IMP
Process View
pro b cell differentiation
The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "pro b cell differentiation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Kdr | kinase insert domain protein receptor | 0.836 | Mouse | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.835 | ||
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.810 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.763 | ||
| Shh | sonic hedgehog | 0.734 | ||
| Meox2 | mesenchyme homeobox 2 | 0.713 | ||
| Trp53 | transformation related protein 53 | 0.598 | ||
| Vegfa | vascular endothelial growth factor A | 0.574 | ||
| Pten | phosphatase and tensin homolog | 0.563 | ||
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.470 | Mouse | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.469 | ||
| Dll1 | delta-like 1 (Drosophila) | 0.429 | ||
| Rb1 | retinoblastoma 1 | 0.406 | ||
| Pkd1 | polycystic kidney disease 1 homolog | 0.364 | ||
| Nf1 | neurofibromatosis 1 | 0.336 | ||
| Foxc1 | forkhead box C1 | 0.316 | ||
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.278 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.257 | ||
| Tie1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 0.247 | ||
| Foxc2 | forkhead box C2 | 0.222 | ||
| Sox2 | SRY-box containing gene 2 | 0.222 | Mouse | |
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.205 | Human | |
| Bmp4 | bone morphogenetic protein 4 | 0.203 | ||
| Psen1 | presenilin 1 | 0.177 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.176 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.176 | ||
| Cdh5 | cadherin 5 | 0.164 | ||
| Slc9a3r2 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 | 0.159 | ||
| Pdgfb | platelet derived growth factor, B polypeptide | 0.153 | ||
| Sox18 | SRY-box containing gene 18 | 0.152 | Mouse | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.139 | ||
| Pax6 | paired box gene 6 | 0.137 | ||
| Rbpj | recombination signal binding protein for immunoglobulin kappa J region | 0.122 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.117 | ||
| Pax3 | paired box gene 3 | 0.113 | ||
| She | src homology 2 domain-containing transforming protein E | 0.110 | ||
| Flt4 | FMS-like tyrosine kinase 4 | 0.109 | Mouse | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.108 | ||
| Cbl | Casitas B-lineage lymphoma | 0.106 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.105 | ||
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.105 | ||
| Hey2 | hairy/enhancer-of-split related with YRPW motif 2 | 0.103 | ||
| Efnb2 | ephrin B2 | 0.102 | ||
| Ptch1 | patched homolog 1 | 0.101 | ||
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.100 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.098 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.097 | ||
| Grb2 | growth factor receptor bound protein 2 | 0.092 | ||
| Sox4 | SRY-box containing gene 4 | 0.091 | ||
| Tgfb2 | transforming growth factor, beta 2 | 0.085 | ||
| Sox9 | SRY-box containing gene 9 | 0.085 | Mouse | |
| Alx4 | aristaless-like homeobox 4 | 0.081 | ||
| Tcfap2a | transcription factor AP-2, alpha | 0.081 | ||
| Egfl7 | EGF-like domain 7 | 0.075 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.070 | ||
| Pik3ca | phosphatidylinositol 3-kinase, catalytic, alpha polypeptide | 0.068 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.063 | ||
| Notch3 | Notch gene homolog 3 (Drosophila) | 0.063 | Mouse | |
| Sox17 | SRY-box containing gene 17 | 0.062 | Mouse | |
| Hhex | hematopoietically expressed homeobox | 0.061 | ||
| Plcg1 | phospholipase C, gamma 1 | 0.061 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.059 | ||
| Fgf8 | fibroblast growth factor 8 | 0.059 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.059 | ||
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.056 | ||
| Nog | noggin | 0.055 | ||
| Runx2 | runt related transcription factor 2 | 0.054 | ||
| Ret | ret proto-oncogene | 0.054 | ||
| Hspg2 | perlecan (heparan sulfate proteoglycan 2) | 0.053 | ||
| Jag1 | jagged 1 | 0.051 | ||
| Egfr | epidermal growth factor receptor | 0.050 | ||
| Kit | kit oncogene | 0.049 | Mouse | |
| Hesx1 | homeobox gene expressed in ES cells | 0.048 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.048 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.047 | ||
| Nfatc2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.047 | ||
| Flt1 | FMS-like tyrosine kinase 1 | 0.045 | Mouse | |
| Vegfc | vascular endothelial growth factor C | 0.043 | ||
| Eng | endoglin | 0.041 | ||
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.039 | ||
| Hey1 | hairy/enhancer-of-split related with YRPW motif 1 | 0.035 | ||
| Smo | smoothened homolog (Drosophila) | 0.035 | ||
