Mus musculus

86 known processes

Otx1

orthodenticle homolog 1 (Drosophila)

(Aliases: A730044F23Rik,jv)

Otx1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
midbrain hindbrain boundary morphogenesis GO:0021555 4 1.000
midbrain hindbrain boundary development GO:0030917 9 1.000
Zebrafish
anterior commissure morphogenesis GO:0021960 6 1.000
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.999
paraxial mesodermal cell differentiation GO:0048342 2 0.998
regionalization GO:0003002 337 0.997
motor neuron migration GO:0097475 4 0.997
rostrocaudal neural tube patterning GO:0021903 12 0.996
Zebrafish
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.995
neural tube patterning GO:0021532 43 0.995
Zebrafish
regulation of rhodopsin gene expression GO:0007468 3 0.995
Fly
neuroblast differentiation GO:0014016 2 0.994
ureteric bud morphogenesis GO:0060675 62 0.992
positive regulation of rhodopsin gene expression GO:0045872 2 0.991
Fly
auditory receptor cell fate determination GO:0042668 3 0.991
nephron epithelium morphogenesis GO:0072088 68 0.990
central nervous system segmentation GO:0035283 3 0.989
Fly
pyramidal neuron migration GO:0021852 1 0.989
lateral motor column neuron migration GO:0097477 3 0.987
paraxial mesodermal cell fate commitment GO:0048343 2 0.987
metanephric dct cell differentiation GO:0072240 3 0.987
cerebral cortex radially oriented cell migration GO:0021799 31 0.986
rhombomere morphogenesis GO:0021593 2 0.986
hindbrain formation GO:0021576 1 0.985
neural tube development GO:0021915 160 0.985
Zebrafish
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.983
appendage morphogenesis GO:0035107 149 0.981
visceral motor neuron differentiation GO:0021524 3 0.981
positive regulation of transcription by glucose GO:0046016 3 0.980
peripheral nervous system neuron axonogenesis GO:0048936 3 0.980
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.980
cerebellum formation GO:0021588 1 0.980
axis elongation involved in somitogenesis GO:0090245 4 0.978
embryonic organ morphogenesis GO:0048562 276 0.978
metanephros morphogenesis GO:0003338 24 0.973
epidermal cell fate specification GO:0009957 1 0.972
renal tubule development GO:0061326 87 0.971
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.971
kidney epithelium development GO:0072073 121 0.971
cell fate commitment GO:0045165 210 0.970
Mouse Worm Fly
metanephric nephron morphogenesis GO:0072273 19 0.969
appendage development GO:0048736 166 0.969
kidney morphogenesis GO:0060993 83 0.968
telencephalon development GO:0021537 186 0.968
spinal cord motor neuron migration GO:0097476 4 0.968
nephron morphogenesis GO:0072028 69 0.966
rhombomere 5 development GO:0021571 4 0.965
hindbrain development GO:0030902 128 0.964
brain segmentation GO:0035284 3 0.963
Fly
retinal ganglion cell axon guidance GO:0031290 18 0.963
metanephric tubule development GO:0072170 18 0.962
embryonic viscerocranium morphogenesis GO:0048703 8 0.960
embryonic retina morphogenesis in camera type eye GO:0060059 7 0.960
forebrain development GO:0030900 302 0.959
closure of optic fissure GO:0061386 2 0.958
olfactory lobe development GO:0021988 32 0.955
loop of henle development GO:0072070 10 0.953
nephron tubule morphogenesis GO:0072078 68 0.952
nephric duct elongation GO:0035849 1 0.952
olfactory bulb development GO:0021772 30 0.952
neural tube closure GO:0001843 90 0.950
lung induction GO:0060492 3 0.949
cerebellum morphogenesis GO:0021587 42 0.948
positive regulation of macrophage colony stimulating factor production GO:1901258 1 0.947
regulation of vascular wound healing GO:0061043 2 0.946
mesonephric tubule development GO:0072164 94 0.945
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.945
mesonephros development GO:0001823 97 0.942
somatotropin secreting cell differentiation GO:0060126 4 0.942
eye photoreceptor cell fate commitment GO:0042706 2 0.942
Mouse
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 0.941
fourth ventricle development GO:0021592 2 0.941
mesonephric duct morphogenesis GO:0072180 4 0.940
