Mus musculus

76 known processes

Nkx2-6

NK2 transcription factor related, locus 6 (Drosophila)

(Aliases: tinman,AV044928,Tix,Nkx-2.6,Nkx2.6)

Nkx2-6 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of transcription via serum response element binding GO:0010735 1 0.799
Mouse
epithelial tube morphogenesis GO:0060562 303 0.734
Mouse
atrial cardiac muscle cell differentiation GO:0055011 2 0.713
atrioventricular node cell development GO:0060928 2 0.680
Mouse
cardiac chamber morphogenesis GO:0003206 93 0.674
Mouse
muscle tissue development GO:0060537 308 0.637
cardiac pacemaker cell fate commitment GO:0060927 1 0.582
Mouse
embryonic organ morphogenesis GO:0048562 276 0.568
Mouse
cardiocyte differentiation GO:0035051 87 0.568
male gamete generation GO:0048232 285 0.566
clara cell differentiation GO:0060486 4 0.547
Mouse
atrial cardiac muscle cell development GO:0055014 2 0.537
telencephalon development GO:0021537 186 0.520
Mouse
forebrain development GO:0030900 302 0.516
ventricular cardiac myofibril assembly GO:0055005 3 0.497
Mouse
cell type specific apoptotic process GO:0097285 268 0.483
Mouse
cell fate commitment GO:0045165 210 0.480
Mouse
muscle cell differentiation GO:0042692 261 0.460
regionalization GO:0003002 337 0.451
Mouse
gland development GO:0048732 330 0.425
Mouse
locomotory behavior GO:0007626 195 0.387
Mouse
regulation of cardioblast differentiation GO:0051890 3 0.358
Mouse
skeletal system development GO:0001501 356 0.349
Mouse
myotube differentiation GO:0014902 105 0.347
spermatogenesis GO:0007283 284 0.338
positive regulation of cardioblast differentiation GO:0051891 3 0.336
Mouse
pancreatic pp cell fate commitment GO:0003329 2 0.335
Mouse
atrioventricular node cell differentiation GO:0060922 2 0.333
Mouse
ventral spinal cord interneuron fate determination GO:0060580 1 0.322
Mouse
cardiac cell fate determination GO:0060913 2 0.315
central nervous system neuron differentiation GO:0021953 162 0.302
Mouse
cardiac muscle tissue morphogenesis GO:0055008 44 0.299
Mouse
heart morphogenesis GO:0003007 178 0.296
Mouse
pulmonary myocardium development GO:0003350 3 0.272
Mouse
cardiac ventricle morphogenesis GO:0003208 50 0.262
Mouse
ear development GO:0043583 200 0.258
Mouse
organelle assembly GO:0070925 177 0.258
Mouse
purkinje myocyte development GO:0003165 1 0.253
Mouse
cell fate determination involved in pattern specification GO:0060582 1 0.245
Mouse
skeletal system morphogenesis GO:0048705 203 0.242
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.240
development of primary male sexual characteristics GO:0046546 88 0.237
Mouse
determination of heart left right asymmetry GO:0061371 48 0.230
Mouse
regulation of ion transmembrane transporter activity GO:0032412 54 0.225
Mouse
striated muscle tissue development GO:0014706 293 0.223
type b pancreatic cell fate commitment GO:0003327 1 0.217
Mouse
heart trabecula morphogenesis GO:0061384 26 0.216
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.214
Mouse
menarche GO:0042696 1 0.208
Mouse
embryonic placenta development GO:0001892 98 0.206
purkinje myocyte differentiation GO:0003168 1 0.205
Mouse
positive regulation of nervous system development GO:0051962 221 0.195
Mouse
cardiac chamber development GO:0003205 108 0.194
Mouse
bone morphogenesis GO:0060349 78 0.193
negative regulation of cell proliferation GO:0008285 296 0.189
Mouse
bone development GO:0060348 120 0.183
respiratory system development GO:0060541 190 0.179
Mouse
male sex differentiation GO:0046661 109 0.178
Mouse
regulation of striated muscle cell differentiation GO:0051153 81 0.177
septum transversum development GO:0003343 2 0.173
Mouse
positive regulation of voltage gated calcium channel activity GO:1901387 2 0.171
Mouse
ventricular cardiac muscle tissue development GO:0003229 38 0.169
Mouse
forebrain generation of neurons GO:0021872 63 0.164
Mouse
pancreatic pp cell differentiation GO:0003312 2 0.160
