Mus musculus

35 known processes

Hcn4

hyperpolarization-activated, cyclic nucleotide-gated K+ 4

(Aliases: Bcng3,Hcn3)

Hcn4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
atrial ventricular junction remodeling GO:0003294 2 0.999
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 0.995
vagus nerve development GO:0021564 3 0.986
regulation of renin secretion into blood stream GO:1900133 4 0.984
av node cell to bundle of his cell communication GO:0086067 2 0.979
regulation of membrane depolarization GO:0003254 11 0.973
cardiac muscle cell contraction GO:0086003 7 0.973
regulation of action potential GO:0098900 4 0.972
positive regulation of skeletal muscle cell differentiation GO:2001016 4 0.970
negative regulation of cardiac chamber morphogenesis GO:1901220 2 0.954
sinoatrial node cell differentiation GO:0060921 3 0.954
regulation of cardiac chamber morphogenesis GO:1901219 2 0.947
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.944
regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 5 0.936
positive regulation of skeletal muscle fiber differentiation GO:1902811 2 0.933
bundle of his development GO:0003166 4 0.930
atrioventricular bundle cell differentiation GO:0003167 1 0.927
ventricular cardiac muscle cell action potential GO:0086005 4 0.920
regulation of tongue muscle cell differentiation GO:2001035 2 0.920
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.914
regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 2 0.906
mammary placode formation GO:0060596 4 0.895
positive regulation of tongue muscle cell differentiation GO:2001037 2 0.895
ion transmembrane transport GO:0034220 361 0.877
cell communication involved in cardiac conduction GO:0086065 9 0.877
regulation of epithelial cell proliferation GO:0050678 141 0.869
transmembrane transport GO:0055085 412 0.853
tricuspid valve development GO:0003175 3 0.840
appendage development GO:0048736 166 0.835
regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060827 1 0.832
regulation of cardiac chamber formation GO:1901210 1 0.825
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.817
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.814
tongue muscle cell differentiation GO:0035981 2 0.812
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 1 0.806
pulmonary valve formation GO:0003193 1 0.779
skeletal system development GO:0001501 356 0.776
his purkinje system cell differentiation GO:0060932 2 0.751
regulation of ion transport GO:0043269 215 0.737
Human Mouse
camera type eye development GO:0043010 266 0.731
Mouse
visceral motor neuron differentiation GO:0021524 3 0.727
sinoatrial node cell development GO:0060931 3 0.724
membrane depolarization during sa node cell action potential GO:0086046 2 0.707
negative regulation of cardiac chamber formation GO:1901211 1 0.703
membrane depolarization GO:0051899 64 0.702
intrinsic apoptotic signaling pathway GO:0097193 132 0.701
cardiac muscle tissue development GO:0048738 130 0.700
negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060829 1 0.692
foramen ovale closure GO:0035922 1 0.683
sa node cell action potential GO:0086015 4 0.680
heart morphogenesis GO:0003007 178 0.671
forebrain development GO:0030900 302 0.660
muscle system process GO:0003012 141 0.656
cytokine production GO:0001816 319 0.645
cardiac conduction GO:0061337 17 0.634
appendage morphogenesis GO:0035107 149 0.628
dna recombination GO:0006310 92 0.624
mapk cascade GO:0000165 281 0.622
sensory perception of mechanical stimulus GO:0050954 107 0.619
cell differentiation involved in embryonic placenta development GO:0060706 26 0.619
embryonic limb morphogenesis GO:0030326 126 0.613
multicellular organismal signaling GO:0035637 91 0.610
cell communication by electrical coupling involved in cardiac conduction GO:0086064 2 0.608
positive regulation of protein phosphorylation GO:0001934 242 0.601