| Gja1 | gap junction protein, alpha 1 | 0.034 | ||
| Rag1 | recombination activating gene 1 | 0.033 | ||
| Kitl | kit ligand | 0.033 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.031 | ||
| Flcn | folliculin | 0.031 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.030 | ||
| Cxcl12 | chemokine (C-X-C motif) ligand 12 | 0.030 | ||
| Fnip1 | folliculin interacting protein 1 | 0.030 | ||
| Epas1 | endothelial PAS domain protein 1 | 0.030 | ||
| Bmp7 | bone morphogenetic protein 7 | 0.029 | ||
| Arap3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 | 0.028 | ||
| Tbx2 | T-box 2 | 0.027 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.026 | ||
| Pthlh | parathyroid hormone-like peptide | 0.026 | ||
| Emcn | endomucin | 0.026 | ||
| Dclre1c | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) | 0.025 | ||
| Tek | endothelial-specific receptor tyrosine kinase | 0.025 | ||
| Cd19 | CD19 antigen | 0.025 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.025 | ||
| Dll4 | delta-like 4 (Drosophila) | 0.024 | ||
| Lepr | leptin receptor | 0.024 | ||
| Adcy4 | adenylate cyclase 4 | 0.024 | ||
| Cldn5 | claudin 5 | 0.024 | ||
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.023 | ||
| Ptprb | protein tyrosine phosphatase, receptor type, B | 0.023 | ||
| Apc | adenomatosis polyposis coli | 0.022 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.022 | ||
| Lama5 | laminin, alpha 5 | 0.021 | ||
| Gli2 | GLI-Kruppel family member GLI2 | 0.020 | ||
| Bmp2 | bone morphogenetic protein 2 | 0.020 | ||
| Crebbp | CREB binding protein | 0.020 | ||
| Ntf3 | neurotrophin 3 | 0.020 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.019 | ||
| Psen2 | presenilin 2 | 0.019 | ||
| Robo4 | roundabout homolog 4 (Drosophila) | 0.018 | ||
| Ldlr | low density lipoprotein receptor | 0.018 | ||
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.018 | ||
| Tyrobp | TYRO protein tyrosine kinase binding protein | 0.018 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.018 | ||
| Esam | endothelial cell-specific adhesion molecule | 0.017 | ||
| Alx1 | ALX homeobox 1 | 0.017 | ||
| Rxra | retinoid X receptor alpha | 0.016 | ||
| Fgd5 | FYVE, RhoGEF and PH domain containing 5 | 0.016 | ||
| 4933421E11Rik | RIKEN cDNA 4933421E11 gene | 0.016 | ||
| Lef1 | lymphoid enhancer binding factor 1 | 0.016 | ||
| Rasip1 | Ras interacting protein 1 | 0.016 | ||
| Tcirg1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 | 0.016 | ||
| Tbx3 | T-box 3 | 0.015 | ||
| Vwf | Von Willebrand factor homolog | 0.015 | ||
| Jag2 | jagged 2 | 0.015 | ||
| Hlx | H2.0-like homeobox | 0.015 | ||
| Foxg1 | forkhead box G1 | 0.014 | ||
| Podxl | podocalyxin-like | 0.014 | ||
| Sirt1 | sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) | 0.014 | ||
| Sall4 | sal-like 4 (Drosophila) | 0.014 | ||
| Smad6 | MAD homolog 6 (Drosophila) | 0.014 | ||
| Prrx1 | paired related homeobox 1 | 0.014 | ||
| Aplnr | apelin receptor | 0.014 | ||
| Sox11 | SRY-box containing gene 11 | 0.014 | Mouse | |
| Gata2 | GATA binding protein 2 | 0.014 | ||
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.013 | ||
| Col15a1 | collagen, type XV, alpha 1 | 0.013 | ||
| Nkx2-3 | NK2 transcription factor related, locus 3 (Drosophila) | 0.013 | ||
| Pofut1 | protein O-fucosyltransferase 1 | 0.013 | ||
| Mmrn2 | multimerin 2 | 0.013 | ||
| Rarb | retinoic acid receptor, beta | 0.012 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.012 | ||
| Mobp | myelin-associated oligodendrocytic basic protein | 0.012 | ||
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.012 | ||
| Klhl24 | kelch-like 24 (Drosophila) | 0.012 | ||
| Cmklr1 | chemokine-like receptor 1 | 0.012 | ||
| Lhx3 | LIM homeobox protein 3 | 0.012 | ||
| Insm1 | insulinoma-associated 1 | 0.012 | ||
| Gja4 | gap junction protein, alpha 4 | 0.011 | ||
| Tmem204 | transmembrane protein 204 | 0.011 | ||
| Col4a2 | collagen, type IV, alpha 2 | 0.011 | ||
| Msx1 | homeobox, msh-like 1 | 0.011 | ||
| Bcl6b | B-cell CLL/lymphoma 6, member B | 0.011 | ||
| Shank3 | SH3/ankyrin domain gene 3 | 0.011 | ||
| Mcl1 | myeloid cell leukemia sequence 1 | 0.011 | ||
| Tcf15 | transcription factor 15 | 0.011 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.011 | ||
| Igh | immunoglobulin heavy chain complex | 0.011 | ||
| Osbpl11 | oxysterol binding protein-like 11 | 0.011 | ||
| Gata4 | GATA binding protein 4 | 0.011 | ||
| Stab1 | stabilin 1 | 0.011 | ||
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.011 | ||
| Plvap | plasmalemma vesicle associated protein | 0.010 | ||
| Icam2 | intercellular adhesion molecule 2 | 0.010 | ||
| Fzd4 | frizzled homolog 4 (Drosophila) | 0.010 |