Mus musculus

0 known processes

Klk1b8

kallikrein 1-related peptidase b8

(Aliases: Klk8,mGK-8,Nrpn,TADG14,MGC18615)

Klk1b8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
bradykinin biosynthetic process GO:0002936 1 0.998
Mouse
tissue kallikrein kinin cascade GO:0002255 1 0.998
Mouse
kinin cascade GO:0002254 2 0.996
Mouse
left ventricular cardiac muscle tissue morphogenesis GO:0003220 2 0.995
Mouse
positive regulation of vasoconstriction GO:0045907 4 0.978
Rat
protein activation cascade GO:0072376 19 0.977
Mouse
positive regulation of lipid kinase activity GO:0090218 11 0.970
Mouse
negative regulation of neuron projection regeneration GO:0070571 3 0.962
Mouse
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.944
Mouse
positive regulation of lipid metabolic process GO:0045834 40 0.919
Mouse
binding of sperm to zona pellucida GO:0007339 34 0.915
Mouse
regulation of blood volume by renin angiotensin GO:0002016 7 0.854
Mouse
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 11 0.819
Mouse
zymogen activation GO:0031638 41 0.778
Mouse
regulation of lipid kinase activity GO:0043550 14 0.763
Mouse
cell cell recognition GO:0009988 44 0.730
Mouse
cellular lipid metabolic process GO:0044255 323 0.688
Mouse
sperm egg recognition GO:0035036 37 0.679
Mouse
keratinocyte proliferation GO:0043616 21 0.669
Mouse
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 18 0.647
Mouse
brain renin angiotensin system GO:0002035 5 0.609
Mouse
inflammatory response GO:0006954 244 0.600
Mouse
action potential GO:0001508 78 0.585
cardiac muscle contraction GO:0060048 32 0.573
Mouse
protein processing GO:0016485 163 0.573
Mouse
muscle system process GO:0003012 141 0.518
Mouse
peptide metabolic process GO:0006518 46 0.502
Mouse
regulation of systemic arterial blood pressure by renin angiotensin GO:0003081 20 0.474
Mouse
protein maturation GO:0051604 176 0.473
Mouse
fertilization GO:0009566 127 0.448
Mouse
single fertilization GO:0007338 82 0.447
Mouse
cognition GO:0050890 149 0.437
Mouse
cardiac chamber development GO:0003205 108 0.395
Mouse
striated muscle contraction GO:0006941 45 0.378
Mouse
regulation of lipid metabolic process GO:0019216 118 0.377
Mouse
phospholipid metabolic process GO:0006644 87 0.354
Mouse
regulation of systemic arterial blood pressure by hormone GO:0001990 25 0.350
Mouse
regulation of transferase activity GO:0051338 263 0.332
Mouse
regulation of blood pressure GO:0008217 93 0.331
Mouse
muscle tissue morphogenesis GO:0060415 53 0.318
Mouse
regulation of neuron projection regeneration GO:0070570 7 0.317
Mouse
cellular amide metabolic process GO:0043603 58 0.308
Mouse
endocrine process GO:0050886 39 0.293
Mouse
regulation of myelination GO:0031641 20 0.288
Mouse
axon ensheathment GO:0008366 76 0.283
Mouse
regulation of neuron differentiation GO:0045664 281 0.280
Mouse
neuronal action potential GO:0019228 54 0.261
heart morphogenesis GO:0003007 178 0.260
Mouse
learning or memory GO:0007611 148 0.254
Mouse
extracellular structure organization GO:0043062 148 0.253
Mouse
positive regulation of transferase activity GO:0051347 167 0.251
Mouse
regulation of membrane potential GO:0042391 192 0.249
cardiac left ventricle morphogenesis GO:0003214 9 0.234
Mouse
regulation of blood circulation GO:1903522 93 0.231
Rat
multicellular organismal signaling GO:0035637 91 0.207
regulation of response to wounding GO:1903034 189 0.200
Mouse
cardiac ventricle morphogenesis GO:0003208 50 0.198
Mouse
cardiac muscle tissue development GO:0048738 130 0.198
Mouse
cardiac ventricle development GO:0003231 83 0.196
Mouse
negative regulation of nervous system development GO:0051961 156 0.195
Mouse
regulation of neuron projection development GO:0010975 169 0.193
Mouse
cardiac chamber morphogenesis GO:0003206 93 0.193
Mouse
small gtpase mediated signal transduction GO:0007264 97 0.192
Mouse
cardiac muscle tissue morphogenesis GO:0055008 44 0.185
Mouse
regulation of systemic arterial blood pressure GO:0003073 61 0.185
Mouse
