IMP

Process View

Mus musculus

3 genes annotated in mouse

atrioventricular node development

The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "atrioventricular node development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "atrioventricular node development" (in gray)

Name	Description	Probability	Func Analog Organism
Notch1	Notch gene homolog 1 (Drosophila)	0.998
Psen1	presenilin 1	0.990
Jag1	jagged 1	0.990
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.958
Hand2	heart and neural crest derivatives expressed transcript 2	0.956
Dll1	delta-like 1 (Drosophila)	0.935
Shh	sonic hedgehog	0.935
Gata4	GATA binding protein 4	0.840
Mesp1	mesoderm posterior 1	0.822
Rxra	retinoid X receptor alpha	0.773
Efnb2	ephrin B2	0.753
Fgfr1	fibroblast growth factor receptor 1	0.746
Fgf8	fibroblast growth factor 8	0.686
Pitx2	paired-like homeodomain transcription factor 2	0.685
Fgfr2	fibroblast growth factor receptor 2	0.681
Notch2	Notch gene homolog 2 (Drosophila)	0.606	Mouse
Vegfa	vascular endothelial growth factor A	0.556
Tbx1	T-box 1	0.510
Hand1	heart and neural crest derivatives expressed transcript 1	0.507
Foxc1	forkhead box C1	0.421
Rb1	retinoblastoma 1	0.417
Chd7	chromodomain helicase DNA binding protein 7	0.383
Tbx5	T-box 5	0.382
Nos3	nitric oxide synthase 3, endothelial cell	0.353
Psen2	presenilin 2	0.312
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.302
Smo	smoothened homolog (Drosophila)	0.296
Ctnnb1	catenin (cadherin associated protein), beta 1	0.285
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.252
Foxc2	forkhead box C2	0.237
Pax3	paired box gene 3	0.217
Vangl2	vang-like 2 (van gogh, Drosophila)	0.197
Ptf1a	pancreas specific transcription factor, 1a	0.182
Tgfb2	transforming growth factor, beta 2	0.169
Gata6	GATA binding protein 6	0.162
Zfpm2	zinc finger protein, multitype 2	0.152
Sox9	SRY-box containing gene 9	0.149
Hes1	hairy and enhancer of split 1 (Drosophila)	0.144
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.138
Gli2	GLI-Kruppel family member GLI2	0.129
Ager	advanced glycosylation end product-specific receptor	0.123
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.120	Mouse
Dll4	delta-like 4 (Drosophila)	0.119
Tbx3	T-box 3	0.110
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.097
Col4a2	collagen, type IV, alpha 2	0.084
Ntf3	neurotrophin 3	0.083
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.082
Foxo1	forkhead box O1	0.081
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.079
Isl1	ISL1 transcription factor, LIM/homeodomain	0.078
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.077
Bmp4	bone morphogenetic protein 4	0.077
Pkd1	polycystic kidney disease 1 homolog	0.076
Gja5	gap junction protein, alpha 5	0.073
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.070
Pitx1	paired-like homeodomain transcription factor 1	0.064
Gata3	GATA binding protein 3	0.063
Rarg	retinoic acid receptor, gamma	0.063
Egfl7	EGF-like domain 7	0.062
Emx1	empty spiracles homolog 1 (Drosophila)	0.060
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.059
Lama5	laminin, alpha 5	0.059
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.056
Egfr	epidermal growth factor receptor	0.056
Hoxa1	homeobox A1	0.056
Scn5a	sodium channel, voltage-gated, type V, alpha	0.054
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.053
Pax9	paired box gene 9	0.051
Zfp362	zinc finger protein 362	0.049
Tcf15	transcription factor 15	0.048
Foxg1	forkhead box G1	0.047
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.043
Omp	olfactory marker protein	0.042
Tcf21	transcription factor 21	0.042
Otp	orthopedia homolog (Drosophila)	0.041
Tcfap2a	transcription factor AP-2, alpha	0.040
Jag2	jagged 2	0.039
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.039	Mouse
Dyrk1b	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b	0.038
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.037
Prm1	protamine 1	0.037
Klf3	Kruppel-like factor 3 (basic)	0.034
Hif1a	hypoxia inducible factor 1, alpha subunit	0.032
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.031
Gja1	gap junction protein, alpha 1	0.030
Evx2	even skipped homeotic gene 2 homolog	0.030
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.030
Pten	phosphatase and tensin homolog	0.030
Nog	noggin	0.029
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.028
Sall4	sal-like 4 (Drosophila)	0.028
Ighmbp2	immunoglobulin mu binding protein 2	0.028
Foxe1	forkhead box E1	0.027
Mybpc3	myosin binding protein C, cardiac	0.027
Vax1	ventral anterior homeobox containing gene 1	0.026
Wnt3a	wingless-related MMTV integration site 3A	0.026
Fgf10	fibroblast growth factor 10	0.024