Mouse
inorganic cation transmembrane transport GO:0098662 207 0.159
Mouse
respiratory tube development GO:0030323 167 0.159
Mouse
atrioventricular node cell fate commitment GO:0060929 1 0.157
Mouse
bmp signaling pathway GO:0030509 93 0.157
Mouse
muscle cell development GO:0055001 133 0.153
proepicardium development GO:0003342 2 0.153
Mouse
limb development GO:0060173 166 0.145
striated muscle cell development GO:0055002 125 0.143
hypophysis morphogenesis GO:0048850 3 0.143
male gonad development GO:0008584 88 0.142
Mouse
regulation of neuron death GO:1901214 134 0.140
cardiac myofibril assembly GO:0055003 12 0.140
Mouse
endocrine system development GO:0035270 98 0.139
Mouse
skeletal muscle organ development GO:0060538 163 0.139
cytokine production GO:0001816 319 0.138
canonical wnt signaling pathway GO:0060070 130 0.137
Mouse
specification of organ identity GO:0010092 30 0.130
blood vessel morphogenesis GO:0048514 285 0.124
Mouse
ventral spinal cord interneuron differentiation GO:0021514 16 0.124
Mouse
embryonic heart tube development GO:0035050 65 0.124
positive regulation of cell development GO:0010720 237 0.123
Mouse
adult behavior GO:0030534 135 0.123
developmental induction GO:0031128 34 0.122
Mouse
somatotropin secreting cell differentiation GO:0060126 4 0.121
atrioventricular node development GO:0003162 3 0.120
Mouse
placenta development GO:0001890 140 0.119
striated muscle contraction GO:0006941 45 0.118
Mouse
response to light stimulus GO:0009416 135 0.118
outflow tract morphogenesis GO:0003151 53 0.118
Mouse
positive regulation of ion transmembrane transporter activity GO:0032414 15 0.117
Mouse
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.115
Mouse
mapk cascade GO:0000165 281 0.114
cardiac muscle contraction GO:0060048 32 0.112
Mouse
sensory perception GO:0007600 245 0.112
mesenchyme development GO:0060485 152 0.110
Mouse
lung development GO:0030324 164 0.109
Mouse
neurohypophysis development GO:0021985 2 0.108
digestive system development GO:0055123 200 0.108
cellular component assembly involved in morphogenesis GO:0010927 139 0.105
Mouse
sperm motility GO:0030317 47 0.105
regulation of homeostatic process GO:0032844 182 0.104
cell fate specification GO:0001708 72 0.103
Mouse
dna metabolic process GO:0006259 303 0.101
spinal cord development GO:0021510 81 0.100
Mouse
organelle fission GO:0048285 170 0.098
regulation of stem cell proliferation GO:0072091 78 0.098
sarcomere organization GO:0045214 24 0.098
Mouse
neuron apoptotic process GO:0051402 142 0.095
regulation of cellular ketone metabolic process GO:0010565 66 0.095
divalent metal ion transport GO:0070838 172 0.094
Mouse
connective tissue development GO:0061448 179 0.094
Mouse
forebrain neuron fate commitment GO:0021877 13 0.093
Mouse
astrocyte fate commitment GO:0060018 4 0.093
morphogenesis of a branching epithelium GO:0061138 193 0.092
regulation of muscle tissue development GO:1901861 97 0.092
Mouse
smoothened signaling pathway GO:0007224 105 0.089
Mouse
epithelial cell proliferation GO:0050673 174 0.089
Mouse
cardiac cell development GO:0055006 41 0.089
regulation of cell projection organization GO:0031344 206 0.088
regulation of neuron differentiation GO:0045664 281 0.088
Mouse
germ cell development GO:0007281 185 0.088
spermatid development GO:0007286 108 0.087
hair cell differentiation GO:0035315 40 0.086
cartilage development GO:0051216 140 0.085
Mouse
cation homeostasis GO:0055080 212 0.085
development of primary sexual characteristics GO:0045137 143 0.085
Mouse
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.083
regulation of mapk cascade GO:0043408 248 0.082
cardiac muscle cell differentiation GO:0055007 69 0.082
pancreatic a cell fate commitment GO:0003326 2 0.082
Mouse
wnt signaling pathway GO:0016055 188 0.081
Mouse
myotube cell development GO:0014904 60 0.080
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.079