spinal cord motor neuron cell fate specification GO:0021520 13 0.940
granulocyte colony stimulating factor production GO:0071611 1 0.938
epidermis development GO:0008544 187 0.936
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.934
kidney development GO:0001822 213 0.933
renal vesicle induction GO:0072034 3 0.925
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.924
photoreceptor cell fate commitment GO:0046552 2 0.923
Mouse Fly
positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 18 0.923
midbrain hindbrain boundary maturation GO:0021732 1 0.923
somitogenesis GO:0001756 69 0.917
Mouse
negative regulation of neuron differentiation GO:0045665 101 0.917
cell fate specification GO:0001708 72 0.916
Mouse Worm
cell proliferation in hindbrain GO:0021534 10 0.915
metanephric nephron tubule formation GO:0072289 4 0.914
bmp signaling pathway GO:0030509 93 0.914
cell proliferation in forebrain GO:0021846 30 0.913
forebrain regionalization GO:0021871 25 0.912
central nervous system neuron differentiation GO:0021953 162 0.912
positive regulation of nephron tubule epithelial cell differentiation GO:2000768 1 0.911
nephron tubule development GO:0072080 84 0.909
neuroblast fate determination GO:0007400 1 0.909
pituitary gland development GO:0021983 38 0.909
ventral spinal cord interneuron specification GO:0021521 11 0.906
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.904
ventral spinal cord interneuron fate commitment GO:0060579 14 0.900
cell differentiation involved in kidney development GO:0061005 33 0.899
cardiac right atrium morphogenesis GO:0003213 3 0.895
neural precursor cell proliferation GO:0061351 121 0.894
hindbrain morphogenesis GO:0021575 46 0.893
axonogenesis GO:0007409 274 0.891
metanephric tubule morphogenesis GO:0072173 9 0.883
dorsal ventral neural tube patterning GO:0021904 28 0.882
ventral spinal cord interneuron differentiation GO:0021514 16 0.880
uterus morphogenesis GO:0061038 2 0.879
stem cell fate determination GO:0048867 2 0.878
forebrain anterior posterior pattern specification GO:0021797 5 0.878
mesonephric epithelium development GO:0072163 94 0.877
central nervous system morphogenesis GO:0021551 2 0.877
metanephric loop of henle development GO:0072236 4 0.876
granulosa cell differentiation GO:0060014 1 0.874
epithelial cell differentiation involved in kidney development GO:0035850 23 0.874
morphogenesis of embryonic epithelium GO:0016331 159 0.872
diencephalon development GO:0021536 63 0.868
specification of loop of henle identity GO:0072086 4 0.866
specification of nephron tubule identity GO:0072081 5 0.861
nephron epithelium development GO:0072009 92 0.861
medial motor column neuron differentiation GO:0021526 2 0.861
somite development GO:0061053 81 0.860
Mouse
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 4 0.859
urogenital system development GO:0001655 261 0.856
renal vesicle morphogenesis GO:0072077 15 0.856
nephric duct formation GO:0072179 4 0.854
pattern specification involved in metanephros development GO:0072268 4 0.853
mesonephric duct formation GO:0072181 2 0.853
branching involved in ureteric bud morphogenesis GO:0001658 56 0.852
rhombomere 3 morphogenesis GO:0021658 2 0.848
trabecular meshwork development GO:0002930 2 0.848
hypophysis morphogenesis GO:0048850 3 0.847
central nervous system neuron development GO:0021954 67 0.845
rhombomere development GO:0021546 8 0.843
regulation of bmp signaling pathway GO:0030510 60 0.843
ureteric bud development GO:0001657 94 0.840
proximal distal pattern formation involved in nephron development GO:0072047 5 0.836
primary neural tube formation GO:0014020 95 0.835
midbrain hindbrain boundary maturation during brain development GO:0022004 1 0.834
metanephros development GO:0001656 79 0.832
epithelial cell maturation involved in prostate gland development GO:0060743 4 0.831
ectoderm formation GO:0001705 3 0.831
cerebellar cortex morphogenesis GO:0021696 32 0.827
glomerulus development GO:0032835 40 0.826
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.822