acute inflammatory response GO:0002526 41 0.183
Mouse
muscle tissue development GO:0060537 308 0.181
Mouse
macromolecule catabolic process GO:0009057 281 0.177
Mouse
regulation of tube size GO:0035150 57 0.173
Mouse Rat
positive regulation of kinase activity GO:0033674 155 0.171
Mouse
blood circulation GO:0008015 195 0.165
Mouse Rat
oxidation reduction process GO:0055114 342 0.164
regulation of cellular response to stress GO:0080135 159 0.164
Mouse
muscle contraction GO:0006936 101 0.159
Mouse
synapse organization GO:0050808 125 0.155
Mouse
vasoconstriction GO:0042310 27 0.151
Rat
positive regulation of blood circulation GO:1903524 22 0.149
Rat
organonitrogen compound biosynthetic process GO:1901566 192 0.146
Mouse
vasodilation GO:0042311 28 0.143
Mouse
ensheathment of neurons GO:0007272 76 0.138
Mouse
cellular response to insulin stimulus GO:0032869 78 0.136
myelination GO:0042552 74 0.127
Mouse
regulation of cell projection organization GO:0031344 206 0.121
Mouse
regulation of neurological system process GO:0031644 22 0.121
Mouse
peptide biosynthetic process GO:0043043 11 0.121
Mouse
negative regulation of cell development GO:0010721 169 0.121
Mouse
circulatory system process GO:0003013 197 0.120
Mouse Rat
neuron projection regeneration GO:0031102 14 0.117
Mouse
cell recognition GO:0008037 83 0.117
Mouse
heart contraction GO:0060047 93 0.116
Mouse
protein catabolic process GO:0030163 221 0.114
Mouse
transmission of nerve impulse GO:0019226 76 0.114
extracellular matrix organization GO:0030198 147 0.109
Mouse
regulation of vasoconstriction GO:0019229 14 0.109
Rat
axon regeneration GO:0031103 12 0.105
Mouse
epithelial cell proliferation GO:0050673 174 0.102
Mouse
negative regulation of neurological system process GO:0031645 7 0.100
Mouse
negative regulation of neuron differentiation GO:0045665 101 0.093
Mouse
negative regulation of response to wounding GO:1903035 77 0.089
Mouse
regulation of blood vessel size GO:0050880 56 0.088
Mouse Rat
negative regulation of cellular component organization GO:0051129 194 0.082
Mouse
heart process GO:0003015 94 0.080
Mouse
regulation of kinase activity GO:0043549 249 0.079
Mouse
negative regulation of neuron projection development GO:0010977 50 0.078
Mouse
amine metabolic process GO:0009308 45 0.075
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.073
Mouse
ventricular cardiac muscle tissue development GO:0003229 38 0.072
Mouse
vascular process in circulatory system GO:0003018 62 0.071
Mouse Rat
multicellular organism growth GO:0035264 161 0.071
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.068
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.068
homeostasis of number of cells GO:0048872 210 0.066
monosaccharide biosynthetic process GO:0046364 44 0.065
olfactory learning GO:0008355 2 0.065
striated muscle tissue development GO:0014706 293 0.065
Mouse
regulation of anatomical structure size GO:0090066 178 0.064
Mouse Rat
amelogenesis GO:0097186 12 0.063
Mouse
cellular amino acid metabolic process GO:0006520 103 0.060
cellular response to testosterone stimulus GO:0071394 1 0.060
regulation of cellular ketone metabolic process GO:0010565 66 0.058
mitochondrion organization GO:0007005 134 0.058
carbohydrate biosynthetic process GO:0016051 74 0.057
cellular response to peptide hormone stimulus GO:0071375 92 0.056
spermatogenesis GO:0007283 284 0.055
gluconeogenesis GO:0006094 39 0.054
regulation of myeloid cell differentiation GO:0045637 96 0.054
cellular ketone metabolic process GO:0042180 84 0.053
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.052
regulation of gluconeogenesis GO:0006111 30 0.052
cellular response to food GO:0071240 1 0.048
lipid biosynthetic process GO:0008610 179 0.048
myeloid cell differentiation GO:0030099 233 0.045
carbohydrate metabolic process GO:0005975 230 0.045
negative regulation of myelination GO:0031642 6 0.044
Mouse
amide biosynthetic process GO:0043604 16 0.044
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.044
cellular carbohydrate metabolic process GO:0044262 119 0.044
