Mus musculus

307 known processes

Il2

interleukin 2

(Aliases: Il-2)

Il2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
t cell proliferation GO:0042098 120 0.984
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.960
regulation of mast cell activation GO:0033003 21 0.953
adaptive immune response GO:0002250 155 0.952
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.950
immunoglobulin mediated immune response GO:0016064 69 0.946
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.930
leukocyte mediated immunity GO:0002443 174 0.905
t cell differentiation in thymus GO:0033077 77 0.905
lymphocyte differentiation GO:0030098 242 0.887
dna metabolic process GO:0006259 303 0.878
lymphocyte mediated immunity GO:0002449 139 0.869
positive regulation of defense response GO:0031349 124 0.863
production of molecular mediator of immune response GO:0002440 103 0.861
regulation of leukocyte mediated immunity GO:0002703 104 0.849
leukocyte activation involved in immune response GO:0002366 126 0.839
positive regulation of b cell activation GO:0050871 49 0.837
regulation of regulated secretory pathway GO:1903305 20 0.828
positive regulation of regulatory t cell differentiation GO:0045591 4 0.824
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.803
regulation of cell activation GO:0050865 289 0.791
mast cell activation GO:0045576 27 0.787
positive regulation of t cell differentiation GO:0045582 52 0.774
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.747
t cell differentiation GO:0030217 174 0.739
somatic diversification of immunoglobulins GO:0016445 43 0.721
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.709
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.694
positive t cell selection GO:0043368 23 0.694
regulation of mast cell activation involved in immune response GO:0033006 17 0.685
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.669
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.659
positive regulation of lymphocyte activation GO:0051251 140 0.658
humoral immune response mediated by circulating immunoglobulin GO:0002455 14 0.653
regulation of cytokine production GO:0001817 266 0.647
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.634
positive regulation of leukocyte mediated immunity GO:0002705 70 0.631
leukocyte differentiation GO:0002521 342 0.631
negative regulation of homeostatic process GO:0032845 71 0.615
cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0002361 4 0.615
leukocyte homeostasis GO:0001776 79 0.615
t cell receptor signaling pathway GO:0050852 46 0.613
isotype switching to ige isotypes GO:0048289 7 0.593
positive regulation of cellular amine metabolic process GO:0033240 5 0.582
regulation of isotype switching GO:0045191 22 0.576
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.575
immunoglobulin secretion GO:0048305 17 0.575
mast cell mediated immunity GO:0002448 20 0.566
regulation of intracellular transport GO:0032386 159 0.562
positive regulation of t cell activation GO:0050870 101 0.561
regulation of isotype switching to ige isotypes GO:0048293 7 0.561
positive regulation of immune effector process GO:0002699 107 0.559
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.558
lymphocyte homeostasis GO:0002260 64 0.553
somatic diversification of immune receptors GO:0002200 53 0.550
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.540
somatic cell dna recombination GO:0016444 51 0.533
positive regulation of macrophage activation GO:0043032 10 0.532
positive regulation of translational initiation GO:0045948 4 0.521
positive regulation of b cell mediated immunity GO:0002714 26 0.519
regulation of alpha beta t cell differentiation GO:0046637 35 0.511
positive regulation of cell killing GO:0031343 33 0.511
regulation of b cell activation GO:0050864 81 0.506
b cell proliferation GO:0042100 53 0.504
regulation of lymphocyte differentiation GO:0045619 107 0.496
t helper 2 cell differentiation GO:0045064 12 0.484
immune response activating signal transduction GO:0002757 116 0.483
regulation of b cell differentiation GO:0045577 23 0.477
