IMP
Process View
neurotrophin signaling pathway
A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "neurotrophin signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Ngfr | nerve growth factor receptor (TNFR superfamily, member 16) | 0.966 | ||
| Ntrk3 | neurotrophic tyrosine kinase, receptor, type 3 | 0.924 | Human Mouse Rat | |
| Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.921 | ||
| Ntf3 | neurotrophin 3 | 0.918 | Mouse | |
| Ret | ret proto-oncogene | 0.899 | ||
| Bdnf | brain derived neurotrophic factor | 0.805 | Mouse | |
| Grb2 | growth factor receptor bound protein 2 | 0.697 | ||
| Erbb3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.593 | ||
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.559 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.501 | ||
| Nrg1 | neuregulin 1 | 0.444 | ||
| Lepr | leptin receptor | 0.430 | ||
| Spry4 | sprouty homolog 4 (Drosophila) | 0.427 | Mouse | |
| Egfr | epidermal growth factor receptor | 0.256 | ||
| Ntf5 | neurotrophin 5 | 0.234 | Mouse | |
| Agtr1a | angiotensin II receptor, type 1a | 0.171 | ||
| Vti1a | vesicle transport through interaction with t-SNAREs homolog 1A (yeast) | 0.161 | ||
| Slc12a1 | solute carrier family 12, member 1 | 0.149 | ||
| Gal | galanin | 0.112 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.099 | ||
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.080 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.078 | ||
| Phox2a | paired-like homeobox 2a | 0.073 | ||
| Hey2 | hairy/enhancer-of-split related with YRPW motif 2 | 0.070 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.069 | ||
| Erbb2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.066 | ||
| Src | Rous sarcoma oncogene | 0.066 | Rat | |
| Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 0.055 | ||
| Pxn | paxillin | 0.054 | ||
| Gabrb3 | gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 | 0.050 | ||
| Nf1 | neurofibromatosis 1 | 0.048 | ||
| Sesn2 | sestrin 2 | 0.048 | ||
| Sos1 | son of sevenless homolog 1 (Drosophila) | 0.045 | ||
| Dst | dystonin | 0.045 | ||
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.045 | ||
| Ren1 | renin 1 structural | 0.045 | ||
| Plcg1 | phospholipase C, gamma 1 | 0.044 | ||
| Vav2 | vav 2 oncogene | 0.043 | ||
| Itga3 | integrin alpha 3 | 0.037 | ||
| Atg13 | ATG13 autophagy related 13 homolog (S. cerevisiae) | 0.037 | ||
| Gnb2 | guanine nucleotide binding protein (G protein), beta 2 | 0.036 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.035 | ||
| Nradd | neurotrophin receptor associated death domain | 0.034 | ||
| Foxc1 | forkhead box C1 | 0.033 | ||
| Fez1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.033 | ||
| Vav1 | vav 1 oncogene | 0.030 | ||
| Cbl | Casitas B-lineage lymphoma | 0.030 | ||
| Klc2 | kinesin light chain 2 | 0.029 | ||
| Maged1 | melanoma antigen, family D, 1 | 0.029 | ||
| Ywhag | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 0.029 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.027 | ||
| Vav3 | vav 3 oncogene | 0.026 | ||
| Tuba1a | tubulin, alpha 1A | 0.025 | ||
| Gab2 | growth factor receptor bound protein 2-associated protein 2 | 0.025 | ||
| Prkce | protein kinase C, epsilon | 0.024 | ||
| Spry2 | sprouty homolog 2 (Drosophila) | 0.023 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.023 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.023 | ||
| Efnb2 | ephrin B2 | 0.022 | ||
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.022 | ||
| Arpc4 | actin related protein 2/3 complex, subunit 4 | 0.022 | ||
| Bcar1 | breast cancer anti-estrogen resistance 1 | 0.022 | Rat | |
| Atp2a2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.021 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.020 | ||
| Mmp17 | matrix metallopeptidase 17 | 0.019 | ||
| Sema6a | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 0.019 | ||
| Lox | lysyl oxidase | 0.019 | ||
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.019 | ||
| Ntrk1 | neurotrophic tyrosine kinase, receptor, type 1 | 0.019 | ||
| Ahi1 | Abelson helper integration site 1 | 0.018 | ||
| Flii | flightless I homolog (Drosophila) | 0.018 | ||
| Ldlr | low density lipoprotein receptor | 0.017 | ||
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.017 | ||
| Dbnl | drebrin-like | 0.016 | ||
| Jup | junction plakoglobin | 0.016 | ||
| Mark4 | MAP/microtubule affinity-regulating kinase 4 | 0.016 | ||
| Gfra1 | glial cell line derived neurotrophic factor family receptor alpha 1 | 0.016 | ||
| Egr3 | early growth response 3 | 0.016 | ||
| Sorcs2 | sortilin-related VPS10 domain containing receptor 2 | 0.016 | ||
| Ticam1 | toll-like receptor adaptor molecule 1 | 0.016 | ||
| Pcdh18 | protocadherin 18 | 0.015 | ||
| Crk | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.015 | ||
| Hbegf | heparin-binding EGF-like growth factor | 0.015 | ||
| Mid1 | midline 1 | 0.014 | ||
| Plcg2 | phospholipase C, gamma 2 | 0.014 | ||
| Vegfa | vascular endothelial growth factor A | 0.014 | ||
| Fyn | Fyn proto-oncogene | 0.014 | ||
| Itgb2 | integrin beta 2 | 0.014 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.013 | ||
| Nr2f1 | nuclear receptor subfamily 2, group F, member 1 | 0.013 | ||
| Npy1r | neuropeptide Y receptor Y1 | 0.013 | ||
| Wdr1 | WD repeat domain 1 | 0.013 | ||
| Ror1 | receptor tyrosine kinase-like orphan receptor 1 | 0.013 | Mouse | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.013 | ||
| Wnt5a | wingless-related MMTV integration site 5A | 0.013 | ||
| Vps26b | vacuolar protein sorting 26 homolog B (yeast) | 0.012 | ||
| Atp1b2 | ATPase, Na+/K+ transporting, beta 2 polypeptide | 0.012 | ||
| Tead4 | TEA domain family member 4 | 0.012 | ||
| Msx2 | homeobox, msh-like 2 | 0.012 | ||
| Siah2 | seven in absentia 2 | 0.012 | ||
| Sema5a | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.012 | ||
| Hprt | hypoxanthine guanine phosphoribosyl transferase | 0.012 | ||
| Adrbk1 | adrenergic receptor kinase, beta 1 | 0.012 | ||
| Hoxa1 | homeobox A1 | 0.011 | ||
| Rb1cc1 | RB1-inducible coiled-coil 1 | 0.011 | ||
| Arrb2 | arrestin, beta 2 | 0.011 | ||
| Ptprs | protein tyrosine phosphatase, receptor type, S | 0.011 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.011 | ||
| Ncs1 | neuronal calcium sensor 1 | 0.010 | ||
| Rb1 | retinoblastoma 1 | 0.010 | ||
| Tsc2 | tuberous sclerosis 2 | 0.010 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.010 | ||
| Nnat | neuronatin | 0.010 | ||
| Prkcb | protein kinase C, beta | 0.010 |