regulation of t cell proliferation GO:0042102 52 0.510
protein oligomerization GO:0051259 67 0.507
Fly
toxin transport GO:1901998 38 0.505
Mouse
negative regulation of growth of symbiont in host GO:0044130 19 0.504
positive regulation by symbiont of defense related host nitric oxide production GO:0052347 1 0.504
peripheral nervous system neuron differentiation GO:0048934 9 0.503
positive regulation of t cell activation GO:0050870 101 0.502
regulation of cellular catabolic process GO:0031329 242 0.501
Mouse Fly
protein modification by small protein conjugation or removal GO:0070647 207 0.499
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.499
negative regulation of molecular function GO:0044092 258 0.499
Mouse
immunoglobulin production GO:0002377 73 0.495
monocyte chemotactic protein 1 production GO:0071605 1 0.489
protein complex localization GO:0031503 19 0.486
regulation of cytoplasmic transport GO:1903649 112 0.486
regulation of protein kinase activity GO:0045859 232 0.486
Mouse
nuclear transport GO:0051169 139 0.484
protein catabolic process GO:0030163 221 0.482
Worm
macrophage activation GO:0042116 27 0.480
positive regulation of antibacterial peptide production GO:0002803 1 0.473
reactive oxygen species metabolic process GO:0072593 84 0.473
regulation of b cell proliferation GO:0030888 39 0.472
Mouse
response to dsrna GO:0043331 30 0.464
negative regulation of transferase activity GO:0051348 85 0.462
Mouse
regulation of transferase activity GO:0051338 263 0.462
Mouse
positive regulation of release of cytochrome c from mitochondria GO:0090200 5 0.461
regulation of interleukin 8 production GO:0032677 3 0.461
response to peptide GO:1901652 136 0.459
microglial cell activation GO:0001774 3 0.456
negative regulation of protein localization to nucleus GO:1900181 23 0.452
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 6 0.446
regulation of prostaglandin endoperoxide synthase activity GO:0060584 2 0.445
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.444
inflammatory response to antigenic stimulus GO:0002437 30 0.442
cellular response to dexamethasone stimulus GO:0071549 8 0.437
Mouse
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.435
response to corticosteroid GO:0031960 20 0.434
Mouse
heterocycle catabolic process GO:0046700 280 0.432
Mouse
regulation of peptide transport GO:0090087 91 0.428
negative regulation of cell activation GO:0050866 111 0.427
Mouse
positive regulation of cytokine biosynthetic process GO:0042108 40 0.425
organic cyclic compound catabolic process GO:1901361 295 0.425
Mouse
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.420
interferon gamma production GO:0032609 67 0.414
negative regulation of myoblast differentiation GO:0045662 18 0.413
regulation of heat generation GO:0031650 8 0.411
regulation of fever generation GO:0031620 6 0.407
interleukin 18 production GO:0032621 4 0.405
acute phase response GO:0006953 10 0.402
sensory perception of sound GO:0007605 97 0.401
Mouse
regulation of skeletal muscle fiber development GO:0048742 36 0.399
myeloid leukocyte differentiation GO:0002573 119 0.392
Mouse
blood vessel morphogenesis GO:0048514 285 0.386
Mouse
fever generation GO:0001660 7 0.385
positive regulation of humoral immune response GO:0002922 11 0.378
regulation of t cell mediated immunity GO:0002709 34 0.376
neuron death GO:0070997 154 0.374
Mouse
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.367
adhesion of symbiont to host GO:0044406 8 0.366
chemokine secretion GO:0090195 5 0.365
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.356
growth involved in symbiotic interaction GO:0044110 23 0.356
humoral immune response GO:0006959 57 0.353
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.353
regulation of fatty acid transport GO:2000191 10 0.352
negative regulation of protein import into nucleus GO:0042308 21 0.352
interleukin 6 secretion GO:0072604 3 0.350
syncytium formation GO:0006949 43 0.347
nitrogen compound transport GO:0071705 271 0.343
reactive oxygen species biosynthetic process GO:1903409 8 0.342
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.339
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.333
positive regulation of acute inflammatory response GO:0002675 16 0.333
positive regulation of inflammatory response GO:0050729 47 0.330
response to ketone GO:1901654 15 0.329
Mouse
positive regulation of chemokine biosynthetic process GO:0045080 6 0.325
striated muscle tissue development GO:0014706 293 0.324
cellular response to alcohol GO:0097306 23 0.318
Mouse
lymphocyte homeostasis GO:0002260 64 0.316
Mouse
positive regulation of intracellular protein transport GO:0090316 42 0.314
defense response to fungus GO:0050832 12 0.313
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.309
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070428 3 0.307
t cell homeostasis GO:0043029 35 0.299
Mouse
