Mus musculus

61 known processes

Lepr

leptin receptor

(Aliases: obl,Leprb,db,MGC105189,OB-RGRP,Modb1,LEPROT,obese-like,Obr,diabetes)

Lepr biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of insulin receptor signaling pathway GO:0046626 21 1.000
activation of janus kinase activity GO:0042976 2 1.000
regulation of activation of jak2 kinase activity GO:0010534 1 1.000
cellular response to peptide GO:1901653 92 1.000
regulation of gluconeogenesis GO:0006111 30 1.000
lactation GO:0007595 25 1.000
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 1.000
regulation of jak stat cascade GO:0046425 34 1.000
drug catabolic process GO:0042737 2 1.000
mammary gland lobule development GO:0061377 22 1.000
positive regulation of fatty acid oxidation GO:0046321 4 1.000
negative regulation of cellular response to insulin stimulus GO:1900077 16 1.000
response to peptide hormone GO:0043434 127 1.000
cellular response to insulin stimulus GO:0032869 78 1.000
jak stat cascade GO:0007259 42 1.000
neuropeptide signaling pathway GO:0007218 19 1.000
negative regulation of t helper 2 cell differentiation GO:0045629 4 1.000
insulin receptor signaling pathway GO:0008286 49 1.000
positive regulation of hydrolase activity GO:0051345 148 1.000
cellular response to peptide hormone stimulus GO:0071375 92 1.000
cellular response to organonitrogen compound GO:0071417 145 1.000
response to peptide GO:1901652 136 1.000
regulation of fatty acid metabolic process GO:0019217 28 1.000
regulation of nitrogen cycle metabolic process GO:1903314 1 1.000
creatinine metabolic process GO:0046449 3 1.000
positive regulation of insulin receptor signaling pathway GO:0046628 4 1.000
regulation of cellular response to insulin stimulus GO:1900076 30 1.000
regulation of renal output by angiotensin GO:0002019 2 1.000
positive regulation of kinase activity GO:0033674 155 1.000
g protein coupled receptor signaling pathway GO:0007186 243 0.999
regulation of kinase activity GO:0043549 249 0.999
cellular carbohydrate metabolic process GO:0044262 119 0.999
monocarboxylic acid metabolic process GO:0032787 191 0.999
cellular response to amino acid stimulus GO:0071230 29 0.999
negative regulation of protein phosphorylation GO:0001933 126 0.999
layer formation in cerebral cortex GO:0021819 13 0.999
steroid metabolic process GO:0008202 119 0.999
response to insulin GO:0032868 100 0.999
regulation of activation of janus kinase activity GO:0010533 1 0.999
response to alcohol GO:0097305 48 0.999
response to organonitrogen compound GO:0010243 246 0.999
regulation of fatty acid oxidation GO:0046320 10 0.999
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.999
regulation of androgen receptor signaling pathway GO:0060765 3 0.999
mammary gland epithelium development GO:0061180 65 0.998
regulation of protein kinase activity GO:0045859 232 0.998
positive regulation of jak stat cascade GO:0046427 22 0.998
reactive oxygen species biosynthetic process GO:1903409 8 0.998
carbohydrate metabolic process GO:0005975 230 0.998
tyrosine phosphorylation of stat protein GO:0007260 23 0.998
negative regulation of growth GO:0045926 99 0.998
hormone mediated signaling pathway GO:0009755 23 0.998
fatty acid metabolic process GO:0006631 121 0.998
negative regulation of protein metabolic process GO:0051248 282 0.998
peptidyl tyrosine phosphorylation GO:0018108 143 0.998
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.998
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.997
positive regulation of protein kinase activity GO:0045860 144 0.997
tyrosine phosphorylation of stat3 protein GO:0042503 12 0.997
intestinal cholesterol absorption GO:0030299 5 0.997
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.997
neuron apoptotic process GO:0051402 142 0.997
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.997
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.997
hexose metabolic process GO:0019318 98 0.997
urogenital system development GO:0001655 261 0.997
Mouse
regulation of triglyceride metabolic process GO:0090207 17 0.997
