Mus musculus

12 known processes

Serpina1c

serine (or cysteine) peptidase inhibitor, clade A, member 1C

(Aliases: Wap3,Skalp,Spi1-6,Pi3,Spi1-3,Pi6)

Serpina1c biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of cholesterol metabolic process GO:0090181 14 0.994
Mouse
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001998 3 0.994
Mouse
regulation of protein kinase c activity GO:1900019 1 0.977
Mouse
alcohol metabolic process GO:0006066 116 0.919
Mouse
positive regulation of protein kinase c activity GO:1900020 1 0.902
Mouse
small molecule biosynthetic process GO:0044283 132 0.872
Mouse
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.865
Mouse
neutral lipid metabolic process GO:0006638 57 0.861
Mouse
negative regulation of hydrolase activity GO:0051346 71 0.808
Human Mouse Rat
response to chromate GO:0046687 1 0.800
Rat
cellular lipid metabolic process GO:0044255 323 0.789
Mouse
acylglycerol metabolic process GO:0006639 55 0.779
Mouse
regulation of protein maturation GO:1903317 96 0.767
Human Mouse Rat
fatty acid metabolic process GO:0006631 121 0.750
Mouse
monocarboxylic acid metabolic process GO:0032787 191 0.730
Mouse
negative regulation of gluconeogenesis GO:0045721 9 0.694
Mouse
regulation of renal output by angiotensin GO:0002019 2 0.680
Mouse
regulation of blood vessel size by renin angiotensin GO:0002034 5 0.655
Mouse
organic acid biosynthetic process GO:0016053 86 0.622
Mouse
organic hydroxy compound metabolic process GO:1901615 203 0.604
Mouse
regulation of systemic arterial blood pressure by hormone GO:0001990 25 0.576
Mouse
gluconeogenesis GO:0006094 39 0.576
Mouse
response to metal ion GO:0010038 47 0.571
Rat
glycerolipid metabolic process GO:0046486 122 0.563
Mouse
regulation of blood vessel size GO:0050880 56 0.554
Mouse
circulatory system process GO:0003013 197 0.539
Mouse
lipid biosynthetic process GO:0008610 179 0.521
Mouse
sterol metabolic process GO:0016125 58 0.519
Mouse
steroid metabolic process GO:0008202 119 0.515
Mouse
monosaccharide biosynthetic process GO:0046364 44 0.514
Mouse
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.510
Mouse
protein processing GO:0016485 163 0.503
Mouse Rat
negative regulation of protein maturation GO:1903318 79 0.493
Human Mouse Rat
protein n linked glycosylation GO:0006487 12 0.492
Mouse
regulation of fatty acid biosynthetic process GO:0042304 12 0.489
Mouse
negative regulation of proteolysis GO:0045861 74 0.476
Human Mouse Rat
negative regulation of endopeptidase activity GO:0010951 44 0.466
Human Mouse Rat
hormone metabolic process GO:0042445 86 0.464
Mouse
cholesterol metabolic process GO:0008203 56 0.460
Mouse
regulation of insulin receptor signaling pathway GO:0046626 21 0.459
Mouse
secondary alcohol metabolic process GO:1902652 3 0.441
astrocyte activation GO:0048143 2 0.433
Mouse
protein maturation GO:0051604 176 0.428
Mouse Rat
ovarian follicle rupture GO:0001543 2 0.426
Mouse
negative regulation of molecular function GO:0044092 258 0.416
Human Mouse Rat
negative regulation of protein processing GO:0010955 79 0.399
Human Mouse Rat
regulation of protein processing GO:0070613 96 0.390
Human Mouse Rat
cellular alcohol metabolic process GO:0044107 3 0.389
regulation of proteolysis GO:0030162 164 0.382
Human Mouse Rat
icosanoid metabolic process GO:0006690 33 0.380
negative regulation of serine type endopeptidase activity GO:1900004 2 0.377
Rat
fat soluble vitamin biosynthetic process GO:0042362 4 0.367
glucose metabolic process GO:0006006 92 0.361
Mouse
unsaturated fatty acid metabolic process GO:0033559 31 0.355
negative regulation of peptidase activity GO:0010466 46 0.352
Human Mouse Rat
regulation of peptidase activity GO:0052547 96 0.350
Human Mouse Rat
negative regulation of cellular protein metabolic process GO:0032269 247 0.337
Human Mouse Rat
cellular response to cadmium ion GO:0071276 3 0.330
positive regulation of fatty acid biosynthetic process GO:0045723 3 0.327
Mouse
negative regulation of lipid metabolic process GO:0045833 30 0.317
