IMP

Process View

Mus musculus

11 genes annotated in mouse

regulation of membrane depolarization

Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of membrane depolarization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of membrane depolarization" (in gray)

Name	Description	Probability	Func Analog Organism
Scn5a	sodium channel, voltage-gated, type V, alpha	1.000	Mouse
Ryr2	ryanodine receptor 2, cardiac	1.000
Tbx5	T-box 5	0.996
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.973
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.929
Gclm	glutamate-cysteine ligase, modifier subunit	0.917
Gclc	glutamate-cysteine ligase, catalytic subunit	0.886
Gja5	gap junction protein, alpha 5	0.833
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.830
Tjp1	tight junction protein 1	0.797
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.745
Tbx3	T-box 3	0.602
Gja1	gap junction protein, alpha 1	0.527
Scn1a	sodium channel, voltage-gated, type I, alpha	0.458	Mouse
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.280	Human
Ntf3	neurotrophin 3	0.273
Prkce	protein kinase C, epsilon	0.254
Xirp1	xin actin-binding repeat containing 1	0.219
Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	0.214
Sstr3	somatostatin receptor 3	0.208
Cav3	caveolin 3	0.193
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.193
Cntn4	contactin 4	0.189
Ldb3	LIM domain binding 3	0.178
Ret	ret proto-oncogene	0.129
Snap25	synaptosomal-associated protein 25	0.127
Gjd3	gap junction protein, delta 3	0.106	Mouse
Ighmbp2	immunoglobulin mu binding protein 2	0.106
Gjb2	gap junction protein, beta 2	0.100	Mouse
Foxn1	forkhead box N1	0.092
Gjb6	gap junction protein, beta 6	0.091	Mouse
Rnf112	ring finger protein 112	0.085
Pcdh12	protocadherin 12	0.085
Kel	Kell blood group	0.077
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.073
Mtap2	microtubule-associated protein 2	0.073
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.072
Rps3	ribosomal protein S3	0.068
Npas1	neuronal PAS domain protein 1	0.063
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.063
Csda	cold shock domain protein A	0.059
Col22a1	collagen, type XXII, alpha 1	0.056
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.056
Hspb2	heat shock protein 2	0.054
Kcnk3	potassium channel, subfamily K, member 3	0.054
Stx1b	syntaxin 1B	0.050
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.047
Kcna6	potassium voltage-gated channel, shaker-related, subfamily, member 6	0.047
S1pr3	sphingosine-1-phosphate receptor 3	0.046
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.045
Scn10a	sodium channel, voltage-gated, type X, alpha	0.045
Scarb2	scavenger receptor class B, member 2	0.045
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.044
Itga7	integrin alpha 7	0.044
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.043
Rem1	rad and gem related GTP binding protein 1	0.042
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.042
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.040
Klhl1	kelch-like 1 (Drosophila)	0.039
Gjb4	gap junction protein, beta 4	0.039	Mouse
Casq2	calsequestrin 2	0.038
Mtap1b	microtubule-associated protein 1B	0.037
Pdcd1	programmed cell death 1	0.037
Crybb1	crystallin, beta B1	0.037
Entpd2	ectonucleoside triphosphate diphosphohydrolase 2	0.037
Tmprss5	transmembrane protease, serine 5 (spinesin)	0.036
Ivl	involucrin	0.035
Sntb1	syntrophin, basic 1	0.035
Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.034
Mpz	myelin protein zero	0.034
Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.034
Gjb5	gap junction protein, beta 5	0.033	Mouse
Ntsr1	neurotensin receptor 1	0.033
Cnr1	cannabinoid receptor 1 (brain)	0.033
Krt15	keratin 15	0.032
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.030
Oprd1	opioid receptor, delta 1	0.030
Sorcs2	sortilin-related VPS10 domain containing receptor 2	0.030
Gad2	glutamic acid decarboxylase 2	0.030
Irx4	Iroquois related homeobox 4 (Drosophila)	0.030
Dhh	desert hedgehog	0.030
Fgf12	fibroblast growth factor 12	0.029	Rat
Atp4b	ATPase, H+/K+ exchanging, beta polypeptide	0.029
Rs1	retinoschisis (X-linked, juvenile) 1 (human)	0.028
Sycn	syncollin	0.028
Dsc1	desmocollin 1	0.027
Ache	acetylcholinesterase	0.027
Map1lc3b	microtubule-associated protein 1 light chain 3 beta	0.027
Nxph1	neurexophilin 1	0.027
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.026
Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.026
Nradd	neurotrophin receptor associated death domain	0.025
Fut1	fucosyltransferase 1	0.025
Esrrb	estrogen related receptor, beta	0.025
Ank1	ankyrin 1, erythroid	0.025
Defa-rs12	defensin, alpha, related sequence 12	0.024
Cadm3	cell adhesion molecule 3	0.024
Kcns1	K+ voltage-gated channel, subfamily S, 1	0.024
Krt17	keratin 17	0.023
Csf1	colony stimulating factor 1 (macrophage)	0.023
Dnajb5	DnaJ (Hsp40) homolog, subfamily B, member 5	0.023
BC051019	cDNA sequence BC051019	0.022
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.022
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.022
Col9a2	collagen, type IX, alpha 2	0.022
Akap12	A kinase (PRKA) anchor protein (gravin) 12	0.021
Krt25	keratin 25	0.021
Sstr1	somatostatin receptor 1	0.021
Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	0.021
Lgals7	lectin, galactose binding, soluble 7	0.020
Fgf14	fibroblast growth factor 14	0.020
Amh	anti-Mullerian hormone	0.020
Myl7	myosin, light polypeptide 7, regulatory	0.020
Fgf7	fibroblast growth factor 7	0.019
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.019
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.019