negative regulation of phosphorylation GO:0042326 166 0.996
positive regulation of lymphocyte activation GO:0051251 140 0.996
positive regulation of mapk cascade GO:0043410 170 0.996
monosaccharide metabolic process GO:0005996 106 0.995
response to amino acid GO:0043200 37 0.995
regulation of glucose metabolic process GO:0010906 60 0.995
cellular response to cytokine stimulus GO:0071345 189 0.995
glucose import GO:0046323 32 0.995
regulation of intestinal cholesterol absorption GO:0030300 4 0.995
intestinal absorption GO:0050892 13 0.995
erk1 and erk2 cascade GO:0070371 77 0.995
radial glia guided migration of purkinje cell GO:0021942 6 0.994
taurine metabolic process GO:0019530 4 0.994
response to organic cyclic compound GO:0014070 198 0.994
protein kinase c activating g protein coupled receptor signaling pathway GO:0007205 4 0.993
glucose metabolic process GO:0006006 92 0.993
positive regulation of map kinase activity GO:0043406 84 0.993
cellular response to growth hormone stimulus GO:0071378 7 0.993
progesterone metabolic process GO:0042448 4 0.993
cytokine mediated signaling pathway GO:0019221 115 0.993
hormone metabolic process GO:0042445 86 0.992
negative regulation of phosphorus metabolic process GO:0010563 184 0.992
metanephric glomerular mesangium development GO:0072223 3 0.992
creatine metabolic process GO:0006600 4 0.992
negative regulation of cell proliferation GO:0008285 296 0.992
cellular amino acid metabolic process GO:0006520 103 0.992
negative regulation of tyrosine phosphorylation of stat3 protein GO:0042518 1 0.992
positive regulation of glial cell proliferation GO:0060252 4 0.992
forebrain development GO:0030900 302 0.991
alpha amino acid metabolic process GO:1901605 59 0.991
regulation of glutamine family amino acid metabolic process GO:0000820 1 0.991
regulation of adrenergic receptor signaling pathway GO:0071877 4 0.990
cellular ketone metabolic process GO:0042180 84 0.990
lipid homeostasis GO:0055088 63 0.990
regulation of secretion by cell GO:1903530 249 0.990
response to hyperoxia GO:0055093 2 0.990
activation of jak2 kinase activity GO:0042977 2 0.990
regulation of cellular amine metabolic process GO:0033238 20 0.989
negative regulation of tyrosine phosphorylation of stat protein GO:0042532 3 0.989
regulation of leukocyte differentiation GO:1902105 159 0.989
exogenous drug catabolic process GO:0042738 1 0.989
regulation of feeding behavior GO:0060259 3 0.989
regulation of secretion GO:0051046 274 0.989
regulation of ras protein signal transduction GO:0046578 114 0.989
glucose homeostasis GO:0042593 128 0.989
regulation of cellular amino acid metabolic process GO:0006521 5 0.989
glycolytic process GO:0006096 20 0.989
negative regulation of cellular amine metabolic process GO:0033239 1 0.989
cholesterol esterification GO:0034435 3 0.988
response to corticosteroid GO:0031960 20 0.988
positive regulation of leukocyte differentiation GO:1902107 86 0.988
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway GO:0051482 4 0.988
negative regulation of phosphate metabolic process GO:0045936 184 0.988
prolactin signaling pathway GO:0038161 5 0.987
mammary gland alveolus development GO:0060749 22 0.987
development of primary sexual characteristics GO:0045137 143 0.987
t cell activation GO:0042110 289 0.986
lipid biosynthetic process GO:0008610 179 0.986
regulation of steroid biosynthetic process GO:0050810 26 0.986
regulation of natural killer cell differentiation GO:0032823 11 0.986
positive regulation of transferase activity GO:0051347 167 0.985
regulation of serotonin uptake GO:0051611 2 0.985
rhythmic process GO:0048511 174 0.984
regulation of hormone levels GO:0010817 211 0.984
neuron death GO:0070997 154 0.984
Mouse
regulation of cell migration GO:0030334 219 0.984
positive regulation of adrenergic receptor signaling pathway GO:0071879 3 0.984
cytokine production GO:0001816 319 0.984
glycerolipid metabolic process GO:0046486 122 0.983
ammonia assimilation cycle GO:0019676 2 0.983
regulation of the force of heart contraction by chemical signal GO:0003057 5 0.983
