Mus musculus

96 known processes

Dlg4

discs, large homolog 4 (Drosophila)

(Aliases: SAP90,PSD95,SAP90A,PSD-95,Dlgh4)

Dlg4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
glutamate receptor signaling pathway GO:0007215 35 1.000
Rat
regulation of excitatory postsynaptic membrane potential GO:0060079 41 1.000
Rat
synaptic transmission GO:0007268 329 1.000
regulation of long term neuronal synaptic plasticity GO:0048169 19 1.000
regulation of glutamate receptor signaling pathway GO:1900449 16 1.000
Rat
regulation of postsynaptic membrane potential GO:0060078 48 1.000
Rat
directional locomotion GO:0033058 3 1.000
regulation of synaptic plasticity GO:0048167 87 1.000
negative regulation of synaptic transmission glutamatergic GO:0051967 4 1.000
regulation of synaptic transmission glutamatergic GO:0051966 19 1.000
ionotropic glutamate receptor signaling pathway GO:0035235 29 1.000
Rat
synaptic vesicle recycling GO:0036465 19 1.000
synaptic growth at neuromuscular junction GO:0051124 6 1.000
Fly
long term synaptic potentiation GO:0060291 25 1.000
synaptic vesicle localization GO:0097479 59 1.000
synaptic transmission gabaergic GO:0051932 19 1.000
ion transmembrane transport GO:0034220 361 1.000
Rat
regulation of neurotransmitter secretion GO:0046928 29 0.999
regulation of neurotransmitter transport GO:0051588 35 0.999
regulation of synaptic vesicle exocytosis GO:2000300 11 0.999
neuromuscular process GO:0050905 99 0.999
neuromuscular process controlling balance GO:0050885 59 0.999
establishment of synaptic vesicle localization GO:0097480 57 0.999
regulation of ion transmembrane transporter activity GO:0032412 54 0.999
Rat
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity GO:2000311 11 0.999
regulation of neurotransmitter levels GO:0001505 87 0.999
synaptic vesicle transport GO:0048489 57 0.999
protein localization to synapse GO:0035418 11 0.999
regulation of membrane potential GO:0042391 192 0.999
Mouse Rat
membrane depolarization GO:0051899 64 0.999
Rat
regulation of ion transport GO:0043269 215 0.998
Rat
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.998
Fly
synaptic vesicle maturation GO:0016188 7 0.998
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.998
Fly
neuron neuron synaptic transmission GO:0007270 69 0.998
neurotransmitter secretion GO:0007269 62 0.997
synaptic transmission glutamatergic GO:0035249 36 0.997
dendritic spine morphogenesis GO:0060997 22 0.997
anatomical structure arrangement GO:0048532 20 0.996
regulation of synaptic vesicle transport GO:1902803 13 0.996
positive regulation of synaptic transmission glutamatergic GO:0051968 8 0.996
pole plasm assembly GO:0007315 2 0.995
Fly
basal protein localization GO:0045175 1 0.995
Fly
morphogenesis of a polarized epithelium GO:0001738 37 0.994
Mouse
positive regulation of membrane potential GO:0045838 15 0.994
Rat
cation transport GO:0006812 399 0.994
synaptic vesicle endocytosis GO:0048488 19 0.993
establishment of vesicle localization GO:0051650 81 0.991
dendrite development GO:0016358 115 0.991
adult behavior GO:0030534 135 0.990
dendritic spine organization GO:0097061 26 0.989
positive regulation of synapse assembly GO:0051965 18 0.989
Fly
male courtship behavior GO:0008049 2 0.988
Fly
membrane hyperpolarization GO:0060081 21 0.985
associative learning GO:0008306 61 0.984
learning or memory GO:0007611 148 0.984
establishment of tissue polarity GO:0007164 28 0.983
Mouse
neurotransmitter gated ion channel clustering GO:0072578 6 0.983
Rat
regulation of neuronal synaptic plasticity GO:0048168 30 0.981
protein localization to membrane GO:0072657 108 0.980
Rat
regulation of synaptic transmission gabaergic GO:0032228 17 0.980
locomotory behavior GO:0007626 195 0.978
gonadotrophin releasing hormone neuronal migration to the hypothalamus GO:0021828 3 0.976
visual behavior GO:0007632 45 0.976
potassium ion transport GO:0006813 52 0.975
positive regulation of nervous system development GO:0051962 221 0.975
Fly
behavioral response to nutrient GO:0051780 1 0.975