morphogenesis of embryonic epithelium GO:0016331 159 0.078
cardioblast migration to the midline involved in heart field formation GO:0060975 1 0.078
divalent inorganic cation transport GO:0072511 178 0.078
Mouse
bundle of his development GO:0003166 4 0.077
Mouse
regulation of cardiac muscle cell proliferation GO:0060043 23 0.077
Mouse
transmembrane transport GO:0055085 412 0.077
Mouse
mammary gland duct morphogenesis GO:0060603 38 0.076
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.076
gonad development GO:0008406 141 0.075
Mouse
cerebral cortex gabaergic interneuron differentiation GO:0021892 9 0.075
Mouse
pallium development GO:0021543 120 0.075
Mouse
endodermal cell fate specification GO:0001714 4 0.074
neuroepithelial cell differentiation GO:0060563 37 0.074
embryonic heart tube left right pattern formation GO:0060971 5 0.073
Mouse
atrial ventricular junction remodeling GO:0003294 2 0.072
organ growth GO:0035265 117 0.072
Mouse
negative regulation of molecular function GO:0044092 258 0.072
stem cell proliferation GO:0072089 117 0.071
heart field specification GO:0003128 6 0.071
ameboidal type cell migration GO:0001667 128 0.071
b cell activation GO:0042113 161 0.070
Mouse
axonogenesis GO:0007409 274 0.070
Mouse
negative regulation of gastrulation GO:2000542 3 0.069
chondrocyte differentiation GO:0002062 72 0.068
Mouse
cellular amine metabolic process GO:0044106 44 0.067
heart contraction GO:0060047 93 0.066
Mouse
positive regulation of neuron apoptotic process GO:0043525 25 0.066
actin cytoskeleton organization GO:0030036 220 0.066
Mouse
negative regulation of neuron differentiation GO:0045665 101 0.066
Mouse
determination of left right symmetry GO:0007368 80 0.066
Mouse
embryonic heart tube morphogenesis GO:0003143 51 0.066
Mouse
protein citrullination GO:0018101 2 0.065
appendage development GO:0048736 166 0.065
tissue remodeling GO:0048771 102 0.064
neuron death GO:0070997 154 0.063
cardiac conduction system development GO:0003161 12 0.063
Mouse
sensory perception of pain GO:0019233 47 0.063
sodium ion transport GO:0006814 73 0.063
Mouse
neuron migration GO:0001764 122 0.063
Mouse
macromolecule catabolic process GO:0009057 281 0.062
muscle system process GO:0003012 141 0.062
Mouse
regulation of voltage gated calcium channel activity GO:1901385 4 0.061
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.061
Mouse
adult locomotory behavior GO:0008344 91 0.061
neuromuscular process GO:0050905 99 0.060
regulation of system process GO:0044057 200 0.059
Mouse
regulation of receptor activity GO:0010469 41 0.059
lung cell differentiation GO:0060479 30 0.059
Mouse
regulation of cellular response to stress GO:0080135 159 0.058
regulation of neuron apoptotic process GO:0043523 122 0.058
regulation of cellular amino acid metabolic process GO:0006521 5 0.058
regulation of endodermal cell fate specification GO:0042663 2 0.058
ventricular cardiac muscle cell differentiation GO:0055012 17 0.057
positive regulation of programmed cell death GO:0043068 218 0.057
regulation of myotube differentiation GO:0010830 62 0.056
myoblast differentiation GO:0045445 52 0.056
regulation of organ morphogenesis GO:2000027 144 0.056
urogenital system development GO:0001655 261 0.056
leukocyte migration GO:0050900 124 0.055
Mouse
epithelial cell development GO:0002064 159 0.055
Mouse
positive regulation of stem cell proliferation GO:2000648 59 0.055
regulation of circadian rhythm GO:0042752 58 0.055
Mouse
positive regulation of ion transport GO:0043270 65 0.055
Mouse
calcium ion transport GO:0006816 159 0.055
Mouse
myeloid leukocyte differentiation GO:0002573 119 0.055
Mouse
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.054
cardiac septum development GO:0003279 59 0.054
blastocyst development GO:0001824 80 0.054
cardiac ventricle development GO:0003231 83 0.053
Mouse
positive regulation of protein modification process GO:0031401 299 0.053
