Mus musculus

40 known processes

Nfkb2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100

(Aliases: lyt,NF-kappaB2,p49/p100,p49,p50B,p52)

Nfkb2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
marginal zone b cell differentiation GO:0002315 2 1.000
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 1.000
positive regulation of cytokine biosynthetic process GO:0042108 40 1.000
Mouse
follicular dendritic cell differentiation GO:0002268 2 1.000
germinal center formation GO:0002467 16 1.000
nik nf kappab signaling GO:0038061 14 1.000
myeloid dendritic cell differentiation GO:0043011 16 1.000
Mouse
t helper 2 cell differentiation GO:0045064 12 1.000
spleen development GO:0048536 39 1.000
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 1.000
Mouse
lymphocyte differentiation GO:0030098 242 1.000
Mouse
interleukin 10 secretion GO:0072608 4 1.000
response to muramyl dipeptide GO:0032495 9 1.000
Mouse
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 1.000
cd4 positive alpha beta t cell activation GO:0035710 45 1.000
Mouse
regulation of antimicrobial humoral response GO:0002759 3 1.000
Fly
leukocyte differentiation GO:0002521 342 1.000
Mouse
interleukin 5 secretion GO:0072603 2 1.000
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 1.000
myeloid dendritic cell activation GO:0001773 25 1.000
Mouse
regulation of antimicrobial peptide production GO:0002784 1 1.000
Fly
positive regulation of translational initiation GO:0045948 4 1.000
t helper cell differentiation GO:0042093 28 1.000
Mouse
i kappab kinase nf kappab signaling GO:0007249 85 1.000
Mouse
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 1.000
defense response to bacterium GO:0042742 119 1.000
Fly
toll like receptor 4 signaling pathway GO:0034142 9 1.000
cd4 positive alpha beta t cell differentiation GO:0043367 41 1.000
Mouse
cellular response to lipopolysaccharide GO:0071222 77 1.000
Mouse
dendritic cell differentiation GO:0097028 26 1.000
Mouse
myeloid cell differentiation GO:0030099 233 1.000
Mouse
immune response activating signal transduction GO:0002757 116 1.000
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 1.000
Mouse
toll like receptor signaling pathway GO:0002224 38 1.000
activation of innate immune response GO:0002218 56 1.000
antimicrobial peptide production GO:0002775 2 1.000
Fly
b cell differentiation GO:0030183 78 1.000
cellular response to molecule of bacterial origin GO:0071219 83 1.000
Mouse
alpha beta t cell differentiation involved in immune response GO:0002293 30 1.000
Mouse
cellular response to biotic stimulus GO:0071216 92 1.000
Mouse
immunoglobulin secretion GO:0048305 17 1.000
follicular dendritic cell activation GO:0002266 2 1.000
nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070427 5 1.000
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 1.000
negative regulation of tumor necrosis factor biosynthetic process GO:0042536 1 1.000
tumor necrosis factor mediated signaling pathway GO:0033209 13 1.000
cytokine mediated signaling pathway GO:0019221 115 1.000
t cell differentiation GO:0030217 174 1.000
Mouse
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 1.000
production of molecular mediator of immune response GO:0002440 103 0.999
Fly
regulation of interleukin 10 biosynthetic process GO:0045074 1 0.999
myeloid leukocyte activation GO:0002274 83 0.999
Mouse
innate immune response activating signal transduction GO:0002758 50 0.999
immunoglobulin mediated immune response GO:0016064 69 0.999
negative regulation of interleukin 10 secretion GO:2001180 2 0.999
positive regulation of chronic inflammatory response GO:0002678 4 0.999
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.999
negative regulation of cytokine biosynthetic process GO:0042036 13 0.999
Mouse
t cell differentiation involved in immune response GO:0002292 30 0.999
Mouse
negative regulation of b cell activation GO:0050869 27 0.999
extracellular structure organization GO:0043062 148 0.999
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.999
Mouse
adaptive immune response GO:0002250 155 0.999
regulation of defense response to fungus GO:1900150 1 0.999
Fly
regulation of interleukin 12 biosynthetic process GO:0045075 8 0.999
