Mus musculus

142 known processes

Egfr

epidermal growth factor receptor

(Aliases: 9030024J15Rik,wa2,wa-2,Erbb,Wa5,Errp,AI552599)

Egfr biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 1.000
stem cell development GO:0048864 219 1.000
Mouse Fly
regulation of epidermal growth factor activated receptor activity GO:0007176 7 1.000
regulation of transferase activity GO:0051338 263 1.000
Rat
gland development GO:0048732 330 1.000
regionalization GO:0003002 337 0.999
Fly
positive regulation of transferase activity GO:0051347 167 0.998
Rat
stem cell maintenance GO:0019827 130 0.996
Fly
epithelial tube morphogenesis GO:0060562 303 0.995
Fly
regulation of receptor activity GO:0010469 41 0.995
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.994
regulation of kinase activity GO:0043549 249 0.994
Rat
stem cell differentiation GO:0048863 268 0.993
Mouse Fly
negative regulation of cell proliferation GO:0008285 296 0.993
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.993
placenta development GO:0001890 140 0.993
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.993
cellular response to hormone stimulus GO:0032870 150 0.992
Rat
regulation of cellular ketone metabolic process GO:0010565 66 0.991
positive regulation of protein kinase activity GO:0045860 144 0.991
Rat
negative regulation of cellular amine metabolic process GO:0033239 1 0.991
positive regulation of kinase activity GO:0033674 155 0.991
Rat
axon guidance GO:0007411 141 0.988
Mouse
hair follicle development GO:0001942 85 0.983
epidermis morphogenesis GO:0048730 33 0.982
regulation of leukocyte differentiation GO:1902105 159 0.982
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.982
activation of mapk activity involved in innate immune response GO:0035419 2 0.980
embryonic placenta development GO:0001892 98 0.980
regulation of protein kinase activity GO:0045859 232 0.978
Rat
positive regulation of protein kinase b signaling GO:0051897 32 0.977
amine metabolic process GO:0009308 45 0.976
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.974
ameboidal type cell migration GO:0001667 128 0.974
Mouse Fly
negative regulation of epidermal growth factor activated receptor activity GO:0007175 3 0.974
branching morphogenesis of an epithelial tube GO:0048754 159 0.973
regulation of protein tyrosine kinase activity GO:0061097 17 0.972
morphogenesis of a branching structure GO:0001763 203 0.971
peptidyl tyrosine modification GO:0018212 145 0.970
response to organonitrogen compound GO:0010243 246 0.970
regulation of t cell differentiation GO:0045580 83 0.969
Mouse
ear development GO:0043583 200 0.968
regulation of mapk cascade GO:0043408 248 0.967
Rat
positive regulation of map kinase activity GO:0043406 84 0.965
Rat
epithelial cell proliferation GO:0050673 174 0.965
positive regulation of epidermal growth factor activated receptor activity GO:0045741 2 0.962
leukocyte differentiation GO:0002521 342 0.960
Mouse
regulation of t cell activation GO:0050863 170 0.950
Mouse
regulation of secretion by cell GO:1903530 249 0.949
striated muscle tissue development GO:0014706 293 0.949
Mouse
prostate glandular acinus development GO:0060525 12 0.946
learning or memory GO:0007611 148 0.942
Rat Fly
cellular response to organonitrogen compound GO:0071417 145 0.941
morphogenesis of a polarized epithelium GO:0001738 37 0.939
Fly
regulation of protein serine threonine kinase activity GO:0071900 157 0.939
Rat
wound healing GO:0042060 157 0.938
Mouse Fly
blood vessel morphogenesis GO:0048514 285 0.937
positive regulation of mapk cascade GO:0043410 170 0.936
Rat
regulation of cellular amino acid metabolic process GO:0006521 5 0.933
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.933
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.932
activation of mapk activity GO:0000187 59 0.930
Rat
cellular response to peptide GO:1901653 92 0.930
cell differentiation involved in embryonic placenta development GO:0060706 26 0.930
epidermal growth factor receptor signaling pathway GO:0007173 28 0.929
