IMP

Process View

Mus musculus

21 genes annotated in mouse

negative regulation of erk1 and erk2 cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of erk1 and erk2 cascade"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of erk1 and erk2 cascade" (in gray)

Name	Description	Probability	Func Analog Organism
Grb2	growth factor receptor bound protein 2	0.979
Cd44	CD44 antigen	0.920
Inpp5d	inositol polyphosphate-5-phosphatase D	0.845
Il10	interleukin 10	0.711
Ptprc	protein tyrosine phosphatase, receptor type, C	0.628
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.607
Dok1	docking protein 1	0.535
Cbl	Casitas B-lineage lymphoma	0.515
Ccr2	chemokine (C-C motif) receptor 2	0.480
Ptk2	PTK2 protein tyrosine kinase 2	0.459
Lepr	leptin receptor	0.429
Cd80	CD80 antigen	0.416
Myd88	myeloid differentiation primary response gene 88	0.397
Il1r1	interleukin 1 receptor, type I	0.385
Lyz2	lysozyme 2	0.334
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.317
Adam17	a disintegrin and metallopeptidase domain 17	0.305
Csf1r	colony stimulating factor 1 receptor	0.288
Mapk1	mitogen-activated protein kinase 1	0.240
Nos2	nitric oxide synthase 2, inducible	0.237
Was	Wiskott-Aldrich syndrome homolog (human)	0.201
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.199
Casp1	caspase 1	0.192
Fcgr1	Fc receptor, IgG, high affinity I	0.178
Tgfb1	transforming growth factor, beta 1	0.149
Dok2	docking protein 2	0.144
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.135	Mouse
Tlr4	toll-like receptor 4	0.133
Csf1	colony stimulating factor 1 (macrophage)	0.128
Egfr	epidermal growth factor receptor	0.120
Ric8	resistance to inhibitors of cholinesterase 8 homolog (C. elegans)	0.115
Blnk	B-cell linker	0.115
Pycard	PYD and CARD domain containing	0.112
Tnf	tumor necrosis factor	0.112
Ccl4	chemokine (C-C motif) ligand 4	0.102
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.098
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.096
Mrc1	mannose receptor, C type 1	0.090
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.089
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.086
Ooep	oocyte expressed protein homolog (dog)	0.074
Lck	lymphocyte protein tyrosine kinase	0.073	Mouse
Ccl2	chemokine (C-C motif) ligand 2	0.072
Hif1a	hypoxia inducible factor 1, alpha subunit	0.068
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.067
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.066
Flii	flightless I homolog (Drosophila)	0.063
Il22	interleukin 22	0.063
Ticam1	toll-like receptor adaptor molecule 1	0.061
Atf2	activating transcription factor 2	0.061
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.061
Spry1	sprouty homolog 1 (Drosophila)	0.058
Itgal	integrin alpha L	0.057
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.055
Plcg2	phospholipase C, gamma 2	0.055
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.054
Fas	Fas (TNF receptor superfamily member 6)	0.054
Pxn	paxillin	0.053
Dab1	disabled homolog 1 (Drosophila)	0.051
Spp1	secreted phosphoprotein 1	0.051
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.051
Cenpj	centromere protein J	0.050
Nsf	N-ethylmaleimide sensitive fusion protein	0.050
Cd86	CD86 antigen	0.049	Mouse
Pparg	peroxisome proliferator activated receptor gamma	0.048
Sykb	spleen tyrosine kinase	0.047
Mmp9	matrix metallopeptidase 9	0.047
C3ar1	complement component 3a receptor 1	0.047
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.046
Cd5	CD5 antigen	0.046
Sh3kbp1	SH3-domain kinase binding protein 1	0.045
Btk	Bruton agammaglobulinemia tyrosine kinase	0.044	Mouse
Bcar1	breast cancer anti-estrogen resistance 1	0.043
Ccr6	chemokine (C-C motif) receptor 6	0.042
Nos1	nitric oxide synthase 1, neuronal	0.042
Tbx21	T-box 21	0.041
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.040