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.471
regulation of cellular amino acid metabolic process GO:0006521 5 0.464
cell fate commitment GO:0045165 210 0.464
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.461
cytokine production GO:0001816 319 0.450
inflammatory response GO:0006954 244 0.446
regulation of cytokine biosynthetic process GO:0042035 59 0.441
cellular response to molecule of bacterial origin GO:0071219 83 0.439
regulation of b cell mediated immunity GO:0002712 37 0.439
cellular amine metabolic process GO:0044106 44 0.437
positive regulation of isotype switching GO:0045830 15 0.435
chronic inflammatory response to antigenic stimulus GO:0002439 3 0.433
positive regulation of innate immune response GO:0045089 80 0.431
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.430
cellular response to cytokine stimulus GO:0071345 189 0.430
myeloid leukocyte activation GO:0002274 83 0.426
regulation of interleukin 6 production GO:0032675 55 0.425
t helper 1 cell lineage commitment GO:0002296 2 0.423
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.422
positive regulation of lymphocyte proliferation GO:0050671 70 0.410
regulation of chronic inflammatory response to antigenic stimulus GO:0002874 3 0.409
regulation of translational initiation GO:0006446 15 0.408
regulation of mast cell proliferation GO:0070666 4 0.395
b cell activation GO:0042113 161 0.391
positive regulation of protein phosphorylation GO:0001934 242 0.384
positive regulation of isotype switching to ige isotypes GO:0048295 4 0.381
antigen receptor mediated signaling pathway GO:0050851 64 0.376
positive regulation of leukocyte differentiation GO:1902107 86 0.370
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.367
antibacterial peptide production GO:0002778 2 0.367
regulation of immunoglobulin production GO:0002637 42 0.363
v d j recombination GO:0033151 14 0.360
myeloid leukocyte differentiation GO:0002573 119 0.352
regulation of secretion by cell GO:1903530 249 0.349
regulation of myeloid leukocyte differentiation GO:0002761 58 0.348
regulation of leukocyte proliferation GO:0070663 121 0.347
regulation of immunoglobulin mediated immune response GO:0002889 37 0.338
inflammatory response to antigenic stimulus GO:0002437 30 0.334
t helper cell differentiation GO:0042093 28 0.315
peptidyl tyrosine phosphorylation GO:0018108 143 0.315
leukocyte degranulation GO:0043299 27 0.313
natural killer cell mediated cytotoxicity GO:0042267 29 0.311
alpha beta t cell differentiation GO:0046632 69 0.310
regulation of inflammatory response GO:0050727 147 0.301
b cell mediated immunity GO:0019724 71 0.300
amine metabolic process GO:0009308 45 0.298
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.293
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.293
syncytium formation GO:0006949 43 0.291
regulation of t helper 17 cell differentiation GO:2000319 2 0.287
positive regulation of b cell proliferation GO:0030890 24 0.284
regulation of jak stat cascade GO:0046425 34 0.283
activation of immune response GO:0002253 138 0.281
leukocyte apoptotic process GO:0071887 71 0.279
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.271
positive regulation of protein kinase b signaling GO:0051897 32 0.269
mast cell activation involved in immune response GO:0002279 20 0.267
regulation of ion transport GO:0043269 215 0.263
negative regulation of interleukin 2 biosynthetic process GO:0045085 3 0.262
regulation of t cell differentiation GO:0045580 83 0.261
cell activation involved in immune response GO:0002263 126 0.258
regulation of protein localization GO:0032880 231 0.257
regulation of b cell proliferation GO:0030888 39 0.256
negative regulation of cytokine production GO:0001818 84 0.253
negative regulation of myeloid cell differentiation GO:0045638 38 0.253
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.250
regulation of adaptive immune response GO:0002819 90 0.249
regulation of response to wounding GO:1903034 189 0.244
lymphocyte proliferation GO:0046651 164 0.240