striated muscle cell proliferation GO:0014855 39 0.053
Mouse
auditory receptor cell fate specification GO:0042667 1 0.053
cellular response to lipid GO:0071396 145 0.053
regulation of cellular amine metabolic process GO:0033238 20 0.052
negative regulation of mesodermal cell fate specification GO:0042662 3 0.052
lymphocyte differentiation GO:0030098 242 0.051
Mouse
chemotaxis GO:0006935 247 0.051
Mouse
regulation of saliva secretion GO:0046877 2 0.051
lung induction GO:0060492 3 0.050
leukocyte proliferation GO:0070661 172 0.050
cell cell signaling involved in cell fate commitment GO:0045168 35 0.049
Mouse
regulation of neural precursor cell proliferation GO:2000177 70 0.049
kidney development GO:0001822 213 0.049
regulation of neuroblast proliferation GO:1902692 27 0.048
skeletal muscle fiber development GO:0048741 58 0.048
lung secretory cell differentiation GO:0061140 13 0.048
Mouse
response to radiation GO:0009314 165 0.048
regulation of transmembrane transport GO:0034762 128 0.048
Mouse
odontogenesis GO:0042476 78 0.048
Mouse
positive regulation of homeostatic process GO:0032846 64 0.048
cellular macromolecule catabolic process GO:0044265 206 0.048
response to acid chemical GO:0001101 111 0.048
regulation of endodermal cell differentiation GO:1903224 2 0.048
wound healing GO:0042060 157 0.047
alpha beta t cell activation GO:0046631 91 0.047
Mouse
cardiac muscle tissue development GO:0048738 130 0.047
auditory receptor cell differentiation GO:0042491 37 0.047
endochondral bone morphogenesis GO:0060350 50 0.047
labyrinthine layer development GO:0060711 49 0.047
ear morphogenesis GO:0042471 118 0.047
Mouse
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 0.046
glandular epithelial cell differentiation GO:0002067 38 0.046
Mouse
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.046
negative regulation of nervous system development GO:0051961 156 0.046
Mouse
type ii pneumocyte differentiation GO:0060510 7 0.046
Mouse
regulation of neuron projection development GO:0010975 169 0.046
regulation of body fluid levels GO:0050878 162 0.046
middle ear morphogenesis GO:0042474 23 0.046
Mouse
regulation of cation channel activity GO:2001257 22 0.046
Mouse
cardiac muscle cell proliferation GO:0060038 31 0.046
Mouse
amine metabolic process GO:0009308 45 0.046
paraxial mesodermal cell differentiation GO:0048342 2 0.046
auditory receptor cell fate determination GO:0042668 3 0.045
regulation of kinase activity GO:0043549 249 0.045
rhythmic process GO:0048511 174 0.045
Mouse
ion transmembrane transport GO:0034220 361 0.045
Mouse
somatostatin signaling pathway GO:0038170 2 0.045
metal ion homeostasis GO:0055065 189 0.045
mesonephros development GO:0001823 97 0.044
meiotic nuclear division GO:0007126 115 0.044
somitogenesis GO:0001756 69 0.044
positive regulation of calcium ion transmembrane transporter activity GO:1901021 8 0.044
Mouse
muscle fiber development GO:0048747 76 0.043
kidney epithelium development GO:0072073 121 0.043
embryonic epithelial tube formation GO:0001838 130 0.043
cardioblast migration GO:0003260 1 0.043
carbohydrate derivative biosynthetic process GO:1901137 183 0.043
negative regulation of gliogenesis GO:0014014 23 0.043
regulation of secretion GO:0051046 274 0.043
positive regulation of growth GO:0045927 104 0.043
cell migration to the midline involved in heart development GO:0003318 1 0.043
t cell differentiation GO:0030217 174 0.042
Mouse
regulation of cell cycle process GO:0010564 160 0.042
hepaticobiliary system development GO:0061008 67 0.042
sensory perception of light stimulus GO:0050953 54 0.042
skeletal muscle cell differentiation GO:0035914 66 0.042
spinal cord oligodendrocyte cell differentiation GO:0021529 3 0.042
Mouse
developmental programmed cell death GO:0010623 41 0.042
Mouse
myofibril assembly GO:0030239 34 0.042
Mouse
regulation of cell motility GO:2000145 236 0.042
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.041