Mouse
positive regulation of interleukin 12 production GO:0032735 21 0.998
Mouse
lymph node development GO:0048535 18 0.998
regulation of myeloid cell differentiation GO:0045637 96 0.998
extrinsic apoptotic signaling pathway GO:0097191 126 0.998
Mouse
positive regulation of translational initiation by iron GO:0045994 2 0.998
regulation of cytokine biosynthetic process GO:0042035 59 0.998
Mouse
t cell activation GO:0042110 289 0.998
Mouse
positive regulation of interleukin 10 biosynthetic process GO:0045082 1 0.998
alpha beta t cell activation involved in immune response GO:0002287 31 0.998
Mouse
circadian rhythm GO:0007623 114 0.997
Mouse
defense response to protozoan GO:0042832 25 0.997
alpha beta t cell differentiation GO:0046632 69 0.997
Mouse
osteoclast proliferation GO:0002158 4 0.997
regulation of antibacterial peptide production GO:0002786 1 0.997
Fly
peptide biosynthetic process GO:0043043 11 0.997
Fly
regulation of lymphocyte differentiation GO:0045619 107 0.997
pattern recognition receptor signaling pathway GO:0002221 47 0.996
b cell activation involved in immune response GO:0002312 50 0.996
lymphocyte proliferation GO:0046651 164 0.996
humoral immune response GO:0006959 57 0.996
Fly
necroptotic signaling pathway GO:0097527 3 0.996
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.996
Fly
regulation of interleukin 13 secretion GO:2000665 2 0.996
b cell activation GO:0042113 161 0.995
positive regulation of leukocyte apoptotic process GO:2000108 21 0.995
positive regulation of myoblast differentiation GO:0045663 8 0.995
regulation of cytokine production GO:0001817 266 0.995
Mouse
negative regulation of myeloid cell differentiation GO:0045638 38 0.995
humoral immune response mediated by circulating immunoglobulin GO:0002455 14 0.995
regulation of t cell activation GO:0050863 170 0.995
positive regulation of lipid transport GO:0032370 22 0.995
regulation of leukocyte differentiation GO:1902105 159 0.995
somatic diversification of immunoglobulins GO:0016445 43 0.995
positive regulation of defense response GO:0031349 124 0.995
Fly
interleukin 10 biosynthetic process GO:0042091 1 0.994
t cell differentiation in thymus GO:0033077 77 0.994
ensheathment of neurons GO:0007272 76 0.994
lymphocyte mediated immunity GO:0002449 139 0.994
negative regulation of interleukin 12 biosynthetic process GO:0045083 1 0.993
Mouse
interleukin 12 biosynthetic process GO:0042090 8 0.993
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.993
Mouse
cytokine biosynthetic process GO:0042089 68 0.993
Mouse
axon ensheathment GO:0008366 76 0.993
regulation of vitamin d biosynthetic process GO:0060556 1 0.993
defense response to other organism GO:0098542 197 0.993
Fly
positive regulation of jun kinase activity GO:0043507 30 0.993
cellular response to dna damage stimulus GO:0006974 207 0.993
Fly
positive regulation of cellular amine metabolic process GO:0033240 5 0.993
negative regulation of t helper 2 cell differentiation GO:0045629 4 0.992
leukocyte proliferation GO:0070661 172 0.992
b cell mediated immunity GO:0019724 71 0.992
t cell receptor signaling pathway GO:0050852 46 0.991
immune response regulating signaling pathway GO:0002764 125 0.991
apoptotic signaling pathway GO:0097190 306 0.991
Mouse
cellular response to amino acid stimulus GO:0071230 29 0.991
antibacterial peptide production GO:0002778 2 0.991
Fly
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.991
interleukin 13 secretion GO:0072611 2 0.991
regulation of multi organism process GO:0043900 111 0.990
Fly
regulation of apoptotic signaling pathway GO:2001233 197 0.990
Mouse
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.990
negative regulation of interleukin 5 production GO:0032714 4 0.990
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.990
fat soluble vitamin biosynthetic process GO:0042362 4 0.990
defense response to fungus GO:0050832 12 0.989
Fly
antimicrobial peptide biosynthetic process GO:0002777 2 0.989
Fly
positive regulation of lymphocyte activation GO:0051251 140 0.988
positive regulation of t cell differentiation GO:0045582 52 0.988
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.986