myeloid cell activation involved in immune response GO:0002275 34 0.240
positive regulation of dna recombination GO:0045911 17 0.240
regulation of antimicrobial peptide production GO:0002784 1 0.239
chronic inflammatory response GO:0002544 9 0.237
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.232
regulation of leukocyte differentiation GO:1902105 159 0.228
alpha beta t cell activation GO:0046631 91 0.227
negative regulation of adaptive immune response GO:0002820 25 0.226
eosinophil differentiation GO:0030222 1 0.222
positive regulation of cell activation GO:0050867 158 0.222
positive regulation of stress activated mapk cascade GO:0032874 48 0.220
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.218
temperature homeostasis GO:0001659 26 0.216
lysosome localization GO:0032418 20 0.212
cell type specific apoptotic process GO:0097285 268 0.212
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.212
positive regulation of intracellular transport GO:0032388 70 0.210
myeloid cell apoptotic process GO:0033028 22 0.210
regulation of defense response GO:0031347 233 0.206
cell killing GO:0001906 67 0.206
regulation of apoptotic signaling pathway GO:2001233 197 0.205
regulation of protein serine threonine kinase activity GO:0071900 157 0.204
cellular response to lipid GO:0071396 145 0.204
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.202
chemokine biosynthetic process GO:0042033 8 0.200
t cell homeostasis GO:0043029 35 0.199
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.198
negative regulation of t helper cell differentiation GO:0045623 9 0.198
interleukin 10 secretion GO:0072608 4 0.198
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.197
carboxylic acid transport GO:0046942 100 0.195
negative regulation of t cell activation GO:0050868 65 0.192
regulation of peptidase activity GO:0052547 96 0.186
regulation of cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0032829 2 0.185
cell adhesion GO:0007155 329 0.183
protein secretion GO:0009306 111 0.183
protein maturation GO:0051604 176 0.182
natural killer cell activation GO:0030101 44 0.182
negative regulation of leukocyte differentiation GO:1902106 51 0.181
detection of stimulus GO:0051606 84 0.181
positive regulation of type iii hypersensitivity GO:0001805 3 0.176
peptidyl tyrosine modification GO:0018212 145 0.176
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.175
gamma delta t cell activation GO:0046629 13 0.174
negative regulation of chronic inflammatory response GO:0002677 3 0.172
immunoglobulin production GO:0002377 73 0.171
regulation of endopeptidase activity GO:0052548 89 0.170
regionalization GO:0003002 337 0.169
regulation of antimicrobial humoral response GO:0002759 3 0.166
regulation of establishment of protein localization GO:0070201 181 0.165
cellular amino acid metabolic process GO:0006520 103 0.165
cytokine secretion GO:0050663 72 0.164
extrinsic apoptotic signaling pathway GO:0097191 126 0.163
negative regulation of interleukin 2 production GO:0032703 8 0.161
regulation of mast cell degranulation GO:0043304 16 0.161
interleukin 2 production GO:0032623 33 0.160
cytokine metabolic process GO:0042107 71 0.159
t cell selection GO:0045058 34 0.159
b cell homeostasis GO:0001782 34 0.154
regulation of t cell activation GO:0050863 170 0.151
myeloid cell differentiation GO:0030099 233 0.150
regulation of humoral immune response GO:0002920 22 0.149
negative regulation of immune effector process GO:0002698 55 0.149
regulation of t cell proliferation GO:0042129 92 0.148
t helper cell lineage commitment GO:0002295 6 0.146
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.145
interleukin 6 production GO:0032635 58 0.145
b cell differentiation GO:0030183 78 0.144
endodermal cell fate specification GO:0001714 4 0.143
regulation of exocytosis GO:0017157 61 0.143
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.143
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.142
positive regulation of myoblast differentiation GO:0045663 8 0.138
regulation of myeloid cell apoptotic process GO:0033032 19 0.137
