Mus musculus

164 known processes

Gclc

glutamate-cysteine ligase, catalytic subunit

(Aliases: Glclc,Ggcs-hs,D9Wsu168e,GLCL-H)

Gclc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
serine family amino acid metabolic process GO:0009069 7 0.995
Human
cellular amino acid biosynthetic process GO:0008652 22 0.985
glutathione metabolic process GO:0006749 16 0.965
cellular modified amino acid biosynthetic process GO:0042398 12 0.946
glutathione biosynthetic process GO:0006750 4 0.941
regulation of membrane depolarization GO:0003254 11 0.886
cysteine metabolic process GO:0006534 3 0.778
Human
sulfur compound metabolic process GO:0006790 100 0.760
peptide metabolic process GO:0006518 46 0.749
organic acid biosynthetic process GO:0016053 86 0.742
cellular amide metabolic process GO:0043603 58 0.683
cellular modified amino acid metabolic process GO:0006575 63 0.658
regulation of mitochondrial depolarization GO:0051900 5 0.646
sulfur amino acid metabolic process GO:0000096 9 0.637
Human
cellular amino acid metabolic process GO:0006520 103 0.619
mitochondrion organization GO:0007005 134 0.559
regulation of membrane potential GO:0042391 192 0.528
membrane depolarization GO:0051899 64 0.448
organonitrogen compound biosynthetic process GO:1901566 192 0.440
regulation of mitochondrial membrane potential GO:0051881 17 0.426
apoptotic mitochondrial changes GO:0008637 48 0.415
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.413
peptide biosynthetic process GO:0043043 11 0.408
response to oxidative stress GO:0006979 123 0.389
Human
small molecule biosynthetic process GO:0044283 132 0.364
regulation of apoptotic signaling pathway GO:2001233 197 0.308
circulatory system process GO:0003013 197 0.304
Human
extrinsic apoptotic signaling pathway GO:0097191 126 0.285
negative regulation of apoptotic signaling pathway GO:2001234 104 0.275
regulation of ion homeostasis GO:2000021 64 0.268
regulation of homeostatic process GO:0032844 182 0.260
vascular process in circulatory system GO:0003018 62 0.258
Human
regulation of blood vessel size GO:0050880 56 0.256
Human
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.226
regulation of ligase activity GO:0051340 10 0.208
regulation of anatomical structure size GO:0090066 178 0.206
Human
regulation of tube size GO:0035150 57 0.202
Human
cellular lipid metabolic process GO:0044255 323 0.080
transmembrane transport GO:0055085 412 0.074
amine metabolic process GO:0009308 45 0.074
cellular amine metabolic process GO:0044106 44 0.073
response to drug GO:0042493 75 0.069
oxidation reduction process GO:0055114 342 0.068
nucleobase containing small molecule metabolic process GO:0055086 352 0.057
purine ribonucleotide metabolic process GO:0009150 290 0.055
cellular ketone metabolic process GO:0042180 84 0.053
purine nucleotide metabolic process GO:0006163 302 0.049
nucleoside metabolic process GO:0009116 246 0.049
cellular homeostasis GO:0019725 240 0.048
Human
regulation of cellular amino acid metabolic process GO:0006521 5 0.046
ribonucleoside metabolic process GO:0009119 245 0.044
organic cyclic compound catabolic process GO:1901361 295 0.043
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.042
anion transport GO:0006820 177 0.040
ion transmembrane transport GO:0034220 361 0.038
chromatin modification GO:0016568 187 0.038
cellular nitrogen compound catabolic process GO:0044270 280 0.037
neural precursor cell proliferation GO:0061351 121 0.037
regulation of cellular amine metabolic process GO:0033238 20 0.037
ribonucleotide metabolic process GO:0009259 291 0.037
histone modification GO:0016570 159 0.037
macromolecule methylation GO:0043414 120 0.036
negative regulation of protein metabolic process GO:0051248 282 0.036
chromatin organization GO:0006325 206 0.036
protein alkylation GO:0008213 81 0.035
stem cell proliferation GO:0072089 117 0.035
protein modification by small protein conjugation or removal GO:0070647 207 0.035
carbohydrate derivative biosynthetic process GO:1901137 183 0.035
organic hydroxy compound metabolic process GO:1901615 203 0.035
nucleoside phosphate metabolic process GO:0006753 338 0.035
skeletal system development GO:0001501 356 0.034
ribose phosphate metabolic process GO:0019693 291 0.033
methylation GO:0032259 134 0.033
purine ribonucleoside metabolic process GO:0046128 241 0.033
peptidyl amino acid modification GO:0018193 336 0.033