cd4 positive alpha beta t cell activation GO:0035710 45 0.983
small gtpase mediated signal transduction GO:0007264 97 0.983
ras protein signal transduction GO:0007265 77 0.983
adrenal gland development GO:0030325 18 0.982
cellular response to acid chemical GO:0071229 68 0.982
response to bile acid GO:1903412 1 0.982
mesonephric tubule development GO:0072164 94 0.981
Mouse
carbohydrate biosynthetic process GO:0016051 74 0.981
morphogenesis of a branching structure GO:0001763 203 0.981
fat cell differentiation GO:0045444 160 0.981
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.981
negative regulation of cellular protein metabolic process GO:0032269 247 0.980
telencephalon development GO:0021537 186 0.980
regulation of vitamin d biosynthetic process GO:0060556 1 0.979
regulation of hydrolase activity GO:0051336 246 0.979
regulation of transferase activity GO:0051338 263 0.979
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.979
cerebral cortex radial glia guided migration GO:0021801 17 0.979
negative regulation of molecular function GO:0044092 258 0.979
response to steroid hormone GO:0048545 56 0.979
inflammatory response GO:0006954 244 0.979
positive regulation of dephosphorylation GO:0035306 6 0.978
negative regulation of interferon gamma mediated signaling pathway GO:0060336 1 0.978
muscle cell proliferation GO:0033002 52 0.977
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.977
response to corticosterone GO:0051412 1 0.977
cellular carbohydrate catabolic process GO:0044275 15 0.976
regulation of carbohydrate catabolic process GO:0043470 12 0.975
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.975
cholesterol storage GO:0010878 4 0.975
drug metabolic process GO:0017144 4 0.975
positive regulation of lymphocyte proliferation GO:0050671 70 0.975
regulation of inflammatory response GO:0050727 147 0.975
apoptotic process involved in mammary gland involution GO:0060057 4 0.974
multicellular organism growth GO:0035264 161 0.974
leukocyte differentiation GO:0002521 342 0.974
lipid transport GO:0006869 98 0.974
negative regulation of feeding behavior GO:2000252 1 0.974
positive regulation of lipid kinase activity GO:0090218 11 0.973
g protein coupled receptor signaling pathway involved in heart process GO:0086103 4 0.973
positive regulation of cholesterol esterification GO:0010873 1 0.973
cellular response to hormone stimulus GO:0032870 150 0.973
cellular response to increased oxygen levels GO:0036295 1 0.973
apoptotic signaling pathway GO:0097190 306 0.972
regulation of mammary gland involution GO:1903519 4 0.972
positive regulation of t cell activation GO:0050870 101 0.972
allantoin metabolic process GO:0000255 3 0.972
labyrinthine layer morphogenesis GO:0060713 21 0.972
cellular response to interferon gamma GO:0071346 25 0.972
regulation of nitric oxide synthase activity GO:0050999 6 0.972
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.971
immune effector process GO:0002252 321 0.971
positive regulation of apoptotic signaling pathway GO:2001235 95 0.971
leukocyte activation involved in immune response GO:0002366 126 0.971
response to growth hormone GO:0060416 7 0.970
protein nitrosylation GO:0017014 4 0.969
t cell differentiation GO:0030217 174 0.969
negative regulation of androgen receptor signaling pathway GO:0060766 3 0.969
energy reserve metabolic process GO:0006112 39 0.968
regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1902238 1 0.968
regulation of the force of heart contraction GO:0002026 17 0.968
positive regulation of leukocyte proliferation GO:0070665 73 0.968
reactive nitrogen species metabolic process GO:2001057 0 0.968
positive regulation of cell activation GO:0050867 158 0.967
negative regulation of neurotransmitter transport GO:0051589 7 0.967
negative regulation of response to food GO:0032096 7 0.967
isoleucine metabolic process GO:0006549 4 0.967
pallium development GO:0021543 120 0.967
negative regulation of neurotrophin trk receptor signaling pathway GO:0051387 2 0.966
carbohydrate catabolic process GO:0016052 32 0.966
mammary gland branching involved in pregnancy GO:0060745 6 0.966