regulation of cellular amine metabolic process GO:0033238 20 0.042
negative regulation of cell proliferation GO:0008285 296 0.041
alpha amino acid metabolic process GO:1901605 59 0.039
positive regulation of programmed cell death GO:0043068 218 0.038
cellular amine metabolic process GO:0044106 44 0.038
monocarboxylic acid metabolic process GO:0032787 191 0.038
response to peptide GO:1901652 136 0.037
negative regulation of insulin secretion GO:0046676 14 0.036
retina development in camera type eye GO:0060041 119 0.036
reactive oxygen species metabolic process GO:0072593 84 0.036
generation of precursor metabolites and energy GO:0006091 103 0.035
skin development GO:0043588 220 0.034
hexose biosynthetic process GO:0019319 39 0.033
tissue homeostasis GO:0001894 115 0.033
positive regulation of cell death GO:0010942 224 0.033
nitrogen compound transport GO:0071705 271 0.033
epidermis development GO:0008544 187 0.033
negative regulation of molecular function GO:0044092 258 0.032
glucose homeostasis GO:0042593 128 0.032
regulation of carbohydrate metabolic process GO:0006109 75 0.032
carboxylic acid biosynthetic process GO:0046394 86 0.031
cellular response to hormone stimulus GO:0032870 150 0.031
cellular response to organonitrogen compound GO:0071417 145 0.030
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.030
insulin receptor signaling pathway GO:0008286 49 0.029
negative regulation of protein metabolic process GO:0051248 282 0.029
response to peptide hormone GO:0043434 127 0.028
digestive tract development GO:0048565 190 0.028
metal ion homeostasis GO:0055065 189 0.028
response to organonitrogen compound GO:0010243 246 0.027
regulation of eosinophil migration GO:2000416 2 0.027
positive regulation of apoptotic process GO:0043065 217 0.027
cation transport GO:0006812 399 0.026
organic acid biosynthetic process GO:0016053 86 0.025
cell maturation GO:0048469 127 0.025
erythrocyte differentiation GO:0030218 88 0.025
regulation of glucose metabolic process GO:0010906 60 0.025
gland development GO:0048732 330 0.025
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.024
lipid localization GO:0010876 126 0.024
glucose metabolic process GO:0006006 92 0.024
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.024
regeneration GO:0031099 38 0.024
Mouse
male gamete generation GO:0048232 285 0.024
regulation of hormone levels GO:0010817 211 0.023
myeloid cell homeostasis GO:0002262 114 0.023
anatomical structure homeostasis GO:0060249 145 0.023
single organismal cell cell adhesion GO:0016337 131 0.023
circadian rhythm GO:0007623 114 0.023
positive regulation of thymocyte migration GO:2000412 2 0.023
cofactor metabolic process GO:0051186 80 0.022
amide transport GO:0042886 138 0.022
neutrophil mediated killing of gram positive bacterium GO:0070946 2 0.022
multicellular organismal homeostasis GO:0048871 164 0.022
peptide transport GO:0015833 133 0.021
axonogenesis GO:0007409 274 0.021
hexose metabolic process GO:0019318 98 0.021
nucleotide metabolic process GO:0009117 332 0.021
morphogenesis of a branching structure GO:0001763 203 0.021
response to organic cyclic compound GO:0014070 198 0.021
isoprenoid metabolic process GO:0006720 29 0.021
negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 4 0.021
cellular response to external stimulus GO:0071496 88 0.020
macromolecule glycosylation GO:0043413 55 0.020
organic cyclic compound catabolic process GO:1901361 295 0.020
regulation of angiotensin levels in blood GO:0002002 4 0.020
vitamin a metabolic process GO:0006776 2 0.020
cellular response to monosaccharide stimulus GO:0071326 47 0.020
positive regulation of protein secretion GO:0050714 52 0.019
regulation of cytokine production GO:0001817 266 0.019
negative regulation of cell projection organization GO:0031345 56 0.019
Mouse
neural tube development GO:0021915 160 0.019
cellular macromolecule catabolic process GO:0044265 206 0.019
protein glycosylation GO:0006486 55 0.019
