Mus musculus

226 known processes

Pkd1

polycystic kidney disease 1 homolog

(Aliases: MGC118471,PC1,mFLJ00285,FLJ00285)

Pkd1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to fluid shear stress GO:0071498 4 0.998
Mouse
kidney development GO:0001822 213 0.998
connective tissue development GO:0061448 179 0.996
skeletal system morphogenesis GO:0048705 203 0.993
limb morphogenesis GO:0035108 149 0.990
limb development GO:0060173 166 0.989
epithelial tube morphogenesis GO:0060562 303 0.987
Human Mouse
urogenital system development GO:0001655 261 0.986
appendage morphogenesis GO:0035107 149 0.983
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.982
skeletal system development GO:0001501 356 0.981
response to fluid shear stress GO:0034405 7 0.979
formation of radial glial scaffolds GO:0021943 4 0.976
regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000163 1 0.976
negative regulation of osteoblast differentiation GO:0045668 30 0.975
detection of chemical stimulus involved in sensory perception of taste GO:0050912 3 0.971
Mouse
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.967
regionalization GO:0003002 337 0.965
Mouse
stem cell development GO:0048864 219 0.949
nephron tubule morphogenesis GO:0072078 68 0.940
Human
negative regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000160 1 0.936
detection of nodal flow GO:0003127 2 0.933
Mouse
bone morphogenesis GO:0060349 78 0.930
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.922
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.921
embryonic limb morphogenesis GO:0030326 126 0.919
embryonic skeletal system morphogenesis GO:0048704 91 0.919
negative regulation of ryanodine sensitive calcium release channel activity GO:0060315 1 0.915
Mouse
embryonic skeletal system development GO:0048706 120 0.913
bone development GO:0060348 120 0.913
retina morphogenesis in camera type eye GO:0060042 45 0.902
regulation of neuron differentiation GO:0045664 281 0.899
determination of heart left right asymmetry GO:0061371 48 0.893
cell aggregation GO:0098743 18 0.884
digestive system development GO:0055123 200 0.884
Human
cilium assembly GO:0042384 81 0.883
respiratory system development GO:0060541 190 0.876
Human
stem cell differentiation GO:0048863 268 0.868
protein localization to nucleus GO:0034504 121 0.866
regulation of cardiac cell fate specification GO:2000043 1 0.844
jak stat cascade GO:0007259 42 0.838
endochondral bone morphogenesis GO:0060350 50 0.838
liver development GO:0001889 66 0.832
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 1 0.831
renal system development GO:0072001 225 0.829
appendage development GO:0048736 166 0.825
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.822
muscle tissue development GO:0060537 308 0.817
cartilage development GO:0051216 140 0.817
hepaticobiliary system development GO:0061008 67 0.813
embryonic heart tube development GO:0035050 65 0.801
striated muscle contraction GO:0006941 45 0.792
renal tubule development GO:0061326 87 0.788
Human Mouse
skeletal muscle organ development GO:0060538 163 0.776
cellular response to acidic ph GO:0071468 4 0.766
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.766
cardiac right atrium morphogenesis GO:0003213 3 0.757
embryonic heart tube morphogenesis GO:0003143 51 0.753
developmental growth involved in morphogenesis GO:0060560 138 0.746
metanephric ascending thin limb development GO:0072218 2 0.737
Human
neural tube development GO:0021915 160 0.736
Human
nephron epithelium development GO:0072009 92 0.725
Human
ascending thin limb development GO:0072021 2 0.721
Human
mesonephric tubule development GO:0072164 94 0.715
Human
negative regulation of glial cell proliferation GO:0060253 4 0.714
positive regulation of apoptotic process GO:0043065 217 0.712
regulation of cell cycle GO:0051726 281 0.701
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 1 0.701
gland development GO:0048732 330 0.689
spermatogenesis GO:0007283 284 0.685