mammary gland duct morphogenesis GO:0060603 38 0.966
cell growth involved in cardiac muscle cell development GO:0061049 3 0.965
epidermal growth factor receptor signaling pathway GO:0007173 28 0.965
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.964
response to camp GO:0051591 14 0.964
regulation of protein localization GO:0032880 231 0.963
regulation of lymphocyte proliferation GO:0050670 117 0.963
regulation of cell activation GO:0050865 289 0.963
succinate metabolic process GO:0006105 4 0.962
generation of precursor metabolites and energy GO:0006091 103 0.961
negative regulation of intracellular signal transduction GO:1902532 167 0.958
regulation of carbohydrate metabolic process GO:0006109 75 0.958
regulation of establishment of protein localization GO:0070201 181 0.958
negative regulation of peptidyl serine phosphorylation GO:0033137 10 0.957
alpha beta t cell activation involved in immune response GO:0002287 31 0.957
regulation of t helper cell differentiation GO:0045622 14 0.956
regulation of cholesterol esterification GO:0010872 2 0.956
negative regulation of smooth muscle cell apoptotic process GO:0034392 1 0.955
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.955
peptide transport GO:0015833 133 0.954
cellular response to bile acid GO:1903413 1 0.953
positive regulation of nucleotide biosynthetic process GO:0030810 26 0.953
negative regulation of systemic arterial blood pressure GO:0003085 15 0.953
adrenergic receptor signaling pathway GO:0071875 13 0.952
regulation of circadian rhythm GO:0042752 58 0.952
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 10 0.952
superoxide metabolic process GO:0006801 27 0.952
positive regulation of cell migration GO:0030335 109 0.951
regulation of cell motility GO:2000145 236 0.951
sterol homeostasis GO:0055092 45 0.951
intracellular receptor signaling pathway GO:0030522 74 0.950
cellular response to biotic stimulus GO:0071216 92 0.950
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.950
cerebral cortex development GO:0021987 86 0.949
alpha beta t cell differentiation GO:0046632 69 0.948
negative regulation of blood pressure GO:0045776 22 0.948
energy derivation by oxidation of organic compounds GO:0015980 77 0.947
response to estradiol GO:0032355 12 0.947
trophectodermal cellular morphogenesis GO:0001831 3 0.947
renin angiotensin regulation of aldosterone production GO:0002018 3 0.946
regulation of lymphocyte activation GO:0051249 240 0.946
development of primary female sexual characteristics GO:0046545 73 0.946
regulation of mapk cascade GO:0043408 248 0.945
regulation of fat cell differentiation GO:0045598 81 0.944
blood circulation GO:0008015 195 0.942
peptidyl tyrosine modification GO:0018212 145 0.941
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.941
regulation of cellular response to growth factor stimulus GO:0090287 82 0.941
organic hydroxy compound metabolic process GO:1901615 203 0.940
body fluid secretion GO:0007589 53 0.940
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.939
sterol esterification GO:0034434 3 0.938
response to food GO:0032094 17 0.938
cerebral cortex cell migration GO:0021795 44 0.937
positive regulation of b cell proliferation GO:0030890 24 0.937
carbohydrate homeostasis GO:0033500 128 0.937
cyclic purine nucleotide metabolic process GO:0052652 43 0.937
acylglycerol metabolic process GO:0006639 55 0.936
monosaccharide biosynthetic process GO:0046364 44 0.936
cholesterol homeostasis GO:0042632 44 0.934
intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1990127 1 0.932
regulation of erk1 and erk2 cascade GO:0070372 71 0.932
response to interferon gamma GO:0034341 34 0.931
embryonic placenta development GO:0001892 98 0.928
nitric oxide biosynthetic process GO:0006809 25 0.928
regulation of lipid metabolic process GO:0019216 118 0.927
response to glucocorticoid GO:0051384 20 0.926
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.926
positive regulation of vasoconstriction GO:0045907 4 0.926
positive regulation of nervous system development GO:0051962 221 0.925