regulation of hydrolase activity GO:0051336 246 0.927
Mouse
embryonic organ morphogenesis GO:0048562 276 0.927
cardiac muscle tissue development GO:0048738 130 0.922
Mouse
cerebral cortex development GO:0021987 86 0.921
protein kinase b signaling GO:0043491 74 0.920
cellular ketone metabolic process GO:0042180 84 0.920
peptidyl amino acid modification GO:0018193 336 0.919
regulation of body fluid levels GO:0050878 162 0.918
Mouse
molting cycle GO:0042303 90 0.913
urogenital system development GO:0001655 261 0.913
Fly
trophoblast giant cell differentiation GO:0060707 15 0.910
positive regulation of leukocyte differentiation GO:1902107 86 0.910
small gtpase mediated signal transduction GO:0007264 97 0.909
ventricular septum morphogenesis GO:0060412 27 0.907
negative regulation of receptor activity GO:2000272 5 0.906
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.905
morphogenesis of a branching epithelium GO:0061138 193 0.905
mapk cascade GO:0000165 281 0.904
Rat
cardiac chamber development GO:0003205 108 0.902
regulation of epidermal cell differentiation GO:0045604 21 0.899
regulation of cellular amine metabolic process GO:0033238 20 0.896
keratinocyte differentiation GO:0030216 48 0.896
regulation of insulin receptor signaling pathway GO:0046626 21 0.893
cellular response to growth factor stimulus GO:0071363 197 0.889
Rat
cell proliferation in hindbrain GO:0021534 10 0.887
cellular amino acid metabolic process GO:0006520 103 0.883
negative regulation of protein metabolic process GO:0051248 282 0.881
regulation of erk1 and erk2 cascade GO:0070372 71 0.880
cytokine mediated signaling pathway GO:0019221 115 0.878
regulation of cell activation GO:0050865 289 0.877
Mouse
organ growth GO:0035265 117 0.872
Mouse
regulation of epidermal growth factor receptor signaling pathway GO:0042058 13 0.872
fibronectin dependent thymocyte migration GO:0072681 1 0.869
negative regulation of phosphorylation GO:0042326 166 0.866
lung vasculature development GO:0060426 7 0.861
prostate gland morphogenesis GO:0060512 32 0.860
epidermis development GO:0008544 187 0.856
rac protein signal transduction GO:0016601 13 0.851
appendage morphogenesis GO:0035107 149 0.850
Fly
negative regulation of release of cytochrome c from mitochondria GO:0090201 6 0.846
positive regulation of t cell differentiation GO:0045582 52 0.843
regulation of secretion GO:0051046 274 0.842
response to peptide GO:1901652 136 0.841
ras protein signal transduction GO:0007265 77 0.841
regulation of protein kinase b signaling GO:0051896 56 0.836
response to fibroblast growth factor GO:0071774 47 0.836
glial cell differentiation GO:0010001 131 0.836
Mouse Rat
response to metal ion GO:0010038 47 0.832
Rat
skin development GO:0043588 220 0.831
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.830
formation of radial glial scaffolds GO:0021943 4 0.829
hair follicle morphogenesis GO:0031069 29 0.828
prostate glandular acinus morphogenesis GO:0060526 7 0.827
regulation of cell migration GO:0030334 219 0.826
Mouse
regulation of cell motility GO:2000145 236 0.826
Mouse
segmentation GO:0035282 93 0.825
Fly
skeletal muscle organ development GO:0060538 163 0.824
regulation of jak stat cascade GO:0046425 34 0.822
Mouse
developmental growth involved in morphogenesis GO:0060560 138 0.809
muscle cell differentiation GO:0042692 261 0.803
bone morphogenesis GO:0060349 78 0.798
positive regulation of cellular amine metabolic process GO:0033240 5 0.798
carbohydrate metabolic process GO:0005975 230 0.796
multicellular organism growth GO:0035264 161 0.790
t cell activation GO:0042110 289 0.788
Mouse
mammary gland alveolus development GO:0060749 22 0.786
Mouse
vesicle localization GO:0051648 86 0.786
pyramidal neuron migration GO:0021852 1 0.781
inflammatory response GO:0006954 244 0.779
Rat
cellular calcium ion homeostasis GO:0006874 119 0.779
neuron projection guidance GO:0097485 141 0.778
Mouse
positive regulation of nervous system development GO:0051962 221 0.776
