Mus musculus

12 known processes

Serpina3n

serine (or cysteine) peptidase inhibitor, clade A, member 3N

(Aliases: Spi2/eb.4,Spi2.2,Spi2-2)

Serpina3n biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
t helper 2 cell cytokine production GO:0035745 4 0.924
regulation of inflammatory response GO:0050727 147 0.719
Mouse
positive regulation of eosinophil migration GO:2000418 2 0.631
natural killer cell chemotaxis GO:0035747 1 0.630
regulation of defense response GO:0031347 233 0.617
Mouse
angiogenesis GO:0001525 201 0.614
positive regulation of natural killer cell chemotaxis GO:2000503 1 0.609
blood vessel morphogenesis GO:0048514 285 0.609
cytokine production GO:0001816 319 0.593
Mouse
regulation of b cell chemotaxis GO:2000537 2 0.587
thymocyte migration GO:0072679 2 0.574
negative regulation of endopeptidase activity GO:0010951 44 0.570
Mouse
positive regulation of thymocyte migration GO:2000412 2 0.557
regulation of dendritic cell dendrite assembly GO:2000547 2 0.553
protein activation cascade GO:0072376 19 0.545
regulation of eosinophil migration GO:2000416 2 0.533
protein processing GO:0016485 163 0.501
Mouse
t helper 1 cell cytokine production GO:0035744 1 0.493
positive regulation of b cell chemotaxis GO:2000538 2 0.488
immune effector process GO:0002252 321 0.475
inflammatory response GO:0006954 244 0.471
Mouse Rat
regulation of cytokine production GO:0001817 266 0.443
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.441
Mouse
positive regulation of dendritic cell dendrite assembly GO:2000549 1 0.439
negative regulation of molecular function GO:0044092 258 0.431
Mouse
myeloid leukocyte migration GO:0097529 57 0.419
positive regulation of t helper 1 cell cytokine production GO:2000556 1 0.418
immunoglobulin mediated immune response GO:0016064 69 0.415
positive regulation of inflammatory response GO:0050729 47 0.413
positive regulation of activation of membrane attack complex GO:0001970 2 0.406
positive regulation of immunoglobulin production in mucosal tissue GO:2000558 1 0.401
regulation of vasculature development GO:1901342 88 0.400
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.398
complement activation GO:0006956 16 0.380
regulation of hydrolase activity GO:0051336 246 0.375
Mouse
glycoprotein biosynthetic process GO:0009101 89 0.375
Mouse
regulation of response to wounding GO:1903034 189 0.373
Mouse
acute inflammatory response GO:0002526 41 0.366
regulation of complement activation GO:0030449 7 0.365
cellular response to cytokine stimulus GO:0071345 189 0.360
Rat
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.358
regulation of angiogenesis GO:0045765 81 0.354
regulation of monocyte chemotaxis GO:0090025 3 0.353
positive regulation of cytokine production GO:0001819 174 0.348
Mouse
regulation of proteolysis GO:0030162 164 0.328
Mouse
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.321
cdc42 protein signal transduction GO:0032488 0 0.319
negative regulation of cellular protein metabolic process GO:0032269 247 0.304
Mouse
regulation of b cell mediated immunity GO:0002712 37 0.300
negative regulation of hydrolase activity GO:0051346 71 0.297
Mouse
immunoglobulin production in mucosal tissue GO:0002426 3 0.291
gland development GO:0048732 330 0.290
regulation of natural killer cell chemotaxis GO:2000501 1 0.285
eosinophil migration GO:0072677 3 0.281
regulation of t helper 2 cell cytokine production GO:2000551 3 0.281
interleukin 12 secretion GO:0072610 3 0.280
positive regulation of angiogenesis GO:0045766 46 0.279
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.278
cell chemotaxis GO:0060326 81 0.278
epithelial cell proliferation GO:0050673 174 0.269
regulation of immunoglobulin production in mucosal tissue GO:2000557 1 0.268
positive regulation of cd4 positive alpha beta t cell proliferation GO:2000563 1 0.248
regulation of protein processing GO:0070613 96 0.246
Mouse
regulation of protein activation cascade GO:2000257 7 0.245
production of molecular mediator of immune response GO:0002440 103 0.244
regulation of peptidase activity GO:0052547 96 0.243
Mouse
dendritic cell dendrite assembly GO:0097026 2 0.238
response to peptide hormone GO:0043434 127 0.234