macromolecule catabolic process GO:0009057 281 0.665
negative regulation of epithelial cell proliferation GO:0050680 64 0.653
regulation of reactive oxygen species metabolic process GO:2000377 40 0.644
tissue homeostasis GO:0001894 115 0.640
regulation of membrane potential GO:0042391 192 0.633
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:2000151 1 0.627
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.627
regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000161 1 0.616
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000164 1 0.615
protein import into nucleus GO:0006606 95 0.615
response to growth factor GO:0070848 198 0.614
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.614
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9 0.613
photoreceptor cell differentiation GO:0046530 52 0.604
regulation of cell migration GO:0030334 219 0.603
regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000159 1 0.596
diencephalon development GO:0021536 63 0.591
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.588
Human
respiratory tube development GO:0030323 167 0.582
Human
negative regulation of cell migration GO:0030336 59 0.581
renal tubule morphogenesis GO:0061333 72 0.572
Human Mouse
gastrulation GO:0007369 116 0.570
homeostasis of number of cells GO:0048872 210 0.564
positive regulation of binding GO:0051099 49 0.561
regulation of cell motility GO:2000145 236 0.552
cell migration involved in endocardial cushion formation GO:0003273 3 0.538
response to oxygen levels GO:0070482 62 0.535
regulation of ossification GO:0030278 112 0.534
intracellular protein transport GO:0006886 204 0.533
canonical wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development GO:0061310 1 0.531
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.531
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.521
eye photoreceptor cell differentiation GO:0001754 41 0.518
lung development GO:0030324 164 0.511
Human
positive regulation of cell migration GO:0030335 109 0.510
regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity GO:0031585 2 0.505
heart formation GO:0060914 16 0.498
muscle contraction GO:0006936 101 0.497
sensory perception of sour taste GO:0050915 2 0.496
Mouse
axonogenesis GO:0007409 274 0.493
negative regulation of calcium ion transmembrane transporter activity GO:1901020 1 0.490
Mouse
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.488
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.479
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.477
renal system vasculature morphogenesis GO:0061438 7 0.471
embryonic hemopoiesis GO:0035162 23 0.471
regulation of planar cell polarity pathway involved in neural tube closure GO:2000167 1 0.466
positive regulation of cell cycle process GO:0090068 61 0.461
positive regulation of neural precursor cell proliferation GO:2000179 42 0.459
determination of left right symmetry GO:0007368 80 0.455
Mouse
ion transmembrane transport GO:0034220 361 0.454
negative regulation of planar cell polarity pathway involved in neural tube closure GO:2000168 1 0.448
endoderm development GO:0007492 45 0.442
digestive tract morphogenesis GO:0048546 147 0.441
endocardial cell differentiation GO:0060956 4 0.441
protein localization to organelle GO:0033365 185 0.437
regulation of protein targeting GO:1903533 61 0.434
ossification GO:0001503 216 0.433
wound healing GO:0042060 157 0.432
aorta development GO:0035904 23 0.428
proximal convoluted tubule development GO:0072019 1 0.425
positive regulation of nervous system development GO:0051962 221 0.424
positive regulation of cell death GO:0010942 224 0.419
cartilage condensation GO:0001502 18 0.414
collagen metabolic process GO:0032963 17 0.414
platelet derived growth factor receptor beta signaling pathway GO:0035791 4 0.413
somatic stem cell maintenance GO:0035019 47 0.405
nephron development GO:0072006 109 0.400
Human
metal ion homeostasis GO:0055065 189 0.397
Mouse