dopaminergic neuron differentiation GO:0071542 14 0.821
renal capsule specification GO:0072130 1 0.818
spemann organizer formation GO:0060061 2 0.817
s shaped body morphogenesis GO:0072050 6 0.816
neuron projection guidance GO:0097485 141 0.815
forebrain neuron differentiation GO:0021879 52 0.814
regulation of neuron differentiation GO:0045664 281 0.812
Fly
metanephric epithelium development GO:0072207 21 0.809
ascending aorta morphogenesis GO:0035910 3 0.807
embryonic appendage morphogenesis GO:0035113 126 0.806
morphogenesis of a branching epithelium GO:0061138 193 0.802
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.798
kidney rudiment formation GO:0072003 3 0.795
neuron fate specification GO:0048665 30 0.792
Worm
segmentation GO:0035282 93 0.788
Mouse Fly
stem cell proliferation GO:0072089 117 0.788
positive regulation of stem cell proliferation GO:2000648 59 0.788
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.784
regulation of nephron tubule epithelial cell differentiation GO:0072182 9 0.777
forebrain neuron fate commitment GO:0021877 13 0.777
cerebral cortex neuron differentiation GO:0021895 19 0.777
muscle cell differentiation GO:0042692 261 0.776
metanephric nephron tubule development GO:0072234 16 0.776
carbon catabolite activation of transcription GO:0045991 4 0.776
mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis GO:0072309 3 0.773
renal system development GO:0072001 225 0.773
eye photoreceptor cell differentiation GO:0001754 41 0.772
Mouse Fly
cervix development GO:0060067 2 0.772
negative regulation of transcription by glucose GO:0045014 1 0.767
axon guidance GO:0007411 141 0.767
inner ear receptor cell differentiation GO:0060113 61 0.764
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.764
gastrulation GO:0007369 116 0.762
Mouse
gland development GO:0048732 330 0.761
spinal cord development GO:0021510 81 0.760
pallium development GO:0021543 120 0.759
neuroblast proliferation GO:0007405 49 0.756
nephron development GO:0072006 109 0.755
cerebellar granule cell precursor proliferation GO:0021930 10 0.754
rhombomere 3 development GO:0021569 4 0.754
cell differentiation in hindbrain GO:0021533 24 0.754
sensory organ morphogenesis GO:0090596 242 0.753
nerve development GO:0021675 67 0.750
spinal cord association neuron differentiation GO:0021527 14 0.749
ear development GO:0043583 200 0.738
gonad morphogenesis GO:0035262 1 0.738
metanephric s shaped body morphogenesis GO:0072284 2 0.738
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072040 4 0.738
neural tube formation GO:0001841 108 0.736
negative regulation of prostatic bud formation GO:0060686 4 0.732
telencephalon cell migration GO:0022029 55 0.731
forebrain generation of neurons GO:0021872 63 0.726
neurohypophysis development GO:0021985 2 0.726
glial cell differentiation GO:0010001 131 0.724
commitment of neuronal cell to specific neuron type in forebrain GO:0021902 7 0.723
endodermal cell fate specification GO:0001714 4 0.720
rhombomere 2 development GO:0021568 2 0.719
metencephalon development GO:0022037 89 0.719
diencephalon morphogenesis GO:0048852 6 0.718
response to fibroblast growth factor GO:0071774 47 0.706
cerebellar purkinje cell granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation GO:0021937 6 0.704
pattern specification involved in kidney development GO:0061004 8 0.703
cerebral cortex gabaergic interneuron differentiation GO:0021892 9 0.701
regulation of mesenchymal cell proliferation GO:0010464 37 0.699
pronephric nephron development GO:0039019 1 0.697
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.696
trophectodermal cell differentiation GO:0001829 21 0.695
positive regulation of transcription from rna polymerase iii promoter GO:0045945 1 0.695
cochlea morphogenesis GO:0090103 22 0.690
lung development GO:0030324 164 0.690
metanephric renal vesicle morphogenesis GO:0072283 12 0.689
mesenchymal cell development GO:0014031 93 0.687
renal vesicle development GO:0072087 17 0.683
