IMP

Process View

Mus musculus

11 genes annotated in mouse

response to transition metal nanoparticle

GO:1990267

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to transition metal nanoparticle"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to transition metal nanoparticle" (in gray)

Name	Description	Probability	Func Analog Organism
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	1.000	Rat
Lyz2	lysozyme 2	0.813
Mt2	metallothionein 2	0.779
Trp53	transformation related protein 53	0.747	Zebrafish
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.641	Rat
Ctnnb1	catenin (cadherin associated protein), beta 1	0.609
Mt1	metallothionein 1	0.594
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.561	Rat
S100a9	S100 calcium binding protein A9 (calgranulin B)	0.547	Rat
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.541	Rat
Cd44	CD44 antigen	0.464
Pten	phosphatase and tensin homolog	0.449
Cdk2	cyclin-dependent kinase 2	0.407
Nos3	nitric oxide synthase 3, endothelial cell	0.365
Apoe	apolipoprotein E	0.346
Bglap	bone gamma carboxyglutamate protein	0.308
Lepr	leptin receptor	0.295
Fas	Fas (TNF receptor superfamily member 6)	0.207
Lep	leptin	0.196
Nos1	nitric oxide synthase 1, neuronal	0.168
Cp	ceruloplasmin	0.160
Cps1	carbamoyl-phosphate synthetase 1	0.143
Fbp1	fructose bisphosphatase 1	0.133
Mmp9	matrix metallopeptidase 9	0.127	Rat
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.122
Cdk4	cyclin-dependent kinase 4	0.121
Il10	interleukin 10	0.117
Il1b	interleukin 1 beta	0.114
Otc	ornithine transcarbamylase	0.112
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.100
Apc	adenomatosis polyposis coli	0.099
Alb	albumin	0.097
Cyp2c29	cytochrome P450, family 2, subfamily c, polypeptide 29	0.097
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.095
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.087
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.086
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.084
Ccna2	cyclin A2	0.079
Slc2a5	solute carrier family 2 (facilitated glucose transporter), member 5	0.073
Tfrc	transferrin receptor	0.073
Ar	androgen receptor	0.072
Esr1	estrogen receptor 1 (alpha)	0.070
Serpina1c	serine (or cysteine) peptidase inhibitor, clade A, member 1C	0.069	Rat
Cyp2a12	cytochrome P450, family 2, subfamily a, polypeptide 12	0.068
Steap3	STEAP family member 3	0.066
Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	0.060
Rdh7	retinol dehydrogenase 7	0.060
Prnp	prion protein	0.057
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.055
Foxn1	forkhead box N1	0.052
Spnb1	spectrin beta 1	0.050
Tdo2	tryptophan 2,3-dioxygenase	0.050
Col1a1	collagen, type I, alpha 1	0.049
Plg	plasminogen	0.048
Ccl2	chemokine (C-C motif) ligand 2	0.048
Fos	FBJ osteosarcoma oncogene	0.047
Tgfbr2	transforming growth factor, beta receptor II	0.046
Myd88	myeloid differentiation primary response gene 88	0.045
Vegfa	vascular endothelial growth factor A	0.045
G6pc	glucose-6-phosphatase, catalytic	0.044
Gc	group specific component	0.043
Stat3	signal transducer and activator of transcription 3	0.042
Il1r1	interleukin 1 receptor, type I	0.040
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.040
Serpind1	serine (or cysteine) peptidase inhibitor, clade D, member 1	0.039
Thrb	thyroid hormone receptor beta	0.038
Brca1	breast cancer 1	0.037
Fga	fibrinogen alpha chain	0.037
Nr1h4	nuclear receptor subfamily 1, group H, member 4	0.037
Serpina1a	serine (or cysteine) peptidase inhibitor, clade A, member 1A	0.037	Rat
Azgp1	alpha-2-glycoprotein 1, zinc	0.036
Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	0.034	Fly
Uox	urate oxidase	0.034
Ambp	alpha 1 microglobulin/bikunin	0.032
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.032
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.031
Akr1c6	aldo-keto reductase family 1, member C6	0.031
Mapk8	mitogen-activated protein kinase 8	0.031
Hfe	hemochromatosis	0.030
Aldob	aldolase B, fructose-bisphosphate	0.029	Rat
Cyp2c50	cytochrome P450, family 2, subfamily c, polypeptide 50	0.027
Pah	phenylalanine hydroxylase	0.027
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.027
Itgb2	integrin beta 2	0.026
Cyp2b10	cytochrome P450, family 2, subfamily b, polypeptide 10	0.025
Hr	hairless	0.025
Cd4	CD4 antigen	0.025
Csf1	colony stimulating factor 1 (macrophage)	0.025
Ptgs1	prostaglandin-endoperoxide synthase 1	0.025
Irs1	insulin receptor substrate 1	0.024
Scp2	sterol carrier protein 2, liver	0.024
Il2rg	interleukin 2 receptor, gamma chain	0.024
Tgfbr1	transforming growth factor, beta receptor I	0.023
Serpina1b	serine (or cysteine) preptidase inhibitor, clade A, member 1B	0.023	Rat
Cd14	CD14 antigen	0.023
Cyp2b9	cytochrome P450, family 2, subfamily b, polypeptide 9	0.023
Slc10a1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.022
Ppl	periplakin	0.022
Notch2	Notch gene homolog 2 (Drosophila)	0.022
Lcn2	lipocalin 2	0.022
Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	0.022
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.021
Hmox1	heme oxygenase (decycling) 1	0.021
Inpp5j	inositol polyphosphate 5-phosphatase J	0.021
