IMP

Process View

Mus musculus

4 genes annotated in mouse

hyperosmotic response

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "hyperosmotic response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "hyperosmotic response" (in gray)

Name	Description	Probability	Func Analog Organism
Mapk14	mitogen-activated protein kinase 14	0.999	Yeast Worm
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.997	Worm
Atf2	activating transcription factor 2	0.990
Mapk8ip3	mitogen-activated protein kinase 8 interacting protein 3	0.744
Pak1	p21 protein (Cdc42/Rac)-activated kinase 1	0.700
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.698
Mapk11	mitogen-activated protein kinase 11	0.486	Yeast Worm
Mapkapk2	MAP kinase-activated protein kinase 2	0.453
Mapk9	mitogen-activated protein kinase 9	0.430	Yeast Worm
Mb	myoglobin	0.417
Cldn16	claudin 16	0.365
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.330
Dlg4	discs, large homolog 4 (Drosophila)	0.306
Rhoa	ras homolog gene family, member A	0.221
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.194
Mapk1	mitogen-activated protein kinase 1	0.191
Mapk8	mitogen-activated protein kinase 8	0.160	Yeast Worm
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.153
Emx1	empty spiracles homolog 1 (Drosophila)	0.127
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.122	Worm
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.111
Grip1	glutamate receptor interacting protein 1	0.101
Gria3	glutamate receptor, ionotropic, AMPA3 (alpha 3)	0.097	Worm
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.073
Prkce	protein kinase C, epsilon	0.068
Wdr1	WD repeat domain 1	0.068
Arpc4	actin related protein 2/3 complex, subunit 4	0.060
Aifm1	apoptosis-inducing factor, mitochondrion-associated 1	0.056
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.054	Worm
Klc1	kinesin light chain 1	0.049
Gpx1	glutathione peroxidase 1	0.045
Arhgap1	Rho GTPase activating protein 1	0.043
Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.043
Pten	phosphatase and tensin homolog	0.042
Rac1	RAS-related C3 botulinum substrate 1	0.042
Capn1	calpain 1	0.041
Fes	feline sarcoma oncogene	0.035
Map3k5	mitogen-activated protein kinase kinase kinase 5	0.034
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.033
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.033
Grm1	glutamate receptor, metabotropic 1	0.032
Map2k4	mitogen-activated protein kinase kinase 4	0.032
Mknk1	MAP kinase-interacting serine/threonine kinase 1	0.030
Clic3	chloride intracellular channel 3	0.028
Adora3	adenosine A3 receptor	0.027
Axin1	axin 1	0.027
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.027
Capza2	capping protein (actin filament) muscle Z-line, alpha 2	0.026
Nsf	N-ethylmaleimide sensitive fusion protein	0.024
Syngr1	synaptogyrin 1	0.024
Pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.024
Coro1a	coronin, actin binding protein 1A	0.023
Epn3	epsin 3	0.023
Dlg1	discs, large homolog 1 (Drosophila)	0.023
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.023
Rgs12	regulator of G-protein signaling 12	0.022
Klc2	kinesin light chain 2	0.022
Pafah1b1	platelet-activating factor acetylhydrolase, isoform 1b, subunit 1	0.021
Hras1	Harvey rat sarcoma virus oncogene 1	0.021
Nos1	nitric oxide synthase 1, neuronal	0.020
Kl	klotho	0.020
Vsx1	visual system homeobox 1 homolog (zebrafish)	0.020
Pthlh	parathyroid hormone-like peptide	0.019
Map2k3	mitogen-activated protein kinase kinase 3	0.019
Tlk1	tousled-like kinase 1	0.019
Cul3	cullin 3	0.019
Map2k1	mitogen-activated protein kinase kinase 1	0.019	Yeast
Exoc3	exocyst complex component 3	0.019
Mtmr1	myotubularin related protein 1	0.019
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.018
Mef2a	myocyte enhancer factor 2A	0.018
Pkp3	plakophilin 3	0.018
Cacng8	calcium channel, voltage-dependent, gamma subunit 8	0.018
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.017
Oxr1	oxidation resistance 1	0.016
Mtmr6	myotubularin related protein 6	0.016
Twist2	twist homolog 2 (Drosophila)	0.016
Necap2	NECAP endocytosis associated 2	0.016
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.016
Vasp	vasodilator-stimulated phosphoprotein	0.016
Msn	moesin	0.016
Adrbk1	adrenergic receptor kinase, beta 1	0.015	Worm
Hdgf	hepatoma-derived growth factor	0.015
Csk	c-src tyrosine kinase	0.015
Pitpna	phosphatidylinositol transfer protein, alpha	0.015
Abcb7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	0.015
Fmnl1	formin-like 1	0.015
Grk1	G protein-coupled receptor kinase 1	0.015
Map2k7	mitogen-activated protein kinase kinase 7	0.015	Worm
Rab10	RAB10, member RAS oncogene family	0.014
Muc5b	mucin 5, subtype B, tracheobronchial	0.014
Mudeng	MU-2/AP1M2 domain containing, death-inducing	0.014
Pja2	praja 2, RING-H2 motif containing	0.014
Scnn1g	sodium channel, nonvoltage-gated 1 gamma	0.014
Foxa2	forkhead box A2	0.014
Adam10	a disintegrin and metallopeptidase domain 10	0.014
Rps6ka5	ribosomal protein S6 kinase, polypeptide 5	0.014
Zbtb7b	zinc finger and BTB domain containing 7B	0.014
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.014
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.013
Exoc4	exocyst complex component 4	0.013
Mecp2	methyl CpG binding protein 2	0.013
Stat6	signal transducer and activator of transcription 6	0.013
Ggps1	geranylgeranyl diphosphate synthase 1	0.013
Nlk	nemo like kinase	0.013
Dusp2	dual specificity phosphatase 2	0.012
Edn1	endothelin 1	0.012
Prkar1b	protein kinase, cAMP dependent regulatory, type I beta	0.012
Gja1	gap junction protein, alpha 1	0.012
Jun	Jun oncogene	0.012
Cblc	Casitas B-lineage lymphoma c	0.012
Rnd3	Rho family GTPase 3	0.012
Prkcd	protein kinase C, delta	0.012
Sirpa	signal-regulatory protein alpha	0.012
Capzb	capping protein (actin filament) muscle Z-line, beta	0.011
Rab23	RAB23, member RAS oncogene family	0.011
Gabrb1	gamma-aminobutyric acid (GABA) A receptor, subunit beta 1	0.011
Ptprcap	protein tyrosine phosphatase, receptor type, C polypeptide-associated protein	0.011
Plp1	proteolipid protein (myelin) 1	0.011
Tspan1	tetraspanin 1	0.011
Cltc	clathrin, heavy polypeptide (Hc)	0.011
Eps15	epidermal growth factor receptor pathway substrate 15	0.011
Spast	spastin	0.010
Cit	citron	0.010
Homer1	homer homolog 1 (Drosophila)	0.010
Hoxd12	homeobox D12	0.010
Lcp1	lymphocyte cytosolic protein 1	0.010
Crb3	crumbs homolog 3 (Drosophila)	0.010
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.010
Mtap2	microtubule-associated protein 2	0.010
Shank2	SH3/ankyrin domain gene 2	0.010
Ate1	arginyltransferase 1	0.010