Mouse
negative regulation of carbohydrate metabolic process GO:0045912 19 0.314
Mouse
cellular response to hormone stimulus GO:0032870 150 0.311
Mouse
hexose metabolic process GO:0019318 98 0.310
Mouse
vascular process in circulatory system GO:0003018 62 0.307
Mouse
regulation of hormone levels GO:0010817 211 0.306
Mouse
glucocorticoid metabolic process GO:0008211 9 0.303
Mouse
oxidative demethylation GO:0070989 1 0.295
regulation of glucose metabolic process GO:0010906 60 0.293
Mouse
response to inorganic substance GO:0010035 96 0.292
Rat
renin angiotensin regulation of aldosterone production GO:0002018 3 0.291
Mouse
renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure GO:0003072 5 0.290
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.271
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.261
Mouse
regulation of tube size GO:0035150 57 0.260
Mouse
response to insulin GO:0032868 100 0.254
Mouse
blood circulation GO:0008015 195 0.250
Mouse
protein glycosylation GO:0006486 55 0.248
Mouse
cellular response to insulin stimulus GO:0032869 78 0.243
Mouse
cellular alcohol biosynthetic process GO:0044108 3 0.241
regulation of triglyceride metabolic process GO:0090207 17 0.238
Mouse
regulation of transferase activity GO:0051338 263 0.220
Mouse
monosaccharide metabolic process GO:0005996 106 0.212
Mouse
fatty acid biosynthetic process GO:0006633 41 0.206
Mouse
positive regulation of hormone secretion GO:0046887 38 0.203
negative regulation of protein metabolic process GO:0051248 282 0.203
Human Mouse Rat
carbohydrate metabolic process GO:0005975 230 0.198
Mouse
renal system development GO:0072001 225 0.195
Mouse
estrogen secretion GO:0035937 1 0.195
macromolecule glycosylation GO:0043413 55 0.194
Mouse
amine metabolic process GO:0009308 45 0.193
renal system process GO:0003014 48 0.193
Mouse
regulation of estrogen secretion GO:2000861 1 0.187
calcitriol biosynthetic process from calciol GO:0036378 3 0.185
regulation of endopeptidase activity GO:0052548 89 0.184
Human Mouse Rat
cellular response to peptide hormone stimulus GO:0071375 92 0.183
Mouse
vasoconstriction GO:0042310 27 0.183
Mouse
regulation of anatomical structure size GO:0090066 178 0.181
Mouse
regulation of kinase activity GO:0043549 249 0.179
Mouse
positive regulation of steroid hormone secretion GO:2000833 2 0.178
vitamin d biosynthetic process GO:0042368 3 0.174
monocarboxylic acid biosynthetic process GO:0072330 61 0.172
Mouse
multicellular organism growth GO:0035264 161 0.169
Mouse
naphthalene containing compound metabolic process GO:0090420 1 0.169
inflammatory response GO:0006954 244 0.168
Mouse Rat
triglyceride metabolic process GO:0006641 51 0.167
Mouse
naphthalene metabolic process GO:0018931 1 0.161
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 6 0.158
Mouse
development of primary female sexual characteristics GO:0046545 73 0.155
Mouse
cell matrix adhesion GO:0007160 68 0.154
Mouse
regulation of hydrolase activity GO:0051336 246 0.153
Human Mouse Rat
regulation of inflammatory response GO:0050727 147 0.151
Mouse
response to peptide GO:1901652 136 0.151
epithelial tube morphogenesis GO:0060562 303 0.149
Mouse
carbohydrate biosynthetic process GO:0016051 74 0.148
Mouse
cofactor metabolic process GO:0051186 80 0.148
kidney epithelium development GO:0072073 121 0.147
Mouse
phasic smooth muscle contraction GO:0014821 8 0.147
Mouse
regulation of fatty acid metabolic process GO:0019217 28 0.146
Mouse
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.146
Mouse
astrocyte differentiation GO:0048708 43 0.143
Mouse
carboxylic acid biosynthetic process GO:0046394 86 0.143
Mouse
hexose biosynthetic process GO:0019319 39 0.142
Mouse
fatty acid derivative metabolic process GO:1901568 33 0.141
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 15 0.141
Mouse
fibrinolysis GO:0042730 3 0.141
response to stilbenoid GO:0035634 22 0.137
positive regulation of secretion GO:0051047 130 0.137
Mouse
toxin catabolic process GO:0009407 1 0.134