lung epithelial cell differentiation GO:0060487 29 0.041
Mouse
spleen development GO:0048536 39 0.041
Mouse
left right pattern formation GO:0060972 23 0.041
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.041
limbic system development GO:0021761 72 0.041
regulation of response to wounding GO:1903034 189 0.040
stem cell development GO:0048864 219 0.040
embryonic skeletal system development GO:0048706 120 0.040
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.039
Mouse
hypothalamus development GO:0021854 16 0.039
nephron epithelium development GO:0072009 92 0.039
hemangioblast cell differentiation GO:0060217 1 0.039
embryonic heart tube formation GO:0003144 1 0.039
epithelial cell fate commitment GO:0072148 13 0.039
Mouse
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.039
morphogenesis of a branching structure GO:0001763 203 0.039
nephron morphogenesis GO:0072028 69 0.039
cell differentiation in spinal cord GO:0021515 53 0.038
Mouse
his purkinje system development GO:0003164 4 0.038
Mouse
regulation of neural retina development GO:0061074 3 0.038
regulation of striated muscle contraction GO:0006942 25 0.038
Mouse
fucosylation GO:0036065 9 0.038
regulation of binding GO:0051098 111 0.037
angiogenesis GO:0001525 201 0.037
negative regulation of organelle organization GO:0010639 90 0.037
cell differentiation involved in embryonic placenta development GO:0060706 26 0.037
regulation of wnt signaling pathway GO:0030111 123 0.037
Mouse
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.037
cellular ketone metabolic process GO:0042180 84 0.037
regulation of epithelial cell proliferation GO:0050678 141 0.037
Mouse
dendrite development GO:0016358 115 0.036
lens development in camera type eye GO:0002088 62 0.036
ossification GO:0001503 216 0.036
inorganic ion transmembrane transport GO:0098660 234 0.036
Mouse
sequestering of calcium ion GO:0051208 18 0.036
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.036
secondary heart field specification GO:0003139 6 0.036
immune effector process GO:0002252 321 0.036
Mouse
cell proliferation in forebrain GO:0021846 30 0.036
spermatid differentiation GO:0048515 115 0.036
regulation of canonical wnt signaling pathway GO:0060828 82 0.036
Mouse
mechanoreceptor differentiation GO:0042490 67 0.036
embryonic limb morphogenesis GO:0030326 126 0.035
aorta morphogenesis GO:0035909 22 0.035
appendage morphogenesis GO:0035107 149 0.035
forebrain morphogenesis GO:0048853 17 0.035
small molecule biosynthetic process GO:0044283 132 0.035
regulation of isoprenoid metabolic process GO:0019747 1 0.035
cellular homeostasis GO:0019725 240 0.035
cell fate commitment involved in pattern specification GO:0060581 14 0.035
Mouse
sclerotome development GO:0061056 4 0.035
regulation of reproductive process GO:2000241 66 0.035
central nervous system vasculogenesis GO:0022009 3 0.035
mesodermal cell migration GO:0008078 4 0.035
negative regulation of cellular amine metabolic process GO:0033239 1 0.035
negative regulation of muscle cell differentiation GO:0051148 33 0.034
oligodendrocyte differentiation GO:0048709 53 0.034
Mouse
regulation of organ formation GO:0003156 34 0.034
negative regulation of cell fate specification GO:0009996 4 0.034
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 20 0.034
spinal cord dorsal ventral patterning GO:0021513 23 0.034
Mouse
mesonephric epithelium development GO:0072163 94 0.034
globus pallidus development GO:0021759 2 0.034
Mouse
regulation of myoblast differentiation GO:0045661 29 0.034
cytosolic calcium ion homeostasis GO:0051480 70 0.033
regulation of heart induction by regulation of canonical wnt signaling pathway GO:0090081 2 0.033
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.033
Mouse
nuclear division GO:0000280 158 0.033
cellular ion homeostasis GO:0006873 165 0.033
regulation of cardiac muscle tissue development GO:0055024 31 0.033
Mouse
