Mus musculus

139 known processes

Ptgs2

prostaglandin-endoperoxide synthase 2

(Aliases: PHS-2,PGHS-2,COX2,TIS10,Pghs2,Cox-2)

Ptgs2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ovulation GO:0030728 15 1.000
Rat
metanephric glomerular mesangium development GO:0072223 3 0.999
placenta development GO:0001890 140 0.998
response to corticosteroid GO:0031960 20 0.996
Rat
branching involved in salivary gland morphogenesis GO:0060445 26 0.996
reactive oxygen species metabolic process GO:0072593 84 0.996
positive regulation of inflammatory response GO:0050729 47 0.996
regulation of ovulation GO:0060278 3 0.996
kidney development GO:0001822 213 0.994
positive regulation of programmed cell death GO:0043068 218 0.994
Rat
regulation of peptidase activity GO:0052547 96 0.993
response to glucocorticoid GO:0051384 20 0.991
Rat
fibrinolysis GO:0042730 3 0.991
negative regulation of cell proliferation GO:0008285 296 0.990
Rat
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.990
inflammatory response GO:0006954 244 0.988
defense response to other organism GO:0098542 197 0.987
chemotaxis GO:0006935 247 0.986
response to peptide hormone GO:0043434 127 0.986
regulation of heat generation GO:0031650 8 0.986
cellular response to lipid GO:0071396 145 0.985
positive regulation of protein modification process GO:0031401 299 0.985
blood coagulation GO:0007596 76 0.983
regulation of inflammatory response GO:0050727 147 0.983
positive regulation of defense response GO:0031349 124 0.983
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.982
interleukin 18 mediated signaling pathway GO:0035655 2 0.982
angiogenesis GO:0001525 201 0.981
Rat
regulation of multi organism process GO:0043900 111 0.980
positive regulation of leukocyte differentiation GO:1902107 86 0.978
renal system development GO:0072001 225 0.977
regulation of peptidyl serine phosphorylation GO:0033135 39 0.977
cell type specific apoptotic process GO:0097285 268 0.977
positive regulation of glial cell proliferation GO:0060252 4 0.975
cellular response to organic cyclic compound GO:0071407 87 0.975
Zebrafish Rat
hepatocyte growth factor receptor signaling pathway GO:0048012 3 0.975
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.974
extrinsic apoptotic signaling pathway GO:0097191 126 0.973
regulation of apoptotic signaling pathway GO:2001233 197 0.972
vasoconstriction GO:0042310 27 0.971
Rat
female gamete generation GO:0007292 74 0.969
Rat
alpha amino acid metabolic process GO:1901605 59 0.969
regulation of cellular amino acid metabolic process GO:0006521 5 0.969
morphogenesis of a branching structure GO:0001763 203 0.965
positive regulation of cell death GO:0010942 224 0.965
Rat
defense response to bacterium GO:0042742 119 0.965
urogenital system development GO:0001655 261 0.964
neuron apoptotic process GO:0051402 142 0.962
smooth muscle cell migration GO:0014909 10 0.961
regulation of protein kinase activity GO:0045859 232 0.959
response to organophosphorus GO:0046683 22 0.956
Rat
regulation of proteolysis GO:0030162 164 0.954
regulation of endopeptidase activity GO:0052548 89 0.954
cellular amine metabolic process GO:0044106 44 0.953
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.952
response to dexamethasone GO:0071548 8 0.952
response to corticosterone GO:0051412 1 0.950
blood vessel morphogenesis GO:0048514 285 0.950
Rat
drug catabolic process GO:0042737 2 0.949
fever generation GO:0001660 7 0.946
response to lipopolysaccharide GO:0032496 128 0.945
Rat
cytokine production GO:0001816 319 0.943
Rat
decidualization GO:0046697 10 0.937
maternal process involved in female pregnancy GO:0060135 32 0.937
positive regulation of proteolysis GO:0045862 85 0.935
response to camp GO:0051591 14 0.935
cell substrate adhesion GO:0031589 130 0.933
renal tubule development GO:0061326 87 0.930
regulation of cell migration GO:0030334 219 0.930
Rat
response to oxygen levels GO:0070482 62 0.930