Mefv	Mediterranean fever	0.040
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.040
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.039
C1qb	complement component 1, q subcomponent, beta polypeptide	0.038	Mouse
Nlrp3	NLR family, pyrin domain containing 3	0.037	Mouse
Grm1	glutamate receptor, metabotropic 1	0.037
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.036
Spry2	sprouty homolog 2 (Drosophila)	0.036
Fnip1	folliculin interacting protein 1	0.036
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.035
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.035
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.035
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.034
Aim2	absent in melanoma 2	0.034
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.034
Stat3	signal transducer and activator of transcription 3	0.034
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.034
Ikzf1	IKAROS family zinc finger 1	0.033
Ret	ret proto-oncogene	0.033
Ncr1	natural cytotoxicity triggering receptor 1	0.033
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.033
Lrp10	low-density lipoprotein receptor-related protein 10	0.032
Cd22	CD22 antigen	0.031
Col1a1	collagen, type I, alpha 1	0.031
Tlr2	toll-like receptor 2	0.031	Mouse
Cd300ld	CD300 molecule-like family member d	0.031
Hcls1	hematopoietic cell specific Lyn substrate 1	0.030
Ly86	lymphocyte antigen 86	0.029
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.029
Apoe	apolipoprotein E	0.029
Mapk8	mitogen-activated protein kinase 8	0.029
Jak2	Janus kinase 2	0.028
Insr	insulin receptor	0.028
Prdm1	PR domain containing 1, with ZNF domain	0.028
Cd40	CD40 antigen	0.027
Ifnar1	interferon (alpha and beta) receptor 1	0.027
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.026
Il1b	interleukin 1 beta	0.026
Cd180	CD180 antigen	0.025	Mouse
Il2rb	interleukin 2 receptor, beta chain	0.025
Dok3	docking protein 3	0.024
Cd160	CD160 antigen	0.024
Ptpra	protein tyrosine phosphatase, receptor type, A	0.024
Lair1	leukocyte-associated Ig-like receptor 1	0.024
Cav1	caveolin 1, caveolae protein	0.024
Siglece	sialic acid binding Ig-like lectin E	0.024
Cd28	CD28 antigen	0.024
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.023
Cd6	CD6 antigen	0.023
Tlr5	toll-like receptor 5	0.023	Mouse
Aif1	allograft inflammatory factor 1	0.023
Vav2	vav 2 oncogene	0.023
Lcp2	lymphocyte cytosolic protein 2	0.023
Col14a1	collagen, type XIV, alpha 1	0.023
Dbnl	drebrin-like	0.022
Shank2	SH3/ankyrin domain gene 2	0.022
Gbp5	guanylate binding protein 5	0.022
Pilrb1	paired immunoglobin-like type 2 receptor beta 1	0.022
Plekho2	pleckstrin homology domain containing, family O member 2	0.022
Nostrin	nitric oxide synthase trafficker	0.022
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.021
Esr1	estrogen receptor 1 (alpha)	0.020
AF251705	cDNA sequence AF251705	0.020
Igf1r	insulin-like growth factor I receptor	0.020
Rasgrp1	RAS guanyl releasing protein 1	0.020
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.020
Ms4a6c	membrane-spanning 4-domains, subfamily A, member 6C	0.020
Cd33	CD33 antigen	0.020
Il10ra	interleukin 10 receptor, alpha	0.020
Ccr1	chemokine (C-C motif) receptor 1	0.019
Il27ra	interleukin 27 receptor, alpha	0.019
Foxc1	forkhead box C1	0.019
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.019
Axl	AXL receptor tyrosine kinase	0.019
Gpr18	G protein-coupled receptor 18	0.019
Plcg1	phospholipase C, gamma 1	0.019
Unc93b1	unc-93 homolog B1 (C. elegans)	0.019
Ebi3	Epstein-Barr virus induced gene 3	0.019
Dnm1	dynamin 1	0.019
Cd4	CD4 antigen	0.019
Cx3cr1	chemokine (C-X3-C) receptor 1	0.019
Itgb2	integrin beta 2	0.019
Prkce	protein kinase C, epsilon	0.019
Src	Rous sarcoma oncogene	0.018	Mouse
Ifna1	interferon alpha 1	0.018