peptide hormone secretion GO:0030072 109 0.019
reactive nitrogen species metabolic process GO:2001057 0 0.019
cellular response to peptide GO:1901653 92 0.019
cellular ion homeostasis GO:0006873 165 0.019
reactive oxygen species biosynthetic process GO:1903409 8 0.019
cell type specific apoptotic process GO:0097285 268 0.019
cellular response to organic cyclic compound GO:0071407 87 0.019
catecholamine uptake GO:0090493 4 0.019
granzyme mediated apoptotic signaling pathway GO:0008626 1 0.018
sensory perception GO:0007600 245 0.018
learning GO:0007612 98 0.018
protein modification by small protein conjugation or removal GO:0070647 207 0.018
spermatid differentiation GO:0048515 115 0.018
carboxylic acid catabolic process GO:0046395 51 0.018
dephosphorylation GO:0016311 129 0.018
regulation of phospholipase c activity GO:1900274 3 0.018
cellular chemical homeostasis GO:0055082 215 0.018
maintenance of location GO:0051235 89 0.017
peptidyl amino acid modification GO:0018193 336 0.017
cellular homeostasis GO:0019725 240 0.017
germ cell development GO:0007281 185 0.017
negative regulation of peptide hormone secretion GO:0090278 16 0.017
negative regulation of phosphorylation GO:0042326 166 0.017
glycosylation GO:0070085 62 0.017
positive regulation of organelle organization GO:0010638 128 0.017
digestive system development GO:0055123 200 0.017
purine containing compound metabolic process GO:0072521 311 0.017
regulation of hydrolase activity GO:0051336 246 0.017
positive regulation of phospholipase activity GO:0010518 3 0.017
response to decreased oxygen levels GO:0036293 59 0.016
negative regulation of protein modification process GO:0031400 163 0.016
cellularization GO:0007349 1 0.016
cellular glucose homeostasis GO:0001678 52 0.016
development of primary sexual characteristics GO:0045137 143 0.016
single organism cell adhesion GO:0098602 156 0.016
defense response to bacterium GO:0042742 119 0.016
negative regulation of intracellular signal transduction GO:1902532 167 0.015
endothelial cell differentiation GO:0045446 41 0.015
response to insulin GO:0032868 100 0.015
regulation of vitamin metabolic process GO:0030656 3 0.015
response to nutrient levels GO:0031667 109 0.015
response to oxygen levels GO:0070482 62 0.015
cell adhesion GO:0007155 329 0.015
visual perception GO:0007601 52 0.015
epithelial cell development GO:0002064 159 0.015
regulation of secretion by cell GO:1903530 249 0.015
negative regulation of cellular protein metabolic process GO:0032269 247 0.015
response to acid chemical GO:0001101 111 0.015
cellular metal ion homeostasis GO:0006875 151 0.015
regulation of reactive oxygen species metabolic process GO:2000377 40 0.015
protein secretion GO:0009306 111 0.014
regulation of body fluid levels GO:0050878 162 0.014
response to inorganic substance GO:0010035 96 0.014
regulation of mapk cascade GO:0043408 248 0.014
defense response to other organism GO:0098542 197 0.014
inorganic cation transmembrane transport GO:0098662 207 0.014
carbohydrate derivative biosynthetic process GO:1901137 183 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
positive regulation of eosinophil migration GO:2000418 2 0.014
anion transport GO:0006820 177 0.014
wound healing GO:0042060 157 0.014
immune effector process GO:0002252 321 0.014
activation of phospholipase c activity GO:0007202 2 0.014
leukocyte differentiation GO:0002521 342 0.013
regulation of lymphocyte differentiation GO:0045619 107 0.013
regulation of t cell differentiation GO:0045580 83 0.013
defense response to gram positive bacterium GO:0050830 50 0.013
monosaccharide metabolic process GO:0005996 106 0.013
leukocyte proliferation GO:0070661 172 0.013
odontogenesis GO:0042476 78 0.013
Mouse
regulation of isoprenoid metabolic process GO:0019747 1 0.013
purine nucleotide metabolic process GO:0006163 302 0.013
terpenoid metabolic process GO:0006721 25 0.013
retinoid metabolic process GO:0001523 24 0.013
sequestering of calcium ion GO:0051208 18 0.013
regulation of cellular component biogenesis GO:0044087 181 0.013