Human
neuron death GO:0070997 154 0.930
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.929
apoptotic signaling pathway GO:0097190 306 0.923
negative regulation of protein metabolic process GO:0051248 282 0.920
lymphocyte homeostasis GO:0002260 64 0.918
mesonephric tubule development GO:0072164 94 0.914
leukocyte migration GO:0050900 124 0.914
regulation of neuron apoptotic process GO:0043523 122 0.911
positive regulation of kinase activity GO:0033674 155 0.910
response to alcohol GO:0097305 48 0.906
Rat
positive regulation of peptidyl serine phosphorylation GO:0033138 25 0.905
neuronal action potential GO:0019228 54 0.895
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.895
t cell differentiation GO:0030217 174 0.891
regulation of neuron death GO:1901214 134 0.891
negative regulation of intracellular signal transduction GO:1902532 167 0.890
cellular response to interleukin 18 GO:0071351 3 0.890
regulation of cell activation GO:0050865 289 0.887
hemostasis GO:0007599 78 0.886
inflammatory response to wounding GO:0090594 4 0.885
response to hypoxia GO:0001666 58 0.883
Human
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.880
positive regulation of neuron apoptotic process GO:0043525 25 0.879
epithelial tube morphogenesis GO:0060562 303 0.878
response to growth factor GO:0070848 198 0.878
synaptic transmission GO:0007268 329 0.878
Rat
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.878
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 2 0.876
regulation of defense response GO:0031347 233 0.875
positive regulation of apoptotic process GO:0043065 217 0.875
Rat
embryonic placenta development GO:0001892 98 0.875
regulation of blood vessel size GO:0050880 56 0.870
Rat
keratinocyte migration GO:0051546 3 0.870
negative regulation of neuron apoptotic process GO:0043524 92 0.869
regulation of blood circulation GO:1903522 93 0.869
Rat
cellular homeostasis GO:0019725 240 0.868
cation homeostasis GO:0055080 212 0.862
regulation of renal output by angiotensin GO:0002019 2 0.859
leukocyte homeostasis GO:0001776 79 0.858
acute phase response GO:0006953 10 0.855
organonitrogen compound biosynthetic process GO:1901566 192 0.854
cellular response to cytokine stimulus GO:0071345 189 0.853
axonogenesis GO:0007409 274 0.851
response to oxidative stress GO:0006979 123 0.846
regulation of cellular amine metabolic process GO:0033238 20 0.844
morphogenesis of a branching epithelium GO:0061138 193 0.842
cellular calcium ion homeostasis GO:0006874 119 0.842
cell matrix adhesion GO:0007160 68 0.842
muscle system process GO:0003012 141 0.840
Rat
metal ion homeostasis GO:0055065 189 0.837
multi multicellular organism process GO:0044706 109 0.835
regulation of lymphocyte differentiation GO:0045619 107 0.832
axon guidance GO:0007411 141 0.828
trophoblast giant cell differentiation GO:0060707 15 0.825
cellular response to molecule of bacterial origin GO:0071219 83 0.825
cellular response to drug GO:0035690 15 0.824
cellular ion homeostasis GO:0006873 165 0.824
response to hyperoxia GO:0055093 2 0.824
cellular response to external stimulus GO:0071496 88 0.823
Rat
response to interleukin 1 GO:0070555 11 0.823
muscle contraction GO:0006936 101 0.821
Rat
muscle cell migration GO:0014812 19 0.820
positive regulation of apoptotic signaling pathway GO:2001235 95 0.818
gland development GO:0048732 330 0.818
regulation of smooth muscle cell migration GO:0014910 6 0.812
cellular response to glucocorticoid stimulus GO:0071385 13 0.812
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.810
response to organic cyclic compound GO:0014070 198 0.805
Zebrafish Rat
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.804
regulation of vasculature development GO:1901342 88 0.803
Rat
rhombomere 5 formation GO:0021666 1 0.801
regulation of homeostatic process GO:0032844 182 0.800
muscle cell differentiation GO:0042692 261 0.800
rhythmic process GO:0048511 174 0.797