Adam22	a disintegrin and metallopeptidase domain 22	0.019
Prdx6	peroxiredoxin 6	0.018
Sort1	sortilin 1	0.018
Syt2	synaptotagmin II	0.018
Bfsp1	beaded filament structural protein 1, in lens-CP94	0.018
Gabrg1	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	0.018
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.018
Sgcg	sarcoglycan, gamma (dystrophin-associated glycoprotein)	0.017
Cnst	consortin, connexin sorting protein	0.017
Lin7b	lin-7 homolog B (C. elegans)	0.017
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.017
Epb4.1l1	erythrocyte protein band 4.1-like 1	0.017
Kcna5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.017
Tff2	trefoil factor 2 (spasmolytic protein 1)	0.017
Scn2a1	sodium channel, voltage-gated, type II, alpha 1	0.017	Mouse
H2-M9	histocompatibility 2, M region locus 9	0.016
Gabrg2	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	0.016
Adam23	a disintegrin and metallopeptidase domain 23	0.016
Klk6	kallikrein related-peptidase 6	0.016
Lnx1	ligand of numb-protein X 1	0.016
Cdh8	cadherin 8	0.016
Pcp2	Purkinje cell protein 2 (L7)	0.016
Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	0.016
Tsg101	tumor susceptibility gene 101	0.016
Tmem40	transmembrane protein 40	0.016
Bmp8b	bone morphogenetic protein 8b	0.015
Dot1l	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.015
9030409G11Rik	RIKEN cDNA 9030409G11 gene	0.015
Grem1	gremlin 1	0.015
Gja3	gap junction protein, alpha 3	0.015	Mouse
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.015
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.015
Necab3	N-terminal EF-hand calcium binding protein 3	0.014
Ly6g6d	lymphocyte antigen 6 complex, locus G6D	0.014
Grin2c	glutamate receptor, ionotropic, NMDA2C (epsilon 3)	0.014
Cryba4	crystallin, beta A4	0.014
Npr3	natriuretic peptide receptor 3	0.014
Slc1a6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.014
Flii	flightless I homolog (Drosophila)	0.014
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.014
Gp9	glycoprotein 9 (platelet)	0.014
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.014
Stac2	SH3 and cysteine rich domain 2	0.014
Cd2	CD2 antigen	0.014
Gria3	glutamate receptor, ionotropic, AMPA3 (alpha 3)	0.014
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.013
Grm8	glutamate receptor, metabotropic 8	0.013
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.013
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.013
F12	coagulation factor XII (Hageman factor)	0.013
Irx3	Iroquois related homeobox 3 (Drosophila)	0.013
Wnt11	wingless-related MMTV integration site 11	0.013
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.013
Trh	thyrotropin releasing hormone	0.013
Mt4	metallothionein 4	0.013
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.013
Nrg3	neuregulin 3	0.013
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.013
Rab37	RAB37, member of RAS oncogene family	0.013
Foxf2	forkhead box F2	0.013
Clvs1	clavesin 1	0.013
Npas2	neuronal PAS domain protein 2	0.013
Scn3a	sodium channel, voltage-gated, type III, alpha	0.012	Mouse
Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.012
Fgf9	fibroblast growth factor 9	0.012
Calcoco2	calcium binding and coiled-coil domain 2	0.012
Kcnip1	Kv channel-interacting protein 1	0.012
Ccr8	chemokine (C-C motif) receptor 8	0.012
Spink3	serine peptidase inhibitor, Kazal type 3	0.012
Prss22	protease, serine, 22	0.012
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.012
Myh10	myosin, heavy polypeptide 10, non-muscle	0.012
Zg16	zymogen granule protein 16	0.012
Klk1b4	kallikrein 1-related pepidase b4	0.012
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.012
Gjb3	gap junction protein, beta 3	0.012	Mouse
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.012
Coro6	coronin 6	0.012
Rhox6	reproductive homeobox 6	0.012
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.011
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.011
Gdap1l1	ganglioside-induced differentiation-associated protein 1-like 1	0.011
Aff2	AF4/FMR2 family, member 2	0.011
Dst	dystonin	0.011
Abcb1a	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	0.011
Slurp1	secreted Ly6/Plaur domain containing 1	0.011
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.011
Chrm4	cholinergic receptor, muscarinic 4	0.011
Prkar2b	protein kinase, cAMP dependent regulatory, type II beta	0.011
Nos3	nitric oxide synthase 3, endothelial cell	0.011
Phkg1	phosphorylase kinase gamma 1	0.011
Snap91	synaptosomal-associated protein 91	0.011
Alox12b	arachidonate 12-lipoxygenase, 12R type	0.011
Lhx6	LIM homeobox protein 6	0.011
St8sia1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	0.011
C77614	EST C77614	0.011
Ctrb1	chymotrypsinogen B1	0.011
Cited4	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4	0.011
Dmd	dystrophin, muscular dystrophy	0.011
Nfe2l3	nuclear factor, erythroid derived 2, like 3	0.011
Ptgdr	prostaglandin D receptor	0.010
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.010
Mid2	midline 2	0.010
Srpk3	serine/arginine-rich protein specific kinase 3	0.010
Gdpd5	glycerophosphodiester phosphodiesterase domain containing 5	0.010
Nkx6-2	NK6 homeobox 2	0.010
Park2	Parkinson disease (autosomal recessive, juvenile) 2, parkin	0.010
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.010
Shc3	src homology 2 domain-containing transforming protein C3	0.010
Trpc7	transient receptor potential cation channel, subfamily C, member 7	0.010
Wnt6	wingless-related MMTV integration site 6	0.010
Col8a1	collagen, type VIII, alpha 1	0.010