small molecule catabolic process GO:0044282 71 0.924
trophectodermal cell proliferation GO:0001834 2 0.924
positive regulation of apoptotic process involved in morphogenesis GO:1902339 4 0.923
regulation of t helper 1 cell differentiation GO:0045625 7 0.923
positive regulation of nucleoside metabolic process GO:0045979 91 0.923
cellular response to lipid GO:0071396 145 0.923
regulation of tube size GO:0035150 57 0.923
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.922
positive regulation of gtpase activity GO:0043547 85 0.922
positive regulation of programmed cell death GO:0043068 218 0.921
cell proliferation in hindbrain GO:0021534 10 0.920
cellular lipid metabolic process GO:0044255 323 0.920
camp mediated signaling GO:0019933 15 0.920
carbon catabolite activation of transcription GO:0045991 4 0.920
cellular metal ion homeostasis GO:0006875 151 0.919
regulation of glycogen metabolic process GO:0070873 13 0.919
triglyceride homeostasis GO:0070328 15 0.918
negative regulation of calcium ion transport GO:0051926 9 0.916
muscle cell differentiation GO:0042692 261 0.915
regulation of protein transport GO:0051223 163 0.914
regulation of glucagon secretion GO:0070092 2 0.914
negative regulation of triglyceride metabolic process GO:0090209 4 0.913
regulation of body fluid levels GO:0050878 162 0.910
sterol transport GO:0015918 38 0.910
regulation of type 2 immune response GO:0002828 18 0.910
oxidation reduction process GO:0055114 342 0.909
peptide secretion GO:0002790 114 0.909
interleukin 18 mediated signaling pathway GO:0035655 2 0.908
nuclear transport GO:0051169 139 0.908
response to purine containing compound GO:0014074 28 0.908
positive regulation of nitric oxide synthase activity GO:0051000 2 0.907
dendritic spine maintenance GO:0097062 4 0.906
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure GO:0002033 2 0.906
response to granulocyte macrophage colony stimulating factor GO:0097012 3 0.905
regulation of transcription involved in cell fate commitment GO:0060850 15 0.905
lymphocyte proliferation GO:0046651 164 0.904
positive regulation of adaptive immune response GO:0002821 61 0.904
positive regulation of phospholipase activity GO:0010518 3 0.904
regulation of glutamate metabolic process GO:2000211 1 0.904
regulation of protein serine threonine kinase activity GO:0071900 157 0.904
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.904
response to vitamin d GO:0033280 3 0.903
regulation of protein targeting GO:1903533 61 0.902
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.902
response to dexamethasone GO:0071548 8 0.902
positive regulation of cellular amine metabolic process GO:0033240 5 0.901
lymphocyte activation involved in immune response GO:0002285 93 0.900
response to estrogen GO:0043627 24 0.898
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.898
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.896
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.896
eye photoreceptor cell differentiation GO:0001754 41 0.896
positive regulation of lipid metabolic process GO:0045834 40 0.896
circadian regulation of gene expression GO:0032922 48 0.895
nitric oxide metabolic process GO:0046209 25 0.894
ossification GO:0001503 216 0.894
regulation of ammonia assimilation cycle GO:2001248 1 0.893
nuclear import GO:0051170 95 0.893
peptidyl amino acid modification GO:0018193 336 0.892
response to nutrient levels GO:0031667 109 0.891
regulation of carbohydrate biosynthetic process GO:0043255 40 0.889
cell activation involved in immune response GO:0002263 126 0.889
female sex differentiation GO:0046660 84 0.885
regulation of glucocorticoid secretion GO:2000849 5 0.883
regulation of blood vessel size GO:0050880 56 0.883
cytoplasmic transport GO:0016482 234 0.882
steroid hormone mediated signaling pathway GO:0043401 6 0.880
regulation of peptidyl serine phosphorylation GO:0033135 39 0.879
erbb signaling pathway GO:0038127 32 0.879
regulation of steroid metabolic process GO:0019218 39 0.879
polysaccharide metabolic process GO:0005976 39 0.878