embryonic heart tube morphogenesis GO:0003143 51 0.599
ventricular septum development GO:0003281 42 0.597
embryonic digit morphogenesis GO:0042733 56 0.596
muscle contraction GO:0006936 101 0.593
ear development GO:0043583 200 0.588
somatic cell dna recombination GO:0016444 51 0.586
epithelial cell proliferation GO:0050673 174 0.586
regulation of system process GO:0044057 200 0.584
sensory perception of sound GO:0007605 97 0.582
sa node cell to atrial cardiac muscle cell communication GO:0086070 5 0.579
regulation of homeostatic process GO:0032844 182 0.574
vagus nerve morphogenesis GO:0021644 2 0.574
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.572
positive regulation of blood circulation GO:1903524 22 0.572
sensory perception GO:0007600 245 0.565
Mouse
canonical wnt signaling pathway GO:0060070 130 0.562
ear morphogenesis GO:0042471 118 0.553
negative regulation of smad protein complex assembly GO:0010991 1 0.548
hindbrain development GO:0030902 128 0.548
cd8 positive alpha beta t cell differentiation involved in immune response GO:0002302 2 0.546
enamel mineralization GO:0070166 7 0.546
embryonic organ morphogenesis GO:0048562 276 0.540
muscle tissue development GO:0060537 308 0.540
positive regulation of epithelial cell proliferation GO:0050679 68 0.537
negative regulation of cardiac muscle tissue development GO:0055026 8 0.537
urogenital system development GO:0001655 261 0.533
striated muscle tissue development GO:0014706 293 0.532
positive regulation of myotube differentiation GO:0010831 24 0.514
neuron migration GO:0001764 122 0.506
sinoatrial node development GO:0003163 4 0.503
regulation of cardioblast differentiation GO:0051890 3 0.502
intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 2 0.486
regulation of wnt signaling pathway GO:0030111 123 0.481
amine metabolic process GO:0009308 45 0.481
positive regulation of striated muscle tissue development GO:0045844 31 0.477
regulation of muscle system process GO:0090257 80 0.475
regulation of cardiac muscle cell contraction GO:0086004 11 0.474
blood vessel morphogenesis GO:0048514 285 0.469
actin mediated cell contraction GO:0070252 15 0.468
cardiac muscle cell action potential GO:0086001 11 0.460
pharynx development GO:0060465 1 0.457
cell communication by chemical coupling GO:0010643 2 0.452
cardiac chamber morphogenesis GO:0003206 93 0.448
regulation of protein secretion GO:0050708 82 0.447
limb development GO:0060173 166 0.442
cellular response to acid chemical GO:0071229 68 0.439
membrane depolarization during action potential GO:0086010 5 0.437
response to muscle inactivity involved in regulation of muscle adaptation GO:0014877 4 0.437
cardiac conduction system development GO:0003161 12 0.435
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.424
embryonic placenta development GO:0001892 98 0.421
cardiac ventricle development GO:0003231 83 0.420
positive regulation of osteoblast differentiation GO:0045669 34 0.420
gland development GO:0048732 330 0.415
neuronal action potential GO:0019228 54 0.408
cellular amine metabolic process GO:0044106 44 0.399
biomineral tissue development GO:0031214 64 0.399
regulation of organ morphogenesis GO:2000027 144 0.396
regulation of membrane depolarization during action potential GO:0098902 1 0.393
positive regulation of heart rate GO:0010460 10 0.393
blood circulation GO:0008015 195 0.390
bone remodeling GO:0046849 53 0.387
cardiac left ventricle formation GO:0003218 1 0.384
regulation of muscle contraction GO:0006937 49 0.382
smad protein complex assembly GO:0007183 1 0.381
stem cell development GO:0048864 219 0.381
positive regulation of muscle tissue development GO:1901863 32 0.380
response to muscle inactivity GO:0014870 4 0.375
regulation of leukocyte mediated immunity GO:0002703 104 0.372
regulation of anatomical structure size GO:0090066 178 0.364
action potential GO:0001508 78 0.363