positive regulation of lymphocyte differentiation GO:0045621 61 0.137
homeostasis of number of cells GO:0048872 210 0.136
regulation of interleukin 2 production GO:0032663 28 0.134
regulation of striated muscle cell differentiation GO:0051153 81 0.134
negative regulation of mast cell apoptotic process GO:0033026 4 0.133
t cell lineage commitment GO:0002360 13 0.133
regulation of myeloid cell differentiation GO:0045637 96 0.132
regulation of cytokine secretion GO:0050707 61 0.132
regulation of dna recombination GO:0000018 34 0.132
lymph node development GO:0048535 18 0.131
b cell activation involved in immune response GO:0002312 50 0.129
regulation of gamma delta t cell activation GO:0046643 9 0.128
negative regulation of myeloid dendritic cell activation GO:0030886 3 0.128
jak stat cascade GO:0007259 42 0.127
gonad development GO:0008406 141 0.127
positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 2 0.127
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.126
positive regulation of immunoglobulin production GO:0002639 28 0.126
defense response to bacterium GO:0042742 119 0.126
regulation of secretion GO:0051046 274 0.125
cell chemotaxis GO:0060326 81 0.124
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.124
syncytium formation by plasma membrane fusion GO:0000768 42 0.124
organelle localization GO:0051640 179 0.122
cellular response to biotic stimulus GO:0071216 92 0.121
type 2 immune response GO:0042092 23 0.120
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.120
regulation of cysteine type endopeptidase activity GO:2000116 65 0.120
b cell receptor signaling pathway GO:0050853 20 0.119
cytoplasmic transport GO:0016482 234 0.119
t cell apoptotic process GO:0070231 39 0.119
regulation of multi organism process GO:0043900 111 0.118
cd4 positive alpha beta t cell activation GO:0035710 45 0.117
negative regulation of multi organism process GO:0043901 68 0.117
immune response regulating signaling pathway GO:0002764 125 0.116
regulation of lymphocyte mediated immunity GO:0002706 84 0.116
regulation of hydrolase activity GO:0051336 246 0.115
mast cell proliferation GO:0070662 4 0.115
mast cell degranulation GO:0043303 19 0.115
negative regulation of molecular function GO:0044092 258 0.114
positive regulation of mhc class ii biosynthetic process GO:0045348 4 0.113
olfactory learning GO:0008355 2 0.113
positive regulation of proteolysis GO:0045862 85 0.113
regulation of protein transport GO:0051223 163 0.110
positive regulation of humoral immune response GO:0002922 11 0.109
maintenance of location GO:0051235 89 0.109
cytokine production involved in immune response GO:0002367 34 0.108
regulation of cell killing GO:0031341 40 0.108
positive regulation of mast cell activation involved in immune response GO:0033008 10 0.108
cytokine mediated signaling pathway GO:0019221 115 0.107
negative regulation of apoptotic signaling pathway GO:2001234 104 0.104
t cell mediated immunity GO:0002456 50 0.104
positive regulation of cell death GO:0010942 224 0.103
negative regulation of isotype switching GO:0045829 4 0.103
striated muscle tissue development GO:0014706 293 0.102
positive regulation of protein modification process GO:0031401 299 0.101
chemotaxis GO:0006935 247 0.101
positive regulation of map kinase activity GO:0043406 84 0.101
positive regulation of organelle organization GO:0010638 128 0.101
positive regulation of adaptive immune response GO:0002821 61 0.100
positive regulation of cytokine secretion GO:0050715 41 0.100
regulation of production of molecular mediator of immune response GO:0002700 65 0.099
positive regulation of cell development GO:0010720 237 0.099
serotonin secretion involved in inflammatory response GO:0002442 4 0.098
dephosphorylation GO:0016311 129 0.096
gland development GO:0048732 330 0.094
dna recombination GO:0006310 92 0.094
myeloid leukocyte mediated immunity GO:0002444 42 0.094
response to organic cyclic compound GO:0014070 198 0.093
positive regulation of activation of membrane attack complex GO:0001970 2 0.093