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.018
Ifng	interferon gamma	0.018
Itga4	integrin alpha 4	0.018
Ciita	class II transactivator	0.018
Abi1	abl-interactor 1	0.018
Lcp1	lymphocyte cytosolic protein 1	0.018
Rc3h1	RING CCCH (C3H) domains 1	0.018
Sos1	son of sevenless homolog 1 (Drosophila)	0.018	Mouse
Clnk	cytokine-dependent hematopoietic cell linker	0.018
Cysltr1	cysteinyl leukotriene receptor 1	0.018
Fyn	Fyn proto-oncogene	0.017	Mouse
Cotl1	coactosin-like 1 (Dictyostelium)	0.017
Slamf8	SLAM family member 8	0.017
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.017
Tyrobp	TYRO protein tyrosine kinase binding protein	0.017
Naip6	NLR family, apoptosis inhibitory protein 6	0.017
Cd14	CD14 antigen	0.017
Vav1	vav 1 oncogene	0.017
Ghr	growth hormone receptor	0.016
Il6st	interleukin 6 signal transducer	0.016
BC013712	cDNA sequence BC013712	0.016
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.016
Ubr3	ubiquitin protein ligase E3 component n-recognin 3	0.016
Cd7	CD7 antigen	0.016
Alms1	Alstrom syndrome 1 homolog (human)	0.016
Selplg	selectin, platelet (p-selectin) ligand	0.016
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.016
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.016
Frs2	fibroblast growth factor receptor substrate 2	0.016
Ins1	insulin I	0.016	Mouse
Tlr6	toll-like receptor 6	0.016	Mouse
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.016
Itgax	integrin alpha X	0.016
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.016
Rgs14	regulator of G-protein signaling 14	0.016	Rat
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.016
Lyz1	lysozyme 1	0.015
Kiss1	KiSS-1 metastasis-suppressor	0.015
Fyb	FYN binding protein	0.015
Ifngr1	interferon gamma receptor 1	0.015
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.015
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.015
Bcan	brevican	0.015
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.015
Nod2	nucleotide-binding oligomerization domain containing 2	0.015	Mouse
Reg3b	regenerating islet-derived 3 beta	0.015
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.015
Tlr9	toll-like receptor 9	0.015
Nfam1	Nfat activating molecule with ITAM motif 1	0.015
Gltp	glycolipid transfer protein	0.014
Cbr1	carbonyl reductase 1	0.014
Rel	reticuloendotheliosis oncogene	0.014
Ccr7	chemokine (C-C motif) receptor 7	0.014
Itga1	integrin alpha 1	0.014
Il18rap	interleukin 18 receptor accessory protein	0.014
Ren1	renin 1 structural	0.014
Dynlt1b	dynein light chain Tctex-type 1D	0.014
Zap70	zeta-chain (TCR) associated protein kinase	0.014
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.014
Gab2	growth factor receptor bound protein 2-associated protein 2	0.014
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.014
Sash3	SAM and SH3 domain containing 3	0.014
Igh	immunoglobulin heavy chain complex	0.014
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.014
Grb10	growth factor receptor bound protein 10	0.013
Il1a	interleukin 1 alpha	0.013
Ncf1	neutrophil cytosolic factor 1	0.013
Ctsw	cathepsin W	0.013
Ticam2	toll-like receptor adaptor molecule 2	0.013
Atl2	atlastin GTPase 2	0.013
Wnt7a	wingless-related MMTV integration site 7A	0.013
Myo1g	myosin IG	0.013
Il18	interleukin 18	0.013
Mpeg1	macrophage expressed gene 1	0.013
Cdh5	cadherin 5	0.013
Cdh15	cadherin 15	0.013
Slc5a4a	solute carrier family 5, member 4a	0.013
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.013
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.013
Thrb	thyroid hormone receptor beta	0.013
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.013
Gpr35	G protein-coupled receptor 35	0.013
Clec4n	C-type lectin domain family 4, member n	0.013
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	0.013