regulation of t helper 1 cell cytokine production GO:2000554 1 0.232
positive regulation of mapk cascade GO:0043410 170 0.231
Mouse
b cell chemotaxis GO:0035754 3 0.231
negative regulation of proteolysis GO:0045861 74 0.227
Mouse
aromatic compound catabolic process GO:0019439 286 0.223
neutrophil migration GO:1990266 37 0.217
regulation of cell activation GO:0050865 289 0.215
regulation of adaptive immune response GO:0002819 90 0.214
guanosine containing compound catabolic process GO:1901069 144 0.213
regulation of cellular ketone metabolic process GO:0010565 66 0.209
Mouse
positive regulation of protein modification process GO:0031401 299 0.207
Mouse
regulation of leukocyte mediated immunity GO:0002703 104 0.202
negative regulation of vasculature development GO:1901343 26 0.199
lymphocyte mediated immunity GO:0002449 139 0.197
positive regulation of type 2 immune response GO:0002830 9 0.196
granulocyte migration GO:0097530 43 0.191
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.189
negative regulation of complement activation GO:0045916 3 0.189
positive regulation of macrophage activation GO:0043032 10 0.188
regulation of protein maturation GO:1903317 96 0.188
Mouse
mapk cascade GO:0000165 281 0.186
Mouse
regulation of epithelial cell proliferation GO:0050678 141 0.185
leukocyte chemotaxis GO:0030595 69 0.185
regulation of insulin receptor signaling pathway GO:0046626 21 0.183
Mouse
b cell mediated immunity GO:0019724 71 0.180
positive regulation of granulocyte chemotaxis GO:0071624 12 0.179
regulation of acute inflammatory response GO:0002673 27 0.179
astrocyte cell migration GO:0043615 3 0.177
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.176
Mouse
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.175
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.174
regulation of cholesterol metabolic process GO:0090181 14 0.173
Mouse
regulation of immunoglobulin production GO:0002637 42 0.172
small gtpase mediated signal transduction GO:0007264 97 0.172
negative regulation of peptidase activity GO:0010466 46 0.170
Mouse
negative regulation of protein maturation GO:1903318 79 0.169
Mouse
protein maturation GO:0051604 176 0.167
Mouse
leukocyte migration GO:0050900 124 0.166
regulation of immunoglobulin mediated immune response GO:0002889 37 0.166
regulation of thymocyte migration GO:2000410 2 0.166
humoral immune response GO:0006959 57 0.164
positive regulation of b cell mediated immunity GO:0002714 26 0.163
regulation of endopeptidase activity GO:0052548 89 0.163
Mouse
mature natural killer cell chemotaxis GO:0035782 1 0.160
response to molecule of bacterial origin GO:0002237 143 0.160
Rat
positive regulation of neutrophil chemotaxis GO:0090023 12 0.159
immunoglobulin production GO:0002377 73 0.159
regulation of mapk cascade GO:0043408 248 0.158
Mouse
negative regulation of protein processing GO:0010955 79 0.157
Mouse
positive regulation of monocyte chemotaxis GO:0090026 2 0.157
leukocyte mediated immunity GO:0002443 174 0.156
positive regulation of behavior GO:0048520 40 0.156
carbohydrate metabolic process GO:0005975 230 0.153
Mouse
cellular chemical homeostasis GO:0055082 215 0.151
sterol metabolic process GO:0016125 58 0.148
Mouse
positive regulation of apoptotic process GO:0043065 217 0.148
regulation of ras gtpase activity GO:0032318 88 0.148
response to organonitrogen compound GO:0010243 246 0.148
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.144
Mouse
positive regulation of gtp catabolic process GO:0033126 85 0.142
chemotaxis GO:0006935 247 0.140
activation of immune response GO:0002253 138 0.139
oxidation reduction process GO:0055114 342 0.139
regulation of neutrophil chemotaxis GO:0090022 14 0.138
alpha beta t cell activation involved in immune response GO:0002287 31 0.133
carbohydrate derivative biosynthetic process GO:1901137 183 0.131
Mouse
regulation of lymphocyte mediated immunity GO:0002706 84 0.129
nucleotide metabolic process GO:0009117 332 0.128
cation homeostasis GO:0055080 212 0.127
regulation of cellular amino acid metabolic process GO:0006521 5 0.126
nucleoside phosphate metabolic process GO:0006753 338 0.126
positive regulation of programmed cell death GO:0043068 218 0.125