regulation of acute inflammatory response GO:0002673 27 0.093
apoptotic signaling pathway GO:0097190 306 0.093
regulation of myotube differentiation GO:0010830 62 0.091
positive regulation of exocytosis GO:0045921 20 0.091
hemostasis GO:0007599 78 0.091
regulation of alpha beta t cell activation GO:0046634 53 0.090
cellular response to organonitrogen compound GO:0071417 145 0.090
nitrogen compound transport GO:0071705 271 0.090
negative regulation of immune system process GO:0002683 209 0.090
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.090
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.090
regulation of chronic inflammatory response GO:0002676 7 0.089
negative regulation of t cell mediated immunity GO:0002710 9 0.088
positive regulation of alpha beta t cell activation GO:0046635 39 0.087
positive regulation of protein kinase activity GO:0045860 144 0.087
leukocyte proliferation GO:0070661 172 0.087
cellular response to lipopolysaccharide GO:0071222 77 0.086
glycoprotein metabolic process GO:0009100 116 0.086
positive regulation of osteoclast development GO:2001206 3 0.086
growth involved in symbiotic interaction GO:0044110 23 0.085
cd4 positive alpha beta t cell lineage commitment GO:0043373 6 0.085
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 17 0.085
response to interleukin 15 GO:0070672 3 0.084
response to lipopolysaccharide GO:0032496 128 0.084
positive regulation of jun kinase activity GO:0043507 30 0.083
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.083
intrinsic apoptotic signaling pathway GO:0097193 132 0.081
regulated secretory pathway GO:0045055 32 0.080
cytokine biosynthetic process GO:0042089 68 0.080
innate immune response GO:0045087 157 0.080
regulation of epithelial cell proliferation GO:0050678 141 0.080
positive regulation of hydrolase activity GO:0051345 148 0.079
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.079
positive regulation of endopeptidase activity GO:0010950 43 0.078
detection of external stimulus GO:0009581 61 0.077
regulation of kinase activity GO:0043549 249 0.077
response to acid chemical GO:0001101 111 0.077
learned vocalization behavior or vocal learning GO:0098598 1 0.077
nuclear transport GO:0051169 139 0.077
innate immune response activating signal transduction GO:0002758 50 0.076
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.076
regulation of protein kinase activity GO:0045859 232 0.076
innate immune response in mucosa GO:0002227 3 0.075
positive regulation of peptidase activity GO:0010952 49 0.075
sulfur compound metabolic process GO:0006790 100 0.075
humoral immune response GO:0006959 57 0.075
natural killer cell proliferation GO:0001787 3 0.074
positive regulation of chronic inflammatory response GO:0002678 4 0.074
i kappab kinase nf kappab signaling GO:0007249 85 0.074
neuron death GO:0070997 154 0.074
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.073
negative regulation of t cell mediated cytotoxicity GO:0001915 3 0.073
regulation of proteolysis GO:0030162 164 0.072
cell cell recognition GO:0009988 44 0.071
negative regulation of protein metabolic process GO:0051248 282 0.071
necroptotic signaling pathway GO:0097527 3 0.070
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.070
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.070
progesterone metabolic process GO:0042448 4 0.069
regulation of vasculature development GO:1901342 88 0.069
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.069
regulation of innate immune response GO:0045088 91 0.068
alpha beta t cell lineage commitment GO:0002363 7 0.068
single organism cell adhesion GO:0098602 156 0.068
negative regulation of phosphate metabolic process GO:0045936 184 0.067
regulation of myeloid leukocyte mediated immunity GO:0002886 25 0.067
translational initiation GO:0006413 24 0.067
antimicrobial peptide production GO:0002775 2 0.067
positive regulation of programmed cell death GO:0043068 218 0.067
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.067
antibacterial peptide biosynthetic process GO:0002780 2 0.066
cellular response to interleukin 15 GO:0071350 2 0.066