regulation of organelle organization GO:0033043 289 0.031
purine ribonucleoside catabolic process GO:0046130 205 0.031
covalent chromatin modification GO:0016569 163 0.031
response to nutrient levels GO:0031667 109 0.030
spermatogenesis GO:0007283 284 0.030
reactive oxygen species metabolic process GO:0072593 84 0.030
heterocycle catabolic process GO:0046700 280 0.030
regulation of nucleotide catabolic process GO:0030811 122 0.030
rab protein signal transduction GO:0032482 1 0.030
cation transport GO:0006812 399 0.030
organonitrogen compound catabolic process GO:1901565 264 0.030
metal ion homeostasis GO:0055065 189 0.029
response to extracellular stimulus GO:0009991 127 0.029
purine containing compound metabolic process GO:0072521 311 0.029
organophosphate catabolic process GO:0046434 232 0.028
regulation of nucleotide metabolic process GO:0006140 169 0.028
purine containing compound catabolic process GO:0072523 213 0.028
forebrain development GO:0030900 302 0.027
regulation of cellular catabolic process GO:0031329 242 0.027
organic acid transport GO:0015849 101 0.027
glycosyl compound catabolic process GO:1901658 206 0.027
positive regulation of cellular catabolic process GO:0031331 148 0.027
positive regulation of cellular amine metabolic process GO:0033240 5 0.027
regulation of cellular ketone metabolic process GO:0010565 66 0.026
sphingolipid metabolic process GO:0006665 45 0.026
glycosyl compound metabolic process GO:1901657 246 0.026
gtp catabolic process GO:0006184 143 0.026
cellular chemical homeostasis GO:0055082 215 0.025
purine nucleoside triphosphate metabolic process GO:0009144 226 0.025
apoptotic signaling pathway GO:0097190 306 0.025
protein ubiquitination GO:0016567 171 0.025
negative regulation of cellular protein metabolic process GO:0032269 247 0.025
neuronal action potential GO:0019228 54 0.025
cellular response to dna damage stimulus GO:0006974 207 0.025
positive regulation of gtpase activity GO:0043547 85 0.025
purine nucleotide catabolic process GO:0006195 211 0.024
response to inorganic substance GO:0010035 96 0.024
respiratory tube development GO:0030323 167 0.023
action potential GO:0001508 78 0.023
organophosphate biosynthetic process GO:0090407 122 0.023
proteasomal protein catabolic process GO:0010498 98 0.023
male gamete generation GO:0048232 285 0.023
maternal determination of anterior posterior axis embryo GO:0008358 2 0.023
posttranscriptional regulation of gene expression GO:0010608 155 0.023
membrane organization GO:0061024 245 0.023
axonogenesis GO:0007409 274 0.022
anion transmembrane transport GO:0098656 71 0.022
nucleoside phosphate catabolic process GO:1901292 222 0.022
protein catabolic process GO:0030163 221 0.022
nucleotide metabolic process GO:0009117 332 0.022
regulation of purine nucleotide metabolic process GO:1900542 169 0.022
carboxylic acid biosynthetic process GO:0046394 86 0.022
oocyte construction GO:0007308 2 0.022
ribonucleotide catabolic process GO:0009261 208 0.021
organelle fission GO:0048285 170 0.021
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.021
ras protein signal transduction GO:0007265 77 0.021
epithelial tube morphogenesis GO:0060562 303 0.021
cell type specific apoptotic process GO:0097285 268 0.021
ribonucleoside triphosphate metabolic process GO:0009199 220 0.021
respiratory system development GO:0060541 190 0.021
positive regulation of cell development GO:0010720 237 0.021
negative regulation of molecular function GO:0044092 258 0.020
positive regulation of nucleotide metabolic process GO:0045981 114 0.020
negative regulation of cellular amine metabolic process GO:0033239 1 0.020
oocyte axis specification GO:0007309 2 0.020
purine nucleoside catabolic process GO:0006152 205 0.020
mrna metabolic process GO:0016071 84 0.020
response to radiation GO:0009314 165 0.020
microtubule based process GO:0007017 236 0.020
cellular response to lipid GO:0071396 145 0.020
compound eye development GO:0048749 1 0.020
membrane lipid biosynthetic process GO:0046467 32 0.020
nucleotide catabolic process GO:0009166 217 0.020
multicellular organismal homeostasis GO:0048871 164 0.020
positive regulation of ras gtpase activity GO:0032320 65 0.020
regulation of cytokine production GO:0001817 266 0.020
myeloid cell differentiation GO:0030099 233 0.020
modification dependent protein catabolic process GO:0019941 133 0.019