signal transduction by p53 class mediator GO:0072331 51 0.795
cell adhesion GO:0007155 329 0.791
positive regulation of protein phosphorylation GO:0001934 242 0.791
cellular response to vitamin d GO:0071305 2 0.790
negative regulation of cellular protein metabolic process GO:0032269 247 0.784
positive regulation of fever generation GO:0031622 6 0.783
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.783
negative regulation of protein processing GO:0010955 79 0.782
adrenal cortex development GO:0035801 2 0.775
negative regulation of secretion by cell GO:1903531 54 0.775
ossification GO:0001503 216 0.773
Rat
cellular chemical homeostasis GO:0055082 215 0.761
cellular response to extracellular stimulus GO:0031668 81 0.761
muscle cell cellular homeostasis GO:0046716 12 0.760
response to organonitrogen compound GO:0010243 246 0.758
Rat
stem cell development GO:0048864 219 0.757
heat generation GO:0031649 13 0.755
regionalization GO:0003002 337 0.754
adrenergic receptor signaling pathway involved in heart process GO:0086023 3 0.752
brown fat cell differentiation GO:0050873 36 0.751
leukocyte apoptotic process GO:0071887 71 0.748
cytokine mediated signaling pathway GO:0019221 115 0.745
response to increased oxygen levels GO:0036296 2 0.743
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.743
response to ketone GO:1901654 15 0.743
cellular response to peptide GO:1901653 92 0.742
wound healing GO:0042060 157 0.741
salivary gland development GO:0007431 37 0.740
regulation of mapk cascade GO:0043408 248 0.738
negative regulation of response to wounding GO:1903035 77 0.738
immune effector process GO:0002252 321 0.734
metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072262 3 0.732
glial cell apoptotic process GO:0034349 3 0.731
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.730
interleukin 5 secretion GO:0072603 2 0.729
regulation of synaptic plasticity GO:0048167 87 0.728
Rat
negative regulation of apoptotic signaling pathway GO:2001234 104 0.727
response to amphetamine GO:0001975 16 0.727
negative regulation of peptidyl serine phosphorylation GO:0033137 10 0.724
cellular response to growth factor stimulus GO:0071363 197 0.721
reactive nitrogen species metabolic process GO:2001057 0 0.720
salivary gland morphogenesis GO:0007435 33 0.719
muscle cell development GO:0055001 133 0.718
positive regulation of organ growth GO:0046622 29 0.715
response to molecule of bacterial origin GO:0002237 143 0.714
Rat
lymphocyte differentiation GO:0030098 242 0.713
gliogenesis GO:0042063 141 0.713
coagulation GO:0050817 78 0.712
ovulation from ovarian follicle GO:0001542 9 0.707
positive regulation of lymphocyte activation GO:0051251 140 0.702
divalent inorganic cation homeostasis GO:0072507 138 0.699
ureteric bud development GO:0001657 94 0.695
nephron tubule development GO:0072080 84 0.694
amine metabolic process GO:0009308 45 0.692
long term synaptic potentiation GO:0060291 25 0.688
regulation of cell adhesion GO:0030155 154 0.684
regulation of glomerular mesangial cell proliferation GO:0072124 1 0.682
leukocyte differentiation GO:0002521 342 0.680
regulation of kinase activity GO:0043549 249 0.677
cellular amino acid metabolic process GO:0006520 103 0.675
vascular process in circulatory system GO:0003018 62 0.674
Rat
negative regulation of proteolysis GO:0045861 74 0.672
negative regulation of neurotransmitter uptake GO:0051581 2 0.671
negative regulation of metanephric glomerulus development GO:0072299 1 0.670
protein maturation GO:0051604 176 0.668
cellular response to biotic stimulus GO:0071216 92 0.667
t cell differentiation in thymus GO:0033077 77 0.666
peptidyl serine modification GO:0018209 83 0.665
negative regulation of chemokine production GO:0032682 4 0.662
positive regulation of acute inflammatory response GO:0002675 16 0.662
negative regulation of endopeptidase activity GO:0010951 44 0.659
t cell activation GO:0042110 289 0.657