response to transforming growth factor beta GO:0071559 88 0.125
positive regulation of nucleotide catabolic process GO:0030813 88 0.124
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.123
purine containing compound metabolic process GO:0072521 311 0.121
regulation of cell migration GO:0030334 219 0.120
lymphocyte migration GO:0072676 26 0.118
fat cell differentiation GO:0045444 160 0.117
adaptive immune response GO:0002250 155 0.117
cellular amine metabolic process GO:0044106 44 0.116
regulation of nucleotide metabolic process GO:0006140 169 0.115
response to interleukin 4 GO:0070670 23 0.110
regulation of glucose metabolic process GO:0010906 60 0.108
Mouse
positive regulation of response to wounding GO:1903036 66 0.108
leukocyte activation involved in immune response GO:0002366 126 0.107
cellular homeostasis GO:0019725 240 0.107
negative regulation of macrophage apoptotic process GO:2000110 3 0.105
complement activation lectin pathway GO:0001867 5 0.105
positive regulation of secretion by cell GO:1903532 114 0.104
Mouse
negative regulation of protein activation cascade GO:2000258 3 0.103
regulation of neuron death GO:1901214 134 0.101
Mouse
regulation of protein kinase activity GO:0045859 232 0.100
Mouse
cellular lipid metabolic process GO:0044255 323 0.100
Mouse
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.098
positive regulation of nucleoside metabolic process GO:0045979 91 0.096
triglyceride metabolic process GO:0006641 51 0.096
Mouse
positive regulation of leukocyte mediated immunity GO:0002705 70 0.096
cellular response to peptide GO:1901653 92 0.095
Mouse
amine metabolic process GO:0009308 45 0.094
acylglycerol metabolic process GO:0006639 55 0.093
Mouse
positive regulation of defense response GO:0031349 124 0.093
positive regulation of cell death GO:0010942 224 0.093
positive regulation of ras gtpase activity GO:0032320 65 0.091
positive regulation of kinase activity GO:0033674 155 0.090
Mouse
alpha beta t cell differentiation GO:0046632 69 0.090
regulation of lymphocyte differentiation GO:0045619 107 0.088
cell cell recognition GO:0009988 44 0.088
renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure GO:0003072 5 0.088
Mouse
positive regulation of protein activation cascade GO:2000259 2 0.087
positive regulation of myeloid leukocyte mediated immunity GO:0002888 14 0.087
positive regulation of protein kinase activity GO:0045860 144 0.086
Mouse
response to radiation GO:0009314 165 0.086
neutrophil chemotaxis GO:0030593 36 0.086
neuron death GO:0070997 154 0.085
Mouse
regulation of secretion GO:0051046 274 0.085
Mouse
regulation of chemotaxis GO:0050920 53 0.085
macrophage activation GO:0042116 27 0.084
positive regulation of rho gtpase activity GO:0032321 41 0.084
negative regulation of immune system process GO:0002683 209 0.083
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.083
cd4 positive alpha beta t cell activation GO:0035710 45 0.082
cholesterol metabolic process GO:0008203 56 0.082
Mouse
regulation of ras protein signal transduction GO:0046578 114 0.082
cellular amino acid metabolic process GO:0006520 103 0.082
mature dendritic cell differentiation GO:0097029 3 0.082
glycosyl compound catabolic process GO:1901658 206 0.081
regulation of fat cell differentiation GO:0045598 81 0.081
positive regulation of epithelial cell proliferation GO:0050679 68 0.081
positive regulation of cellular component biogenesis GO:0044089 94 0.081
homeostasis of number of cells GO:0048872 210 0.080
positive regulation of cellular amine metabolic process GO:0033240 5 0.079
glycoprotein metabolic process GO:0009100 116 0.079
Mouse
regulation of protein transport GO:0051223 163 0.078
Mouse
cellular response to hormone stimulus GO:0032870 150 0.078
Mouse Rat
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.078
response to lipopolysaccharide GO:0032496 128 0.078
Rat
ras protein signal transduction GO:0007265 77 0.078
guanosine containing compound metabolic process GO:1901068 144 0.077
positive regulation of cellular catabolic process GO:0031331 148 0.077
nucleoside triphosphate metabolic process GO:0009141 230 0.077
cellular response to interleukin 4 GO:0071353 21 0.077