limb morphogenesis GO:0035108 149 0.359
transmission of nerve impulse GO:0019226 76 0.358
retina development in camera type eye GO:0060041 119 0.352
Mouse
cell differentiation in spinal cord GO:0021515 53 0.349
odontogenesis GO:0042476 78 0.348
regulation of heart looping GO:1901207 1 0.347
metencephalon development GO:0022037 89 0.347
regulation of protein localization GO:0032880 231 0.343
telencephalon development GO:0021537 186 0.343
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.342
apoptotic signaling pathway GO:0097190 306 0.341
myotube cell development GO:0014904 60 0.341
spinal cord development GO:0021510 81 0.339
immunoglobulin production GO:0002377 73 0.338
protein secretion GO:0009306 111 0.337
regulation of secretion by cell GO:1903530 249 0.336
cardiac muscle cell action potential involved in contraction GO:0086002 6 0.335
regulation of blood vessel size GO:0050880 56 0.331
dna metabolic process GO:0006259 303 0.331
detection of light stimulus GO:0009583 25 0.329
lymphocyte mediated immunity GO:0002449 139 0.329
segmentation GO:0035282 93 0.327
regionalization GO:0003002 337 0.326
circulatory system process GO:0003013 197 0.324
neuron projection guidance GO:0097485 141 0.323
response to stimulus involved in regulation of muscle adaptation GO:0014874 6 0.320
cation transport GO:0006812 399 0.318
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.316
tissue remodeling GO:0048771 102 0.315
peptidyl tyrosine modification GO:0018212 145 0.314
embryonic heart tube elongation GO:0036306 1 0.314
somatic diversification of immune receptors GO:0002200 53 0.314
detection of stimulus involved in sensory perception GO:0050906 44 0.313
kidney development GO:0001822 213 0.313
chemotaxis GO:0006935 247 0.308
striated muscle contraction GO:0006941 45 0.305
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.303
regulation of cell motility GO:2000145 236 0.302
angiogenesis GO:0001525 201 0.302
embryonic appendage morphogenesis GO:0035113 126 0.302
digestive tract development GO:0048565 190 0.300
production of molecular mediator of immune response GO:0002440 103 0.297
positive regulation of leukocyte mediated immunity GO:0002705 70 0.296
respiratory system development GO:0060541 190 0.296
muscle cell differentiation GO:0042692 261 0.294
positive regulation of immune effector process GO:0002699 107 0.294
regulation of membrane depolarization during cardiac muscle cell action potential GO:1900825 1 0.291
regulation of canonical wnt signaling pathway GO:0060828 82 0.289
placenta development GO:0001890 140 0.287
his purkinje system development GO:0003164 4 0.286
morphogenesis of embryonic epithelium GO:0016331 159 0.286
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.285
negative regulation of heart looping GO:1901208 1 0.283
aorta morphogenesis GO:0035909 22 0.279
renal system development GO:0072001 225 0.276
immunoglobulin mediated immune response GO:0016064 69 0.275
ventricular septum morphogenesis GO:0060412 27 0.274
digestive tract morphogenesis GO:0048546 147 0.269
detection of visible light GO:0009584 14 0.268
regulation of ion transmembrane transport GO:0034765 119 0.266
Human Mouse
cardiac septum development GO:0003279 59 0.266
regulation of protein transport GO:0051223 163 0.265
heart contraction GO:0060047 93 0.265
odontogenesis of dentin containing tooth GO:0042475 66 0.264
cellular response to growth factor stimulus GO:0071363 197 0.262
regulation of smad protein complex assembly GO:0010990 1 0.261
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.260
forebrain regionalization GO:0021871 25 0.259
axon ensheathment GO:0008366 76 0.259
central nervous system neuron differentiation GO:0021953 162 0.259
regulation of cardiac muscle contraction GO:0055117 21 0.253
determination of left right symmetry GO:0007368 80 0.252
multicellular organismal response to stress GO:0033555 62 0.249