metanephric nephron development GO:0072210 34 0.676
spinal cord dorsal ventral patterning GO:0021513 23 0.675
brain morphogenesis GO:0048854 32 0.674
regulation of neural precursor cell proliferation GO:2000177 70 0.674
primitive streak formation GO:0090009 10 0.673
Mouse
carbon catabolite repression of transcription GO:0045013 1 0.673
negative regulation of transcription from rna polymerase ii promoter by glucose GO:0000433 1 0.673
embryonic skeletal system morphogenesis GO:0048704 91 0.668
positive regulation of smoothened signaling pathway GO:0045880 23 0.667
striated muscle tissue development GO:0014706 293 0.661
mesangial cell differentiation GO:0072007 4 0.661
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.660
endodermal cell fate commitment GO:0001711 12 0.659
ventral midline development GO:0007418 4 0.652
epithelial tube formation GO:0072175 130 0.651
cerebellar cortex formation GO:0021697 22 0.648
positive regulation of epithelial cell differentiation involved in kidney development GO:2000698 2 0.643
labyrinthine layer blood vessel development GO:0060716 21 0.640
mesonephric tubule morphogenesis GO:0072171 63 0.639
regulation of branching involved in ureteric bud morphogenesis GO:0090189 22 0.638
metanephric nephron epithelium development GO:0072243 19 0.638
negative regulation of cell development GO:0010721 169 0.638
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.637
regulation of auditory receptor cell differentiation GO:0045607 4 0.636
cerebral cortex development GO:0021987 86 0.635
regulation of cerebellar granule cell precursor proliferation GO:0021936 12 0.635
epithalamus development GO:0021538 2 0.633
forebrain neuron development GO:0021884 30 0.633
planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 2 0.629
hair cell differentiation GO:0035315 40 0.625
ureter morphogenesis GO:0072197 4 0.622
morphogenesis of a branching structure GO:0001763 203 0.621
neuron projection extension GO:1990138 64 0.618
cell fate specification involved in pattern specification GO:0060573 11 0.616
lateral sprouting involved in mammary gland duct morphogenesis GO:0060599 2 0.616
forebrain cell migration GO:0021885 58 0.606
limb development GO:0060173 166 0.604
branching morphogenesis of an epithelial tube GO:0048754 159 0.604
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.601
mesonephric tubule formation GO:0072172 11 0.600
regulation of somitogenesis GO:0014807 6 0.597
hindlimb morphogenesis GO:0035137 42 0.595
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.592
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072039 4 0.592
establishment of organ orientation GO:0048561 1 0.588
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.587
stem cell differentiation GO:0048863 268 0.587
regulation of smoothened signaling pathway GO:0008589 58 0.584
positive regulation of bmp signaling pathway GO:0030513 23 0.584
epithelial cell morphogenesis GO:0003382 41 0.581
establishment of planar polarity involved in nephron morphogenesis GO:0072046 1 0.581
renal capsule formation GO:0072129 1 0.577
negative regulation of pancreatic a cell differentiation GO:2000227 1 0.577
gamma aminobutyric acid metabolic process GO:0009448 3 0.573
cerebral cortex radial glia guided migration GO:0021801 17 0.564
regulation of neuroblast proliferation GO:1902692 27 0.563
forelimb morphogenesis GO:0035136 40 0.557
cell proliferation in external granule layer GO:0021924 10 0.555
cerebellar cortex development GO:0021695 48 0.553
camera type eye development GO:0043010 266 0.545
Zebrafish Mouse
foregut regionalization GO:0060423 3 0.545
cerebral cortex cell migration GO:0021795 44 0.535
inner medullary collecting duct development GO:0072061 2 0.535
regulation of neuron projection development GO:0010975 169 0.532
eye photoreceptor cell development GO:0042462 31 0.531
Fly
horizontal cell localization GO:0035852 1 0.531
digestive system development GO:0055123 200 0.530
Mouse
regulation of heart morphogenesis GO:2000826 22 0.523
outer medullary collecting duct development GO:0072060 1 0.523