lipid biosynthetic process GO:0008610 179 0.077
Mouse
regulation of t cell activation GO:0050863 170 0.075
gtp metabolic process GO:0046039 144 0.075
regulation of t helper 1 cell differentiation GO:0045625 7 0.075
divalent inorganic cation homeostasis GO:0072507 138 0.075
positive regulation of nucleotide metabolic process GO:0045981 114 0.075
regulation of nucleotide catabolic process GO:0030811 122 0.074
positive regulation of tumor necrosis factor production GO:0032760 30 0.074
positive regulation of cytokine secretion GO:0050715 41 0.074
Mouse
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.074
positive regulation of lymphocyte differentiation GO:0045621 61 0.074
negative regulation of cell proliferation GO:0008285 296 0.073
Mouse
positive regulation of endocytosis GO:0045807 42 0.073
regulation of chemokine secretion GO:0090196 4 0.072
regulation of endocytosis GO:0030100 69 0.072
positive regulation of t cell activation GO:0050870 101 0.071
interleukin 8 production GO:0032637 4 0.071
nucleobase containing small molecule metabolic process GO:0055086 352 0.071
striated muscle cell development GO:0055002 125 0.070
response to steroid hormone GO:0048545 56 0.069
Rat
positive regulation of cell activation GO:0050867 158 0.069
cellular ketone metabolic process GO:0042180 84 0.069
Mouse
organ regeneration GO:0031100 2 0.068
regulation of carbohydrate metabolic process GO:0006109 75 0.068
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.068
Mouse
organ or tissue specific immune response GO:0002251 13 0.068
cellular response to growth factor stimulus GO:0071363 197 0.067
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.067
purine ribonucleotide catabolic process GO:0009154 208 0.066
neuron apoptotic process GO:0051402 142 0.066
Mouse
regulation of rho gtpase activity GO:0032319 58 0.065
organic cyclic compound catabolic process GO:1901361 295 0.065
regulation of nucleoside metabolic process GO:0009118 130 0.064
purine ribonucleoside metabolic process GO:0046128 241 0.064
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.063
regulation of muscle tissue development GO:1901861 97 0.063
regulation of leukocyte differentiation GO:1902105 159 0.063
regulation of type ii hypersensitivity GO:0002892 4 0.063
cellular ion homeostasis GO:0006873 165 0.062
rho protein signal transduction GO:0007266 32 0.062
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.062
positive regulation of neutrophil migration GO:1902624 12 0.061
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.061
glycosyl compound metabolic process GO:1901657 246 0.061
apoptotic signaling pathway GO:0097190 306 0.061
cytokine mediated signaling pathway GO:0019221 115 0.060
cellular response to insulin stimulus GO:0032869 78 0.060
Mouse
regulation of homeostatic process GO:0032844 182 0.060
positive regulation of alpha beta t cell activation GO:0046635 39 0.060
sequestering of metal ion GO:0051238 19 0.060
t cell proliferation GO:0042098 120 0.059
regulation of granulocyte chemotaxis GO:0071622 17 0.059
gliogenesis GO:0042063 141 0.059
Mouse
t cell activation involved in immune response GO:0002286 43 0.059
macromolecule glycosylation GO:0043413 55 0.058
Mouse
regulation of kinase activity GO:0043549 249 0.058
Mouse
muscle tissue development GO:0060537 308 0.057
purine ribonucleotide metabolic process GO:0009150 290 0.057
cation transport GO:0006812 399 0.056
regulation of secretion by cell GO:1903530 249 0.056
Mouse
steroid metabolic process GO:0008202 119 0.056
Mouse
alcohol metabolic process GO:0006066 116 0.056
Mouse
t helper 1 type immune response GO:0042088 25 0.055
morphogenesis of a branching epithelium GO:0061138 193 0.055
Mouse
purine nucleotide catabolic process GO:0006195 211 0.055
positive regulation of leukocyte proliferation GO:0070665 73 0.055
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.055
response to oxidative stress GO:0006979 123 0.054
protein n linked glycosylation GO:0006487 12 0.054
Mouse
t cell activation GO:0042110 289 0.054
regulation of t cell proliferation GO:0042129 92 0.054
glycerolipid metabolic process GO:0046486 122 0.054
Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.054