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 13 0.247
commitment of neuronal cell to specific neuron type in forebrain GO:0021902 7 0.247
muscle cell fate specification GO:0042694 1 0.246
detection of stimulus GO:0051606 84 0.242
digestive system development GO:0055123 200 0.242
regulation of neuron projection development GO:0010975 169 0.240
cardiac chamber development GO:0003205 108 0.239
pulmonary valve development GO:0003177 5 0.239
wnt signaling pathway GO:0016055 188 0.239
intracellular receptor signaling pathway GO:0030522 74 0.239
somite development GO:0061053 81 0.237
regulation of cell activation GO:0050865 289 0.237
wound healing GO:0042060 157 0.236
lymphocyte activation involved in immune response GO:0002285 93 0.234
cell aging GO:0007569 35 0.234
regulation of adaptive immune response GO:0002819 90 0.233
olfactory bulb development GO:0021772 30 0.233
negative regulation of organ growth GO:0046621 17 0.232
regulation of neuron differentiation GO:0045664 281 0.231
skeletal muscle fiber development GO:0048741 58 0.230
regulation of cell adhesion GO:0030155 154 0.230
leukocyte mediated immunity GO:0002443 174 0.228
cardiac left ventricle morphogenesis GO:0003214 9 0.225
regulation of ion homeostasis GO:2000021 64 0.224
skeletal muscle fiber differentiation GO:0098528 5 0.224
cellular response to lipid GO:0071396 145 0.224
spongiotrophoblast layer development GO:0060712 15 0.223
neural tube formation GO:0001841 108 0.222
sensory organ morphogenesis GO:0090596 242 0.221
Mouse
regulation of muscle tissue development GO:1901861 97 0.220
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 6 0.219
response to organic cyclic compound GO:0014070 198 0.217
Human Mouse
regulation of blood pressure GO:0008217 93 0.217
stem cell maintenance GO:0019827 130 0.215
regulation of production of molecular mediator of immune response GO:0002700 65 0.215
isotype switching GO:0045190 36 0.213
somitogenesis GO:0001756 69 0.213
notochord formation GO:0014028 5 0.211
bone mineralization GO:0030282 54 0.211
negative regulation of nervous system development GO:0051961 156 0.210
cell maturation GO:0048469 127 0.210
inorganic cation transmembrane transport GO:0098662 207 0.209
Human Mouse
gastrulation GO:0007369 116 0.209
regulation of systemic arterial blood pressure GO:0003073 61 0.209
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.208
regulation of lymphocyte mediated immunity GO:0002706 84 0.208
tongue development GO:0043586 18 0.208
regulation of establishment of protein localization GO:0070201 181 0.208
lymphocyte differentiation GO:0030098 242 0.207
determination of heart left right asymmetry GO:0061371 48 0.207
atrial cardiac muscle cell development GO:0055014 2 0.206
membrane repolarization GO:0086009 7 0.203
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.202
optic nerve development GO:0021554 8 0.202
negative regulation of cell proliferation GO:0008285 296 0.200
positive regulation of protein modification process GO:0031401 299 0.200
leukocyte differentiation GO:0002521 342 0.200
regulation of cell migration GO:0030334 219 0.200
cerebellum development GO:0021549 77 0.199
morphogenesis of a branching structure GO:0001763 203 0.197
regulation of lymphocyte activation GO:0051249 240 0.197
intraspecies interaction between organisms GO:0051703 21 0.196
regulation of mapk cascade GO:0043408 248 0.196
sodium ion transmembrane transport GO:0035725 49 0.193
Human
single organismal cell cell adhesion GO:0016337 131 0.190
cell communication by electrical coupling GO:0010644 4 0.190
cell type specific apoptotic process GO:0097285 268 0.189
myelination GO:0042552 74 0.189
positive regulation of heart contraction GO:0045823 14 0.188
actin filament based movement GO:0030048 23 0.186
regulation of blood circulation GO:1903522 93 0.186
b cell activation involved in immune response GO:0002312 50 0.186