negative regulation of cellular component organization GO:0051129 194 0.775
clara cell differentiation GO:0060486 4 0.774
cellular response to insulin stimulus GO:0032869 78 0.773
multi multicellular organism process GO:0044706 109 0.772
digestive tract development GO:0048565 190 0.771
gonad development GO:0008406 141 0.770
Fly
peptidyl tyrosine phosphorylation GO:0018108 143 0.767
regulation of map kinase activity GO:0043405 120 0.765
Rat
signal transduction in absence of ligand GO:0038034 55 0.764
release of cytochrome c from mitochondria GO:0001836 23 0.762
regulation of glucose metabolic process GO:0010906 60 0.759
negative regulation of fibroblast migration GO:0010764 2 0.758
insulin receptor signaling pathway GO:0008286 49 0.756
cell migration involved in gastrulation GO:0042074 13 0.755
regulation of keratinocyte differentiation GO:0045616 11 0.755
muscle tissue development GO:0060537 308 0.753
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.750
regulation of neural precursor cell proliferation GO:2000177 70 0.749
negative regulation of cell migration GO:0030336 59 0.748
response to peptide hormone GO:0043434 127 0.748
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.747
forebrain development GO:0030900 302 0.747
ovarian follicle development GO:0001541 40 0.746
lung epithelium development GO:0060428 37 0.746
regulation of anoikis GO:2000209 2 0.742
cerebral cortex cell migration GO:0021795 44 0.739
epithelial cell development GO:0002064 159 0.738
Fly
lactation GO:0007595 25 0.736
Mouse
heart morphogenesis GO:0003007 178 0.735
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.733
Rat
extracellular matrix dependent thymocyte migration GO:0072680 1 0.730
positive regulation of neural precursor cell proliferation GO:2000179 42 0.730
prostate gland stromal morphogenesis GO:0060741 2 0.728
sensory organ morphogenesis GO:0090596 242 0.723
Fly
hair cycle GO:0042633 90 0.718
regulation of t cell proliferation GO:0042129 92 0.716
Mouse
regulation of lymphocyte proliferation GO:0050670 117 0.716
Mouse
camera type eye development GO:0043010 266 0.713
cellular response to peptide hormone stimulus GO:0071375 92 0.713
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.706
protein processing GO:0016485 163 0.705
negative regulation of molecular function GO:0044092 258 0.704
positive regulation of thymocyte migration GO:2000412 2 0.704
digestive system development GO:0055123 200 0.702
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.701
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 2 0.692
regulation of ion homeostasis GO:2000021 64 0.691
lung development GO:0030324 164 0.690
Rat
positive regulation of lymphocyte differentiation GO:0045621 61 0.690
mesenchyme development GO:0060485 152 0.689
Mouse
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.689
regulation of cell projection organization GO:0031344 206 0.689
positive regulation of programmed cell death GO:0043068 218 0.688
salivary gland development GO:0007431 37 0.685
regulation of fibroblast proliferation GO:0048145 34 0.685
mitochondrion organization GO:0007005 134 0.680
prostate gland morphogenetic growth GO:0060737 4 0.677
sulfur compound biosynthetic process GO:0044272 37 0.676
negative regulation of growth GO:0045926 99 0.676
glycerolipid metabolic process GO:0046486 122 0.662
positive regulation of hydrolase activity GO:0051345 148 0.659
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.657
regulation of ion transport GO:0043269 215 0.652
wnt signaling pathway planar cell polarity pathway GO:0060071 27 0.651
positive regulation of apoptotic process GO:0043065 217 0.650
response to acid chemical GO:0001101 111 0.650
neuron apoptotic process GO:0051402 142 0.650
Mouse
cell type specific apoptotic process GO:0097285 268 0.649
Mouse
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 20 0.648
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.648
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 7 0.643
tissue regeneration GO:0042246 22 0.643