regulation of adiponectin secretion GO:0070163 2 0.054
myeloid cell apoptotic process GO:0033028 22 0.054
protein secretion GO:0009306 111 0.053
Mouse
positive regulation of immune effector process GO:0002699 107 0.053
regulation of cellular component biogenesis GO:0044087 181 0.053
regulation of carbohydrate biosynthetic process GO:0043255 40 0.053
Mouse
innate immune response GO:0045087 157 0.052
Rat
positive regulation of immunoglobulin production GO:0002639 28 0.052
regulation of cellular amine metabolic process GO:0033238 20 0.052
purine nucleoside triphosphate metabolic process GO:0009144 226 0.052
lymphocyte activation involved in immune response GO:0002285 93 0.052
cell activation involved in immune response GO:0002263 126 0.052
nucleoside triphosphate catabolic process GO:0009143 205 0.052
ribonucleoside triphosphate catabolic process GO:0009203 199 0.052
myeloid cell differentiation GO:0030099 233 0.051
t helper 1 cell differentiation GO:0045063 13 0.051
acute inflammatory response to antigenic stimulus GO:0002438 12 0.051
dendritic cell chemotaxis GO:0002407 7 0.051
striated muscle tissue development GO:0014706 293 0.051
regulation of cellular response to stress GO:0080135 159 0.051
gtp catabolic process GO:0006184 143 0.050
adiponectin secretion GO:0070162 2 0.050
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.050
Mouse
nucleoside catabolic process GO:0009164 206 0.050
regulation of purine nucleotide catabolic process GO:0033121 122 0.050
t cell differentiation involved in immune response GO:0002292 30 0.049
developmental growth involved in morphogenesis GO:0060560 138 0.049
regulation of lymphocyte activation GO:0051249 240 0.049
purine containing compound catabolic process GO:0072523 213 0.049
positive regulation of chemotaxis GO:0050921 38 0.048
regulation of t helper 1 type immune response GO:0002825 17 0.048
leukocyte apoptotic process GO:0071887 71 0.048
regulation of rho protein signal transduction GO:0035023 71 0.048
positive regulation of protein secretion GO:0050714 52 0.048
Mouse
positive regulation of transferase activity GO:0051347 167 0.048
Mouse
spermatogenesis GO:0007283 284 0.048
Mouse
positive regulation of hydrolase activity GO:0051345 148 0.048
ribonucleoside catabolic process GO:0042454 206 0.048
nucleoside metabolic process GO:0009116 246 0.047
circulatory system process GO:0003013 197 0.047
Mouse
positive regulation of adaptive immune response GO:0002821 61 0.047
granulocyte chemotaxis GO:0071621 39 0.047
cellular metal ion homeostasis GO:0006875 151 0.047
regulation of type 2 immune response GO:0002828 18 0.047
regulation of neuron apoptotic process GO:0043523 122 0.046
Mouse
regulation of type iia hypersensitivity GO:0001796 4 0.046
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.046
response to tumor necrosis factor GO:0034612 26 0.046
regulation of gtp catabolic process GO:0033124 113 0.046
response to peptide GO:1901652 136 0.046
regulation of cellular catabolic process GO:0031329 242 0.046
glial cell migration GO:0008347 7 0.046
regulation of humoral immune response GO:0002920 22 0.046
regulation of production of molecular mediator of immune response GO:0002700 65 0.046
purine nucleoside catabolic process GO:0006152 205 0.045
monosaccharide biosynthetic process GO:0046364 44 0.045
Mouse
regulation of cytokine production involved in immune response GO:0002718 26 0.045
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 17 0.044
nucleoside phosphate catabolic process GO:1901292 222 0.044
positive regulation of muscle cell differentiation GO:0051149 39 0.044
positive regulation of type ii hypersensitivity GO:0002894 4 0.044
response to oxygen levels GO:0070482 62 0.044
ribonucleotide catabolic process GO:0009261 208 0.044
regulation of alpha beta t cell differentiation GO:0046637 35 0.044
positive regulation of t cell differentiation GO:0045582 52 0.043
ribonucleoside metabolic process GO:0009119 245 0.043
regulation of protein localization GO:0032880 231 0.043
Mouse
positive regulation of leukocyte differentiation GO:1902107 86 0.042
negative regulation of intracellular signal transduction GO:1902532 167 0.042