cardiac muscle tissue morphogenesis GO:0055008 44 0.186
positive regulation of cellular amine metabolic process GO:0033240 5 0.184
skeletal muscle cell differentiation GO:0035914 66 0.183
inflammatory response GO:0006954 244 0.181
regulation of cellular amino acid metabolic process GO:0006521 5 0.181
cd8 positive alpha beta t cell activation GO:0036037 9 0.180
positive regulation of lymphocyte activation GO:0051251 140 0.180
epithelial tube formation GO:0072175 130 0.178
labyrinthine layer development GO:0060711 49 0.178
immune effector process GO:0002252 321 0.178
brainstem development GO:0003360 3 0.176
regulation of heart rate by cardiac conduction GO:0086091 6 0.175
regulation of muscle adaptation GO:0043502 31 0.175
cardiac atrium development GO:0003230 24 0.174
anatomical structure homeostasis GO:0060249 145 0.172
regulation of secretion GO:0051046 274 0.170
skeletal system morphogenesis GO:0048705 203 0.170
leukocyte migration GO:0050900 124 0.168
metal ion homeostasis GO:0055065 189 0.168
cardiac muscle contraction GO:0060048 32 0.167
organ growth GO:0035265 117 0.167
regulation of transmembrane transport GO:0034762 128 0.166
Human Mouse
regulation of tissue remodeling GO:0034103 38 0.166
vasodilation GO:0042311 28 0.166
execution phase of apoptosis GO:0097194 19 0.165
morphogenesis of a branching epithelium GO:0061138 193 0.165
reactive oxygen species metabolic process GO:0072593 84 0.165
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.164
cell cell signaling involved in cardiac conduction GO:0086019 6 0.163
negative regulation of growth GO:0045926 99 0.162
diencephalon development GO:0021536 63 0.161
ameboidal type cell migration GO:0001667 128 0.161
mammary gland epithelium development GO:0061180 65 0.161
sensory perception of light stimulus GO:0050953 54 0.160
negative regulation of cell development GO:0010721 169 0.160
stem cell differentiation GO:0048863 268 0.159
cardiac muscle cell differentiation GO:0055007 69 0.159
response to acid chemical GO:0001101 111 0.159
lens development in camera type eye GO:0002088 62 0.157
cardiac cell development GO:0055006 41 0.157
inorganic ion transmembrane transport GO:0098660 234 0.156
Human Mouse
detection of external stimulus GO:0009581 61 0.156
somatic diversification of immunoglobulins GO:0016445 43 0.156
regulation of stem cell differentiation GO:2000736 50 0.156
endoderm development GO:0007492 45 0.156
adaptive immune response GO:0002250 155 0.156
neuromuscular process GO:0050905 99 0.154
positive regulation of proteolysis GO:0045862 85 0.154
t cell differentiation GO:0030217 174 0.154
tube closure GO:0060606 91 0.154
t cell activation GO:0042110 289 0.153
cation transmembrane transport GO:0098655 266 0.153
cardiocyte differentiation GO:0035051 87 0.153
membrane depolarization during cardiac muscle cell action potential GO:0086012 5 0.152
b cell activation GO:0042113 161 0.152
response to light stimulus GO:0009416 135 0.151
forebrain generation of neurons GO:0021872 63 0.151
negative regulation of cell maturation GO:1903430 9 0.151
developmental growth involved in morphogenesis GO:0060560 138 0.151
leukocyte activation involved in immune response GO:0002366 126 0.150
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.149
smad protein signal transduction GO:0060395 21 0.149
peptide transport GO:0015833 133 0.149
response to growth factor GO:0070848 198 0.149
embryonic epithelial tube formation GO:0001838 130 0.149
protein modification by small protein conjugation GO:0032446 187 0.148
epithelial tube morphogenesis GO:0060562 303 0.148
regulation of embryonic development GO:0045995 71 0.147
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.147
muscle adaptation GO:0043500 39 0.147
positive regulation of apoptotic process GO:0043065 217 0.147
regulation of fat cell differentiation GO:0045598 81 0.146
cell adhesion GO:0007155 329 0.145