regulation of leukocyte proliferation GO:0070663 121 0.986
nuclear import GO:0051170 95 0.986
cellular amide metabolic process GO:0043603 58 0.986
Fly
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.986
protein import into nucleus translocation GO:0000060 12 0.986
positive regulation of innate immune response GO:0045089 80 0.985
Fly
amine metabolic process GO:0009308 45 0.985
extracellular matrix organization GO:0030198 147 0.984
response to molecule of bacterial origin GO:0002237 143 0.984
Mouse
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.984
positive regulation of interferon gamma production GO:0032729 39 0.983
negative regulation of alpha beta t cell differentiation GO:0046639 12 0.983
positive regulation of osteoclast differentiation GO:0045672 15 0.982
melanin metabolic process GO:0006582 12 0.982
regulation of neutrophil differentiation GO:0045658 2 0.982
positive regulation of cytokine production GO:0001819 174 0.982
Mouse
regulation of interleukin 5 secretion GO:2000662 2 0.981
regulation of cellular amino acid metabolic process GO:0006521 5 0.981
positive regulation of cell death GO:0010942 224 0.981
regulation of tumor necrosis factor production GO:0032680 49 0.981
regulation of translational initiation by iron GO:0006447 2 0.981
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.981
negative regulation of t helper 1 cell differentiation GO:0045626 3 0.980
gliogenesis GO:0042063 141 0.980
positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 2 0.980
response to protozoan GO:0001562 28 0.979
cellular amine metabolic process GO:0044106 44 0.979
skeletal muscle fiber development GO:0048741 58 0.978
protein localization to nucleus GO:0034504 121 0.976
positive regulation of antimicrobial peptide production GO:0002225 1 0.975
Fly
regulation of interleukin 10 production GO:0032653 21 0.975
regulation of reactive oxygen species metabolic process GO:2000377 40 0.975
response to peptide GO:1901652 136 0.974
Mouse
molting cycle GO:0042303 90 0.972
Mouse
regulation of binding GO:0051098 111 0.972
defense response to gram negative bacterium GO:0050829 28 0.970
Fly
positive regulation of heat generation GO:0031652 7 0.969
regulation of interleukin 10 secretion GO:2001179 4 0.969
protein targeting GO:0006605 143 0.968
cellular response to tumor necrosis factor GO:0071356 21 0.966
cellular response to lipid GO:0071396 145 0.966
Mouse
regulation of b cell proliferation GO:0030888 39 0.966
intrinsic apoptotic signaling pathway GO:0097193 132 0.965
regulation of map kinase activity GO:0043405 120 0.963
regulation of fever generation by regulation of prostaglandin secretion GO:0071810 2 0.963
regulation of ion transport GO:0043269 215 0.962
lymphocyte apoptotic process GO:0070227 54 0.961
negative regulation of t cell differentiation GO:0045581 23 0.961
cytokine metabolic process GO:0042107 71 0.961
Mouse
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.960
Mouse
positive regulation of defense response to bacterium GO:1900426 1 0.959
Fly
response to dsrna GO:0043331 30 0.957
response to lipopolysaccharide GO:0032496 128 0.957
Mouse
calcium ion transport GO:0006816 159 0.956
cellular amino acid metabolic process GO:0006520 103 0.956
regulation of lipid transport GO:0032368 36 0.955
negative regulation of apoptotic signaling pathway GO:2001234 104 0.955
Mouse
lymphocyte activation involved in immune response GO:0002285 93 0.955
Mouse
positive regulation of humoral immune response GO:0002922 11 0.954
Fly
response to organonitrogen compound GO:0010243 246 0.954
Mouse
erk1 and erk2 cascade GO:0070371 77 0.954
cell chemotaxis GO:0060326 81 0.954
regulation of cellular amine metabolic process GO:0033238 20 0.954
positive regulation of fever generation GO:0031622 6 0.952
regulation of humoral immune response GO:0002920 22 0.951
Fly
telencephalon development GO:0021537 186 0.950
t helper 1 type immune response GO:0042088 25 0.946
Mouse
regulation of myd88 independent toll like receptor signaling pathway GO:0034127 1 0.946
cell fate commitment GO:0045165 210 0.945
epidermis development GO:0008544 187 0.942
Mouse
regulation of type 2 immune response GO:0002828 18 0.940