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.042
monosaccharide metabolic process GO:0005996 106 0.042
Mouse
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.042
insulin receptor signaling pathway GO:0008286 49 0.041
Mouse
i kappab kinase nf kappab signaling GO:0007249 85 0.041
organic hydroxy compound metabolic process GO:1901615 203 0.041
Mouse
positive regulation of jun kinase activity GO:0043507 30 0.041
response to insulin GO:0032868 100 0.040
Mouse
ribonucleoside triphosphate metabolic process GO:0009199 220 0.040
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.040
regulation of triglyceride metabolic process GO:0090207 17 0.040
Mouse
urogenital system development GO:0001655 261 0.040
Mouse
protein glycosylation GO:0006486 55 0.040
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.040
Mouse Rat
positive regulation of neuron death GO:1901216 28 0.040
positive regulation of gtpase activity GO:0043547 85 0.040
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.040
hexose metabolic process GO:0019318 98 0.040
Mouse
regulation of transferase activity GO:0051338 263 0.039
Mouse
response to acid chemical GO:0001101 111 0.039
positive regulation of cd4 positive alpha beta t cell differentiation GO:0043372 14 0.039
regulation of purine nucleotide metabolic process GO:1900542 169 0.039
regulation of lipid biosynthetic process GO:0046890 54 0.039
Mouse
cellular response to molecule of bacterial origin GO:0071219 83 0.039
positive regulation of complement activation GO:0045917 2 0.039
purine ribonucleoside catabolic process GO:0046130 205 0.039
purine nucleoside metabolic process GO:0042278 241 0.038
t helper cell differentiation GO:0042093 28 0.038
intrinsic apoptotic signaling pathway GO:0097193 132 0.038
organonitrogen compound catabolic process GO:1901565 264 0.038
myotube cell development GO:0014904 60 0.038
cell type specific apoptotic process GO:0097285 268 0.038
Mouse
multicellular organismal macromolecule metabolic process GO:0044259 19 0.038
regulation of alpha beta t cell activation GO:0046634 53 0.038
regulation of t helper cell differentiation GO:0045622 14 0.038
interleukin 1 production GO:0032612 31 0.038
regulation of t cell differentiation GO:0045580 83 0.038
regulation of vesicle mediated transport GO:0060627 139 0.038
nucleotide catabolic process GO:0009166 217 0.038
release of sequestered calcium ion into cytosol GO:0051209 42 0.037
skeletal muscle fiber development GO:0048741 58 0.037
regulation of lipid metabolic process GO:0019216 118 0.037
Mouse
antigen processing and presentation GO:0019882 47 0.037
brown fat cell differentiation GO:0050873 36 0.036
cellular calcium ion homeostasis GO:0006874 119 0.036
regulation of cell projection organization GO:0031344 206 0.036
antibacterial peptide biosynthetic process GO:0002780 2 0.036
cytoplasmic transport GO:0016482 234 0.036
jnk cascade GO:0007254 72 0.036
regulation of alpha beta t cell proliferation GO:0046640 18 0.035
negative regulation of fat cell differentiation GO:0045599 36 0.035
t cell differentiation GO:0030217 174 0.035
regulation of stress activated mapk cascade GO:0032872 69 0.035
neutral lipid metabolic process GO:0006638 57 0.035
Mouse
response to ionizing radiation GO:0010212 42 0.035
wound healing GO:0042060 157 0.035
positive regulation of t cell proliferation GO:0042102 52 0.035
phagocytosis GO:0006909 66 0.034
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.034
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.034
ossification GO:0001503 216 0.034
alpha beta t cell activation GO:0046631 91 0.034
response to decreased oxygen levels GO:0036293 59 0.033
calcium ion homeostasis GO:0055074 127 0.033
organophosphate catabolic process GO:0046434 232 0.033
purine nucleoside triphosphate catabolic process GO:0009146 203 0.033
positive regulation of phagocytosis GO:0050766 26 0.033
negative regulation of myoblast differentiation GO:0045662 18 0.033
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.033
cofactor metabolic process GO:0051186 80 0.033
male gamete generation GO:0048232 285 0.032
Mouse
regulation of tumor necrosis factor production GO:0032680 49 0.032