positive regulation of systemic arterial blood pressure GO:0003084 9 0.130
Mouse
endocrine process GO:0050886 39 0.127
Mouse
cellular amine metabolic process GO:0044106 44 0.127
regulation of defense response GO:0031347 233 0.124
Mouse
arachidonic acid metabolic process GO:0019369 14 0.123
endothelial cell differentiation GO:0045446 41 0.123
Mouse
extracellular matrix organization GO:0030198 147 0.118
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.118
Mouse
response to peptide hormone GO:0043434 127 0.118
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 13 0.117
Mouse
positive regulation of blood pressure GO:0045777 21 0.111
Mouse
kidney development GO:0001822 213 0.108
Mouse
cellular amino acid metabolic process GO:0006520 103 0.107
cell adhesion GO:0007155 329 0.105
Mouse
insulin receptor signaling pathway GO:0008286 49 0.104
Mouse
extracellular structure organization GO:0043062 148 0.102
Mouse
female gonad development GO:0008585 71 0.102
Mouse
negative regulation of cell proliferation GO:0008285 296 0.102
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.101
positive regulation of protein phosphorylation GO:0001934 242 0.101
Mouse
positive regulation of lipid biosynthetic process GO:0046889 18 0.100
Mouse
renal tubule development GO:0061326 87 0.100
Mouse
lipid localization GO:0010876 126 0.100
response to molecule of bacterial origin GO:0002237 143 0.099
Rat
porphyrin containing compound metabolic process GO:0006778 22 0.098
regulation of secretion by cell GO:1903530 249 0.098
Mouse
cellular ketone metabolic process GO:0042180 84 0.096
Mouse
oxidation reduction process GO:0055114 342 0.095
regulation of systemic arterial blood pressure by renin angiotensin GO:0003081 20 0.094
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.094
terpenoid metabolic process GO:0006721 25 0.094
vitamin metabolic process GO:0006766 23 0.094
response to organic cyclic compound GO:0014070 198 0.092
Rat
spermatogenesis GO:0007283 284 0.090
Mouse
vitamin d3 metabolic process GO:0070640 3 0.089
regulation of cellular ketone metabolic process GO:0010565 66 0.089
Mouse
response to phenylpropanoid GO:0080184 22 0.089
inositol lipid mediated signaling GO:0048017 41 0.086
Mouse
cellular response to peptide GO:1901653 92 0.085
Mouse
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 20 0.080
Mouse
peristalsis GO:0030432 8 0.079
Mouse
tetrapyrrole metabolic process GO:0033013 22 0.078
kidney morphogenesis GO:0060993 83 0.077
Mouse
ureteric bud development GO:0001657 94 0.077
Mouse
ethanol metabolic process GO:0006067 3 0.077
regulation of lipid biosynthetic process GO:0046890 54 0.076
Mouse
positive regulation of lipid metabolic process GO:0045834 40 0.075
Mouse
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.074
Mouse
fat soluble vitamin metabolic process GO:0006775 11 0.074
regulation of protein serine threonine kinase activity GO:0071900 157 0.073
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.072
regulation of organ growth GO:0046620 61 0.071
Mouse
diterpenoid metabolic process GO:0016101 24 0.071
wound healing GO:0042060 157 0.070
cytokine secretion GO:0050663 72 0.070
Mouse
blood vessel morphogenesis GO:0048514 285 0.069
endothelial cell development GO:0001885 20 0.069
Mouse
response to transition metal nanoparticle GO:1990267 11 0.069
Rat
reactive oxygen species metabolic process GO:0072593 84 0.068
regulation of carbohydrate biosynthetic process GO:0043255 40 0.068
Mouse
mapk cascade GO:0000165 281 0.068
Mouse
regulation of cytokine secretion GO:0050707 61 0.068
Mouse
regulation of cellular response to insulin stimulus GO:1900076 30 0.067
Mouse
regulation of protein transport GO:0051223 163 0.066
Mouse
gonad development GO:0008406 141 0.066
Mouse
regulation of protein localization GO:0032880 231 0.065
Mouse
progesterone metabolic process GO:0042448 4 0.065
regulation of hormone secretion GO:0046883 88 0.065
female sex differentiation GO:0046660 84 0.064
Mouse
secondary metabolite catabolic process GO:0090487 1 0.064