dicarboxylic acid metabolic process GO:0043648 18 0.876
regulation of monooxygenase activity GO:0032768 7 0.876
carboxylic acid catabolic process GO:0046395 51 0.876
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.876
positive regulation of cellular response to insulin stimulus GO:1900078 9 0.875
regulation of steroid hormone biosynthetic process GO:0090030 4 0.873
response to testosterone GO:0033574 3 0.872
angiogenesis GO:0001525 201 0.872
establishment of protein localization to organelle GO:0072594 118 0.872
gluconeogenesis GO:0006094 39 0.870
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.869
forebrain cell migration GO:0021885 58 0.869
citrate metabolic process GO:0006101 3 0.868
positive regulation of neuron differentiation GO:0045666 141 0.867
vasodilation GO:0042311 28 0.867
hexose biosynthetic process GO:0019319 39 0.867
morphogenesis of a branching epithelium GO:0061138 193 0.867
gland development GO:0048732 330 0.865
cellular response to vitamin GO:0071295 2 0.865
glycogen metabolic process GO:0005977 32 0.865
regulation of ras gtpase activity GO:0032318 88 0.864
response to interleukin 15 GO:0070672 3 0.863
positive regulation of activated t cell proliferation GO:0042104 8 0.863
negative regulation of appetite GO:0032099 7 0.863
female gonad development GO:0008585 71 0.862
acylglycerol homeostasis GO:0055090 16 0.861
response to lipopolysaccharide GO:0032496 128 0.861
protein processing GO:0016485 163 0.861
regulation of leukocyte apoptotic process GO:2000106 56 0.860
regulation of lipid kinase activity GO:0043550 14 0.860
intracellular protein transport GO:0006886 204 0.859
leukocyte apoptotic process GO:0071887 71 0.859
negative regulation of protein modification process GO:0031400 163 0.855
protein ubiquitination GO:0016567 171 0.855
cell type specific apoptotic process GO:0097285 268 0.855
Mouse
cyclic nucleotide mediated signaling GO:0019935 18 0.854
organic acid catabolic process GO:0016054 51 0.853
triglyceride metabolic process GO:0006641 51 0.853
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.853
hindbrain development GO:0030902 128 0.852
regulation of dna templated transcription in response to stress GO:0043620 9 0.852
response to ethanol GO:0045471 18 0.852
embryonic placenta morphogenesis GO:0060669 25 0.851
cellular lactam metabolic process GO:0072338 3 0.850
positive regulation of glycolytic process GO:0045821 4 0.850
regulation of fatty acid beta oxidation GO:0031998 1 0.848
fat soluble vitamin biosynthetic process GO:0042362 4 0.848
regulation of generation of precursor metabolites and energy GO:0043467 38 0.847
regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902253 13 0.847
lymphocyte differentiation GO:0030098 242 0.846
positive regulation of protein modification process GO:0031401 299 0.846
cerebral cortex radially oriented cell migration GO:0021799 31 0.845
response to increased oxygen levels GO:0036296 2 0.845
ovulation from ovarian follicle GO:0001542 9 0.844
regulation of neuron death GO:1901214 134 0.842
Mouse
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.842
negative regulation of lipid metabolic process GO:0045833 30 0.840
signal transduction in absence of ligand GO:0038034 55 0.840
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.840
branching involved in labyrinthine layer morphogenesis GO:0060670 9 0.839
positive regulation of smooth muscle cell migration GO:0014911 4 0.839
activation of cysteine type endopeptidase activity GO:0097202 27 0.838
hindbrain radial glia guided cell migration GO:0021932 12 0.838
extrinsic apoptotic signaling pathway GO:0097191 126 0.836
valine metabolic process GO:0006573 4 0.836
cerebellar granule cell precursor proliferation GO:0021930 10 0.836
circadian rhythm GO:0007623 114 0.836
negative regulation of inflammatory response GO:0050728 61 0.836
regulation of response to wounding GO:1903034 189 0.836
response to amphetamine GO:0001975 16 0.836
positive regulation of neuron apoptotic process GO:0043525 25 0.835
fatty acid catabolic process GO:0009062 25 0.834
regulation of glycolytic process GO:0006110 10 0.834