response to light stimulus GO:0009416 135 0.974
Fly
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.974
positive regulation of rac gtpase activity GO:0032855 14 0.972
protein kinase a signaling GO:0010737 7 0.972
regulation of secretion by cell GO:1903530 249 0.971
regulation of neuron projection development GO:0010975 169 0.968
alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor clustering GO:0097113 3 0.967
Rat
cognition GO:0050890 149 0.967
axonogenesis GO:0007409 274 0.967
inorganic cation transmembrane transport GO:0098662 207 0.966
synapse assembly GO:0007416 56 0.964
Rat Fly
neurotransmitter transport GO:0006836 76 0.963
positive regulation of ras gtpase activity GO:0032320 65 0.963
endocytosis GO:0006897 168 0.962
positive regulation of gtpase activity GO:0043547 85 0.961
vesicle localization GO:0051648 86 0.960
dendritic spine development GO:0060996 30 0.959
multicellular organismal signaling GO:0035637 91 0.958
regulation of short term neuronal synaptic plasticity GO:0048172 8 0.955
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 10 0.955
Rat
social behavior GO:0035176 21 0.955
trunk neural crest cell migration GO:0036484 4 0.951
membrane organization GO:0061024 245 0.950
Mouse Rat
regulation of transporter activity GO:0032409 57 0.948
Rat
regulation of grooming behavior GO:2000821 4 0.945
regulation of neuron differentiation GO:0045664 281 0.944
positive regulation of neuron projection development GO:0010976 79 0.943
organelle localization GO:0051640 179 0.942
transmembrane transport GO:0055085 412 0.936
Rat
cell division GO:0051301 120 0.935
maternal determination of anterior posterior axis embryo GO:0008358 2 0.935
Fly
establishment of planar polarity GO:0001736 28 0.935
Mouse
fear response GO:0042596 33 0.935
positive regulation of rho gtpase activity GO:0032321 41 0.934
establishment of protein localization to membrane GO:0090150 54 0.933
regulation of receptor activity GO:0010469 41 0.932
Rat
positive regulation of excitatory postsynaptic membrane potential GO:2000463 14 0.930
Rat
mating behavior sex discrimination GO:0048047 1 0.929
cation homeostasis GO:0055080 212 0.928
Rat
adherens junction organization GO:0034332 28 0.928
Mouse Worm
hypothalamus gonadotrophin releasing hormone neuron development GO:0021888 4 0.924
developmental maturation GO:0021700 193 0.922
locomotory exploration behavior GO:0035641 10 0.921
action potential GO:0001508 78 0.920
transmission of nerve impulse GO:0019226 76 0.920
sympathetic neuron projection extension GO:0097490 4 0.920
regionalization GO:0003002 337 0.917
Fly
adult locomotory behavior GO:0008344 91 0.915
guanosine containing compound metabolic process GO:1901068 144 0.915
cranial nerve structural organization GO:0021604 13 0.915
protein localization to adherens junction GO:0071896 2 0.912
Mouse
apical junction assembly GO:0043297 15 0.910
Mouse Worm
multicellular organismal response to stress GO:0033555 62 0.910
gtp metabolic process GO:0046039 144 0.909
ribonucleoside triphosphate catabolic process GO:0009203 199 0.908
regulation of system process GO:0044057 200 0.908
long term memory GO:0007616 15 0.908
synaptic vesicle membrane organization GO:0048499 1 0.907
neural crest cell migration involved in sympathetic nervous system development GO:1903045 1 0.907
neuron projection extension GO:1990138 64 0.906
regulation of protein kinase a signaling GO:0010738 6 0.906
mitotic cell cycle GO:0000278 195 0.903
Fly
learning GO:0007612 98 0.902
behavioral fear response GO:0001662 28 0.902
positive regulation of protein phosphorylation GO:0001934 242 0.899
Mouse
positive regulation of glutamate secretion GO:0014049 2 0.899
cell cell junction organization GO:0045216 72 0.898
Mouse Worm
neural crest cell migration involved in autonomic nervous system development GO:1901166 5 0.897
inorganic ion transmembrane transport GO:0098660 234 0.896
ventral trunk neural crest cell migration GO:0036486 4 0.895
positive regulation of synaptic transmission gabaergic GO:0032230 8 0.895