olfactory bulb interneuron differentiation GO:0021889 12 0.522
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.518
spinal cord motor neuron differentiation GO:0021522 35 0.514
embryonic heart tube development GO:0035050 65 0.513
auditory receptor cell differentiation GO:0042491 37 0.512
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.512
metanephric capsule specification GO:0072267 1 0.509
cardiac muscle cell myoblast differentiation GO:0060379 8 0.502
regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003339 5 0.501
olfactory bulb interneuron development GO:0021891 7 0.501
mammary placode formation GO:0060596 4 0.499
renal outer medulla development GO:0072054 2 0.497
negative regulation of glial cell proliferation GO:0060253 4 0.497
proprioception GO:0019230 4 0.496
lung morphogenesis GO:0060425 50 0.496
embryonic placenta development GO:0001892 98 0.492
anterior head development GO:0097065 2 0.487
retina development in camera type eye GO:0060041 119 0.486
Zebrafish Mouse
cardiac ventricle morphogenesis GO:0003208 50 0.486
cellular amino acid biosynthetic process GO:0008652 22 0.486
cerebellar purkinje cell layer development GO:0021680 26 0.482
dct cell differentiation GO:0072069 3 0.482
apoptotic process involved in outflow tract morphogenesis GO:0003275 2 0.479
limb morphogenesis GO:0035108 149 0.478
developmental growth involved in morphogenesis GO:0060560 138 0.478
neuron apoptotic process GO:0051402 142 0.477
epithelial mesenchymal signaling involved in prostate gland development GO:0060738 2 0.477
regulation of asymmetric cell division GO:0009786 4 0.476
stem cell development GO:0048864 219 0.473
glomerular mesangial cell differentiation GO:0072008 3 0.473
regulation of transcription involved in primary germ layer cell fate commitment GO:0060796 2 0.473
myotube differentiation GO:0014902 105 0.468
cerebral cortex gabaergic interneuron migration GO:0021853 6 0.466
glomerulus vasculature development GO:0072012 14 0.466
epithelial to mesenchymal transition GO:0001837 47 0.466
negative regulation of stomach neuroendocrine cell differentiation GO:0061106 1 0.465
regulation of anagen GO:0051884 1 0.464
renal tubule morphogenesis GO:0061333 72 0.464
ventricular septum morphogenesis GO:0060412 27 0.462
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.460
mesoderm development GO:0007498 100 0.455
neuroendocrine cell differentiation GO:0061101 7 0.452
trachea cartilage morphogenesis GO:0060535 4 0.450
paraxial mesoderm morphogenesis GO:0048340 10 0.450
mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9 0.449
multicellular organismal signaling GO:0035637 91 0.446
neural plate morphogenesis GO:0001839 9 0.445
digestive tract development GO:0048565 190 0.445
Mouse
central nervous system projection neuron axonogenesis GO:0021952 21 0.445
nephron tubule epithelial cell differentiation GO:0072160 11 0.442
androgen biosynthetic process GO:0006702 4 0.440
regulation of chondrocyte differentiation GO:0032330 33 0.440
retina morphogenesis in camera type eye GO:0060042 45 0.437
digestive tract morphogenesis GO:0048546 147 0.434
Mouse
canonical wnt signaling pathway GO:0060070 130 0.431
compartment pattern specification GO:0007386 4 0.429
cerebellar purkinje cell differentiation GO:0021702 13 0.426
inner cell mass cell differentiation GO:0001826 7 0.424
positive regulation of anagen GO:0051885 1 0.423
heart morphogenesis GO:0003007 178 0.422
neuroblast fate commitment GO:0014017 1 0.421
respiratory system development GO:0060541 190 0.420
metanephric mesenchymal cell differentiation GO:0072162 3 0.418
skeletal muscle fiber development GO:0048741 58 0.417
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 3 0.415
regulation of kidney development GO:0090183 40 0.411
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification GO:0021913 4 0.411
regulation of axon diameter GO:0031133 6 0.410
otolith morphogenesis GO:0032474 3 0.409
nephron tubule formation GO:0072079 20 0.405
embryonic eye morphogenesis GO:0048048 29 0.405