transcription factor import into nucleus GO:0042991 26 0.298
positive regulation of b cell mediated immunity GO:0002714 26 0.297
positive regulation of interleukin 10 production GO:0032733 12 0.292
purine containing compound metabolic process GO:0072521 311 0.292
skin development GO:0043588 220 0.292
Mouse
t helper 2 cell cytokine production GO:0035745 4 0.291
growth of symbiont in host GO:0044117 23 0.288
regulation of mitochondrial membrane potential GO:0051881 17 0.288
Mouse
negative regulation of macrophage apoptotic process GO:2000110 3 0.285
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.278
regulation of neuron death GO:1901214 134 0.275
Mouse
regulation of humoral immune response GO:0002920 22 0.275
negative regulation of nik nf kappab signaling GO:1901223 2 0.274
leukocyte mediated immunity GO:0002443 174 0.273
glycosyl compound catabolic process GO:1901658 206 0.271
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.270
cell type specific apoptotic process GO:0097285 268 0.267
Mouse Fly
angiogenesis GO:0001525 201 0.265
Mouse
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.265
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 5 0.263
positive regulation of cytoplasmic transport GO:1903651 40 0.263
induction by organism of immune response of other organism involved in symbiotic interaction GO:0052558 1 0.262
antimicrobial humoral response GO:0019730 11 0.260
positive regulation of multi organism process GO:0043902 26 0.259
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 17 0.257
regulation of response to cytokine stimulus GO:0060759 23 0.256
negative regulation of interferon beta production GO:0032688 3 0.253
negative regulation of nf kappab transcription factor activity GO:0032088 15 0.253
t cell differentiation involved in immune response GO:0002292 30 0.252
negative regulation of inflammatory response GO:0050728 61 0.252
positive regulation of fever generation GO:0031622 6 0.252
regulation of protein processing GO:0070613 96 0.251
negative regulation of intracellular protein transport GO:0090317 27 0.251
nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070427 5 0.249
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.249
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.248
positive regulation of natural killer cell chemotaxis GO:2000503 1 0.248
b cell activation involved in immune response GO:0002312 50 0.248
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.247
t cell activation involved in immune response GO:0002286 43 0.245
response to purine containing compound GO:0014074 28 0.245
Mouse
myoblast differentiation GO:0045445 52 0.241
t helper 1 type immune response GO:0042088 25 0.241
response to molecule of fungal origin GO:0002238 4 0.240
neutrophil mediated killing of fungus GO:0070947 3 0.240
innate immune response in mucosa GO:0002227 3 0.239
positive regulation of neutrophil mediated killing of fungus GO:0070965 1 0.239
regulation of b cell mediated immunity GO:0002712 37 0.239
positive regulation of interleukin 18 production GO:0032741 2 0.236
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.236
helper t cell enhancement of adaptive immune response GO:0035397 1 0.233
modulation of growth of symbiont involved in interaction with host GO:0044144 19 0.231
regulation of body fluid levels GO:0050878 162 0.231
nucleoside metabolic process GO:0009116 246 0.230
epidermis development GO:0008544 187 0.227
Mouse
interleukin 2 production GO:0032623 33 0.226
interleukin 10 production GO:0032613 23 0.224
sensory perception of mechanical stimulus GO:0050954 107 0.222
Mouse
regulation of nucleotide metabolic process GO:0006140 169 0.222
positive regulation of behavior GO:0048520 40 0.220
interferon alpha production GO:0032607 7 0.220
cellular response to abiotic stimulus GO:0071214 56 0.220
t helper cell differentiation GO:0042093 28 0.219
regulation of neutrophil mediated killing of symbiont cell GO:0070949 2 0.217
rac protein signal transduction GO:0016601 13 0.215
fatty acid derivative transport GO:1901571 14 0.215
necrotic cell death GO:0070265 30 0.211
Mouse
response to organonitrogen compound GO:0010243 246 0.210
Mouse
response to peptidoglycan GO:0032494 9 0.210
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.208
chemokine metabolic process GO:0050755 10 0.207
spermatogenesis GO:0007283 284 0.201
Fly
endoplasmic reticulum unfolded protein response GO:0030968 19 0.201
Mouse
lymphocyte differentiation GO:0030098 242 0.200
wound healing GO:0042060 157 0.200
negative regulation of erk1 and erk2 cascade GO:0070373 21 0.199
nik nf kappab signaling GO:0038061 14 0.198
regulation of cellular amide metabolic process GO:0034248 10 0.198
myeloid dendritic cell activation GO:0001773 25 0.197

Casp4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.675
disease of cellular proliferation DOID:14566 0 0.675
organ system cancer DOID:0050686 0 0.412