Sp110	Sp110 nuclear body protein	0.013
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.013
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.013
Spry4	sprouty homolog 4 (Drosophila)	0.012	Mouse
Gm3776	predicted gene 3776	0.012
Pten	phosphatase and tensin homolog	0.012
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.012
Alox8	arachidonate 8-lipoxygenase	0.012
Homer1	homer homolog 1 (Drosophila)	0.012
Il6	interleukin 6	0.012
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.012
Igf2r	insulin-like growth factor 2 receptor	0.012
Shkbp1	Sh3kbp1 binding protein 1	0.012
Rb1	retinoblastoma 1	0.012
Fcgr3	Fc receptor, IgG, low affinity III	0.012
Itgb3	integrin beta 3	0.012
Trem1	triggering receptor expressed on myeloid cells 1	0.012
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.012
Fcgr4	Fc receptor, IgG, low affinity IV	0.012
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.012
Socs3	suppressor of cytokine signaling 3	0.012
Skil	SKI-like	0.012
Fasl	Fas ligand (TNF superfamily, member 6)	0.012
Mcoln2	mucolipin 2	0.012
Npy2r	neuropeptide Y receptor Y2	0.012
Sh3bp2	SH3-domain binding protein 2	0.012
Cd300lf	CD300 antigen like family member F	0.012
Msr1	macrophage scavenger receptor 1	0.012
2410004A20Rik	RIKEN cDNA 2410004A20 gene	0.012
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.012
Plec	plectin	0.012
Pou2af1	POU domain, class 2, associating factor 1	0.012
Xcr1	chemokine (C motif) receptor 1	0.012
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.012
Gstm1	glutathione S-transferase, mu 1	0.012
Blk	B lymphoid kinase	0.012	Mouse
Plek	pleckstrin	0.012
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.012
Trpc4	transient receptor potential cation channel, subfamily C, member 4	0.011
Tek	endothelial-specific receptor tyrosine kinase	0.011
Rab3il1	RAB3A interacting protein (rabin3)-like 1	0.011
Mpzl2	myelin protein zero-like 2	0.011
Rtn4r	reticulon 4 receptor	0.011
Pgr	progesterone receptor	0.011
Timp1	tissue inhibitor of metalloproteinase 1	0.011
Dlgap4	discs, large homolog-associated protein 4 (Drosophila)	0.011
Cd72	CD72 antigen	0.011
Ldlr	low density lipoprotein receptor	0.011
Gzma	granzyme A	0.011
Cblb	Casitas B-lineage lymphoma b	0.011
Nckap1l	NCK associated protein 1 like	0.011
P2ry13	purinergic receptor P2Y, G-protein coupled 13	0.011
Aoah	acyloxyacyl hydrolase	0.011
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.011
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.011
Ms4a6b	membrane-spanning 4-domains, subfamily A, member 6B	0.011
Gna11	guanine nucleotide binding protein, alpha 11	0.011
Ccl24	chemokine (C-C motif) ligand 24	0.011
Cd244	CD244 natural killer cell receptor 2B4	0.011
P2ry6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.011
Laptm5	lysosomal-associated protein transmembrane 5	0.011
Slamf6	SLAM family member 6	0.011
Ins2	insulin II	0.011	Mouse
Nkg7	natural killer cell group 7 sequence	0.011
Tsc1	tuberous sclerosis 1	0.011
Pfdn2	prefoldin 2	0.011
Drd1a	dopamine receptor D1A	0.011
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.011
Npy1r	neuropeptide Y receptor Y1	0.011
4732456N10Rik	RIKEN cDNA 4732456N10 gene	0.011
Myo1f	myosin IF	0.010
Med1	mediator complex subunit 1	0.010
Mfsd5	major facilitator superfamily domain containing 5	0.010
Clec5a	C-type lectin domain family 5, member a	0.010
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.010
Srpx2	sushi-repeat-containing protein, X-linked 2	0.010
Cd96	CD96 antigen	0.010
Slit1	slit homolog 1 (Drosophila)	0.010
Hgf	hepatocyte growth factor	0.010
Irf1	interferon regulatory factor 1	0.010
Rac2	RAS-related C3 botulinum substrate 2	0.010
Cyld	cylindromatosis (turban tumor syndrome)	0.010
Havcr2	hepatitis A virus cellular receptor 2	0.010
Jak1	Janus kinase 1	0.010
Ubd	ubiquitin D	0.010