aromatic compound catabolic process GO:0019439 286 0.019
protein methylation GO:0006479 81 0.019
lung development GO:0030324 164 0.019
cellular metal ion homeostasis GO:0006875 151 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.019
germ cell development GO:0007281 185 0.019
response to light stimulus GO:0009416 135 0.019
transmission of nerve impulse GO:0019226 76 0.019
regulation of translation GO:0006417 71 0.019
locomotory behavior GO:0007626 195 0.019
nucleoside catabolic process GO:0009164 206 0.019
regulation of hydrolase activity GO:0051336 246 0.019
carbohydrate derivative catabolic process GO:1901136 231 0.019
regulation of reactive oxygen species metabolic process GO:2000377 40 0.018
inorganic cation transmembrane transport GO:0098662 207 0.018
regulation of transmembrane transport GO:0034762 128 0.018
guanosine containing compound metabolic process GO:1901068 144 0.018
pole plasm assembly GO:0007315 2 0.018
multicellular organismal signaling GO:0035637 91 0.018
divalent inorganic cation transport GO:0072511 178 0.018
inorganic ion transmembrane transport GO:0098660 234 0.018
nitrogen compound transport GO:0071705 271 0.018
purine ribonucleotide catabolic process GO:0009154 208 0.018
ribonucleoside catabolic process GO:0042454 206 0.018
asymmetric stem cell division GO:0098722 3 0.018
cation homeostasis GO:0055080 212 0.018
alpha amino acid metabolic process GO:1901605 59 0.018
Human
actin cytoskeleton organization GO:0030036 220 0.018
sulfur compound biosynthetic process GO:0044272 37 0.018
positive regulation of cell death GO:0010942 224 0.018
rna processing GO:0006396 105 0.018
response to acid chemical GO:0001101 111 0.018
purine nucleoside metabolic process GO:0042278 241 0.018
regulation of stem cell proliferation GO:0072091 78 0.018
small gtpase mediated signal transduction GO:0007264 97 0.017
cellular response to cytokine stimulus GO:0071345 189 0.017
ubiquitin dependent protein catabolic process GO:0006511 129 0.017
gland development GO:0048732 330 0.017
ribonucleoside triphosphate catabolic process GO:0009203 199 0.017
positive regulation of nervous system development GO:0051962 221 0.017
positive regulation of apoptotic process GO:0043065 217 0.017
positive regulation of nucleoside metabolic process GO:0045979 91 0.017
chemotaxis GO:0006935 247 0.017
glycoprotein metabolic process GO:0009100 116 0.017
response to organonitrogen compound GO:0010243 246 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.016
nuclear transport GO:0051169 139 0.016
regulation of purine nucleotide catabolic process GO:0033121 122 0.016
renal system development GO:0072001 225 0.016
cellular response to external stimulus GO:0071496 88 0.016
regulation of cell cycle GO:0051726 281 0.016
membrane lipid metabolic process GO:0006643 53 0.016
phospholipid metabolic process GO:0006644 87 0.016
carbohydrate metabolic process GO:0005975 230 0.016
regulation of ion transmembrane transport GO:0034765 119 0.016
cation transmembrane transport GO:0098655 266 0.016
inflammatory response GO:0006954 244 0.016
regulation of ion transport GO:0043269 215 0.016
intracellular protein transport GO:0006886 204 0.016
establishment of protein localization to organelle GO:0072594 118 0.016
macromolecule catabolic process GO:0009057 281 0.016
blood circulation GO:0008015 195 0.016
Human
divalent inorganic cation homeostasis GO:0072507 138 0.016
regulation of gtp catabolic process GO:0033124 113 0.015
nucleoside triphosphate metabolic process GO:0009141 230 0.015
lipoprotein metabolic process GO:0042157 43 0.015
negative regulation of transferase activity GO:0051348 85 0.015
glucose homeostasis GO:0042593 128 0.015
response to organic cyclic compound GO:0014070 198 0.015
protein localization to organelle GO:0033365 185 0.015
regulation of neural precursor cell proliferation GO:2000177 70 0.015
gtp metabolic process GO:0046039 144 0.015
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.015
microtubule cytoskeleton organization GO:0000226 157 0.015
positive regulation of gtp catabolic process GO:0033126 85 0.015
myeloid cell homeostasis GO:0002262 114 0.015
cytokine production GO:0001816 319 0.015
cell maturation GO:0048469 127 0.015
regulation of kinase activity GO:0043549 249 0.015
modification dependent macromolecule catabolic process GO:0043632 133 0.015
regulation of secretion GO:0051046 274 0.015