positive regulation of amino acid transport GO:0051957 4 0.893
mating GO:0007618 27 0.890
Fly
sensory perception of pain GO:0019233 47 0.890
Mouse
calcium ion transport GO:0006816 159 0.889
neuron projection guidance GO:0097485 141 0.888
sensory perception GO:0007600 245 0.882
Mouse
regulation of actin filament length GO:0030832 45 0.881
Mouse
regulation of extent of cell growth GO:0061387 52 0.879
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.877
nucleoside phosphate catabolic process GO:1901292 222 0.877
courtship behavior GO:0007619 5 0.876
Fly
nucleotide catabolic process GO:0009166 217 0.875
regulation of ion transmembrane transport GO:0034765 119 0.875
Rat
cerebellum development GO:0021549 77 0.870
negative regulation of potassium ion transport GO:0043267 7 0.870
regulation of long term synaptic potentiation GO:1900271 4 0.866
establishment of organelle localization GO:0051656 122 0.861
cell junction assembly GO:0034329 52 0.860
Mouse Worm
reflex GO:0060004 22 0.858
purine nucleoside triphosphate metabolic process GO:0009144 226 0.856
regulation of cellular catabolic process GO:0031329 242 0.854
synaptic transmission cholinergic GO:0007271 7 0.852
cytokinesis GO:0000910 17 0.851
regulation of relaxation of muscle GO:1901077 8 0.844
regulation of anatomical structure size GO:0090066 178 0.843
Mouse
regulation of glutamate secretion GO:0014048 3 0.841
regulation of actin filament based process GO:0032970 99 0.840
Mouse
regulation of potassium ion transport GO:0043266 16 0.840
synaptic vesicle fusion to presynaptic membrane GO:0031629 3 0.834
t cell activation GO:0042110 289 0.831
Mouse
facioacoustic ganglion development GO:1903375 3 0.821
nucleoside triphosphate catabolic process GO:0009143 205 0.821
response to radiation GO:0009314 165 0.820
Fly
visual learning GO:0008542 44 0.815
sensory perception of chemical stimulus GO:0007606 51 0.807
mitochondrion transport along microtubule GO:0047497 3 0.806
mating behavior GO:0007617 20 0.805
Fly
cerebral cortex tangential migration using cell axon interactions GO:0021824 3 0.805
memory GO:0007613 58 0.803
positive regulation of endocytosis GO:0045807 42 0.802
hypothalamic tangential migration using cell axon interactions GO:0021856 3 0.800
rho protein signal transduction GO:0007266 32 0.793
oocyte construction GO:0007308 2 0.792
Fly
dephosphorylation GO:0016311 129 0.791
endomembrane system organization GO:0010256 147 0.789
negative regulation of phosphorus metabolic process GO:0010563 184 0.787
regulation of metal ion transport GO:0010959 106 0.784
negative regulation of axon guidance GO:1902668 8 0.782
sympathetic neuron projection guidance GO:0097491 4 0.781
positive regulation of necrotic cell death GO:0010940 1 0.781
metencephalon development GO:0022037 89 0.778
negative regulation of phosphate metabolic process GO:0045936 184 0.776
microtubule based process GO:0007017 236 0.774
Fly
blood coagulation GO:0007596 76 0.774
hypothalamus cell migration GO:0021855 5 0.770
exocytosis GO:0006887 121 0.767
regulation of exocytosis GO:0017157 61 0.763
cell cell recognition GO:0009988 44 0.763
Mouse
hypothalamus gonadotrophin releasing hormone neuron differentiation GO:0021886 4 0.759
regulation of vesicle mediated transport GO:0060627 139 0.759
Rat
sympathetic ganglion development GO:0061549 9 0.759
glycosyl compound catabolic process GO:1901658 206 0.755
establishment of mitochondrion localization GO:0051654 4 0.752
membrane assembly GO:0071709 12 0.747
blood circulation GO:0008015 195 0.746
positive regulation of cellular catabolic process GO:0031331 148 0.745
response to pain GO:0048265 26 0.736
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.733
muscle contraction GO:0006936 101 0.733
Mouse
axonogenesis involved in innervation GO:0060385 5 0.729
organonitrogen compound catabolic process GO:1901565 264 0.729
dicarboxylic acid transport GO:0006835 29 0.724
neuromuscular synaptic transmission GO:0007274 16 0.721
primary amino compound metabolic process GO:1901160 8 0.719