metanephric glomerulus vasculature development GO:0072239 7 0.654
cellular response to hypoxia GO:0071456 17 0.652
Human
cellular response to lipopolysaccharide GO:0071222 77 0.645
regulation of protein catabolic process GO:0042176 108 0.645
multicellular organism growth GO:0035264 161 0.642
mapk cascade GO:0000165 281 0.640
regulation of branching involved in salivary gland morphogenesis GO:0060693 11 0.640
cellular response to acid chemical GO:0071229 68 0.638
cell fate commitment GO:0045165 210 0.632
anion transport GO:0006820 177 0.625
regulation of acute inflammatory response GO:0002673 27 0.625
regulation of superoxide anion generation GO:0032928 4 0.624
mammary gland lobule development GO:0061377 22 0.623
ameboidal type cell migration GO:0001667 128 0.622
Rat
cellular divalent inorganic cation homeostasis GO:0072503 127 0.621
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 22 0.619
negative regulation of chemokine biosynthetic process GO:0045079 2 0.616
regulation of protein serine threonine kinase activity GO:0071900 157 0.615
response to decreased oxygen levels GO:0036293 59 0.615
Human
cellular metal ion homeostasis GO:0006875 151 0.614
glomerulus development GO:0032835 40 0.614
kidney epithelium development GO:0072073 121 0.613
response to steroid hormone GO:0048545 56 0.612
Rat
regulation of myeloid cell differentiation GO:0045637 96 0.612
positive t cell selection GO:0043368 23 0.611
regulation of tube size GO:0035150 57 0.607
Rat
regulation of cellular ketone metabolic process GO:0010565 66 0.606
cell chemotaxis GO:0060326 81 0.605
positive regulation of cytokine production GO:0001819 174 0.601
Rat
development of primary sexual characteristics GO:0045137 143 0.600
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.598
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.597
negative regulation of hydrolase activity GO:0051346 71 0.591
peptidyl serine phosphorylation GO:0018105 74 0.590
positive regulation of cellular amine metabolic process GO:0033240 5 0.582
muscle tissue development GO:0060537 308 0.582
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.581
negative regulation of vasculature development GO:1901343 26 0.581
negative regulation of fat cell differentiation GO:0045599 36 0.580
response to radiation GO:0009314 165 0.580
Rat
developmental growth involved in morphogenesis GO:0060560 138 0.578
positive regulation of t cell proliferation GO:0042102 52 0.577
wound healing involved in inflammatory response GO:0002246 4 0.576
regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902253 13 0.574
peptidyl amino acid modification GO:0018193 336 0.574
cellular response to steroid hormone stimulus GO:0071383 33 0.574
regulation of cell substrate adhesion GO:0010810 73 0.573
renin angiotensin regulation of aldosterone production GO:0002018 3 0.573
nitric oxide metabolic process GO:0046209 25 0.573
Rat
negative regulation of protein maturation GO:1903318 79 0.571
negative regulation of phosphate metabolic process GO:0045936 184 0.567
muscle adaptation GO:0043500 39 0.566
regulation of protein processing GO:0070613 96 0.564
regulation of ion transport GO:0043269 215 0.563
Rat
regulation of interleukin 6 production GO:0032675 55 0.563
kidney morphogenesis GO:0060993 83 0.562
regulation of muscle system process GO:0090257 80 0.562
Rat
positive regulation of response to wounding GO:1903036 66 0.562
regulation of wnt signaling pathway GO:0030111 123 0.561
regulation of membrane potential GO:0042391 192 0.561
cellular response to peptide hormone stimulus GO:0071375 92 0.557
regulation of interleukin 5 secretion GO:2000662 2 0.557
lipid modification GO:0030258 65 0.557
mesonephros development GO:0001823 97 0.556
regulation of organelle organization GO:0033043 289 0.556
regulation of organ morphogenesis GO:2000027 144 0.554
spermatid development GO:0007286 108 0.553
skeletal muscle organ development GO:0060538 163 0.552