testosterone biosynthetic process GO:0061370 2 0.401
angiogenesis GO:0001525 201 0.401
regulation of establishment of planar polarity GO:0090175 28 0.400
regulation of stem cell proliferation GO:0072091 78 0.397
positive regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000081 1 0.396
smoothened signaling pathway GO:0007224 105 0.395
chemotaxis GO:0006935 247 0.395
metanephric nephron tubule morphogenesis GO:0072282 7 0.391
defecation GO:0030421 1 0.391
epithelial cell development GO:0002064 159 0.390
tube closure GO:0060606 91 0.390
cellular ketone metabolic process GO:0042180 84 0.388
glomerular epithelial cell differentiation GO:0072311 10 0.385
cell type specific apoptotic process GO:0097285 268 0.385
skeletal system development GO:0001501 356 0.384
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.382
alcohol metabolic process GO:0006066 116 0.381
somatic motor neuron differentiation GO:0021523 6 0.381
regulation of transcription by glucose GO:0046015 3 0.378
development of primary sexual characteristics GO:0045137 143 0.378
limbic system development GO:0021761 72 0.375
planar cell polarity pathway involved in heart morphogenesis GO:0061346 3 0.374
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.371
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.370
outflow tract morphogenesis GO:0003151 53 0.370
lung field specification GO:0060424 3 0.369
negative regulation of mesodermal cell fate specification GO:0042662 3 0.369
renal capsule development GO:0072127 1 0.368
canonical wnt signaling pathway involved in regulation of type b pancreatic cell proliferation GO:0044343 1 0.367
positive regulation of kidney development GO:0090184 28 0.366
regulation of transcription from rna polymerase ii promoter by glucose GO:0000430 3 0.365
regulation of granulocyte macrophage colony stimulating factor production GO:0032645 3 0.359
somite rostral caudal axis specification GO:0032525 13 0.358
Mouse
cerebellar purkinje cell layer morphogenesis GO:0021692 14 0.358
lateral inhibition GO:0046331 1 0.357
metanephric capsule morphogenesis GO:0072265 1 0.353
skeletal muscle cell differentiation GO:0035914 66 0.350
forebrain radial glial cell differentiation GO:0021861 4 0.348
developmental cell growth GO:0048588 84 0.348
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.347
skeletal system morphogenesis GO:0048705 203 0.347
cerebellar granule cell differentiation GO:0021707 9 0.345
embryonic heart tube morphogenesis GO:0003143 51 0.343
cerebellum development GO:0021549 77 0.343
renal capsule morphogenesis GO:0072128 1 0.342
renal inner medulla development GO:0072053 3 0.340
cardiac muscle cell differentiation GO:0055007 69 0.337
establishment of protein localization to membrane GO:0090150 54 0.335
regulation of cellular amine metabolic process GO:0033238 20 0.333
positive regulation of granulocyte macrophage colony stimulating factor production GO:0032725 3 0.332
mechanoreceptor differentiation GO:0042490 67 0.332
central nervous system vasculogenesis GO:0022009 3 0.331
mrna transcription from rna polymerase ii promoter GO:0042789 4 0.330
oviduct development GO:0060066 3 0.329
mesenchyme morphogenesis GO:0072132 32 0.328
mesenchyme development GO:0060485 152 0.328
embryonic epithelial tube formation GO:0001838 130 0.327
negative regulation of axon extension GO:0030517 19 0.325
oviduct epithelium development GO:0035846 1 0.324
lymphocyte proliferation GO:0046651 164 0.323
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.322
muscle cell development GO:0055001 133 0.322
stomach neuroendocrine cell differentiation GO:0061102 2 0.321
maintenance of apical basal cell polarity GO:0035090 3 0.319
cell fate determination GO:0001709 32 0.318
Mouse
regulation of lens epithelial cell proliferation GO:2001109 1 0.317
cell differentiation in spinal cord GO:0021515 53 0.317
positive regulation of lymphocyte activation GO:0051251 140 0.316
kidney vasculature development GO:0061440 15 0.316
primary prostatic bud elongation GO:0060516 2 0.314