mitotic nuclear division GO:0007067 48 0.394
skeletal muscle fiber development GO:0048741 58 0.386
cilium morphogenesis GO:0060271 102 0.385
neuroblast fate determination GO:0007400 1 0.385
organelle assembly GO:0070925 177 0.380
cardiac endothelial cell differentiation GO:0003348 4 0.380
calcium ion transmembrane transport GO:0070588 85 0.379
response to denervation involved in regulation of muscle adaptation GO:0014894 4 0.378
cation transport GO:0006812 399 0.375
ureteric bud development GO:0001657 94 0.374
regulation of cellular response to growth factor stimulus GO:0090287 82 0.367
pro b cell differentiation GO:0002328 10 0.364
detection of external stimulus GO:0009581 61 0.363
establishment of protein localization to organelle GO:0072594 118 0.362
regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:2000150 1 0.358
cellular protein catabolic process GO:0044257 155 0.356
nephron tubule development GO:0072080 84 0.354
Human
ventricular zone neuroblast division GO:0021847 3 0.354
regulation of receptor activity GO:0010469 41 0.352
regulation of cellular catabolic process GO:0031329 242 0.351
regulation of canonical wnt signaling pathway GO:0060828 82 0.348
placenta blood vessel development GO:0060674 31 0.343
peptidyl amino acid modification GO:0018193 336 0.343
negative regulation of platelet derived growth factor receptor beta signaling pathway GO:2000587 2 0.340
positive regulation of programmed cell death GO:0043068 218 0.338
protein import GO:0017038 101 0.336
regulation of osteoblast differentiation GO:0045667 67 0.334
thalamus development GO:0021794 11 0.334
stem cell maintenance GO:0019827 130 0.332
striated muscle tissue development GO:0014706 293 0.325
retina development in camera type eye GO:0060041 119 0.325
negative regulation of ossification GO:0030279 49 0.321
chemotaxis GO:0006935 247 0.319
intracellular cholesterol transport GO:0032367 3 0.319
positive regulation of protein modification process GO:0031401 299 0.319
Human
response to transforming growth factor beta GO:0071559 88 0.316
regulation of neural precursor cell proliferation GO:2000177 70 0.310
second messenger mediated signaling GO:0019932 73 0.306
canonical wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324 2 0.303
response to folic acid GO:0051593 2 0.303
inorganic cation transmembrane transport GO:0098662 207 0.300
morphogenesis of embryonic epithelium GO:0016331 159 0.298
embryonic digit morphogenesis GO:0042733 56 0.297
regulation of extracellular matrix assembly GO:1901201 2 0.294
gliogenesis GO:0042063 141 0.294
cellular response to abiotic stimulus GO:0071214 56 0.286
Mouse
negative regulation of neuron differentiation GO:0045665 101 0.286
aorta morphogenesis GO:0035909 22 0.286
epidermis development GO:0008544 187 0.285
protein catabolic process GO:0030163 221 0.284
protein localization to membrane GO:0072657 108 0.282
branching involved in ureteric bud morphogenesis GO:0001658 56 0.280
response to oxidative stress GO:0006979 123 0.279
kidney epithelium development GO:0072073 121 0.278
Human
skeletal muscle cell differentiation GO:0035914 66 0.278
cell surface receptor signaling pathway involved in heart development GO:0061311 15 0.277
regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000165 1 0.275
lymphoid progenitor cell differentiation GO:0002320 17 0.274
embryonic appendage morphogenesis GO:0035113 126 0.274
muscle fiber development GO:0048747 76 0.273
nuclear division GO:0000280 158 0.272
regulation of protein catabolic process GO:0042176 108 0.265
canonical wnt signaling pathway involved in neural crest cell differentiation GO:0044335 1 0.265
mesenchyme development GO:0060485 152 0.264
male gamete generation GO:0048232 285 0.263
circulatory system process GO:0003013 197 0.262
neuron projection guidance GO:0097485 141 0.262
anatomical structure homeostasis GO:0060249 145 0.260
regulation of homeostatic process GO:0032844 182 0.258
Mouse
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.256