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.938
t cell chemotaxis GO:0010818 6 0.937
negative regulation of leukocyte differentiation GO:1902106 51 0.933
t cell activation involved in immune response GO:0002286 43 0.932
Mouse
retinal cell programmed cell death GO:0046666 8 0.931
leukocyte activation involved in immune response GO:0002366 126 0.930
Mouse
positive regulation of translation GO:0045727 19 0.929
positive regulation of adaptive immune response GO:0002821 61 0.929
positive regulation of mirna metabolic process GO:2000630 1 0.928
hair cycle GO:0042633 90 0.927
Mouse
gland development GO:0048732 330 0.927
Mouse
mammary gland lobule development GO:0061377 22 0.926
regulation of fever generation GO:0031620 6 0.926
regulation of transcription factor import into nucleus GO:0042990 24 0.926
necrotic cell death GO:0070265 30 0.925
chronic inflammatory response to antigenic stimulus GO:0002439 3 0.924
regulation of intracellular transport GO:0032386 159 0.923
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.923
hair follicle development GO:0001942 85 0.922
Mouse
antibacterial peptide biosynthetic process GO:0002780 2 0.922
Fly
negative regulation of alcohol biosynthetic process GO:1902931 4 0.921
programmed necrotic cell death GO:0097300 28 0.919
glycoprotein metabolic process GO:0009100 116 0.918
myeloid leukocyte differentiation GO:0002573 119 0.917
Mouse
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.916
positive regulation of ion transport GO:0043270 65 0.915
dna metabolic process GO:0006259 303 0.914
antigen processing and presentation GO:0019882 47 0.912
Mouse
negative regulation of cytokine production GO:0001818 84 0.909
Mouse
positive regulation of programmed cell death GO:0043068 218 0.909
activation of jun kinase activity GO:0007257 15 0.908
t cell apoptotic process GO:0070231 39 0.905
liver development GO:0001889 66 0.904
Mouse
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.902
Fly
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.902
circadian regulation of gene expression GO:0032922 48 0.900
Mouse
regulation of cytokine secretion involved in immune response GO:0002739 4 0.897
mammary gland alveolus development GO:0060749 22 0.896
somatic cell dna recombination GO:0016444 51 0.895
chronic inflammatory response GO:0002544 9 0.894
regulation of t helper 1 cell differentiation GO:0045625 7 0.893
regulation of b cell activation GO:0050864 81 0.892
response to organic cyclic compound GO:0014070 198 0.891
regulation of immunoglobulin mediated immune response GO:0002889 37 0.886
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.886
negative regulation of odontogenesis of dentin containing tooth GO:0042489 1 0.885
rhythmic process GO:0048511 174 0.883
Mouse
sensory organ morphogenesis GO:0090596 242 0.881
regionalization GO:0003002 337 0.878
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.877
protein complex localization GO:0031503 19 0.876
positive regulation of osteoclast development GO:2001206 3 0.873
histamine production involved in inflammatory response GO:0002349 1 0.872
regulation of immunoglobulin production GO:0002637 42 0.866
positive regulation of cd4 positive alpha beta t cell differentiation GO:0043372 14 0.863
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.862
regulation of osteoclast differentiation GO:0045670 36 0.860
tumor necrosis factor biosynthetic process GO:0042533 10 0.859
glial cell apoptotic process GO:0034349 3 0.856
prostaglandin transport GO:0015732 7 0.855
regulation of myoblast differentiation GO:0045661 29 0.855
regulation of cellular amide metabolic process GO:0034248 10 0.853
Fly
regulation of vitamin metabolic process GO:0030656 3 0.851
polysaccharide metabolic process GO:0005976 39 0.851
positive regulation of mapk cascade GO:0043410 170 0.849
neutrophil differentiation GO:0030223 3 0.849
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.849
regulation of organic acid transport GO:0032890 16 0.847
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.847
Fly
fatty acid derivative transport GO:1901571 14 0.847
activation of immune response GO:0002253 138 0.846
positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 6 0.845