metanephric comma shaped body morphogenesis GO:0072278 1 0.314
tube formation GO:0035148 140 0.312
midbrain development GO:0030901 35 0.312
sensory organ boundary specification GO:0008052 1 0.312
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.312
peripheral nervous system neuron development GO:0048935 9 0.310
carbon catabolite regulation of transcription GO:0045990 4 0.310
cardiac septum development GO:0003279 59 0.307
axon target recognition GO:0007412 4 0.306
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.306
cranial nerve development GO:0021545 41 0.306
cell differentiation involved in metanephros development GO:0072202 12 0.305
negative regulation of neuron projection development GO:0010977 50 0.304
lymphocyte differentiation GO:0030098 242 0.301
hypothalamus development GO:0021854 16 0.301
formation of primary germ layer GO:0001704 77 0.301
negative regulation of glucokinase activity GO:0033132 4 0.300
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.298
glomerular mesangial cell development GO:0072144 3 0.298
photoreceptor cell development GO:0042461 40 0.298
Fly
metanephric distal convoluted tubule development GO:0072221 5 0.297
glomerular endothelium development GO:0072011 2 0.296
muscle tissue development GO:0060537 308 0.295
regulation of wnt signaling pathway GO:0030111 123 0.295
kidney interstitial fibroblast differentiation GO:0072071 5 0.294
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.294
motor neuron axon guidance GO:0008045 26 0.292
cardiac cell fate determination GO:0060913 2 0.290
positive regulation of neural precursor cell proliferation GO:2000179 42 0.288
myotube cell development GO:0014904 60 0.287
mesenchymal to epithelial transition GO:0060231 12 0.282
regulation of epithelial cell differentiation involved in kidney development GO:2000696 10 0.281
regulation of organ formation GO:0003156 34 0.280
skin development GO:0043588 220 0.279
metanephric nephron tubule epithelial cell differentiation GO:0072257 5 0.279
tissue migration GO:0090130 68 0.279
embryonic skeletal system development GO:0048706 120 0.278
tongue morphogenesis GO:0043587 8 0.277
neural crest cell development GO:0014032 48 0.277
placenta development GO:0001890 140 0.275
regulation of timing of neuron differentiation GO:0060164 5 0.274
negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 4 0.273
positive regulation of cerebellar granule cell precursor proliferation GO:0021940 10 0.272
macrophage colony stimulating factor production GO:0036301 1 0.272
somatic sex determination GO:0018993 2 0.272
negative regulation of apoptotic signaling pathway GO:2001234 104 0.272
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.269
negative regulation of bmp signaling pathway GO:0030514 35 0.268
forebrain ventricular zone progenitor cell division GO:0021869 6 0.267
ear morphogenesis GO:0042471 118 0.265
tertiary branching involved in mammary gland duct morphogenesis GO:0060748 3 0.265
striated muscle cell development GO:0055002 125 0.264
interleukin 8 production GO:0032637 4 0.264
comma shaped body morphogenesis GO:0072049 5 0.262
astrocyte differentiation GO:0048708 43 0.261
maintenance of epithelial cell apical basal polarity GO:0045199 2 0.261
midgut development GO:0007494 4 0.260
apoptotic process involved in patterning of blood vessels GO:1902262 6 0.259
positive regulation of interleukin 8 secretion GO:2000484 1 0.257
mesenchymal cell apoptotic process involved in nephron morphogenesis GO:1901145 4 0.257
prostate gland development GO:0030850 48 0.254
regulation of binding GO:0051098 111 0.254
endocrine system development GO:0035270 98 0.252
positive regulation of endothelial cell migration GO:0010595 12 0.251
prostate gland epithelium morphogenesis GO:0060740 31 0.251
cellular response to retinoic acid GO:0071300 25 0.249

Otx1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.706
disease of anatomical entity DOID:7 0 0.706
eye and adnexa disease DOID:1492 0 0.706
nervous system disease DOID:863 0 0.706
eye disease DOID:5614 0 0.548