camera type eye development GO:0043010 266 0.249
artery development GO:0060840 53 0.248
mitotic cell cycle process GO:1903047 159 0.247
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.246
cellular amine metabolic process GO:0044106 44 0.245
epithelium migration GO:0090132 63 0.243
embryonic organ morphogenesis GO:0048562 276 0.243
camera type eye photoreceptor cell differentiation GO:0060219 15 0.243
regulation of cardioblast differentiation GO:0051890 3 0.241
mesonephros development GO:0001823 97 0.240
Human
erythrocyte differentiation GO:0030218 88 0.240
filopodium assembly GO:0046847 19 0.239
membrane organization GO:0061024 245 0.239
chondrocyte development GO:0002063 24 0.239
metanephric nephron morphogenesis GO:0072273 19 0.238
Human
negative regulation of cell proliferation GO:0008285 296 0.234
digestive tract development GO:0048565 190 0.232
Human
regulation of neuron projection development GO:0010975 169 0.232
chondrocyte differentiation GO:0002062 72 0.228
regulation of secretion GO:0051046 274 0.228
Mouse
regulation of cell cycle process GO:0010564 160 0.226
sensory organ morphogenesis GO:0090596 242 0.226
cellular response to acid chemical GO:0071229 68 0.224
carbohydrate metabolic process GO:0005975 230 0.224
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.224
sensory perception of mechanical stimulus GO:0050954 107 0.221
growth plate cartilage development GO:0003417 14 0.221
positive regulation of protein kinase activity GO:0045860 144 0.220
Human
tissue migration GO:0090130 68 0.218
positive regulation of stem cell proliferation GO:2000648 59 0.216
neural tube patterning GO:0021532 43 0.216
regulation of protein binding GO:0043393 60 0.213
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.213
mechanoreceptor differentiation GO:0042490 67 0.212
organelle fission GO:0048285 170 0.209
palate development GO:0060021 76 0.208
prostate gland morphogenetic growth GO:0060737 4 0.206
mitotic cell cycle GO:0000278 195 0.205
cardiac ventricle development GO:0003231 83 0.203
response to inorganic substance GO:0010035 96 0.202
left right pattern formation GO:0060972 23 0.200
Mouse
regulation of platelet derived growth factor receptor beta signaling pathway GO:2000586 2 0.200
response to organic cyclic compound GO:0014070 198 0.197
regulation of endodermal cell fate specification GO:0042663 2 0.196
neural tube closure GO:0001843 90 0.196
muscle cell development GO:0055001 133 0.195
developmental maturation GO:0021700 193 0.191
regulation of collagen metabolic process GO:0010712 6 0.189
cell migration involved in coronary angiogenesis GO:0060981 1 0.189
response to acid chemical GO:0001101 111 0.188
kidney vasculature morphogenesis GO:0061439 7 0.187
regulation of mesenchymal cell proliferation GO:0010464 37 0.183
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.183
apoptotic process in bone marrow GO:0071839 1 0.182
chromatin modification GO:0016568 187 0.181
rhythmic process GO:0048511 174 0.179
negative regulation of bone mineralization GO:0030502 10 0.178
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.177
positive regulation of extracellular matrix organization GO:1903055 4 0.176
regulation of cell proliferation involved in outflow tract morphogenesis GO:1901963 2 0.175
response to decreased oxygen levels GO:0036293 59 0.172
epithelial cell proliferation involved in prostate gland development GO:0060767 11 0.171
bmp signaling pathway GO:0030509 93 0.171
peptide hormone secretion GO:0030072 109 0.170
apoptotic process involved in embryonic digit morphogenesis GO:1902263 3 0.168
endodermal cell fate determination GO:0007493 2 0.168
positive regulation of cell cycle GO:0045787 92 0.167
Human
positive regulation of protein phosphorylation GO:0001934 242 0.167
Human
regulation of chromatin modification GO:1903308 57 0.166
cellular ketone metabolic process GO:0042180 84 0.166
oocyte axis specification GO:0007309 2 0.166