microtubule based movement GO:0007018 84 0.716
protein localization to cell junction GO:1902414 3 0.713
Mouse
vesicle organization GO:0016050 60 0.711
olfactory learning GO:0008355 2 0.708
divalent metal ion transport GO:0070838 172 0.707
adherens junction maintenance GO:0034334 1 0.702
cellular potassium ion transport GO:0071804 43 0.701
purine nucleoside metabolic process GO:0042278 241 0.699
positive regulation of ion transport GO:0043270 65 0.699
regulation of cell projection organization GO:0031344 206 0.699
positive regulation of ion transmembrane transporter activity GO:0032414 15 0.694
activation of meiosis involved in egg activation GO:0060466 2 0.692
regulation of secretion GO:0051046 274 0.690
semaphorin plexin signaling pathway involved in bone trabecula morphogenesis GO:1900220 2 0.678
regulation of tight junction assembly GO:2000810 2 0.676
regulation of protein kinase activity GO:0045859 232 0.675
Mouse
divalent inorganic cation transport GO:0072511 178 0.675
long term synaptic depression GO:0060292 13 0.672
protein oligomerization GO:0051259 67 0.671
regulation of nucleoside metabolic process GO:0009118 130 0.670
regulation of inhibitory postsynaptic membrane potential GO:0060080 13 0.666
activation of meiosis GO:0090427 4 0.663
gtp catabolic process GO:0006184 143 0.661
ribonucleotide catabolic process GO:0009261 208 0.661
oocyte axis specification GO:0007309 2 0.658
Fly
regulation of protein localization GO:0032880 231 0.655
cell maturation GO:0048469 127 0.654
Fly
negative regulation of protein phosphorylation GO:0001933 126 0.653
negative regulation of hepatocyte differentiation GO:0070367 1 0.646
organic anion transport GO:0015711 137 0.645
response to extracellular stimulus GO:0009991 127 0.643
circulatory system process GO:0003013 197 0.639
syncytiotrophoblast cell differentiation involved in labyrinthine layer development GO:0060715 2 0.638
establishment of mitotic spindle localization GO:0040001 12 0.633
Fly
regulation of g protein coupled receptor protein signaling pathway GO:0008277 37 0.629
cation transmembrane transport GO:0098655 266 0.627
cellular metal ion homeostasis GO:0006875 151 0.625
Rat
cell recognition GO:0008037 83 0.617
Mouse
axon guidance GO:0007411 141 0.617
serotonin metabolic process GO:0042428 8 0.615
purine ribonucleoside metabolic process GO:0046128 241 0.613
multi organism behavior GO:0051705 62 0.612
cell junction organization GO:0034330 77 0.604
Mouse Worm
organic acid transport GO:0015849 101 0.599
maintenance of presynaptic active zone structure GO:0048790 1 0.599
axon ensheathment GO:0008366 76 0.597
Mouse
ras protein signal transduction GO:0007265 77 0.596
muscle system process GO:0003012 141 0.595
Mouse
regulation of muscle system process GO:0090257 80 0.593
response to amine GO:0014075 16 0.589
purine ribonucleotide metabolic process GO:0009150 290 0.582
mitotic cell cycle process GO:1903047 159 0.580
Fly
regulation of calcium ion transport GO:0051924 69 0.580
positive regulation of cell migration GO:0030335 109 0.574
synapse organization GO:0050808 125 0.572
Rat Fly
anion transport GO:0006820 177 0.571
regulation of gtp catabolic process GO:0033124 113 0.569
regulation of sensory perception of pain GO:0051930 8 0.569
regulation of synapse assembly GO:0051963 29 0.569
Fly
cellular calcium ion homeostasis GO:0006874 119 0.568
Rat
regulation of protein kinase b signaling GO:0051896 56 0.567
Mouse
mitotic cytokinesis GO:0000281 4 0.567
synaptic vesicle exocytosis GO:0016079 26 0.566
sensory perception of mechanical stimulus GO:0050954 107 0.566
negative regulation of lymphocyte activation GO:0051250 91 0.565
Mouse
oocyte anterior posterior axis specification GO:0007314 2 0.562
Fly
ganglion development GO:0061548 13 0.559
negative regulation of neurotransmitter transport GO:0051589 7 0.558
negative regulation of execution phase of apoptosis GO:1900118 4 0.558
regulation of amine transport GO:0051952 21 0.553
developmental growth involved in morphogenesis GO:0060560 138 0.550