response to oxidative stress GO:0006979 123 0.013
cation homeostasis GO:0055080 212 0.013
regulation of system process GO:0044057 200 0.013
Mouse Rat
heterocycle catabolic process GO:0046700 280 0.013
organelle fission GO:0048285 170 0.013
cellular response to carbohydrate stimulus GO:0071322 50 0.013
negative regulation of leukocyte differentiation GO:1902106 51 0.013
cation transmembrane transport GO:0098655 266 0.013
response to monosaccharide GO:0034284 67 0.012
regulation of epithelial cell proliferation GO:0050678 141 0.012
cellular divalent inorganic cation homeostasis GO:0072503 127 0.012
regulation of inward rectifier potassium channel activity GO:1901979 1 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
renal system development GO:0072001 225 0.012
eosinophil migration GO:0072677 3 0.012
chromatin organization GO:0006325 206 0.012
response to lipopolysaccharide GO:0032496 128 0.012
t cell differentiation GO:0030217 174 0.012
branching morphogenesis of an epithelial tube GO:0048754 159 0.012
hormone secretion GO:0046879 128 0.012
leukocyte homeostasis GO:0001776 79 0.012
placenta development GO:0001890 140 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
cellular respiration GO:0045333 38 0.012
epithalamus development GO:0021538 2 0.012
regulation of carbohydrate biosynthetic process GO:0043255 40 0.012
positive regulation of thyroid hormone generation GO:2000611 2 0.012
apoptotic signaling pathway GO:0097190 306 0.012
blood vessel morphogenesis GO:0048514 285 0.012
glycoprotein metabolic process GO:0009100 116 0.012
nucleobase containing small molecule metabolic process GO:0055086 352 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.011
lymphocyte mediated immunity GO:0002449 139 0.011
peptide secretion GO:0002790 114 0.011
positive regulation of protein modification process GO:0031401 299 0.011
insulin secretion GO:0030073 89 0.011
cellular potassium ion transport GO:0071804 43 0.011
energy reserve metabolic process GO:0006112 39 0.011
dibenzo p dioxin metabolic process GO:0018894 1 0.011
negative regulation of immune effector process GO:0002698 55 0.011
thymocyte migration GO:0072679 2 0.011
positive regulation of phospholipase c activity GO:0010863 2 0.011
cellular response to lipid GO:0071396 145 0.011
positive regulation of keratinocyte proliferation GO:0010838 4 0.011
retinal blood vessel morphogenesis GO:0061304 3 0.011
negative regulation of peptide secretion GO:0002792 16 0.011
purine ribonucleoside metabolic process GO:0046128 241 0.011
positive regulation of cell development GO:0010720 237 0.011
rho protein signal transduction GO:0007266 32 0.011
stem cell proliferation GO:0072089 117 0.011
drug metabolic process GO:0017144 4 0.011
cellular modified amino acid metabolic process GO:0006575 63 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
monocarboxylic acid biosynthetic process GO:0072330 61 0.011
divalent metal ion transport GO:0070838 172 0.011
viral gene expression GO:0019080 3 0.011
protein acylation GO:0043543 64 0.011
wnt signaling pathway GO:0016055 188 0.011
sperm motility GO:0030317 47 0.011
mast cell proliferation GO:0070662 4 0.011
calcium mediated signaling GO:0019722 46 0.010
ribonucleotide metabolic process GO:0009259 291 0.010
calcium ion homeostasis GO:0055074 127 0.010
regulation of proteolysis GO:0030162 164 0.010
regulation of leukocyte differentiation GO:1902105 159 0.010
energy derivation by oxidation of organic compounds GO:0015980 77 0.010
activation of mapk activity involved in innate immune response GO:0035419 2 0.010
regulation of organelle organization GO:0033043 289 0.010
digestion GO:0007586 40 0.010

Klk1b8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.017
disease of anatomical entity DOID:7 0 0.017
neurodegenerative disease DOID:1289 0 0.017
central nervous system disease DOID:331 0 0.017
bone disease DOID:0080001 0 0.011
connective tissue disease DOID:65 0 0.011
musculoskeletal system disease DOID:17 0 0.011