metanephros development GO:0001656 79 0.548
regulation of wound healing GO:0061041 40 0.548
protein catabolic process GO:0030163 221 0.547
regulation of gliogenesis GO:0014013 50 0.546
regulation of fibroblast proliferation GO:0048145 34 0.543
branching involved in ureteric bud morphogenesis GO:0001658 56 0.541
negative regulation of wound healing GO:0061045 14 0.541
lymphocyte migration GO:0072676 26 0.535
acute inflammatory response GO:0002526 41 0.535
negative regulation of reactive oxygen species biosynthetic process GO:1903427 0 0.531
purine nucleotide biosynthetic process GO:0006164 65 0.530
interleukin 13 secretion GO:0072611 2 0.529
positive regulation of cell activation GO:0050867 158 0.529
hepaticobiliary system development GO:0061008 67 0.526
camera type eye development GO:0043010 266 0.525
circadian rhythm GO:0007623 114 0.524
extracellular matrix organization GO:0030198 147 0.523
neuron projection guidance GO:0097485 141 0.523
cellular response to alcohol GO:0097306 23 0.523
regulation of cysteine type endopeptidase activity GO:2000116 65 0.521
response to ionizing radiation GO:0010212 42 0.520
positive regulation of b cell proliferation GO:0030890 24 0.515
activation of cysteine type endopeptidase activity GO:0097202 27 0.513
regulation of ossification GO:0030278 112 0.512
striated muscle tissue development GO:0014706 293 0.510
regulation of fever generation GO:0031620 6 0.510
positive regulation of adrenergic receptor signaling pathway GO:0071879 3 0.507
dna metabolic process GO:0006259 303 0.507
positive regulation of leukocyte mediated immunity GO:0002705 70 0.506
development of primary female sexual characteristics GO:0046545 73 0.505
negative regulation of hemostasis GO:1900047 11 0.504
adrenal cortex formation GO:0035802 2 0.503
negative regulation of ion transport GO:0043271 28 0.501
Rat
regulation of dna templated transcription in response to stress GO:0043620 9 0.500
chronic inflammatory response GO:0002544 9 0.499
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.497
myelination GO:0042552 74 0.496
metanephric part of ureteric bud development GO:0035502 2 0.495
intracellular protein transport GO:0006886 204 0.495
Rat
intrinsic apoptotic signaling pathway GO:0097193 132 0.494
multicellular organismal signaling GO:0035637 91 0.494
cellular response to inorganic substance GO:0071241 37 0.493
ion transmembrane transport GO:0034220 361 0.493
alpha beta t cell differentiation GO:0046632 69 0.493
regulation of body fluid levels GO:0050878 162 0.491
myotube differentiation GO:0014902 105 0.491
regulation of hemostasis GO:1900046 28 0.488
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 4 0.488
arginine metabolic process GO:0006525 2 0.488
ensheathment of neurons GO:0007272 76 0.486
positive regulation of lymphocyte proliferation GO:0050671 70 0.486
positive regulation of vasoconstriction GO:0045907 4 0.486
Rat
cytosolic calcium ion homeostasis GO:0051480 70 0.483
developmental maturation GO:0021700 193 0.482
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.482
regulation of ion transmembrane transport GO:0034765 119 0.482
response to metal ion GO:0010038 47 0.480
Rat
brain segmentation GO:0035284 3 0.479
female sex differentiation GO:0046660 84 0.478
cellular amide metabolic process GO:0043603 58 0.477
negative regulation of bmp signaling pathway GO:0030514 35 0.476
cellular ketone metabolic process GO:0042180 84 0.476
drug metabolic process GO:0017144 4 0.475
rhombomere 5 development GO:0021571 4 0.475
regulation of interleukin 13 secretion GO:2000665 2 0.474
regulation of epithelial cell proliferation GO:0050678 141 0.474
cgmp mediated signaling GO:0019934 3 0.473
cellular response to amino acid stimulus GO:0071230 29 0.471
positive regulation of neuron death GO:1901216 28 0.471
exogenous drug catabolic process GO:0042738 1 0.470
cellular response to camp GO:0071320 11 0.468