stem cell proliferation GO:0072089 117 0.144
cardiac muscle cell proliferation GO:0060038 31 0.143
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.143
branching morphogenesis of an epithelial tube GO:0048754 159 0.143
interferon gamma production GO:0032609 67 0.142
regulation of cardiac muscle tissue growth GO:0055021 26 0.142
mesenchymal cell development GO:0014031 93 0.142
regulation of immunoglobulin production GO:0002637 42 0.140
positive regulation of stem cell differentiation GO:2000738 23 0.140
axon guidance GO:0007411 141 0.138
cardiac septum morphogenesis GO:0060411 46 0.138
regulation of cardiac muscle cell proliferation GO:0060043 23 0.138
neural tube development GO:0021915 160 0.137
epidermis development GO:0008544 187 0.137
sodium ion transport GO:0006814 73 0.137
Human
septum primum development GO:0003284 4 0.137
cerebral cortex development GO:0021987 86 0.135
mesenchyme morphogenesis GO:0072132 32 0.134
cellular component disassembly involved in execution phase of apoptosis GO:0006921 9 0.133
mesoderm development GO:0007498 100 0.132
regulation of cytokine production GO:0001817 266 0.132
glycerolipid metabolic process GO:0046486 122 0.132
regulation of striated muscle contraction GO:0006942 25 0.130
heart process GO:0003015 94 0.128
negative regulation of neuron differentiation GO:0045665 101 0.128
negative regulation of cardiac muscle tissue growth GO:0055022 7 0.127
regulation of cellular component biogenesis GO:0044087 181 0.126
embryonic camera type eye development GO:0031076 36 0.126
regulation of transferase activity GO:0051338 263 0.125
mesenchyme development GO:0060485 152 0.125
cardiac muscle cell development GO:0055013 39 0.125
tongue morphogenesis GO:0043587 8 0.124
cell migration involved in gastrulation GO:0042074 13 0.124
cardiac ventricle morphogenesis GO:0003208 50 0.124
endocardial cushion morphogenesis GO:0003203 18 0.124
regulation of dna recombination GO:0000018 34 0.123
apoptotic nuclear changes GO:0030262 9 0.123
forebrain neuron differentiation GO:0021879 52 0.122
reflex GO:0060004 22 0.122
b cell mediated immunity GO:0019724 71 0.121
hormone secretion GO:0046879 128 0.121
negative regulation of wnt signaling pathway GO:0030178 73 0.120
skeletal muscle organ development GO:0060538 163 0.120
neural crest cell development GO:0014032 48 0.120
positive regulation of b cell mediated immunity GO:0002714 26 0.118
bmp signaling pathway GO:0030509 93 0.118
positive regulation of cellular catabolic process GO:0031331 148 0.117
ventral spinal cord development GO:0021517 48 0.117
fat cell differentiation GO:0045444 160 0.117
response to retinoic acid GO:0032526 56 0.117
single organism cell adhesion GO:0098602 156 0.117
embryonic eye morphogenesis GO:0048048 29 0.116
embryonic skeletal system morphogenesis GO:0048704 91 0.115
notochord development GO:0030903 20 0.115
negative regulation of cell migration GO:0030336 59 0.115
ossification GO:0001503 216 0.113
regulation of heart rate GO:0002027 36 0.113
Human
membrane organization GO:0061024 245 0.113
vascular process in circulatory system GO:0003018 62 0.112
negative regulation of cardiac muscle cell proliferation GO:0060044 5 0.112
inner ear morphogenesis GO:0042472 101 0.112
negative regulation of phosphate metabolic process GO:0045936 184 0.112
face morphogenesis GO:0060325 29 0.112
mesoderm morphogenesis GO:0048332 64 0.111
cochlea morphogenesis GO:0090103 22 0.111
protein modification by small protein conjugation or removal GO:0070647 207 0.110
regulation of protein kinase activity GO:0045859 232 0.110
blastocyst development GO:0001824 80 0.110
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.109
lung development GO:0030324 164 0.109
thymus development GO:0048538 41 0.108
developmental maturation GO:0021700 193 0.106
tube formation GO:0035148 140 0.106
muscle cell development GO:0055001 133 0.106
negative regulation of heart growth GO:0061117 7 0.105