mammary gland morphogenesis GO:0060443 54 0.033
negative regulation of myeloid cell differentiation GO:0045638 38 0.033
trophectodermal cell differentiation GO:0001829 21 0.032
hair cycle GO:0042633 90 0.032
t cell apoptotic process GO:0070231 39 0.032
cellular chemical homeostasis GO:0055082 215 0.032
cellular response to acid chemical GO:0071229 68 0.032
response to molecule of bacterial origin GO:0002237 143 0.032
regulation of adaptive immune response GO:0002819 90 0.032
septum primum development GO:0003284 4 0.032
regulation of retina development in camera type eye GO:1902866 3 0.032
white fat cell proliferation GO:0070343 2 0.032
response to water deprivation GO:0009414 1 0.032
regulation of notch signaling pathway GO:0008593 35 0.032
neural precursor cell proliferation GO:0061351 121 0.032
polarity specification of proximal distal axis GO:0010085 2 0.031
regulation of heart growth GO:0060420 31 0.031
Mouse
positive regulation of muscle cell differentiation GO:0051149 39 0.031
regulation of cardiac muscle tissue growth GO:0055021 26 0.031
Mouse
av node cell to bundle of his cell communication GO:0086067 2 0.031
regulation of intestinal epithelial structure maintenance GO:0060730 1 0.031
floor plate morphogenesis GO:0033505 3 0.031
jak stat cascade GO:0007259 42 0.031
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.031
camera type eye development GO:0043010 266 0.031
cilium morphogenesis GO:0060271 102 0.031
cellular response to growth factor stimulus GO:0071363 197 0.031
negative regulation of wnt signaling pathway GO:0030178 73 0.031
Mouse
stem cell maintenance GO:0019827 130 0.031
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.031
Mouse
retina development in camera type eye GO:0060041 119 0.031
epidermis development GO:0008544 187 0.030
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.030
heart formation GO:0060914 16 0.030
aortic valve morphogenesis GO:0003180 4 0.030
endoderm development GO:0007492 45 0.030
Mouse
intracellular protein transport GO:0006886 204 0.030
hindbrain development GO:0030902 128 0.030
metanephric dct cell differentiation GO:0072240 3 0.030
neural nucleus development GO:0048857 22 0.030
Mouse
neural tube development GO:0021915 160 0.029
renal inner medulla development GO:0072053 3 0.029
organic acid biosynthetic process GO:0016053 86 0.029
inner ear morphogenesis GO:0042472 101 0.029
positive regulation of angiogenesis GO:0045766 46 0.029
negative regulation of protein metabolic process GO:0051248 282 0.029
segmentation GO:0035282 93 0.029
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.029
regulation of ossification GO:0030278 112 0.029
regulation of transferase activity GO:0051338 263 0.029
organic acid transport GO:0015849 101 0.029
glial cell development GO:0021782 54 0.029
Mouse
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:2000764 1 0.028
heart induction GO:0003129 2 0.028
nerve development GO:0021675 67 0.028
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.028
ventral spinal cord development GO:0021517 48 0.028
Mouse
translation GO:0006412 93 0.028
regulation of heart morphogenesis GO:2000826 22 0.028
organic hydroxy compound metabolic process GO:1901615 203 0.028
positive regulation of mapk cascade GO:0043410 170 0.028
b cell proliferation GO:0042100 53 0.028
spemann organizer formation GO:0060061 2 0.028
otic vesicle development GO:0071599 14 0.027
cytoplasmic transport GO:0016482 234 0.027
cell maturation GO:0048469 127 0.027
mesenchymal cell development GO:0014031 93 0.027
metencephalon development GO:0022037 89 0.027
positive regulation of cation channel activity GO:2001259 8 0.027
Mouse
detection of external stimulus GO:0009581 61 0.027
positive regulation of renal sodium excretion GO:0035815 2 0.027
regulation of anagen GO:0051884 1 0.027
cellular metal ion homeostasis GO:0006875 151 0.027
positive regulation of apoptotic process GO:0043065 217 0.027