Mouse
erbb signaling pathway GO:0038127 32 0.642
cellular amine metabolic process GO:0044106 44 0.640
carbon catabolite activation of transcription GO:0045991 4 0.639
protein maturation GO:0051604 176 0.638
jak stat cascade GO:0007259 42 0.638
Mouse
regulation of lymphocyte activation GO:0051249 240 0.634
Mouse
purine ribonucleotide metabolic process GO:0009150 290 0.629
Mouse
kidney development GO:0001822 213 0.626
placenta blood vessel development GO:0060674 31 0.625
prostate gland epithelium morphogenesis GO:0060740 31 0.617
response to growth factor GO:0070848 198 0.612
Rat
regulation of proteolysis GO:0030162 164 0.610
protein catabolic process GO:0030163 221 0.605
atrial ventricular junction remodeling GO:0003294 2 0.602
skin morphogenesis GO:0043589 38 0.599
wnt signaling pathway GO:0016055 188 0.597
angiogenesis GO:0001525 201 0.594
mesodermal cell migration GO:0008078 4 0.592
mammary gland epithelium development GO:0061180 65 0.592
Mouse
cognition GO:0050890 149 0.587
Rat Fly
mammary gland morphogenesis GO:0060443 54 0.585
positive regulation of protein catabolic process GO:0045732 60 0.580
cell adhesion GO:0007155 329 0.580
Fly
pma inducible membrane protein ectodomain proteolysis GO:0051088 1 0.575
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.572
wound healing spreading of cells GO:0044319 8 0.570
negative regulation of phosphorus metabolic process GO:0010563 184 0.568
regulation of inflammatory response GO:0050727 147 0.566
Rat
humoral immune response GO:0006959 57 0.563
mammary gland lobule development GO:0061377 22 0.559
Mouse
regulation of cellular catabolic process GO:0031329 242 0.556
Mouse
regulation of androgen receptor signaling pathway GO:0060765 3 0.555
positive regulation of angiogenesis GO:0045766 46 0.553
regeneration GO:0031099 38 0.551
Mouse
digestive tract morphogenesis GO:0048546 147 0.551
connective tissue development GO:0061448 179 0.551
positive regulation of protein modification process GO:0031401 299 0.544
Mouse Rat
olfactory learning GO:0008355 2 0.541
Fly
response to insulin GO:0032868 100 0.540
somitogenesis GO:0001756 69 0.538
regulation of defense response GO:0031347 233 0.535
Rat
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.533
regulation of protein localization GO:0032880 231 0.529
Mouse
response to corticosteroid GO:0031960 20 0.527
Rat
cardiac septum development GO:0003279 59 0.522
tissue migration GO:0090130 68 0.516
Fly
maternal process involved in female pregnancy GO:0060135 32 0.515
memory GO:0007613 58 0.514
respiratory system development GO:0060541 190 0.511
Rat Fly
regulation of mitochondrion organization GO:0010821 27 0.510
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.510
developmental maturation GO:0021700 193 0.506
Fly
proteoglycan biosynthetic process GO:0030166 20 0.504
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.499
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.497
neuron migration GO:0001764 122 0.496
limb development GO:0060173 166 0.494
purine nucleotide metabolic process GO:0006163 302 0.492
Mouse
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.490
regulation of establishment of protein localization GO:0070201 181 0.482
Mouse
positive regulation of bmp signaling pathway GO:0030513 23 0.479
locomotory behavior GO:0007626 195 0.478
chemotaxis GO:0006935 247 0.478
Mouse
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 6 0.478
macromolecule catabolic process GO:0009057 281 0.478
cytoplasmic transport GO:0016482 234 0.477
Mouse
energy derivation by oxidation of organic compounds GO:0015980 77 0.474
divalent inorganic cation transport GO:0072511 178 0.473
acylglycerol metabolic process GO:0006639 55 0.471
phosphatidylinositol mediated signaling GO:0048015 41 0.468
epithelial cell maturation GO:0002070 15 0.467
regulation of cellular component biogenesis GO:0044087 181 0.466
retinal blood vessel morphogenesis GO:0061304 3 0.464
negative regulation of kinase activity GO:0033673 81 0.463
respiratory tube development GO:0030323 167 0.462