branching morphogenesis of an epithelial tube GO:0048754 159 0.164
Human
regulation of binding GO:0051098 111 0.164
regulation of intracellular protein transport GO:0033157 82 0.164
epithelial tube formation GO:0072175 130 0.164
ear development GO:0043583 200 0.164
multicellular organismal homeostasis GO:0048871 164 0.163
regulation of cell adhesion GO:0030155 154 0.162
regulation of organ morphogenesis GO:2000027 144 0.162
regulation of skeletal muscle fiber development GO:0048742 36 0.162
detection of chemical stimulus involved in sensory perception GO:0050907 10 0.162
Mouse
negative regulation of cholesterol transport GO:0032375 4 0.159
regulation of embryonic development GO:0045995 71 0.158
negative regulation of intracellular protein transport GO:0090317 27 0.158
negative regulation of mesodermal cell fate specification GO:0042662 3 0.157
mesoderm formation GO:0001707 62 0.157
fertilization GO:0009566 127 0.154
Mouse
regulation of proteolysis GO:0030162 164 0.154
regulation of heart morphogenesis GO:2000826 22 0.154
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.153
mesenchymal cell differentiation GO:0048762 107 0.153
cell migration involved in gastrulation GO:0042074 13 0.151
myotube differentiation GO:0014902 105 0.151
regulation of spindle organization GO:0090224 2 0.150
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.149
intracellular lipid transport GO:0032365 3 0.149
cyclic nucleotide metabolic process GO:0009187 59 0.148
Mouse
negative regulation of cell cycle GO:0045786 123 0.147
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 6 0.147
Human
regulation of cell projection organization GO:0031344 206 0.147
regulation of transporter activity GO:0032409 57 0.146
Mouse
nuclear import GO:0051170 95 0.145
regulation of leukocyte differentiation GO:1902105 159 0.144
nucleocytoplasmic transport GO:0006913 139 0.144
intrahepatic bile duct development GO:0035622 2 0.144
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.144
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.144
receptor mediated endocytosis of low density lipoprotein particle involved in cholesterol transport GO:0090118 1 0.143
nuclear transport GO:0051169 139 0.141
positive regulation of metanephric mesenchymal cell migration GO:2000591 1 0.141
hair cycle GO:0042633 90 0.141
morphogenesis of an epithelial sheet GO:0002011 27 0.140
face development GO:0060324 38 0.140
regulation of calcium ion dependent exocytosis GO:0017158 16 0.140
Mouse
regulation of kinase activity GO:0043549 249 0.139
Human
ureteric bud morphogenesis GO:0060675 62 0.139
associative learning GO:0008306 61 0.138
regulation of protein import into nucleus GO:0042306 52 0.135
divalent inorganic cation transport GO:0072511 178 0.135
carbohydrate homeostasis GO:0033500 128 0.134
regulation of cellular ketone metabolic process GO:0010565 66 0.134
regulation of retinal ganglion cell axon guidance GO:0090259 2 0.134
lymph vessel morphogenesis GO:0036303 11 0.133
ribonucleotide metabolic process GO:0009259 291 0.133
Mouse
regulation of endodermal cell differentiation GO:1903224 2 0.132
response to ph GO:0009268 14 0.132
Mouse
regulation of transmembrane transport GO:0034762 128 0.132
Mouse
cardiac right ventricle formation GO:0003219 3 0.132
spermatid differentiation GO:0048515 115 0.131
aminoglycan metabolic process GO:0006022 34 0.130
positive regulation of dna templated transcription elongation GO:0032786 2 0.130
positive regulation of cell motility GO:2000147 116 0.130
negative regulation of calcium ion transmembrane transport GO:1903170 1 0.129
Mouse
cardiac septum morphogenesis GO:0060411 46 0.129
presynaptic membrane organization GO:0097090 8 0.128
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:1900238 1 0.128
response to radiation GO:0009314 165 0.128
mammary gland epithelium development GO:0061180 65 0.127
heart valve development GO:0003170 23 0.126
regulation of myoblast differentiation GO:0045661 29 0.126
brain morphogenesis GO:0048854 32 0.125