interleukin 12 production GO:0032615 32 0.844
Mouse
mapk cascade GO:0000165 281 0.843
positive regulation of response to biotic stimulus GO:0002833 15 0.841
Fly
positive regulation of leukocyte proliferation GO:0070665 73 0.840
t helper 1 cell differentiation GO:0045063 13 0.839
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.835
regulation of oligodendrocyte differentiation GO:0048713 23 0.834
negative regulation of interleukin 5 secretion GO:2000663 1 0.834
cellular senescence GO:0090398 11 0.834
regulation of inflammatory response GO:0050727 147 0.834
Mouse
negative regulation of molecular function GO:0044092 258 0.833
negative regulation of cell activation GO:0050866 111 0.832
regulation of toll like receptor signaling pathway GO:0034121 20 0.832
negative regulation of protein catabolic process GO:0042177 36 0.831
Mouse
regulation of b cell mediated immunity GO:0002712 37 0.829
negative regulation of interleukin 13 secretion GO:2000666 1 0.825
regulation of icosanoid secretion GO:0032303 8 0.825
regulation of b cell differentiation GO:0045577 23 0.825
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.824
inflammatory response GO:0006954 244 0.823
Mouse
cytoplasmic transport GO:0016482 234 0.821
prostaglandin secretion GO:0032310 5 0.821
regulation of fatty acid transport GO:2000191 10 0.820
regulation of cell motility GO:2000145 236 0.820
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.818
negative regulation of lymphocyte differentiation GO:0045620 32 0.817
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.816
positive regulation of apoptotic signaling pathway GO:2001235 95 0.815
regulation of translational initiation GO:0006446 15 0.814
positive regulation of hair cycle GO:0042635 7 0.811
negative regulation of immune system process GO:0002683 209 0.809
t helper 2 cell cytokine production GO:0035745 4 0.808
response to inorganic substance GO:0010035 96 0.805
mammary gland epithelial cell proliferation GO:0033598 24 0.805
muscle cell development GO:0055001 133 0.805
cytokine production involved in immune response GO:0002367 34 0.804
protein localization to organelle GO:0033365 185 0.801
positive regulation of b cell proliferation GO:0030890 24 0.801
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.800
t cell selection GO:0045058 34 0.800
t cell migration GO:0072678 19 0.799
mature b cell differentiation GO:0002335 13 0.795
positive regulation of jnk cascade GO:0046330 46 0.795
interleukin 10 production GO:0032613 23 0.793
regulation of lymphocyte proliferation GO:0050670 117 0.791
syncytium formation by plasma membrane fusion GO:0000768 42 0.789
regulation of cytoplasmic transport GO:1903649 112 0.788
regulation of striated muscle cell differentiation GO:0051153 81 0.787
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.786
natural killer cell proliferation GO:0001787 3 0.786
pigment metabolic process GO:0042440 32 0.781
intracellular protein transport GO:0006886 204 0.781
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.780
Fly
lymphocyte chemotaxis GO:0048247 10 0.779
positive regulation of t cell activation GO:0050870 101 0.778
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 2 0.777
fever generation GO:0001660 7 0.777
oogenesis GO:0048477 56 0.775
regulation of cytokine production involved in immune response GO:0002718 26 0.769
mature b cell differentiation involved in immune response GO:0002313 9 0.768
carboxylic acid transport GO:0046942 100 0.768
growth involved in symbiotic interaction GO:0044110 23 0.764
b cell apoptotic process GO:0001783 19 0.764
maintenance of location GO:0051235 89 0.763
negative regulation of growth of symbiont in host GO:0044130 19 0.763
response to amino acid GO:0043200 37 0.750
regulation of t cell chemotaxis GO:0010819 5 0.748
jnk cascade GO:0007254 72 0.745
icosanoid secretion GO:0032309 12 0.743
negative regulation of interleukin 13 production GO:0032696 2 0.742
regulation of skeletal muscle fiber development GO:0048742 36 0.740
single organism nuclear import GO:1902593 95 0.740
hyaluronan biosynthetic process GO:0030213 3 0.740
cellular response to external stimulus GO:0071496 88 0.739
Fly