carbohydrate derivative biosynthetic process GO:1901137 183 0.064
Mouse
reactive nitrogen species metabolic process GO:2001057 0 0.064
maintenance of location GO:0051235 89 0.063
positive regulation of kinase activity GO:0033674 155 0.062
Mouse
mesonephric tubule development GO:0072164 94 0.061
Mouse
response to organonitrogen compound GO:0010243 246 0.061
cellular carbohydrate metabolic process GO:0044262 119 0.061
Mouse
regulation of protein kinase activity GO:0045859 232 0.061
Mouse
positive regulation of secretion by cell GO:1903532 114 0.060
Mouse
ovulation cycle GO:0042698 59 0.060
Mouse
response to lipopolysaccharide GO:0032496 128 0.060
Rat
positive regulation of transferase activity GO:0051347 167 0.059
Mouse
positive regulation of protein modification process GO:0031401 299 0.058
Mouse
glycoprotein metabolic process GO:0009100 116 0.058
Mouse
response to cadmium ion GO:0046686 8 0.058
regulation of reactive oxygen species metabolic process GO:2000377 40 0.057
reactive oxygen species biosynthetic process GO:1903409 8 0.057
regulation of steroid metabolic process GO:0019218 39 0.057
Mouse
negative regulation of fibrinolysis GO:0051918 1 0.057
nik nf kappab signaling GO:0038061 14 0.056
Mouse
negative regulation of neuron death GO:1901215 98 0.055
Mouse
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.055
Mouse
muscle system process GO:0003012 141 0.055
Mouse
positive regulation of protein kinase activity GO:0045860 144 0.055
Mouse
protein activation cascade GO:0072376 19 0.054
cellular response to inorganic substance GO:0071241 37 0.054
nephron epithelium morphogenesis GO:0072088 68 0.054
Mouse
urogenital system development GO:0001655 261 0.054
Mouse
endothelium development GO:0003158 45 0.053
Mouse
hormone secretion GO:0046879 128 0.053
renal tubular secretion GO:0097254 2 0.053
regulation of homeostatic process GO:0032844 182 0.053
muscle cell differentiation GO:0042692 261 0.053
Mouse
response to cold GO:0009409 19 0.053
Mouse
protein secretion GO:0009306 111 0.053
Mouse
angiogenesis GO:0001525 201 0.052
response to testosterone GO:0033574 3 0.052
ovulation GO:0030728 15 0.052
Mouse
drug metabolic process GO:0017144 4 0.051
glycosylation GO:0070085 62 0.050
Mouse
blood coagulation GO:0007596 76 0.050
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.049
Mouse
positive regulation of growth GO:0045927 104 0.049
Mouse
glial cell development GO:0021782 54 0.049
Mouse
organonitrogen compound catabolic process GO:1901565 264 0.047
regulation of systemic arterial blood pressure GO:0003073 61 0.047
Mouse
activation of nf kappab inducing kinase activity GO:0007250 4 0.047
Mouse
gliogenesis GO:0042063 141 0.046
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.046
long chain fatty acid metabolic process GO:0001676 26 0.046
response to acid chemical GO:0001101 111 0.045
Rat
regulation of carbohydrate metabolic process GO:0006109 75 0.045
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.045
regulation of cytokine production GO:0001817 266 0.045
Mouse
regulation of protein secretion GO:0050708 82 0.044
Mouse
epithelial cell development GO:0002064 159 0.044
Mouse
nitrogen compound transport GO:0071705 271 0.044
cell substrate adhesion GO:0031589 130 0.043
Mouse
hematopoietic progenitor cell differentiation GO:0002244 143 0.043
regulation of lipid transport GO:0032368 36 0.043
response to temperature stimulus GO:0009266 55 0.042
Mouse
establishment of blood nerve barrier GO:0008065 3 0.042
Mouse
glycoprotein biosynthetic process GO:0009101 89 0.041
Mouse
regulation of lipid metabolic process GO:0019216 118 0.041
Mouse
camera type eye development GO:0043010 266 0.041
regulation of protein activation cascade GO:2000257 7 0.041
regulation of complement activation GO:0030449 7 0.041
peptidyl serine phosphorylation GO:0018105 74 0.040
Mouse
muscle cell proliferation GO:0033002 52 0.040
Mouse
complement activation GO:0006956 16 0.039
isoprenoid metabolic process GO:0006720 29 0.039