second messenger mediated signaling GO:0019932 73 0.547
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 30 0.545
regulation of cell size GO:0008361 72 0.540
semaphorin plexin signaling pathway involved in axon guidance GO:1902287 6 0.539
protein catabolic process GO:0030163 221 0.538
nucleoside metabolic process GO:0009116 246 0.537
regulation of long term synaptic depression GO:1900452 3 0.536
sensory perception of bitter taste GO:0050913 6 0.533
divalent inorganic cation homeostasis GO:0072507 138 0.532
Rat
regulation of purine nucleotide catabolic process GO:0033121 122 0.531
regulation of purine nucleotide metabolic process GO:1900542 169 0.518
regulation of cytoskeleton organization GO:0051493 122 0.516
Mouse
ventricular system development GO:0021591 27 0.515
vocalization behavior GO:0071625 7 0.514
regulation of endocytosis GO:0030100 69 0.512
Rat
positive regulation of glutamate receptor signaling pathway GO:1900451 3 0.510
positive regulation of gtp catabolic process GO:0033126 85 0.509
g protein coupled receptor signaling pathway GO:0007186 243 0.507
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.507
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.503
positive regulation of protein modification process GO:0031401 299 0.503
Mouse
phasic smooth muscle contraction GO:0014821 8 0.503
Mouse
skeletal system development GO:0001501 356 0.498
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.497
regulation of body fluid levels GO:0050878 162 0.496
chorionic trophoblast cell proliferation GO:0097360 1 0.492
multi organism reproductive behavior GO:0044705 29 0.491
Fly
actin filament organization GO:0007015 113 0.491
Mouse
regulation of respiratory gaseous exchange GO:0043576 18 0.490
regulation of actin polymerization or depolymerization GO:0008064 45 0.490
Mouse
heart process GO:0003015 94 0.489
olfactory bulb axon guidance GO:0071678 1 0.489
actin cytoskeleton organization GO:0030036 220 0.488
Mouse
prepulse inhibition GO:0060134 10 0.488
leukocyte mediated immunity GO:0002443 174 0.487
Mouse
relaxation of cardiac muscle GO:0055119 9 0.485
purine ribonucleoside catabolic process GO:0046130 205 0.485
receptor internalization GO:0031623 16 0.481
Rat
axonal fasciculation GO:0007413 15 0.477
circadian rhythm GO:0007623 114 0.476
Fly
hemostasis GO:0007599 78 0.476
response to amphetamine GO:0001975 16 0.475
organophosphate catabolic process GO:0046434 232 0.473
embryonic skeletal system development GO:0048706 120 0.470
Mouse
calcium ion transmembrane transport GO:0070588 85 0.462
feeding behavior GO:0007631 62 0.460
substrate dependent cerebral cortex tangential migration GO:0021825 3 0.458
indole containing compound metabolic process GO:0042430 12 0.457
detection of light stimulus GO:0009583 25 0.453
regulation of synaptic vesicle priming GO:0010807 4 0.453
conditioned taste aversion GO:0001661 4 0.452
positive regulation of cardiac muscle cell apoptotic process GO:0010666 3 0.452
nucleoside triphosphate metabolic process GO:0009141 230 0.451
positive regulation of organelle organization GO:0010638 128 0.447
Mouse
progesterone secretion GO:0042701 1 0.444
ensheathment of neurons GO:0007272 76 0.444
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.443
regulation of circadian sleep wake cycle GO:0042749 3 0.442
positive regulation of nucleotide metabolic process GO:0045981 114 0.440
positive regulation of transferase activity GO:0051347 167 0.440
Mouse
positive regulation of calcium ion transport GO:0051928 27 0.438
optic nerve structural organization GO:0021633 2 0.438
hindbrain development GO:0030902 128 0.437
regulation of cellular component biogenesis GO:0044087 181 0.435
Mouse Fly
detection of external stimulus GO:0009581 61 0.426
chemotaxis GO:0006935 247 0.424
negative regulation of mitotic cell cycle embryonic GO:0045976 2 0.423
plasma membrane organization GO:0007009 90 0.423
regulation of potassium ion transmembrane transporter activity GO:1901016 7 0.422
carboxylic acid transport GO:0046942 100 0.422