Rat
layer formation in cerebral cortex GO:0021819 13 0.461
negative regulation of cell development GO:0010721 169 0.458
Fly
negative regulation of phosphate metabolic process GO:0045936 184 0.456
lung cell differentiation GO:0060479 30 0.454
glycoprotein biosynthetic process GO:0009101 89 0.447
prevention of polyspermy GO:0060468 4 0.446
lung lobe morphogenesis GO:0060463 9 0.445
positive regulation of proteolysis GO:0045862 85 0.444
regulation of cardiac muscle tissue growth GO:0055021 26 0.442
Mouse
gastrulation GO:0007369 116 0.439
pallium development GO:0021543 120 0.439
development of primary sexual characteristics GO:0045137 143 0.434
Fly
multicellular organismal catabolic process GO:0044243 7 0.432
b cell differentiation GO:0030183 78 0.432
hindlimb morphogenesis GO:0035137 42 0.431
organ regeneration GO:0031100 2 0.430
positive regulation of cell migration GO:0030335 109 0.430
regulation of cardiac muscle tissue development GO:0055024 31 0.430
Mouse
synapse organization GO:0050808 125 0.426
Mouse
negative regulation of protein phosphorylation GO:0001933 126 0.425
axonogenesis GO:0007409 274 0.423
Mouse
cellular divalent inorganic cation homeostasis GO:0072503 127 0.423
regulation of corticosteroid hormone secretion GO:2000846 5 0.419
blood coagulation GO:0007596 76 0.416
skeletal system development GO:0001501 356 0.412
positive regulation of rac protein signal transduction GO:0035022 1 0.411
cardiocyte differentiation GO:0035051 87 0.409
response to extracellular stimulus GO:0009991 127 0.409
Rat
spermatid differentiation GO:0048515 115 0.403
positive regulation of protein phosphorylation GO:0001934 242 0.402
Mouse Rat
divalent metal ion transport GO:0070838 172 0.402
wound healing spreading of epidermal cells GO:0035313 5 0.401
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.400
leukocyte proliferation GO:0070661 172 0.399
Mouse
synaptic vesicle localization GO:0097479 59 0.399
regulation of establishment of planar polarity GO:0090175 28 0.399
positive regulation of t cell activation GO:0050870 101 0.398
positive regulation of eosinophil migration GO:2000418 2 0.397
myoblast proliferation GO:0051450 11 0.395
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.394
regulation of wound healing GO:0061041 40 0.392
Fly
positive regulation of leukocyte apoptotic process GO:2000108 21 0.392
regulation of cellular response to insulin stimulus GO:1900076 30 0.389
glycoprotein metabolic process GO:0009100 116 0.389
male gamete generation GO:0048232 285 0.387
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.386
lymphocyte apoptotic process GO:0070227 54 0.386
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.385
negative regulation of anoikis GO:2000811 2 0.384
ventricular septum development GO:0003281 42 0.384
organonitrogen compound biosynthetic process GO:1901566 192 0.383
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.383
embryonic appendage morphogenesis GO:0035113 126 0.382
limb morphogenesis GO:0035108 149 0.380
regulation of epidermis development GO:0045682 33 0.380
outflow tract morphogenesis GO:0003151 53 0.379
axis elongation GO:0003401 30 0.377
negative regulation of androgen receptor signaling pathway GO:0060766 3 0.377
anatomical structure homeostasis GO:0060249 145 0.376
Fly
primary neural tube formation GO:0014020 95 0.376
epithelial cell maturation involved in prostate gland development GO:0060743 4 0.374
regulation of cell cycle GO:0051726 281 0.374
Rat Fly
germ line stem cell division GO:0042078 2 0.374
neural precursor cell proliferation GO:0061351 121 0.373
positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 3 0.372
steroid metabolic process GO:0008202 119 0.372
negative regulation of cardiac muscle tissue development GO:0055026 8 0.372
regulation of fat cell differentiation GO:0045598 81 0.370
bmp signaling pathway GO:0030509 93 0.370
lateral mesodermal cell differentiation GO:0048371 3 0.370
lateral mesoderm morphogenesis GO:0048369 3 0.370