negative regulation of protein phosphorylation GO:0001933 126 0.464
carbohydrate homeostasis GO:0033500 128 0.461
regulation of osteoblast differentiation GO:0045667 67 0.461
epithelial cell proliferation GO:0050673 174 0.461
regulation of reproductive process GO:2000241 66 0.460
positive regulation of myeloid cell differentiation GO:0045639 43 0.459
bmp signaling pathway GO:0030509 93 0.458
muscle cell proliferation GO:0033002 52 0.457
Rat
regulation of chronic inflammatory response to antigenic stimulus GO:0002874 3 0.456
negative regulation of ovulation GO:0060280 1 0.454
regulation of serotonin uptake GO:0051611 2 0.449
regulation of morphogenesis of a branching structure GO:0060688 53 0.448
positive regulation of protein kinase activity GO:0045860 144 0.446
positive regulation of endopeptidase activity GO:0010950 43 0.446
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.443
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.442
glial cell differentiation GO:0010001 131 0.441
positive regulation of histone modification GO:0031058 28 0.441
negative regulation of systemic arterial blood pressure GO:0003085 15 0.438
cell differentiation involved in embryonic placenta development GO:0060706 26 0.437
regulation of smad protein import into nucleus GO:0060390 3 0.437
cellular response to gamma radiation GO:0071480 4 0.434
production of molecular mediator of immune response GO:0002440 103 0.431
negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 4 0.431
regulation of leukocyte differentiation GO:1902105 159 0.426
regulation of transferase activity GO:0051338 263 0.424
organ growth GO:0035265 117 0.423
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.423
genetic imprinting GO:0071514 27 0.423
leukocyte mediated immunity GO:0002443 174 0.422
regulation of metanephric glomerulus development GO:0072298 5 0.421
metanephric mesenchyme morphogenesis GO:0072133 4 0.420
regulation of transforming growth factor beta2 production GO:0032909 2 0.420
cell growth involved in cardiac muscle cell development GO:0061049 3 0.419
response to drug GO:0042493 75 0.418
Rat
zymogen activation GO:0031638 41 0.417
interleukin 10 secretion GO:0072608 4 0.416
peptidyl tyrosine phosphorylation GO:0018108 143 0.412
negative regulation of protein modification process GO:0031400 163 0.411
regulation of t cell proliferation GO:0042129 92 0.409
granulocyte chemotaxis GO:0071621 39 0.409
action potential GO:0001508 78 0.407
regulation of metanephros development GO:0072215 15 0.407
reactive oxygen species biosynthetic process GO:1903409 8 0.405
adrenergic receptor signaling pathway GO:0071875 13 0.405
cellular response to oxidative stress GO:0034599 76 0.404
nephron epithelium development GO:0072009 92 0.402
response to peptide GO:1901652 136 0.402
gonad development GO:0008406 141 0.401
smooth muscle contraction GO:0006939 44 0.399
Rat
regulation of response to wounding GO:1903034 189 0.399
dna methylation GO:0006306 43 0.398
positive regulation of smooth muscle cell migration GO:0014911 4 0.395
regulation of hydrolase activity GO:0051336 246 0.395
interspecies interaction between organisms GO:0044419 83 0.394
heart morphogenesis GO:0003007 178 0.392
rhombomere 3 morphogenesis GO:0021658 2 0.391
organic anion transport GO:0015711 137 0.391
carbon catabolite activation of transcription GO:0045991 4 0.389
response to low density lipoprotein particle GO:0055098 2 0.389
mesonephric epithelium development GO:0072163 94 0.389
metanephric nephron development GO:0072210 34 0.388
negative regulation of molecular function GO:0044092 258 0.387
regulation of protein transport GO:0051223 163 0.386
Rat
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.385
rhombomere 3 development GO:0021569 4 0.385
positive regulation of map kinase activity GO:0043406 84 0.382
female gonad development GO:0008585 71 0.380
positive regulation of osteoclast differentiation GO:0045672 15 0.379