Foxa2	forkhead box A2	0.024
Fgfrl1	fibroblast growth factor receptor-like 1	0.024
Pdx1	pancreatic and duodenal homeobox 1	0.024
Ikzf1	IKAROS family zinc finger 1	0.023
Lactbl1	lactamase, beta-like 1	0.023
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.022
Barx1	BarH-like homeobox 1	0.022
Efnb1	ephrin B1	0.021
Meox2	mesenchyme homeobox 2	0.021
Ncstn	nicastrin	0.021
Fgf3	fibroblast growth factor 3	0.021
Bcl2	B-cell leukemia/lymphoma 2	0.021
Trp53	transformation related protein 53	0.021
Tlx2	T-cell leukemia, homeobox 2	0.020
Ptk7	PTK7 protein tyrosine kinase 7	0.020
BC057022	cDNA sequence BC057022	0.020
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.020
Acvr1	activin A receptor, type 1	0.020
Hoxa13	homeobox A13	0.020
Sox4	SRY-box containing gene 4	0.019
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.019
Grid2ip	glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1	0.019
Sp6	trans-acting transcription factor 6	0.019
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.019
Foxh1	forkhead box H1	0.019
Pitx3	paired-like homeodomain transcription factor 3	0.019
Chrd	chordin	0.019
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.018
Msx1	homeobox, msh-like 1	0.018
Alx3	aristaless-like homeobox 3	0.018
Tgfbr2	transforming growth factor, beta receptor II	0.018
Gata5	GATA binding protein 5	0.018
Sox13	SRY-box containing gene 13	0.018
Gsc	goosecoid homeobox	0.017
Rara	retinoic acid receptor, alpha	0.017
Pax8	paired box gene 8	0.017
Ski	ski sarcoma viral oncogene homolog (avian)	0.017
Sycn	syncollin	0.016
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.016
Pax6	paired box gene 6	0.016
Akp3	alkaline phosphatase 3, intestine, not Mn requiring	0.016
Adam17	a disintegrin and metallopeptidase domain 17	0.016
Foxe3	forkhead box E3	0.015
Runx1	runt related transcription factor 1	0.015
Hdac7	histone deacetylase 7	0.015
Kcnk3	potassium channel, subfamily K, member 3	0.015
6030468B19Rik	RIKEN cDNA 6030468B19 gene	0.015
Pmfbp1	polyamine modulated factor 1 binding protein 1	0.015
Atoh7	atonal homolog 7 (Drosophila)	0.015
Lhx3	LIM homeobox protein 3	0.015
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.015
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.014
Jup	junction plakoglobin	0.014
4930527J03Rik	RIKEN cDNA 4930527J03 gene	0.014
Hoxd3	homeobox D3	0.014
Klk6	kallikrein related-peptidase 6	0.014
5730559C18Rik	RIKEN cDNA 5730559C18 gene	0.014
Ece1	endothelin converting enzyme 1	0.014
Fgfr3	fibroblast growth factor receptor 3	0.014
Mn1	meningioma 1	0.013
Cabp2	calcium binding protein 2	0.013
Fgf17	fibroblast growth factor 17	0.013
Ptch1	patched homolog 1	0.013
Pthlh	parathyroid hormone-like peptide	0.013
Hes2	hairy and enhancer of split 2 (Drosophila)	0.013
Gh	growth hormone	0.013
Eln	elastin	0.013
Fgf22	fibroblast growth factor 22	0.013
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.013
Cxcr4	chemokine (C-X-C motif) receptor 4	0.013
Ucn	urocortin	0.013
Pdgfb	platelet derived growth factor, B polypeptide	0.012
Ms4a15	membrane-spanning 4-domains, subfamily A, member 15	0.012
Nf1	neurofibromatosis 1	0.012
Mzf1	myeloid zinc finger 1	0.012
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.012
Sct	secretin	0.012
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.012
Nkx3-2	NK3 homeobox 2	0.012	Mouse
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.012
Hoxa5	homeobox A5	0.012
Eya1	eyes absent 1 homolog (Drosophila)	0.012
Ltbp4	latent transforming growth factor beta binding protein 4	0.012
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.012
Foxb1	forkhead box B1	0.012
Mapk14	mitogen-activated protein kinase 14	0.012
Tbx20	T-box 20	0.012
Hist1h1t	histone cluster 1, H1t	0.012
Gipc3	GIPC PDZ domain containing family, member 3	0.012
Odf3	outer dense fiber of sperm tails 3	0.012
Hcrt	hypocretin	0.011
Alx4	aristaless-like homeobox 4	0.011
Idua	iduronidase, alpha-L-	0.011
Tlx3	T-cell leukemia, homeobox 3	0.011
Gip	gastric inhibitory polypeptide	0.011
Pcdh12	protocadherin 12	0.011
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.011
Foxb2	forkhead box B2	0.011
Pou4f3	POU domain, class 4, transcription factor 3	0.011
Utf1	undifferentiated embryonic cell transcription factor 1	0.011
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.011
Atoh1	atonal homolog 1 (Drosophila)	0.011
Amac1	acyl-malonyl condensing enzyme 1	0.011
Shank1	SH3/ankyrin domain gene 1	0.011
Hmx2	H6 homeobox 2	0.011
Braf	Braf transforming gene	0.010
Bmp10	bone morphogenetic protein 10	0.010
Znrf4	zinc and ring finger 4	0.010
Amotl2	angiomotin-like 2	0.010
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.010
Foxd3	forkhead box D3	0.010
Midn	midnolin	0.010