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.124
negative regulation of cell motility GO:2000146 61 0.124
collagen biosynthetic process GO:0032964 7 0.122
regulation of chromosome organization GO:0033044 83 0.121
pronephros morphogenesis GO:0072114 1 0.121
g1 s transition of mitotic cell cycle GO:0000082 57 0.121
Human
protein export from nucleus GO:0006611 20 0.120
transmembrane transport GO:0055085 412 0.120
glomerular capillary formation GO:0072104 6 0.120
regulation of hormone secretion GO:0046883 88 0.119
nitrogen compound transport GO:0071705 271 0.117
divalent inorganic cation homeostasis GO:0072507 138 0.117
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.117
glucose metabolic process GO:0006006 92 0.117
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.115
dna metabolic process GO:0006259 303 0.115
cell growth GO:0016049 130 0.115
purine nucleotide metabolic process GO:0006163 302 0.115
Mouse
face morphogenesis GO:0060325 29 0.114
mesonephric tubule morphogenesis GO:0072171 63 0.114
detection of stimulus involved in sensory perception GO:0050906 44 0.114
Mouse
cytoplasmic transport GO:0016482 234 0.114
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:0035793 1 0.113
response to hyperoxia GO:0055093 2 0.113
external genitalia morphogenesis GO:0035261 1 0.113
organonitrogen compound biosynthetic process GO:1901566 192 0.113
cerebellum development GO:0021549 77 0.113
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.112
regulation of calcium ion transport GO:0051924 69 0.112
Mouse
molting cycle GO:0042303 90 0.111
negative regulation of sterol transport GO:0032372 4 0.111
cholesterol homeostasis GO:0042632 44 0.111
regulation of cell cycle g1 s phase transition GO:1902806 35 0.111
multi organism reproductive behavior GO:0044705 29 0.110
Worm
purine containing compound metabolic process GO:0072521 311 0.109
Mouse
negative regulation of cell development GO:0010721 169 0.108
covalent chromatin modification GO:0016569 163 0.108
divalent metal ion transport GO:0070838 172 0.108
regulation of lymphocyte differentiation GO:0045619 107 0.108
primary neural tube formation GO:0014020 95 0.108
nucleotide metabolic process GO:0009117 332 0.108
Mouse
cardiac chamber development GO:0003205 108 0.108
regulation of microtubule cytoskeleton organization GO:0070507 37 0.108
microtubule based process GO:0007017 236 0.107
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.107
negative regulation of cation channel activity GO:2001258 1 0.106
Mouse
cation transmembrane transport GO:0098655 266 0.106
positive regulation of bmp signaling pathway GO:0030513 23 0.105
regulation of protein serine threonine kinase activity GO:0071900 157 0.105
Human
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.104
extracellular matrix organization GO:0030198 147 0.104
neuroblast differentiation GO:0014016 2 0.104
regulation of removal of superoxide radicals GO:2000121 4 0.103
ameboidal type cell migration GO:0001667 128 0.103
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 3 0.103
negative regulation of immune system process GO:0002683 209 0.103
sulfur compound metabolic process GO:0006790 100 0.102
spinal cord development GO:0021510 81 0.102
Human
positive regulation of sterol transport GO:0032373 9 0.101
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.101
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.100
intracellular sterol transport GO:0032366 3 0.099
multi organism behavior GO:0051705 62 0.099
Worm
negative regulation of muscle cell differentiation GO:0051148 33 0.099
positive regulation of presynaptic membrane organization GO:1901631 1 0.098
regulation of microtubule based process GO:0032886 52 0.098
endodermal digestive tract morphogenesis GO:0061031 4 0.098
nephron morphogenesis GO:0072028 69 0.097
Human
developmental pigmentation GO:0048066 40 0.095
locomotory behavior GO:0007626 195 0.095
positive regulation of keratinocyte differentiation GO:0045618 3 0.095
