Mus musculus

252 known processes

Six3

sine oculis-related homeobox 3 homolog (Drosophila)

(Aliases: Six3beta,Six3alpha,Six3a,Six3b,E130112M24Rik)

Six3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell fate commitment GO:0045165 210 0.995
sensory organ morphogenesis GO:0090596 242 0.974
embryonic organ morphogenesis GO:0048562 276 0.970
neuron fate specification GO:0048665 30 0.970
Mouse
nerve development GO:0021675 67 0.928
Mouse
camera type eye development GO:0043010 266 0.928
central nervous system neuron differentiation GO:0021953 162 0.917
lens morphogenesis in camera type eye GO:0002089 24 0.912
pancreatic a cell fate commitment GO:0003326 2 0.909
axonogenesis GO:0007409 274 0.908
forebrain neuron differentiation GO:0021879 52 0.898
telencephalon development GO:0021537 186 0.897
regulation of neuron differentiation GO:0045664 281 0.896
regionalization GO:0003002 337 0.893
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.892
pancreatic pp cell differentiation GO:0003312 2 0.879
cerebral cortex development GO:0021987 86 0.875
cerebral cortex neuron differentiation GO:0021895 19 0.870
synaptic transmission GO:0007268 329 0.870
Mouse
gland development GO:0048732 330 0.867
astrocyte fate commitment GO:0060018 4 0.860
forebrain development GO:0030900 302 0.855
cerebral cortex gabaergic interneuron differentiation GO:0021892 9 0.854
auditory receptor cell fate determination GO:0042668 3 0.848
regulation of membrane potential GO:0042391 192 0.844
regulation of neuron projection development GO:0010975 169 0.842
somatotropin secreting cell differentiation GO:0060126 4 0.839
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.837
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.829
pituitary gland development GO:0021983 38 0.826
forebrain cell migration GO:0021885 58 0.823
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.799
cellular amino acid metabolic process GO:0006520 103 0.791
skeletal system development GO:0001501 356 0.790
Mouse
forebrain neuron development GO:0021884 30 0.790
lens development in camera type eye GO:0002088 62 0.786
auditory receptor cell fate specification GO:0042667 1 0.785
pancreatic pp cell fate commitment GO:0003329 2 0.782
glial cell differentiation GO:0010001 131 0.779
telencephalon cell migration GO:0022029 55 0.776
embryonic skeletal system development GO:0048706 120 0.768
Mouse
forebrain generation of neurons GO:0021872 63 0.767
negative regulation of neuron differentiation GO:0045665 101 0.763
endocrine system development GO:0035270 98 0.760
pallium development GO:0021543 120 0.757
striated muscle tissue development GO:0014706 293 0.748
Mouse
cerebral cortex gabaergic interneuron migration GO:0021853 6 0.746
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.736
ventral spinal cord interneuron fate commitment GO:0060579 14 0.735
stem cell development GO:0048864 219 0.729
Mouse
cell fate specification GO:0001708 72 0.723
Mouse
leukocyte differentiation GO:0002521 342 0.723
globus pallidus development GO:0021759 2 0.698
diencephalon development GO:0021536 63 0.696
ion transmembrane transport GO:0034220 361 0.690
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.688
somatic stem cell maintenance GO:0035019 47 0.684
Mouse
astrocyte differentiation GO:0048708 43 0.683
ear morphogenesis GO:0042471 118 0.675
Mouse
bmp signaling pathway GO:0030509 93 0.669
cerebral cortex cell migration GO:0021795 44 0.668
cell cell signaling involved in cell fate commitment GO:0045168 35 0.667
forebrain anterior posterior pattern specification GO:0021797 5 0.663
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.660
forebrain regionalization GO:0021871 25 0.652
regulation of cellular amine metabolic process GO:0033238 20 0.651
limbic system development GO:0021761 72 0.651
embryonic epithelial tube formation GO:0001838 130 0.648
Mouse
olfactory lobe development GO:0021988 32 0.644
olfactory bulb development GO:0021772 30 0.641
neural tube development GO:0021915 160 0.631
regulation of cell cycle GO:0051726 281 0.630
transmembrane transport GO:0055085 412 0.624
spinal cord development GO:0021510 81 0.624
retina development in camera type eye GO:0060041 119 0.616
stem cell differentiation GO:0048863 268 0.613
appendage development GO:0048736 166 0.612
inner ear receptor cell differentiation GO:0060113 61 0.612
cellular amine metabolic process GO:0044106 44 0.612
kidney development GO:0001822 213 0.609
Mouse
hemangioblast cell differentiation GO:0060217 1 0.608
cardiac chamber development GO:0003205 108 0.607
negative regulation of wnt signaling pathway GO:0030178 73 0.598
negative regulation of cell proliferation GO:0008285 296 0.598
Mouse
limb development GO:0060173 166 0.593
oligodendrocyte cell fate commitment GO:0021779 5 0.590
mesenchymal cell proliferation GO:0010463 44 0.590
Mouse
retinal ganglion cell axon guidance GO:0031290 18 0.585
embryonic skeletal system morphogenesis GO:0048704 91 0.580
Mouse
cell type specific apoptotic process GO:0097285 268 0.571