positive regulation of transcription by glucose GO:0046016 3 0.369
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.365
positive regulation of cell growth GO:0030307 33 0.364
establishment of organelle localization GO:0051656 122 0.363
regulation of canonical wnt signaling pathway GO:0060828 82 0.362
negative regulation of t cell proliferation GO:0042130 38 0.362
Mouse
positive regulation of secretion by cell GO:1903532 114 0.362
cellular response to amino acid stimulus GO:0071230 29 0.362
negative regulation of erbb signaling pathway GO:1901185 7 0.359
positive regulation of cardioblast differentiation GO:0051891 3 0.357
cellular response to steroid hormone stimulus GO:0071383 33 0.354
Rat
lung morphogenesis GO:0060425 50 0.354
determination of heart left right asymmetry GO:0061371 48 0.349
cytokine production GO:0001816 319 0.349
extracellular matrix organization GO:0030198 147 0.348
associative learning GO:0008306 61 0.347
Fly
ventricular zone neuroblast division GO:0021847 3 0.345
canonical wnt signaling pathway GO:0060070 130 0.343
regulation of bmp signaling pathway GO:0030510 60 0.342
positive regulation of steroid biosynthetic process GO:0010893 4 0.341
regulation of neuron differentiation GO:0045664 281 0.341
neural fold elevation formation GO:0021502 1 0.337
myeloid cell differentiation GO:0030099 233 0.335
eosinophil migration GO:0072677 3 0.334
negative regulation of intracellular signal transduction GO:1902532 167 0.333
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 0.330
response to drug GO:0042493 75 0.327
Rat
regulation of eosinophil migration GO:2000416 2 0.326
negative regulation of neural precursor cell proliferation GO:2000178 18 0.324
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.320
skeletal system morphogenesis GO:0048705 203 0.320
mammary gland duct morphogenesis GO:0060603 38 0.319
response to monosaccharide GO:0034284 67 0.318
inositol lipid mediated signaling GO:0048017 41 0.317
regulation of neuron apoptotic process GO:0043523 122 0.317
Mouse
chondrocyte differentiation GO:0002062 72 0.316
positive regulation of cardiac muscle cell proliferation GO:0060045 15 0.316
Mouse
regulation of cellular response to growth factor stimulus GO:0090287 82 0.315
phospholipid metabolic process GO:0006644 87 0.315
intermediate filament based process GO:0045103 27 0.314
negative regulation of hydrolase activity GO:0051346 71 0.313
blood vessel remodeling GO:0001974 33 0.313
mitotic cell cycle process GO:1903047 159 0.313
Fly
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 13 0.313
cell substrate adhesion GO:0031589 130 0.313
face morphogenesis GO:0060325 29 0.313
embryonic skeletal system development GO:0048706 120 0.312
embryonic skeletal system morphogenesis GO:0048704 91 0.311
positive regulation of ras protein signal transduction GO:0046579 13 0.311
blastoderm segmentation GO:0007350 13 0.310
Fly
glycosaminoglycan metabolic process GO:0030203 34 0.308
regulation of skeletal muscle fiber development GO:0048742 36 0.305
mitral valve morphogenesis GO:0003183 4 0.304
prostate epithelial cord elongation GO:0060523 3 0.304
positive regulation of axon extension GO:0045773 20 0.302
positive regulation of glucose import in response to insulin stimulus GO:2001275 5 0.301
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.300
wnt signaling pathway involved in kidney development GO:0061289 2 0.299
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.298
erk1 and erk2 cascade GO:0070371 77 0.298
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.297
peptide hormone secretion GO:0030072 109 0.297
negative regulation of neuron death GO:1901215 98 0.296
Mouse
female gamete generation GO:0007292 74 0.296
Worm Fly
labyrinthine layer development GO:0060711 49 0.295
activation of janus kinase activity GO:0042976 2 0.295
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.292
cardiac chamber morphogenesis GO:0003206 93 0.291
branching involved in prostate gland morphogenesis GO:0060442 15 0.288
cellular homeostasis GO:0019725 240 0.288