t cell differentiation involved in immune response GO:0002292 30 0.066
negative regulation of cytokine production involved in immune response GO:0002719 5 0.066
negative regulation of toll like receptor 2 signaling pathway GO:0034136 3 0.066
protein processing GO:0016485 163 0.064
activation of cysteine type endopeptidase activity GO:0097202 27 0.064
platelet activation GO:0030168 40 0.064
lipid localization GO:0010876 126 0.063
endoderm development GO:0007492 45 0.063
skeletal muscle organ development GO:0060538 163 0.062
cellular calcium ion homeostasis GO:0006874 119 0.062
learning GO:0007612 98 0.062
positive regulation of cytokine production GO:0001819 174 0.062
cellular chemical homeostasis GO:0055082 215 0.062
regulation of transferase activity GO:0051338 263 0.062
detection of abiotic stimulus GO:0009582 60 0.061
cellular ketone metabolic process GO:0042180 84 0.061
regulation of jun kinase activity GO:0043506 40 0.061
divalent inorganic cation transport GO:0072511 178 0.061
osteoclast differentiation GO:0030316 62 0.060
regulation of lymphocyte activation GO:0051249 240 0.060
lymphocyte activation involved in immune response GO:0002285 93 0.059
mast cell apoptotic process GO:0033024 5 0.059
negative regulation of myeloid cell apoptotic process GO:0033033 11 0.059
defense response to gram negative bacterium GO:0050829 28 0.058
regulation of binding GO:0051098 111 0.058
reactive oxygen species metabolic process GO:0072593 84 0.058
isotype switching to igg isotypes GO:0048291 10 0.058
regulation of cellular amine metabolic process GO:0033238 20 0.058
positive regulation of apoptotic process GO:0043065 217 0.058
zymogen activation GO:0031638 41 0.057
multicellular organismal homeostasis GO:0048871 164 0.057
positive regulation of transferase activity GO:0051347 167 0.057
negative regulation of interleukin 5 production GO:0032714 4 0.057
myotube differentiation GO:0014902 105 0.057
positive regulation of activated t cell proliferation GO:0042104 8 0.057
leukocyte mediated cytotoxicity GO:0001909 62 0.056
positive regulation of mast cell activation GO:0033005 12 0.055
muscle cell proliferation GO:0033002 52 0.055
regulation of cellular ketone metabolic process GO:0010565 66 0.054
regulation of activated t cell proliferation GO:0046006 16 0.054
t cell activation involved in immune response GO:0002286 43 0.054
calcium ion transport GO:0006816 159 0.053
positive regulation of protein transport GO:0051222 93 0.053
regulation of leukocyte degranulation GO:0043300 20 0.052
regulation of map kinase activity GO:0043405 120 0.052
isotype switching GO:0045190 36 0.052
cell division GO:0051301 120 0.052
immune effector process GO:0002252 321 0.052
antimicrobial peptide biosynthetic process GO:0002777 2 0.052
negative regulation of nervous system development GO:0051961 156 0.051
sensory perception GO:0007600 245 0.051
tolerance induction dependent upon immune response GO:0002461 1 0.051
protein modification by small protein conjugation GO:0032446 187 0.051
positive regulation of cytokine biosynthetic process GO:0042108 40 0.050
cellular zinc ion homeostasis GO:0006882 9 0.050
divalent metal ion transport GO:0070838 172 0.050
metal ion homeostasis GO:0055065 189 0.050
regulation of neuron death GO:1901214 134 0.050
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.050
response to molecule of bacterial origin GO:0002237 143 0.049
mast cell homeostasis GO:0033023 5 0.049
positive regulation of myeloid leukocyte mediated immunity GO:0002888 14 0.049
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.049
carbohydrate metabolic process GO:0005975 230 0.049
lymphocyte costimulation GO:0031294 15 0.049
immune response inhibiting signal transduction GO:0002765 4 0.049
sequestering of metal ion GO:0051238 19 0.048
response to testosterone GO:0033574 3 0.048
t helper 2 cell cytokine production GO:0035745 4 0.048
regulation of protein kinase b signaling GO:0051896 56 0.047
t cell activation GO:0042110 289 0.047
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.047