multicellular organismal homeostasis GO:0048871 164 0.039
peptidyl serine modification GO:0018209 83 0.039
Mouse
steroid biosynthetic process GO:0006694 47 0.038
regulation of establishment of protein localization GO:0070201 181 0.038
Mouse
locomotory behavior GO:0007626 195 0.037
positive regulation of lipid transport GO:0032370 22 0.037
regulation of mapk cascade GO:0043408 248 0.037
Mouse
nephron morphogenesis GO:0072028 69 0.036
Mouse
ovulation from ovarian follicle GO:0001542 9 0.036
Mouse
cofactor transport GO:0051181 4 0.036
regulation of vasculature development GO:1901342 88 0.036
positive regulation of protein activation cascade GO:2000259 2 0.035
single organismal cell cell adhesion GO:0016337 131 0.035
regulation of neuron death GO:1901214 134 0.035
Mouse
lung development GO:0030324 164 0.035
branching involved in ureteric bud morphogenesis GO:0001658 56 0.035
Mouse
coagulation GO:0050817 78 0.034
organ regeneration GO:0031100 2 0.034
regulation of secretion GO:0051046 274 0.034
Mouse
branching morphogenesis of an epithelial tube GO:0048754 159 0.034
Mouse
female gamete generation GO:0007292 74 0.033
Mouse
cytokine production GO:0001816 319 0.033
Mouse
toxin metabolic process GO:0009404 5 0.033
respiratory system development GO:0060541 190 0.033
organic hydroxy compound biosynthetic process GO:1901617 77 0.033
regulation of vesicle mediated transport GO:0060627 139 0.032
negative regulation of neuron apoptotic process GO:0043524 92 0.032
Mouse
peripheral nervous system development GO:0007422 53 0.032
Mouse
regulation of angiogenesis GO:0045765 81 0.032
innate immune response GO:0045087 157 0.032
smooth muscle contraction GO:0006939 44 0.032
Mouse
cellular response to food GO:0071240 1 0.031
metal ion homeostasis GO:0055065 189 0.031
negative regulation of iron ion transport GO:0034757 1 0.031
response to decreased oxygen levels GO:0036293 59 0.031
Rat
morphogenesis of a branching structure GO:0001763 203 0.031
Mouse
linoleic acid metabolic process GO:0043651 6 0.031
regulation of cell motility GO:2000145 236 0.031
epithelial cell proliferation GO:0050673 174 0.030
positive regulation of response to wounding GO:1903036 66 0.030
regulation of cell growth GO:0001558 91 0.030
neuron death GO:0070997 154 0.029
Mouse
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.029
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.029
sequestering of calcium ion GO:0051208 18 0.029
single organism cell adhesion GO:0098602 156 0.029
heme metabolic process GO:0042168 16 0.029
positive regulation of cellular response to insulin stimulus GO:1900078 9 0.029
Mouse
response to oxidative stress GO:0006979 123 0.029
rhythmic process GO:0048511 174 0.029
Mouse
positive regulation of estrogen secretion GO:2000863 1 0.028
regulation of wound healing GO:0061041 40 0.028
retinol metabolic process GO:0042572 9 0.028
cation transport GO:0006812 399 0.027
cellular response to external stimulus GO:0071496 88 0.027
regulation of system process GO:0044057 200 0.027
opsonization GO:0008228 3 0.027
cell type specific apoptotic process GO:0097285 268 0.027
Mouse
ureteric bud morphogenesis GO:0060675 62 0.027
Mouse
regulation of cellular catabolic process GO:0031329 242 0.026
cellular response to metal ion GO:0071248 31 0.026
positive regulation of protein transport GO:0051222 93 0.026
Mouse
apoptotic signaling pathway GO:0097190 306 0.026
nephron development GO:0072006 109 0.026
Mouse
positive regulation of cytokine production GO:0001819 174 0.026
Mouse
folic acid containing compound metabolic process GO:0006760 3 0.026
cellular homeostasis GO:0019725 240 0.026
peptidyl amino acid modification GO:0018193 336 0.026
Mouse
negative regulation of cell adhesion mediated by integrin GO:0033629 2 0.025
positive regulation of organ growth GO:0046622 29 0.025
Mouse
regulation of cell adhesion GO:0030155 154 0.025
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.025
Mouse
myeloid cell differentiation GO:0030099 233 0.025
regulation of intracellular transport GO:0032386 159 0.024