receptor recycling GO:0001881 11 0.421
regulation of purine nucleotide biosynthetic process GO:1900371 34 0.421
labyrinthine layer blood vessel development GO:0060716 21 0.420
purine containing compound catabolic process GO:0072523 213 0.420
macromolecule catabolic process GO:0009057 281 0.419
regulation of organelle organization GO:0033043 289 0.417
Mouse
aromatic compound catabolic process GO:0019439 286 0.417
negative regulation of smooth muscle cell migration GO:0014912 2 0.411
cellular chemical homeostasis GO:0055082 215 0.405
Rat
alpha amino acid biosynthetic process GO:1901607 15 0.405
establishment of spindle orientation GO:0051294 15 0.394
Fly
cytoskeleton dependent intracellular transport GO:0030705 50 0.393
acid secretion GO:0046717 33 0.392
branchiomotor neuron axon guidance GO:0021785 7 0.387
detection of stimulus GO:0051606 84 0.385
postsynaptic membrane organization GO:0001941 18 0.384
Rat
muscular septum morphogenesis GO:0003150 4 0.383
regulation of t cell activation GO:0050863 170 0.380
Mouse
developmental cell growth GO:0048588 84 0.380
regulation of dendritic spine development GO:0060998 22 0.380
neuron migration GO:0001764 122 0.380
guanosine containing compound catabolic process GO:1901069 144 0.380
negative regulation of cellular protein metabolic process GO:0032269 247 0.376
stress activated protein kinase signaling cascade GO:0031098 81 0.376
positive regulation of smooth muscle cell migration GO:0014911 4 0.375
relaxation of muscle GO:0090075 18 0.375
intraspecies interaction between organisms GO:0051703 21 0.374
actin filament polymerization GO:0030041 44 0.373
Mouse
negative regulation of catenin import into nucleus GO:0035414 2 0.371
regulation of sensory perception GO:0051931 8 0.370
adherens junction assembly GO:0034333 22 0.370
Mouse Worm
grooming behavior GO:0007625 16 0.369
maintenance of cell number GO:0098727 3 0.366
positive regulation of mapk cascade GO:0043410 170 0.364
central nervous system neuron differentiation GO:0021953 162 0.364
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.364
male mating behavior GO:0060179 6 0.362
Fly
negative regulation of phosphorylation GO:0042326 166 0.361
positive regulation of nucleoside metabolic process GO:0045979 91 0.360
negative regulation of neuron projection development GO:0010977 50 0.359
myelination GO:0042552 74 0.358
Mouse
negative regulation of protein catabolic process GO:0042177 36 0.357
peristalsis GO:0030432 8 0.356
Mouse
phototransduction GO:0007602 17 0.355
trunk segmentation GO:0035290 4 0.355
embryonic organ morphogenesis GO:0048562 276 0.354
Mouse
purine nucleoside catabolic process GO:0006152 205 0.353
central nervous system neuron development GO:0021954 67 0.349
regulation of chorionic trophoblast cell proliferation GO:1901382 1 0.346
terminal button organization GO:0072553 3 0.345
detection of abiotic stimulus GO:0009582 60 0.344
amino acid transport GO:0006865 61 0.343
regulation of cellular amino acid metabolic process GO:0006521 5 0.340
regulation of synaptic activity GO:0060025 1 0.339
negative regulation of axon extension GO:0030517 19 0.336
regulation of dephosphorylation GO:0035303 18 0.333
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.332
Mouse
regulation of terminal button organization GO:2000331 1 0.330
desensitization of g protein coupled receptor protein signaling pathway GO:0002029 5 0.329
cell growth GO:0016049 130 0.327
regulation of intracellular transport GO:0032386 159 0.327
ribonucleoside catabolic process GO:0042454 206 0.324
response to ischemia GO:0002931 14 0.323
sensory perception of sound GO:0007605 97 0.320
embryonic placenta development GO:0001892 98 0.317
purine nucleoside triphosphate catabolic process GO:0009146 203 0.316
forebrain development GO:0030900 302 0.316
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.315
potassium ion transmembrane transport GO:0071805 43 0.313
regulation of dendritic spine morphogenesis GO:0061001 17 0.311
cellular ion homeostasis GO:0006873 165 0.306
Rat