regulation of protein localization to nucleus GO:1900180 60 0.738
cell activation involved in immune response GO:0002263 126 0.738
Mouse
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.735
Mouse
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.733
immunoglobulin production GO:0002377 73 0.732
negative regulation of regulatory t cell differentiation GO:0045590 2 0.731
regulation of kinase activity GO:0043549 249 0.731
regulation of cell activation GO:0050865 289 0.730
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.729
positive regulation of organic acid transport GO:0032892 11 0.725
dephosphorylation GO:0016311 129 0.723
response to exogenous dsrna GO:0043330 22 0.723
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.721
regulation of alpha beta t cell proliferation GO:0046640 18 0.717
homeostasis of number of cells GO:0048872 210 0.717
innate immune response GO:0045087 157 0.714
Fly
regulation of corticotropin releasing hormone secretion GO:0043397 2 0.714
positive regulation of immune effector process GO:0002699 107 0.713
Fly
positive regulation of lymphocyte proliferation GO:0050671 70 0.712
isotype switching GO:0045190 36 0.712
negative regulation of adaptive immune response GO:0002820 25 0.711
positive regulation of protein kinase b signaling GO:0051897 32 0.711
regulation of response to biotic stimulus GO:0002831 38 0.710
Fly
reactive oxygen species metabolic process GO:0072593 84 0.708
positive regulation of icosanoid secretion GO:0032305 7 0.708
single organismal cell cell adhesion GO:0016337 131 0.708
regulation of defense response GO:0031347 233 0.707
Mouse Fly
icosanoid transport GO:0071715 14 0.702
stress activated mapk cascade GO:0051403 80 0.699
necroptotic process GO:0070266 21 0.694
negative regulation of glucose transport GO:0010829 9 0.693
regulation of alpha beta t cell differentiation GO:0046637 35 0.693
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.692
cation transport GO:0006812 399 0.684
regulation of intracellular protein transport GO:0033157 82 0.683
positive regulation of prostaglandin secretion GO:0032308 5 0.683
metal ion homeostasis GO:0055065 189 0.682
positive regulation of interleukin 12 biosynthetic process GO:0045084 6 0.682
Mouse
regulation of cell cycle GO:0051726 281 0.679
mammary gland epithelium development GO:0061180 65 0.677
skeletal muscle organ development GO:0060538 163 0.673
regulation of growth of symbiont in host GO:0044126 19 0.671
osteoclast development GO:0036035 9 0.670
branching involved in salivary gland morphogenesis GO:0060445 26 0.669
regulation of jnk cascade GO:0046328 62 0.665
negative regulation of phosphatase activity GO:0010923 5 0.664
glycosaminoglycan biosynthetic process GO:0006024 15 0.661
regulation of peptide transport GO:0090087 91 0.661
positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 2 0.659
establishment of protein localization to organelle GO:0072594 118 0.654
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.652
antibacterial humoral response GO:0019731 8 0.648
Fly
response to peptide hormone GO:0043434 127 0.647
bone resorption GO:0045453 38 0.647
cell fate determination GO:0001709 32 0.645
ossification GO:0001503 216 0.644
axonogenesis GO:0007409 274 0.637
negative regulation of b cell proliferation GO:0030889 13 0.637
pallium development GO:0021543 120 0.635
monocarboxylic acid transport GO:0015718 44 0.634
regulation of membrane potential GO:0042391 192 0.631
somatic diversification of immune receptors GO:0002200 53 0.631
regulation of chronic inflammatory response to antigenic stimulus GO:0002874 3 0.630
regulation of anion transport GO:0044070 27 0.628
negative regulation of interleukin 12 production GO:0032695 10 0.626
Mouse
regulation of organ morphogenesis GO:2000027 144 0.624
regulation of myotube differentiation GO:0010830 62 0.622
regulation of polysaccharide metabolic process GO:0032881 13 0.621
carbohydrate derivative biosynthetic process GO:1901137 183 0.619
response to tumor necrosis factor GO:0034612 26 0.615
activation of mapk activity GO:0000187 59 0.609
regulation of chronic inflammatory response GO:0002676 7 0.609
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.609