mitotic spindle organization GO:0007052 10 0.095
forebrain development GO:0030900 302 0.094
neural retina development GO:0003407 41 0.093
negative regulation of myotube differentiation GO:0010832 9 0.093
regulation of cellular component biogenesis GO:0044087 181 0.092
cardiac septum development GO:0003279 59 0.092
endocrine system development GO:0035270 98 0.092
mitral valve morphogenesis GO:0003183 4 0.092
histone modification GO:0016570 159 0.091
lung alveolus development GO:0048286 45 0.091
detection of stimulus GO:0051606 84 0.091
histone acetylation GO:0016573 41 0.090
distal tubule development GO:0072017 8 0.090
Human
muscle cell differentiation GO:0042692 261 0.090
positive regulation of protein catabolic process GO:0045732 60 0.089
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.089
regulation of multicellular organismal metabolic process GO:0044246 14 0.089
regulation of cellular protein catabolic process GO:1903362 61 0.088
positive regulation of leukocyte differentiation GO:1902107 86 0.088
heart field specification GO:0003128 6 0.088
ovarian follicle development GO:0001541 40 0.087
negative regulation of leukocyte differentiation GO:1902106 51 0.087
regulation of secretion by cell GO:1903530 249 0.087
Mouse
positive regulation of axon extension GO:0045773 20 0.087
cellular glucose homeostasis GO:0001678 52 0.087
amine metabolic process GO:0009308 45 0.086
cellular response to glucose stimulus GO:0071333 45 0.086
gonad development GO:0008406 141 0.086
chondroitin sulfate proteoglycan metabolic process GO:0050654 20 0.086
cardiocyte differentiation GO:0035051 87 0.085
cardiac cell fate specification GO:0060912 2 0.085
renal system vasculature development GO:0061437 15 0.085
cation homeostasis GO:0055080 212 0.085
Mouse
ventricular septum morphogenesis GO:0060412 27 0.085
regulation of establishment of protein localization GO:0070201 181 0.084
mammary gland alveolus development GO:0060749 22 0.084
positive regulation of hydrolase activity GO:0051345 148 0.084
cell matrix adhesion GO:0007160 68 0.083
positive regulation of mitotic cell cycle GO:0045931 41 0.083
replacement ossification GO:0036075 26 0.082
somite specification GO:0001757 4 0.082
response to reactive oxygen species GO:0000302 56 0.082
ascending aorta morphogenesis GO:0035910 3 0.082
leukocyte differentiation GO:0002521 342 0.081
regulation of muscle tissue development GO:1901861 97 0.081
peptidyl lysine modification GO:0018205 77 0.080
beta amyloid clearance GO:0097242 2 0.080
mesenchymal cell development GO:0014031 93 0.080
sensory perception of sound GO:0007605 97 0.080
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 2 0.080
cellular metal ion homeostasis GO:0006875 151 0.080
Mouse
mucopolysaccharide metabolic process GO:1903510 25 0.079
forebrain radial glial cell differentiation GO:0021861 4 0.079
positive regulation of cell development GO:0010720 237 0.079
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.079
Human
positive regulation of mitosis GO:0045840 14 0.078
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.078
glial cell fate determination GO:0007403 3 0.078
negative regulation of cell fate specification GO:0009996 4 0.077
regulation of wnt signaling pathway involved in heart development GO:0003307 5 0.077
mesoderm morphogenesis GO:0048332 64 0.077
left right axis specification GO:0070986 13 0.077
Mouse
response to organonitrogen compound GO:0010243 246 0.077
frontal suture morphogenesis GO:0060364 2 0.077
atrioventricular node development GO:0003162 3 0.076
multi multicellular organism process GO:0044706 109 0.076
Worm

Pkd1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.987
musculoskeletal system disease DOID:17 0 0.987
connective tissue disease DOID:65 0 0.987
bone disease DOID:0080001 0 0.661
bone development disease DOID:0080006 0 0.382
dysostosis DOID:1934 0 0.382
osteochondrodysplasia DOID:2256 0 0.231
disease of cellular proliferation DOID:14566 0 0.202