positive regulation of meiotic cell cycle GO:0051446 15 0.306
hyperosmotic response GO:0006972 4 0.306
purine nucleotide catabolic process GO:0006195 211 0.305
purine nucleotide metabolic process GO:0006163 302 0.304
segmentation GO:0035282 93 0.302
Fly
heart contraction GO:0060047 93 0.301
cell junction maintenance GO:0034331 4 0.301
calcium ion homeostasis GO:0055074 127 0.299
Rat
leukocyte differentiation GO:0002521 342 0.299
positive regulation of cell development GO:0010720 237 0.298
metanephric collecting duct development GO:0072205 7 0.296
Mouse
regulation of hydrolase activity GO:0051336 246 0.292
t cell differentiation GO:0030217 174 0.290
positive regulation of nucleotide catabolic process GO:0030813 88 0.290
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.287
auditory behavior GO:0031223 3 0.286
smooth muscle cell migration GO:0014909 10 0.285
response to nutrient levels GO:0031667 109 0.284
response to metal ion GO:0010038 47 0.284
regulation of mitochondrial membrane permeability GO:0046902 17 0.283
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.281
positive regulation of apoptotic process GO:0043065 217 0.280
purine containing compound metabolic process GO:0072521 311 0.280
regulation of rho gtpase activity GO:0032319 58 0.277
protein localization to plasma membrane GO:0072659 57 0.277
neuronal action potential GO:0019228 54 0.275
single organism cell adhesion GO:0098602 156 0.275
cellular response to metal ion GO:0071248 31 0.274
negative regulation of protein kinase b signaling GO:0051898 18 0.274
Mouse
positive regulation of secretion GO:0051047 130 0.271
negative regulation of t cell activation GO:0050868 65 0.267
Mouse
substrate adhesion dependent cell spreading GO:0034446 30 0.265
cerebellum vasculature morphogenesis GO:0061301 1 0.263
carbohydrate derivative catabolic process GO:1901136 231 0.263
t cell proliferation GO:0042098 120 0.261
Mouse
regulation of ras gtpase activity GO:0032318 88 0.261
vesicle fusion GO:0006906 16 0.257
cgmp metabolic process GO:0046068 20 0.256
lymphocyte differentiation GO:0030098 242 0.256
negative regulation of protein localization to cell surface GO:2000009 2 0.255
intracellular protein transport GO:0006886 204 0.251
ovulation GO:0030728 15 0.250
Worm
sleep GO:0030431 7 0.250
cellular amino acid metabolic process GO:0006520 103 0.250
locomotor rhythm GO:0045475 8 0.249
Fly
cell proliferation in midbrain GO:0033278 2 0.249
organelle transport along microtubule GO:0072384 14 0.247
negative regulation of lyase activity GO:0051350 1 0.245
lipid transport GO:0006869 98 0.240
nucleobase containing small molecule metabolic process GO:0055086 352 0.239
regulation of erbb signaling pathway GO:1901184 16 0.234
Fly
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.232
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.232
positive regulation of axon extension GO:0045773 20 0.229
epidermal growth factor receptor signaling pathway GO:0007173 28 0.229
Fly
positive regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity GO:2000969 3 0.229
leukocyte migration GO:0050900 124 0.228
skeletal system morphogenesis GO:0048705 203 0.226
Mouse
positive regulation of ion transmembrane transport GO:0034767 24 0.225
negative regulation of cellular amine metabolic process GO:0033239 1 0.225
regulation of t cell proliferation GO:0042129 92 0.224
Mouse
glutamate secretion GO:0014047 8 0.223
regulation of cell cycle GO:0051726 281 0.223
protein tetramerization GO:0051262 23 0.222
rhythmic process GO:0048511 174 0.222
Fly
inclusion body assembly GO:0070841 3 0.221
negative regulation of phosphatase activity GO:0010923 5 0.220
regulation of actin cytoskeleton organization GO:0032956 84 0.220
Mouse
glycosyl compound metabolic process GO:1901657 246 0.219

Dlg4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.947
nervous system disease DOID:863 0 0.947
epilepsy syndrome DOID:1826 0 0.836
central nervous system disease DOID:331 0 0.836
brain disease DOID:936 0 0.836
electroclinical syndrome DOID:0050701 0 0.836