organic hydroxy compound metabolic process GO:1901615 203 0.609
regulation of interferon gamma production GO:0032649 57 0.608
positive regulation of response to wounding GO:1903036 66 0.604
defense response to virus GO:0051607 68 0.602
Fly
corticotropin releasing hormone secretion GO:0043396 2 0.601
acid secretion GO:0046717 33 0.599
defense response to gram positive bacterium GO:0050830 50 0.597
dendrite development GO:0016358 115 0.596
Fly
type i interferon signaling pathway GO:0060337 10 0.594
positive regulation of cell development GO:0010720 237 0.594
amine transport GO:0015837 21 0.594
regulation of mirna metabolic process GO:2000628 4 0.591
alcohol metabolic process GO:0006066 116 0.578
regulation of response to wounding GO:1903034 189 0.577
Mouse
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 17 0.577
negative regulation of defense response GO:0031348 77 0.577
Mouse
cytokine secretion involved in immune response GO:0002374 6 0.576
striated muscle cell development GO:0055002 125 0.575
tissue remodeling GO:0048771 102 0.573
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.573
regulation of nucleotide catabolic process GO:0030811 122 0.572
positive regulation of intracellular protein transport GO:0090316 42 0.572
regulation of cellular response to stress GO:0080135 159 0.571
negative regulation of alkaline phosphatase activity GO:0010693 3 0.568
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.568
regulation of stem cell proliferation GO:0072091 78 0.568
Fly
divalent metal ion transport GO:0070838 172 0.562
cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0002361 4 0.560
osteoclast differentiation GO:0030316 62 0.552
regulation of osteoblast differentiation GO:0045667 67 0.550
positive regulation of hair follicle development GO:0051798 6 0.548
protein import GO:0017038 101 0.547
regulation of protein localization GO:0032880 231 0.547
regulation of lipid biosynthetic process GO:0046890 54 0.547
regulation of stress activated mapk cascade GO:0032872 69 0.545
chromatin organization GO:0006325 206 0.545
positive regulation of protein phosphorylation GO:0001934 242 0.541
cellular response to peptide GO:1901653 92 0.538
gonad development GO:0008406 141 0.535
thymic t cell selection GO:0045061 22 0.533
positive regulation of transferase activity GO:0051347 167 0.533
regulation of mapk cascade GO:0043408 248 0.532
negative regulation of immune effector process GO:0002698 55 0.532
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.532
posttranscriptional regulation of gene expression GO:0010608 155 0.529
positive regulation of secretion GO:0051047 130 0.528
negative regulation of protein modification process GO:0031400 163 0.527
response to metal ion GO:0010038 47 0.526
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.525
muscle tissue development GO:0060537 308 0.522
alpha beta t cell activation GO:0046631 91 0.522
Mouse
epithelial cell proliferation GO:0050673 174 0.521
positive regulation of cytokine secretion involved in immune response GO:0002741 2 0.520
purine ribonucleoside metabolic process GO:0046128 241 0.519
b cell receptor signaling pathway GO:0050853 20 0.519
mucosal associated lymphoid tissue development GO:0048537 12 0.518
erythrocyte differentiation GO:0030218 88 0.517
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.517
covalent chromatin modification GO:0016569 163 0.516
tumor necrosis factor production GO:0032640 50 0.515
regulation of innate immune response GO:0045088 91 0.515
Fly

Nfkb2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
primary immunodeficiency disease DOID:612 0 0.860
Human
blood protein disease DOID:620 0 0.860
Human
immune system disease DOID:2914 0 0.860
Human
agammaglobulinemia DOID:2583 0 0.860
Human
disease of anatomical entity DOID:7 0 0.860
Human
common variable immunodeficiency DOID:12177 0 0.860
Human
b cell deficiency DOID:2115 0 0.860
Human
hematopoietic system disease DOID:74 0 0.860
Human
musculoskeletal system disease DOID:17 0 0.763
connective tissue disease DOID:65 0 0.763
bone remodeling disease DOID:0080005 0 0.662
bone disease DOID:0080001 0 0.662
osteopetrosis DOID:13533 0 0.662
osteosclerosis DOID:4254 0 0.662