regulation of oxidative phosphorylation uncoupler activity GO:2000275 3 0.027
prostate gland development GO:0030850 48 0.027
cerebellum formation GO:0021588 1 0.027
metanephric nephron tubule formation GO:0072289 4 0.027
spinal cord patterning GO:0021511 25 0.027
Mouse
response to growth factor GO:0070848 198 0.027
muscle tissue morphogenesis GO:0060415 53 0.026
Mouse
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 0.026
organophosphate biosynthetic process GO:0090407 122 0.026
nephron tubule morphogenesis GO:0072078 68 0.026
negative regulation of transferase activity GO:0051348 85 0.026
blastocyst formation GO:0001825 33 0.026
pharyngeal system development GO:0060037 17 0.026
cardiac septum morphogenesis GO:0060411 46 0.026
negative regulation of immune system process GO:0002683 209 0.026
ventricular trabecula myocardium morphogenesis GO:0003222 11 0.026
Mouse
brain morphogenesis GO:0048854 32 0.026
muscle contraction GO:0006936 101 0.026
Mouse
carboxylic acid biosynthetic process GO:0046394 86 0.026
ventricular septum development GO:0003281 42 0.026
lung field specification GO:0060424 3 0.026
neuroblast differentiation GO:0014016 2 0.026
spinal cord motor neuron differentiation GO:0021522 35 0.026
Mouse
horizontal cell localization GO:0035852 1 0.026
aorta development GO:0035904 23 0.026
maintenance of location GO:0051235 89 0.026
circadian rhythm GO:0007623 114 0.026
Mouse
atrial septum primum morphogenesis GO:0003289 3 0.025
cardiac cell fate commitment GO:0060911 10 0.025
Mouse
maternal process involved in female pregnancy GO:0060135 32 0.025
mammary gland epithelium development GO:0061180 65 0.025
regulation of lymphocyte proliferation GO:0050670 117 0.025
telencephalon cell migration GO:0022029 55 0.025
Mouse
sensory organ morphogenesis GO:0090596 242 0.025
Mouse
adaptive immune response GO:0002250 155 0.025
endocrine pancreas development GO:0031018 29 0.025
Mouse
cellular potassium ion transport GO:0071804 43 0.025
myeloid cell differentiation GO:0030099 233 0.025
Mouse
positive regulation of transferase activity GO:0051347 167 0.025
cellular response to hormone stimulus GO:0032870 150 0.024
positive regulation of cell activation GO:0050867 158 0.024
catecholamine metabolic process GO:0006584 30 0.024
protein modification by small protein conjugation GO:0032446 187 0.024
regulation of cell activation GO:0050865 289 0.024
midgut development GO:0007494 4 0.024
activation of mapk activity GO:0000187 59 0.024
diencephalon development GO:0021536 63 0.024
somatostatin receptor signaling pathway GO:0038169 2 0.024
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.024
positive regulation of cytokine production GO:0001819 174 0.024
cell cell recognition GO:0009988 44 0.024
regulation of mast cell differentiation GO:0060375 3 0.024
neuron fate specification GO:0048665 30 0.024
Mouse
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.024
regulation of cellular component biogenesis GO:0044087 181 0.024
Mouse
positive regulation of lymphocyte activation GO:0051251 140 0.024
neuron projection guidance GO:0097485 141 0.024
Mouse
stress activated protein kinase signaling cascade GO:0031098 81 0.024
positive regulation of wnt signaling pathway GO:0030177 45 0.024
positive regulation of cellular amine metabolic process GO:0033240 5 0.024
developmental maturation GO:0021700 193 0.024
regulation of interleukin 1 alpha production GO:0032650 4 0.023
tube formation GO:0035148 140 0.023
regulation of heart contraction GO:0008016 77 0.023
Mouse
calcium ion transmembrane transport GO:0070588 85 0.023
Mouse
interleukin 8 secretion GO:0072606 3 0.023
organ induction GO:0001759 21 0.023
oxidation reduction process GO:0055114 342 0.023

Nkx2-6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
Human
nervous system disease DOID:863 0 0.035
cancer DOID:162 0 0.030
disease of cellular proliferation DOID:14566 0 0.030
organ system cancer DOID:0050686 0 0.030