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.378
cellular response to hormone stimulus GO:0032870 150 0.377
t cell apoptotic process GO:0070231 39 0.377
negative regulation of neuron death GO:1901215 98 0.376
blood circulation GO:0008015 195 0.375
glomerular epithelial cell development GO:0072310 6 0.374
homeostasis of number of cells GO:0048872 210 0.371
organic acid transport GO:0015849 101 0.370
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.370
negative regulation of metanephric glomerular mesangial cell proliferation GO:0072302 1 0.369
negative regulation of interleukin 13 production GO:0032696 2 0.368
transmission of nerve impulse GO:0019226 76 0.367
mesonephric tubule morphogenesis GO:0072171 63 0.366
response to iron ion GO:0010039 4 0.366
defense response to gram negative bacterium GO:0050829 28 0.365
liver development GO:0001889 66 0.364
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation GO:2000721 2 0.362
regulation of activation of jak2 kinase activity GO:0010534 1 0.362
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 3 0.361
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.361
regulation of cell cycle GO:0051726 281 0.356
Rat
tissue regeneration GO:0042246 22 0.356
regulation of cytokine production GO:0001817 266 0.356
Rat
response to inorganic substance GO:0010035 96 0.356
Rat
cellular response to metal ion GO:0071248 31 0.355
lipid biosynthetic process GO:0008610 179 0.355
g protein coupled receptor signaling pathway involved in heart process GO:0086103 4 0.354
cellular response to abiotic stimulus GO:0071214 56 0.353
Rat
thorax and anterior abdomen determination GO:0007356 1 0.352
positive regulation of b cell mediated immunity GO:0002714 26 0.351
nephron epithelium morphogenesis GO:0072088 68 0.351
superoxide anion generation GO:0042554 11 0.350
myeloid leukocyte activation GO:0002274 83 0.349
cholesterol esterification GO:0034435 3 0.349
cellular response to increased oxygen levels GO:0036295 1 0.346
divalent metal ion transport GO:0070838 172 0.345
Rat
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.343
cellular response to corticosteroid stimulus GO:0071384 13 0.342
fatty acid metabolic process GO:0006631 121 0.341
macromolecule catabolic process GO:0009057 281 0.340
activation of janus kinase activity GO:0042976 2 0.339
regulation of glomerulus development GO:0090192 6 0.338
response to monosaccharide GO:0034284 67 0.337
Rat
mammary gland morphogenesis GO:0060443 54 0.333
positive regulation of mapk cascade GO:0043410 170 0.332
antibacterial peptide secretion GO:0002779 1 0.332
respiratory system development GO:0060541 190 0.331
maternal placenta development GO:0001893 20 0.330
odontogenesis GO:0042476 78 0.328
antibacterial peptide production GO:0002778 2 0.327
male gamete generation GO:0048232 285 0.326
regulation of coagulation GO:0050818 31 0.326
germ cell development GO:0007281 185 0.325
translation GO:0006412 93 0.324
regulation of reactive oxygen species metabolic process GO:2000377 40 0.321
negative regulation of wnt signaling pathway GO:0030178 73 0.321
nephron development GO:0072006 109 0.320
skin development GO:0043588 220 0.320
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.314
microglia development GO:0014005 2 0.313
metanephric mesenchyme development GO:0072075 10 0.312
carbohydrate metabolic process GO:0005975 230 0.312
axon ensheathment GO:0008366 76 0.312

Ptgs2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.984
cancer DOID:162 0 0.908
disease of anatomical entity DOID:7 0 0.876
gastrointestinal system disease DOID:77 0 0.876
inflammatory bowel disease DOID:0050589 0 0.712
intestinal disease DOID:5295 0 0.712
organ system cancer DOID:0050686 0 0.618
hypertension DOID:10763 0 0.524
artery disease DOID:0050828 0 0.524
vascular disease DOID:178 0 0.524
essential hypertension DOID:10825 0 0.524
cardiovascular system disease DOID:1287 0 0.524