trophectodermal cell differentiation GO:0001829 21 0.105
regulation of membrane potential GO:0042391 192 0.105
Human Mouse
neuron death GO:0070997 154 0.105
regulation of b cell mediated immunity GO:0002712 37 0.104
response to fibroblast growth factor GO:0071774 47 0.104
response to denervation involved in regulation of muscle adaptation GO:0014894 4 0.104
positive regulation of cell development GO:0010720 237 0.103
peptidyl amino acid modification GO:0018193 336 0.103
cellular response to retinoic acid GO:0071300 25 0.103
positive regulation of cell activation GO:0050867 158 0.103
lymphocyte migration GO:0072676 26 0.101
axonogenesis GO:0007409 274 0.101
regulation of cellular ketone metabolic process GO:0010565 66 0.101
cellular lipid metabolic process GO:0044255 323 0.101
follicle stimulating hormone secretion GO:0046884 1 0.100
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.100
t cell activation involved in immune response GO:0002286 43 0.100
heart trabecula formation GO:0060347 14 0.099
neural crest cell differentiation GO:0014033 54 0.099
single fertilization GO:0007338 82 0.099
pigmentation GO:0043473 71 0.098
spinal cord motor neuron differentiation GO:0021522 35 0.097
striated muscle cell proliferation GO:0014855 39 0.097
nitrogen compound transport GO:0071705 271 0.097
mesoderm formation GO:0001707 62 0.097
mammary gland morphogenesis GO:0060443 54 0.096
artery development GO:0060840 53 0.096
myotube differentiation GO:0014902 105 0.096
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.095
regulation of membrane repolarization GO:0060306 7 0.095
renin secretion into blood stream GO:0002001 5 0.095
cerebral cortex neuron differentiation GO:0021895 19 0.094
negative regulation of cellular amine metabolic process GO:0033239 1 0.094
cell cell junction organization GO:0045216 72 0.094
positive regulation of cardioblast differentiation GO:0051891 3 0.094
mesenchymal cell differentiation GO:0048762 107 0.093
regulation of mesenchymal cell proliferation GO:0010464 37 0.093
regulation of heart contraction GO:0008016 77 0.093
cell proliferation involved in heart morphogenesis GO:0061323 15 0.093
rho protein signal transduction GO:0007266 32 0.092
pituitary gland development GO:0021983 38 0.092
regulation of organelle organization GO:0033043 289 0.091
respiratory tube development GO:0030323 167 0.091
labyrinthine layer morphogenesis GO:0060713 21 0.091
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.091
regulation of striated muscle cell differentiation GO:0051153 81 0.091
protein processing GO:0016485 163 0.091
myeloid cell differentiation GO:0030099 233 0.090
ventricular cardiac muscle tissue development GO:0003229 38 0.090
muscle tissue morphogenesis GO:0060415 53 0.089
pharyngeal system development GO:0060037 17 0.089
regulation of organ formation GO:0003156 34 0.089
epithelial cell development GO:0002064 159 0.089
heart valve morphogenesis GO:0003179 21 0.088
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.088
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 6 0.088
negative regulation of mesenchymal cell apoptotic process GO:2001054 11 0.087
protein ubiquitination GO:0016567 171 0.087
synapse assembly GO:0007416 56 0.087
macromolecule catabolic process GO:0009057 281 0.086
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.086
amelogenesis GO:0097186 12 0.086
adult walking behavior GO:0007628 41 0.085
alpha beta t cell activation GO:0046631 91 0.085
syncytium formation by plasma membrane fusion GO:0000768 42 0.085
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.084
neural crest cell migration GO:0001755 32 0.084
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.083
regulation of hormone levels GO:0010817 211 0.083
regulation of osteoblast differentiation GO:0045667 67 0.081

Hcn4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org