anatomical structure homeostasis GO:0060249 145 0.024
generation of precursor metabolites and energy GO:0006091 103 0.024
glycolytic process GO:0006096 20 0.024
cellular response to cytokine stimulus GO:0071345 189 0.024
regulation of ion transport GO:0043269 215 0.024
platelet activation GO:0030168 40 0.024
regulation of blood coagulation GO:0030193 28 0.024
regulation of blood pressure GO:0008217 93 0.024
Mouse
cellular response to testosterone stimulus GO:0071394 1 0.024
positive regulation of activation of membrane attack complex GO:0001970 2 0.024
peptide secretion GO:0002790 114 0.024
mesonephros development GO:0001823 97 0.024
Mouse
astrocyte development GO:0014002 12 0.023
Mouse
cellular response to starvation GO:0009267 57 0.023
response to estrogen GO:0043627 24 0.023
Rat
retinoid metabolic process GO:0001523 24 0.023
neuron apoptotic process GO:0051402 142 0.023
Mouse
organic cyclic compound catabolic process GO:1901361 295 0.023
phosphatidylinositol mediated signaling GO:0048015 41 0.022
Mouse
macromolecule catabolic process GO:0009057 281 0.022
small gtpase mediated signal transduction GO:0007264 97 0.022
thermosensory behavior GO:0040040 1 0.022
cell growth GO:0016049 130 0.021
regulation of response to wounding GO:1903034 189 0.021
Mouse
interleukin 8 production GO:0032637 4 0.021
regulation of serine type endopeptidase activity GO:1900003 2 0.021
Rat
response to steroid hormone GO:0048545 56 0.021
Rat
negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 4 0.021
sulfur compound metabolic process GO:0006790 100 0.021
cellular divalent inorganic cation homeostasis GO:0072503 127 0.021
glial cell differentiation GO:0010001 131 0.021
Mouse
positive regulation of programmed cell death GO:0043068 218 0.020
cellular chemical homeostasis GO:0055082 215 0.020
regulation of gluconeogenesis GO:0006111 30 0.020
Mouse
negative regulation of complement activation GO:0045916 3 0.020
cellular lipid catabolic process GO:0044242 52 0.020
regulation of body fluid levels GO:0050878 162 0.020
demethylation GO:0070988 23 0.020
cellular response to extracellular stimulus GO:0031668 81 0.020
cytoplasmic transport GO:0016482 234 0.020
respiratory tube development GO:0030323 167 0.020
regulation of epithelial cell proliferation GO:0050678 141 0.020
negative regulation of growth GO:0045926 99 0.020
regulation of blood volume by renin angiotensin GO:0002016 7 0.020
Mouse
cellular calcium ion homeostasis GO:0006874 119 0.020
cellular modified amino acid metabolic process GO:0006575 63 0.019
phospholipid metabolic process GO:0006644 87 0.019
polyol metabolic process GO:0019751 26 0.019
renal tubule morphogenesis GO:0061333 72 0.019
Mouse
regulation of interleukin 8 production GO:0032677 3 0.019
regulation of complement activation classical pathway GO:0030450 1 0.019
muscle tissue development GO:0060537 308 0.019
negative regulation of coagulation GO:0050819 11 0.019
lipid transport GO:0006869 98 0.019
adaptive immune response GO:0002250 155 0.019
carbohydrate homeostasis GO:0033500 128 0.019
negative regulation of homeostatic process GO:0032845 71 0.019
glucose homeostasis GO:0042593 128 0.018
extrinsic apoptotic signaling pathway GO:0097191 126 0.018
negative regulation of endothelial cell migration GO:0010596 4 0.018
response to nutrient levels GO:0031667 109 0.018
rna processing GO:0006396 105 0.018
membrane lipid metabolic process GO:0006643 53 0.018
hemostasis GO:0007599 78 0.018
regulation of hemostasis GO:1900046 28 0.018
regulation of peptide secretion GO:0002791 77 0.017
regulation of b cell mediated immunity GO:0002712 37 0.017
negative regulation of hemostasis GO:1900047 11 0.017
negative regulation of protein activation cascade GO:2000258 3 0.017
cellular ion homeostasis GO:0006873 165 0.017
response to oxygen levels GO:0070482 62 0.017
Rat
negative regulation of response to wounding GO:1903035 77 0.017
negative regulation of intracellular signal transduction GO:1902532 167 0.017
nephron epithelium development GO:0072009 92 0.017