cellular response to peptide hormone stimulus GO:0071375 92 0.032
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.032
regulation of myotube differentiation GO:0010830 62 0.032
cell recognition GO:0008037 83 0.032
lymphocyte differentiation GO:0030098 242 0.032
ribonucleotide metabolic process GO:0009259 291 0.032
cellular divalent inorganic cation homeostasis GO:0072503 127 0.032
macromolecule catabolic process GO:0009057 281 0.031
multi multicellular organism process GO:0044706 109 0.031
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.031
regulation of cell motility GO:2000145 236 0.031
divalent metal ion transport GO:0070838 172 0.031
response to drug GO:0042493 75 0.031
collagen fibril organization GO:0030199 32 0.031
positive regulation of protein kinase b signaling GO:0051897 32 0.031
cellular carbohydrate metabolic process GO:0044262 119 0.031
Mouse
positive regulation of stress activated mapk cascade GO:0032874 48 0.030
carbohydrate derivative catabolic process GO:1901136 231 0.030
negative regulation of carbohydrate metabolic process GO:0045912 19 0.030
Mouse
regulation of glycoprotein biosynthetic process GO:0010559 12 0.030
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.030
Mouse
carbohydrate biosynthetic process GO:0016051 74 0.030
Mouse
nitrogen compound transport GO:0071705 271 0.030
t cell migration GO:0072678 19 0.030
muscle cell development GO:0055001 133 0.029
regulation of macrophage activation GO:0043030 17 0.029
stress activated mapk cascade GO:0051403 80 0.029
peptidyl amino acid modification GO:0018193 336 0.029
Mouse
small molecule biosynthetic process GO:0044283 132 0.029
Mouse
divalent inorganic cation transport GO:0072511 178 0.029
response to inorganic substance GO:0010035 96 0.029
reactive oxygen species biosynthetic process GO:1903409 8 0.029
response to hypoxia GO:0001666 58 0.029
negative regulation of lipid metabolic process GO:0045833 30 0.029
Mouse
defense response to other organism GO:0098542 197 0.029
positive regulation of protein transport GO:0051222 93 0.029
Mouse
stress activated protein kinase signaling cascade GO:0031098 81 0.029
positive regulation of apoptotic cell clearance GO:2000427 3 0.029
regulation of chemokine production GO:0032642 30 0.029
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.029
regulation of cytokine secretion GO:0050707 61 0.028
Mouse
positive regulation of interleukin 1 secretion GO:0050716 14 0.028
regulation of skeletal muscle fiber development GO:0048742 36 0.028
positive regulation of nervous system development GO:0051962 221 0.028
regulation of blood vessel size GO:0050880 56 0.028
Mouse
positive regulation of lymphocyte activation GO:0051251 140 0.027
negative regulation of gluconeogenesis GO:0045721 9 0.027
Mouse
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.027
Mouse
myoblast differentiation GO:0045445 52 0.027
ribose phosphate metabolic process GO:0019693 291 0.027
mucosal immune response GO:0002385 13 0.027
cellular response to oxidative stress GO:0034599 76 0.027
response to growth factor GO:0070848 198 0.027
syncytium formation by plasma membrane fusion GO:0000768 42 0.027
negative regulation of epithelial cell proliferation GO:0050680 64 0.027
t cell mediated immunity GO:0002456 50 0.026
response to organic cyclic compound GO:0014070 198 0.026
Rat
positive regulation of toll like receptor 4 signaling pathway GO:0034145 1 0.026
gluconeogenesis GO:0006094 39 0.026
Mouse
hindbrain development GO:0030902 128 0.026
positive regulation of secretion GO:0051047 130 0.026
Mouse
regulation of neutrophil mediated killing of symbiont cell GO:0070949 2 0.026
hexose biosynthetic process GO:0019319 39 0.026
Mouse

Serpina3n disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.206
hemolytic anemia DOID:583 0 0.104
hemolytic uremic syndrome DOID:12554 0 0.104
immune system disease DOID:2914 0 0.104
normocytic anemia DOID:720 0 0.104
disease of anatomical entity DOID:7 0 0.104
anemia DOID:2355 0 0.104
hematopoietic system disease DOID:74 0 0.104
acquired metabolic disease DOID:0060158 0 0.083
nervous system disease DOID:863 0 0.079
integumentary system disease DOID:16 0 0.069
inherited metabolic disorder DOID:655 0 0.032