regulation of mast cell differentiation GO:0060375 3 0.046
striated muscle cell development GO:0055002 125 0.046
cellular ion homeostasis GO:0006873 165 0.046
fever generation GO:0001660 7 0.046
positive regulation of myotube differentiation GO:0010831 24 0.045
gamma delta t cell differentiation GO:0042492 11 0.045
sensory organ morphogenesis GO:0090596 242 0.045
hormone secretion GO:0046879 128 0.045
circadian rhythm GO:0007623 114 0.045
regulation of reactive oxygen species metabolic process GO:2000377 40 0.045
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.044
positive regulation of myeloid cell differentiation GO:0045639 43 0.043
skeletal muscle fiber development GO:0048741 58 0.043
detection of mechanical stimulus involved in sensory perception GO:0050974 23 0.043
response to protozoan GO:0001562 28 0.043
negative regulation of muscle cell differentiation GO:0051148 33 0.043
detection of mechanical stimulus GO:0050982 27 0.042
positive regulation of defense response to bacterium GO:1900426 1 0.042
regulation of humoral immune response mediated by circulating immunoglobulin GO:0002923 10 0.042
muscle cell differentiation GO:0042692 261 0.041
regulation of body fluid levels GO:0050878 162 0.041
positive regulation of kinase activity GO:0033674 155 0.041
actin cytoskeleton organization GO:0030036 220 0.041
pre b cell differentiation GO:0002329 7 0.041
epidermis development GO:0008544 187 0.041
erk1 and erk2 cascade GO:0070371 77 0.041
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.040
cellular lipid metabolic process GO:0044255 323 0.040
defense response to gram positive bacterium GO:0050830 50 0.040
positive regulation of jak stat cascade GO:0046427 22 0.040
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.040
activation of innate immune response GO:0002218 56 0.039
negative regulation of leukocyte proliferation GO:0070664 46 0.039
positive regulation of t cell proliferation GO:0042102 52 0.039
mature dendritic cell differentiation GO:0097029 3 0.039
negative regulation of cytokine secretion GO:0050710 15 0.038
regulation of natural killer cell mediated immunity GO:0002715 19 0.038
protein localization to nucleus GO:0034504 121 0.038
wnt signaling pathway GO:0016055 188 0.038
positive regulation of jnk cascade GO:0046330 46 0.038
exocytosis GO:0006887 121 0.038
myoblast differentiation GO:0045445 52 0.038
organelle assembly GO:0070925 177 0.038
organic hydroxy compound metabolic process GO:1901615 203 0.038
negative regulation of interferon gamma production GO:0032689 18 0.038
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.038
anatomical structure homeostasis GO:0060249 145 0.038
intracellular protein transport GO:0006886 204 0.038
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.037
response to organonitrogen compound GO:0010243 246 0.037
muscle cell development GO:0055001 133 0.037
regulation of cellular component biogenesis GO:0044087 181 0.037
pattern recognition receptor signaling pathway GO:0002221 47 0.037
defense response to other organism GO:0098542 197 0.037
interleukin 2 mediated signaling pathway GO:0038110 2 0.037
muscle tissue development GO:0060537 308 0.037
cellular homeostasis GO:0019725 240 0.037
cholesterol metabolic process GO:0008203 56 0.037
positive regulation of protein localization to nucleus GO:1900182 30 0.037
mammary gland lobule development GO:0061377 22 0.037
neuromuscular synaptic transmission GO:0007274 16 0.036
positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 6 0.036
mammary gland epithelial cell proliferation GO:0033598 24 0.035

Il2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.090
disease of anatomical entity DOID:7 0 0.090
cancer DOID:162 0 0.064
disease of cellular proliferation DOID:14566 0 0.064
organ system cancer DOID:0050686 0 0.041
nervous system disease DOID:863 0 0.040
diabetes mellitus DOID:9351 0 0.037
disease of metabolism DOID:0014667 0 0.037
carbohydrate metabolism disease DOID:0050013 0 0.037
glucose metabolism disease DOID:4194 0 0.037
acquired metabolic disease DOID:0060158 0 0.037