regulation of nucleoside metabolic process GO:0009118 130 0.015
regulation of hormone levels GO:0010817 211 0.015
rho protein signal transduction GO:0007266 32 0.014
alcohol metabolic process GO:0006066 116 0.014
sensory perception GO:0007600 245 0.014
cellular protein complex assembly GO:0043623 116 0.014
lipid biosynthetic process GO:0008610 179 0.014
anatomical structure homeostasis GO:0060249 145 0.014
regulation of secretion by cell GO:1903530 249 0.014
nucleoside triphosphate catabolic process GO:0009143 205 0.014
neuron death GO:0070997 154 0.014
cellular divalent inorganic cation homeostasis GO:0072503 127 0.014
regulation of protein kinase activity GO:0045859 232 0.014
cellular ion homeostasis GO:0006873 165 0.014
mapk cascade GO:0000165 281 0.014
camera type eye development GO:0043010 266 0.014
intracellular mrna localization GO:0008298 4 0.014
guanosine containing compound catabolic process GO:1901069 144 0.014
negative regulation of cell proliferation GO:0008285 296 0.014
purine nucleoside triphosphate catabolic process GO:0009146 203 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
regulation of response to wounding GO:1903034 189 0.014
ossification GO:0001503 216 0.014
regulation of neuron differentiation GO:0045664 281 0.014
positive regulation of protein phosphorylation GO:0001934 242 0.014
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.014
urogenital system development GO:0001655 261 0.014
fat cell differentiation GO:0045444 160 0.014
carbohydrate homeostasis GO:0033500 128 0.014
regulation of protein localization GO:0032880 231 0.014
response to reactive oxygen species GO:0000302 56 0.013
snrna processing GO:0016180 1 0.013
regulation of system process GO:0044057 200 0.013
endomembrane system organization GO:0010256 147 0.013
innate immune response GO:0045087 157 0.013
regulation of lymphocyte activation GO:0051249 240 0.013
glycerolipid metabolic process GO:0046486 122 0.013
primary neural tube formation GO:0014020 95 0.013
glycoprotein biosynthetic process GO:0009101 89 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.013
dna endoreduplication GO:0042023 4 0.013
carboxylic acid transport GO:0046942 100 0.013
regulation of chromatin modification GO:1903308 57 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
morphogenesis of embryonic epithelium GO:0016331 159 0.013
regulation of cell activation GO:0050865 289 0.013
monocarboxylic acid metabolic process GO:0032787 191 0.013
regulation of cellular component size GO:0032535 121 0.013
cytoplasmic transport GO:0016482 234 0.013
digestive system development GO:0055123 200 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
organic hydroxy compound transport GO:0015850 93 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.013
nucleoside monophosphate metabolic process GO:0009123 85 0.013
response to metal ion GO:0010038 47 0.013
homeostasis of number of cells GO:0048872 210 0.013
negative regulation of protein phosphorylation GO:0001933 126 0.013
regulation of inflammatory response GO:0050727 147 0.013
cognition GO:0050890 149 0.013
embryonic organ morphogenesis GO:0048562 276 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.013
lipid transport GO:0006869 98 0.013
placenta development GO:0001890 140 0.013
cellular response to hormone stimulus GO:0032870 150 0.012
response to uv GO:0009411 44 0.012
leukocyte differentiation GO:0002521 342 0.012
cellularization GO:0007349 1 0.012
myelination GO:0042552 74 0.012
protein maturation GO:0051604 176 0.012
bone development GO:0060348 120 0.012
mitotic cell cycle process GO:1903047 159 0.012
monocarboxylic acid transport GO:0015718 44 0.012
striated muscle tissue development GO:0014706 293 0.012
carbon catabolite activation of transcription GO:0045991 4 0.012
negative regulation of protein modification process GO:0031400 163 0.012
positive regulation of secretion GO:0051047 130 0.012
negative regulation of growth GO:0045926 99 0.012
fertilization GO:0009566 127 0.012
regulation of ras protein signal transduction GO:0046578 114 0.012
protein modification by small protein conjugation GO:0032446 187 0.012
divalent metal ion transport GO:0070838 172 0.012
muscle system process GO:0003012 141 0.012
cofactor transport GO:0051181 4 0.012
oocyte anterior posterior axis specification GO:0007314 2 0.012
ear development GO:0043583 200 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