Apob	apolipoprotein B	0.021
Adam17	a disintegrin and metallopeptidase domain 17	0.021
Atf3	activating transcription factor 3	0.021
C9	complement component 9	0.021
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.021
F7	coagulation factor VII	0.020
Ptgs2	prostaglandin-endoperoxide synthase 2	0.020	Rat
Atox1	ATX1 (antioxidant protein 1) homolog 1 (yeast)	0.020
Ahsg	alpha-2-HS-glycoprotein	0.020	Mouse
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.020
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.019
Ikzf1	IKAROS family zinc finger 1	0.019
Hamp	hepcidin antimicrobial peptide	0.019
Mag	myelin-associated glycoprotein	0.019
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.019
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.019
Chuk	conserved helix-loop-helix ubiquitous kinase	0.019
Aadac	arylacetamide deacetylase (esterase)	0.019
Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.018
Ccr2	chemokine (C-C motif) receptor 2	0.018
Ngp	neutrophilic granule protein	0.018
Lat	linker for activation of T cells	0.018
Serpina6	serine (or cysteine) peptidase inhibitor, clade A, member 6	0.018
Crp	C-reactive protein, pentraxin-related	0.018
Apoh	apolipoprotein H	0.017
Rxra	retinoid X receptor alpha	0.017
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.017
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.017
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.016
Spry4	sprouty homolog 4 (Drosophila)	0.016
Mat1a	methionine adenosyltransferase I, alpha	0.016
Hck	hemopoietic cell kinase	0.016
App	amyloid beta (A4) precursor protein	0.016
Pzp	pregnancy zone protein	0.016
Mep1a	meprin 1 alpha	0.016
Ttr	transthyretin	0.016
Fgfr2	fibroblast growth factor receptor 2	0.016
Irs2	insulin receptor substrate 2	0.016
Cyp2d10	cytochrome P450, family 2, subfamily d, polypeptide 10	0.016
1100001G20Rik	RIKEN cDNA 1100001G20 gene	0.016
Itih3	inter-alpha trypsin inhibitor, heavy chain 3	0.015
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.015
Apoa1	apolipoprotein A-I	0.015
Pick1	protein interacting with C kinase 1	0.015
Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.015
Mug2	murinoglobulin 2	0.015
Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	0.014	Fly
Mavs	mitochondrial antiviral signaling protein	0.014
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.014
Ep300	E1A binding protein p300	0.014
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.014
P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3	0.014	Mouse
Ins2	insulin II	0.014
Ncoa3	nuclear receptor coactivator 3	0.014
Ikbkb	inhibitor of kappaB kinase beta	0.014
Cyp3a13	cytochrome P450, family 3, subfamily a, polypeptide 13	0.014	Fly
Drd1a	dopamine receptor D1A	0.014
Gstm1	glutathione S-transferase, mu 1	0.013
Atp6v0c	ATPase, H+ transporting, lysosomal V0 subunit C	0.013
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.013	Rat
Ces1g	carboxylesterase 1G	0.013
Nr1i2	nuclear receptor subfamily 1, group I, member 2	0.013
Rbms1	RNA binding motif, single stranded interacting protein 1	0.013
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.013
Nf1	neurofibromatosis 1	0.013
Smad3	MAD homolog 3 (Drosophila)	0.013
Drd2	dopamine receptor D2	0.013	Rat
F10	coagulation factor X	0.013
Ghr	growth hormone receptor	0.013
Plat	plasminogen activator, tissue	0.012
Ugt2b34	UDP glucuronosyltransferase 2 family, polypeptide B34	0.012
F2	coagulation factor II	0.012
Nppa	natriuretic peptide type A	0.012
Fbxl5	F-box and leucine-rich repeat protein 5	0.012
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.012
Hpd	4-hydroxyphenylpyruvic acid dioxygenase	0.012
Upp2	uridine phosphorylase 2	0.012
Aqp9	aquaporin 9	0.012
Canx	calnexin	0.012
Pcna	proliferating cell nuclear antigen	0.012
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.012
Bhmt	betaine-homocysteine methyltransferase	0.012
Mbl2	mannose-binding lectin (protein C) 2	0.012
Snca	synuclein, alpha	0.012	Human
Cdc6	cell division cycle 6 homolog (S. cerevisiae)	0.012
Ahr	aryl-hydrocarbon receptor	0.011
Gstm3	glutathione S-transferase, mu 3	0.011
Smn1	survival motor neuron 1	0.011
Camp	cathelicidin antimicrobial peptide	0.011
Rag1	recombination activating gene 1	0.011
Cyb5	cytochrome b-5	0.011
Gck	glucokinase	0.011
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.011
H1	histocompatibility 1	0.011
Ces3a	carboxylesterase 3A	0.011
Vsig4	V-set and immunoglobulin domain containing 4	0.011
Epb4.1	erythrocyte protein band 4.1	0.011
Aatk	apoptosis-associated tyrosine kinase	0.011
Invs	inversin	0.011
Mettl7a1	methyltransferase like 7A1	0.011
Ccnd1	cyclin D1	0.011	Rat
Ireb2	iron responsive element binding protein 2	0.011
Dlg4	discs, large homolog 4 (Drosophila)	0.011
Vdr	vitamin D receptor	0.011
Gata3	GATA binding protein 3	0.010
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.010
Gcgr	glucagon receptor	0.010
Braf	Braf transforming gene	0.010
Prlr	prolactin receptor	0.010
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.010
F9	coagulation factor IX	0.010
Slc39a4	solute carrier family 39 (zinc transporter), member 4	0.010