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.286
cardiac endothelial cell differentiation GO:0003348 4 0.285
regulation of muscle tissue development GO:1901861 97 0.284
Mouse
regulation of cell adhesion GO:0030155 154 0.283
negative regulation of immune system process GO:0002683 209 0.283
Mouse
female genitalia morphogenesis GO:0048807 3 0.281
cardioblast migration to the midline involved in heart field formation GO:0060975 1 0.281
aminoglycan metabolic process GO:0006022 34 0.280
bone resorption GO:0045453 38 0.280
cytosolic calcium ion transport GO:0060401 48 0.279
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.279
positive regulation of apoptotic signaling pathway GO:2001235 95 0.277
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.274
Mouse
peptide secretion GO:0002790 114 0.274
positive regulation of stem cell proliferation GO:2000648 59 0.274
cellular response to organic cyclic compound GO:0071407 87 0.272
Rat
positive regulation of growth GO:0045927 104 0.272
Mouse
synaptic transmission GO:0007268 329 0.271
Rat
regulation of organ morphogenesis GO:2000027 144 0.269
Fly
regulation of hormone levels GO:0010817 211 0.269
cell surface receptor signaling pathway involved in heart development GO:0061311 15 0.269
endodermal cell fate specification GO:0001714 4 0.268
multi organism reproductive behavior GO:0044705 29 0.267
regulation of endothelial cell chemotaxis GO:2001026 1 0.266
regulation of organelle organization GO:0033043 289 0.265
glial cell development GO:0021782 54 0.264
Rat
neural crest cell migration GO:0001755 32 0.264
Mouse
activation of immune response GO:0002253 138 0.263
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.263
intermediate filament cytoskeleton organization GO:0045104 26 0.263
negative regulation of neuron projection development GO:0010977 50 0.263
regulation of angiogenesis GO:0045765 81 0.261
amide transport GO:0042886 138 0.260
endocrine process GO:0050886 39 0.260
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.259
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.259
neurotrophin trk receptor signaling pathway GO:0048011 8 0.259
cell growth involved in cardiac muscle cell development GO:0061049 3 0.257
compound eye development GO:0048749 1 0.256
Fly
neurotrophin signaling pathway GO:0038179 12 0.256
growth plate cartilage development GO:0003417 14 0.255
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.255
Mouse
myelination in peripheral nervous system GO:0022011 19 0.254
regulation of protein transport GO:0051223 163 0.254
Mouse
keratinocyte migration GO:0051546 3 0.252
response to steroid hormone GO:0048545 56 0.252
Rat
regulation of actin filament based process GO:0032970 99 0.251
regulation of cholesterol metabolic process GO:0090181 14 0.251
lateral mesoderm formation GO:0048370 3 0.250
female sex differentiation GO:0046660 84 0.250
regulation of carbohydrate metabolic process GO:0006109 75 0.248
negative regulation of response to wounding GO:1903035 77 0.248
hindbrain radial glia guided cell migration GO:0021932 12 0.246
alpha beta t cell differentiation GO:0046632 69 0.245
response to ethanol GO:0045471 18 0.245
Fly
ossification GO:0001503 216 0.245
keratinocyte proliferation GO:0043616 21 0.245
cellular chemical homeostasis GO:0055082 215 0.242
regulation of rac protein signal transduction GO:0035020 19 0.241
regulation of ras protein signal transduction GO:0046578 114 0.239
Mouse
positive regulation of fibronectin dependent thymocyte migration GO:2000415 1 0.239
regulation of cell shape GO:0008360 39 0.239
prostate gland development GO:0030850 48 0.237
activation of mapkk activity GO:0000186 15 0.236
Rat
inner ear receptor cell differentiation GO:0060113 61 0.235

Egfr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
heart disease DOID:114 0 0.792
disease of anatomical entity DOID:7 0 0.792
cardiovascular system disease DOID:1287 0 0.792
disease of cellular proliferation DOID:14566 0 0.701
noonan syndrome DOID:3490 0 0.517