organ growth GO:0035265 117 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
dephosphorylation GO:0016311 129 0.012
cellular response to acid chemical GO:0071229 68 0.012
immune effector process GO:0002252 321 0.012
positive regulation of transferase activity GO:0051347 167 0.012
regulation of cellular response to stress GO:0080135 159 0.012
histone h3 k4 methylation GO:0051568 23 0.012
regulation of body fluid levels GO:0050878 162 0.012
asymmetric neuroblast division GO:0055059 1 0.012
neutral lipid metabolic process GO:0006638 57 0.011
multi multicellular organism process GO:0044706 109 0.011
sensory organ morphogenesis GO:0090596 242 0.011
lateral inhibition GO:0046331 1 0.011
calcium ion homeostasis GO:0055074 127 0.011
developmental maturation GO:0021700 193 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
tube formation GO:0035148 140 0.011
epithelial cell development GO:0002064 159 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.011
wnt signaling pathway GO:0016055 188 0.011
heart process GO:0003015 94 0.011
ear morphogenesis GO:0042471 118 0.011
muscle tissue development GO:0060537 308 0.011
transition metal ion homeostasis GO:0055076 54 0.011
positive regulation of kinase activity GO:0033674 155 0.011
development of primary sexual characteristics GO:0045137 143 0.011
nucleotide transmembrane transport GO:1901679 2 0.011
synaptic transmission GO:0007268 329 0.011
regulation of neuron death GO:1901214 134 0.011
cell adhesion GO:0007155 329 0.011
positive regulation of protein modification process GO:0031401 299 0.011
organic anion transport GO:0015711 137 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
epidermis development GO:0008544 187 0.011
purine containing compound biosynthetic process GO:0072522 70 0.011
cellular response to nutrient levels GO:0031669 64 0.011
organelle assembly GO:0070925 177 0.011
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
snrna metabolic process GO:0016073 1 0.011
tube closure GO:0060606 91 0.011
response to peptide GO:1901652 136 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.011
skeletal muscle organ development GO:0060538 163 0.011
regulation of ossification GO:0030278 112 0.011
positive regulation of nucleotide catabolic process GO:0030813 88 0.011
single organism nuclear import GO:1902593 95 0.011
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.011
regulation of metal ion transport GO:0010959 106 0.011
cellular response to extracellular stimulus GO:0031668 81 0.011
i kappab kinase nf kappab signaling GO:0007249 85 0.011
regulation of protein catabolic process GO:0042176 108 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.011
regulation of defense response GO:0031347 233 0.010
cardiac chamber development GO:0003205 108 0.010
acylglycerol metabolic process GO:0006639 55 0.010
sequestering of metal ion GO:0051238 19 0.010
regulation of ras gtpase activity GO:0032318 88 0.010
protein processing GO:0016485 163 0.010
gonad development GO:0008406 141 0.010
myeloid leukocyte differentiation GO:0002573 119 0.010
negative regulation of phosphorylation GO:0042326 166 0.010
skin development GO:0043588 220 0.010
appendage development GO:0048736 166 0.010
sphingolipid biosynthetic process GO:0030148 26 0.010
response to endoplasmic reticulum stress GO:0034976 53 0.010
response to oxygen radical GO:0000305 16 0.010
cellular macromolecule catabolic process GO:0044265 206 0.010
limb morphogenesis GO:0035108 149 0.010
dna repair GO:0006281 107 0.010
mitotic cell cycle GO:0000278 195 0.010
actin filament polymerization GO:0030041 44 0.010
positive regulation of homeostatic process GO:0032846 64 0.010
ribonucleoside monophosphate metabolic process GO:0009161 80 0.010
regulation of mitotic cell cycle GO:0007346 126 0.010
production of molecular mediator of immune response GO:0002440 103 0.010
monosaccharide metabolic process GO:0005996 106 0.010

Gclc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.032
inherited metabolic disorder DOID:655 0 0.032
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017
musculoskeletal system disease DOID:17 0 0.016
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015
bone disease DOID:0080001 0 0.013
connective tissue disease DOID:65 0 0.013
immune system disease DOID:2914 0 0.012
hematopoietic system disease DOID:74 0 0.012
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.010