pyruvate metabolic process GO:0006090 28 0.833
arginine metabolic process GO:0006525 2 0.832
regulation of cholesterol metabolic process GO:0090181 14 0.831
negative regulation of release of cytochrome c from mitochondria GO:0090201 6 0.830
purine ribonucleotide metabolic process GO:0009150 290 0.830
regulation of cytokine production GO:0001817 266 0.828
positive regulation of intracellular steroid hormone receptor signaling pathway GO:0033145 4 0.827
regulation of anatomical structure size GO:0090066 178 0.827
trophoblast giant cell differentiation GO:0060707 15 0.825
positive regulation of protein phosphorylation GO:0001934 242 0.825
white fat cell differentiation GO:0050872 15 0.825
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.824
regulation of phospholipase c activity GO:1900274 3 0.824
positive regulation of apoptotic process GO:0043065 217 0.823
negative regulation of muscle adaptation GO:0014745 2 0.822
tor signaling GO:0031929 21 0.822
myotube differentiation GO:0014902 105 0.821
positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 0.821
mapk cascade GO:0000165 281 0.819
vascular process in circulatory system GO:0003018 62 0.816
positive regulation of mammary gland involution GO:1903521 4 0.816
adipose tissue development GO:0060612 25 0.815
keratinocyte migration GO:0051546 3 0.813
negative regulation of serotonin uptake GO:0051612 2 0.813
positive regulation of brown fat cell differentiation GO:0090336 4 0.813
cellular response to drug GO:0035690 15 0.810
regulation of appetite GO:0032098 12 0.810
regulation of homeostatic process GO:0032844 182 0.809
organic hydroxy compound transport GO:0015850 93 0.809
negative regulation of peptide hormone secretion GO:0090278 16 0.809
steroid esterification GO:0034433 3 0.809
positive regulation of glycogen metabolic process GO:0070875 8 0.807
regulation of cellular catabolic process GO:0031329 242 0.805
response to epidermal growth factor GO:0070849 4 0.805
regulation of t helper 2 cell differentiation GO:0045628 8 0.805
regulation of cellular response to stress GO:0080135 159 0.803
positive regulation of carbohydrate metabolic process GO:0045913 30 0.803
regulation of nucleotide biosynthetic process GO:0030808 34 0.802
response to isoquinoline alkaloid GO:0014072 9 0.802
intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 2 0.800
negative regulation of neuron death GO:1901215 98 0.799
Mouse
pancreas development GO:0031016 57 0.799
regulation of peptidase activity GO:0052547 96 0.798
ribonucleotide biosynthetic process GO:0009260 59 0.798
bile acid metabolic process GO:0008206 17 0.797
negative regulation of apoptotic signaling pathway GO:2001234 104 0.796
regulation of systemic arterial blood pressure GO:0003073 61 0.796
intrinsic apoptotic signaling pathway GO:0097193 132 0.796
amine metabolic process GO:0009308 45 0.795
glucagon secretion GO:0070091 3 0.794
cellular glucan metabolic process GO:0006073 32 0.794
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.793
epithelial tube morphogenesis GO:0060562 303 0.793
negative regulation of cytosolic calcium ion concentration GO:0051481 2 0.792
glucocorticoid mediated signaling pathway GO:0043402 3 0.792
glucan metabolic process GO:0044042 32 0.791
response to morphine GO:0043278 9 0.790
regulation of protein import into nucleus GO:0042306 52 0.790
monocarboxylic acid catabolic process GO:0072329 27 0.789
leukocyte mediated immunity GO:0002443 174 0.788

Lepr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 1.000
inherited metabolic disorder DOID:655 0 1.000
diabetes mellitus DOID:9351 0 1.000
type 2 diabetes mellitus DOID:9352 0 1.000
carbohydrate metabolism disease DOID:0050013 0 1.000
glucose metabolism disease DOID:4194 0 1.000
acquired metabolic disease DOID:0060158 0 1.000
hypertension DOID:10763 0 0.871
artery disease DOID:0050828 0 0.871
disease of anatomical entity DOID:7 0 0.871
vascular disease DOID:178 0 0.871
essential hypertension DOID:10825 0 0.871
cardiovascular system disease DOID:1287 0 0.871
lipid metabolism disorder DOID:3146 0 0.836