Mouse
cellular protein complex assembly GO:0043623 116 0.017
positive regulation of endocytosis GO:0045807 42 0.017
divalent inorganic cation homeostasis GO:0072507 138 0.017
polyol biosynthetic process GO:0046173 13 0.017
regulation of organelle organization GO:0033043 289 0.017
coenzyme metabolic process GO:0006732 52 0.017
skeletal system development GO:0001501 356 0.017
regulation of actin filament based process GO:0032970 99 0.017
amide transport GO:0042886 138 0.016
gland development GO:0048732 330 0.016
positive regulation of vasoconstriction GO:0045907 4 0.016
regulation of nik nf kappab signaling GO:1901222 10 0.016
Mouse
response to monosaccharide GO:0034284 67 0.016
regulation of peptide transport GO:0090087 91 0.016
fat cell differentiation GO:0045444 160 0.016
asymmetric stem cell division GO:0098722 3 0.016
cellular nitrogen compound catabolic process GO:0044270 280 0.016
transmembrane transport GO:0055085 412 0.016
response to osmotic stress GO:0006970 21 0.016
Mouse
development of primary sexual characteristics GO:0045137 143 0.016
Mouse
activation of membrane attack complex GO:0001905 4 0.015
regulation of cell adhesion mediated by integrin GO:0033628 13 0.015
alcohol biosynthetic process GO:0046165 43 0.015
retinal blood vessel morphogenesis GO:0061304 3 0.015
retina development in camera type eye GO:0060041 119 0.015
response to iron ion GO:0010039 4 0.015
negative regulation of apoptotic signaling pathway GO:2001234 104 0.015
peptide transport GO:0015833 133 0.015
cell adhesion mediated by integrin GO:0033627 18 0.015
regulation of chloride transport GO:2001225 2 0.015
cellular response to dna damage stimulus GO:0006974 207 0.015
cellular response to growth factor stimulus GO:0071363 197 0.015
ras protein signal transduction GO:0007265 77 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.014
response to starvation GO:0042594 65 0.014
cellular aldehyde metabolic process GO:0006081 12 0.014
one carbon metabolic process GO:0006730 1 0.014
positive regulation of cell adhesion GO:0045785 80 0.014
regulation of cell activation GO:0050865 289 0.014
striated muscle tissue development GO:0014706 293 0.014
purine nucleoside metabolic process GO:0042278 241 0.014
secondary metabolic process GO:0019748 18 0.014
nephron tubule morphogenesis GO:0072078 68 0.014
Mouse
myeloid cell homeostasis GO:0002262 114 0.014
collagen fibril organization GO:0030199 32 0.014
activation of immune response GO:0002253 138 0.014
vitamin biosynthetic process GO:0009110 7 0.014
organophosphate catabolic process GO:0046434 232 0.014
intrinsic apoptotic signaling pathway GO:0097193 132 0.014
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.014
homeostasis of number of cells GO:0048872 210 0.014
inter male aggressive behavior GO:0002121 3 0.014
divalent inorganic cation transport GO:0072511 178 0.014
immune effector process GO:0002252 321 0.013
peptide hormone secretion GO:0030072 109 0.013
pallium development GO:0021543 120 0.013
tissue remodeling GO:0048771 102 0.013
male gamete generation GO:0048232 285 0.013
Mouse
myeloid leukocyte differentiation GO:0002573 119 0.013

Serpina1c disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.971
Human
plasma protein metabolism disease DOID:2345 0 0.971
Human
inherited metabolic disorder DOID:655 0 0.971
Human
immune system disease DOID:2914 0 0.195
disease of anatomical entity DOID:7 0 0.195
hematopoietic system disease DOID:74 0 0.195
blood coagulation disease DOID:1247 0 0.175
inherited blood coagulation disease DOID:2214 0 0.122
artery disease DOID:0050828 0 0.082
vascular disease DOID:178 0 0.082
cardiovascular system disease DOID:1287 0 0.082
hemolytic anemia DOID:583 0 0.055
hemolytic uremic syndrome DOID:12554 0 0.055
normocytic anemia DOID:720 0 0.055
anemia DOID:2355 0 0.055
nervous system disease DOID:863 0 0.040
acquired metabolic disease DOID:0060158 0 0.026
lipid metabolism disorder DOID:3146 0 0.021
steroid inherited metabolic disorder DOID:1701 0 0.021