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.571
visual perception GO:0007601 52 0.570
ventricular cardiac myofibril assembly GO:0055005 3 0.569
paraxial mesodermal cell differentiation GO:0048342 2 0.566
smoothened signaling pathway GO:0007224 105 0.564
central nervous system neuron development GO:0021954 67 0.554
connective tissue development GO:0061448 179 0.552
Mouse
neuron death GO:0070997 154 0.547
Mouse
spinal cord oligodendrocyte cell fate specification GO:0021530 3 0.544
trophectodermal cell differentiation GO:0001829 21 0.540
cerebral cortex radially oriented cell migration GO:0021799 31 0.539
circadian rhythm GO:0007623 114 0.538
negative regulation of nervous system development GO:0051961 156 0.538
amine metabolic process GO:0009308 45 0.536
motor neuron migration GO:0097475 4 0.528
transdifferentiation GO:0060290 1 0.521
outflow tract morphogenesis GO:0003151 53 0.520
Mouse
morphogenesis of embryonic epithelium GO:0016331 159 0.516
Mouse
regulation of secretion GO:0051046 274 0.515
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.508
cardiac ventricle morphogenesis GO:0003208 50 0.502
oligodendrocyte development GO:0014003 20 0.498
epidermis development GO:0008544 187 0.495
limb morphogenesis GO:0035108 149 0.494
inner ear morphogenesis GO:0042472 101 0.489
Mouse
placenta development GO:0001890 140 0.488
determination of heart left right asymmetry GO:0061371 48 0.485
retina morphogenesis in camera type eye GO:0060042 45 0.484
cell proliferation in forebrain GO:0021846 30 0.483
ear development GO:0043583 200 0.476
Mouse
lateral motor column neuron migration GO:0097477 3 0.475
atrial cardiac muscle cell differentiation GO:0055011 2 0.474
neural precursor cell proliferation GO:0061351 121 0.472
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.470
ventral spinal cord interneuron differentiation GO:0021514 16 0.470
hypothalamus development GO:0021854 16 0.466
digestive tract development GO:0048565 190 0.463
Mouse
positive regulation of mechanoreceptor differentiation GO:0045633 1 0.462
adenohypophysis development GO:0021984 14 0.458
neuron projection guidance GO:0097485 141 0.456
substrate independent telencephalic tangential interneuron migration GO:0021843 8 0.453
chondrocyte differentiation GO:0002062 72 0.452
Mouse
mechanoreceptor differentiation GO:0042490 67 0.451
regulation of neurotransmitter levels GO:0001505 87 0.450
cardiac chamber morphogenesis GO:0003206 93 0.446
regulation of auditory receptor cell differentiation GO:0045607 4 0.445
digestive system development GO:0055123 200 0.440
Mouse
stem cell proliferation GO:0072089 117 0.438
skeletal system morphogenesis GO:0048705 203 0.438
Mouse
metanephros development GO:0001656 79 0.431
Mouse
neuron migration GO:0001764 122 0.430
dendrite development GO:0016358 115 0.429
Fly
substrate independent telencephalic tangential migration GO:0021826 8 0.427
regulation of cellular amino acid metabolic process GO:0006521 5 0.426
cardiac muscle tissue morphogenesis GO:0055008 44 0.421
epithelial tube morphogenesis GO:0060562 303 0.420
Mouse
forebrain neuron fate commitment GO:0021877 13 0.417
positive regulation of neuron differentiation GO:0045666 141 0.417
myeloid cell differentiation GO:0030099 233 0.416
regulation of circadian rhythm GO:0042752 58 0.415
positive regulation of nervous system development GO:0051962 221 0.413
regulation of neuron apoptotic process GO:0043523 122 0.412
Mouse
epithelial cell morphogenesis GO:0003382 41 0.412
Mouse
regulation of timing of cell differentiation GO:0048505 11 0.409
glial cell fate specification GO:0021780 5 0.408
neurohypophysis development GO:0021985 2 0.408
mesenchymal cell development GO:0014031 93 0.405
positive regulation of transcription via serum response element binding GO:0010735 1 0.401
regulation of neuron death GO:1901214 134 0.400
Mouse
tongue development GO:0043586 18 0.399
Mouse
renal tubule development GO:0061326 87 0.397
Mouse
cell differentiation in spinal cord GO:0021515 53 0.393
circulatory system process GO:0003013 197 0.388
regulation of retina development in camera type eye GO:1902866 3 0.387
cation transport GO:0006812 399 0.384
appendage morphogenesis GO:0035107 149 0.382
skeletal muscle cell differentiation GO:0035914 66 0.381
Mouse
cardiac ventricle development GO:0003231 83 0.379
sensory system development GO:0048880 3 0.378
axon guidance GO:0007411 141 0.377
regulation of embryonic development GO:0045995 71 0.376
Mouse
midbrain development GO:0030901 35 0.376
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.375
regulation of wnt signaling pathway GO:0030111 123 0.371
positive regulation of cell cycle GO:0045787 92 0.369
tube formation GO:0035148 140 0.369
Mouse
regulation of muscle tissue development GO:1901861 97 0.368
Mouse
positive regulation of protein modification process GO:0031401 299 0.366
immune effector process GO:0002252 321 0.366
b cell differentiation GO:0030183 78 0.364
atrioventricular node cell fate commitment GO:0060929 1 0.363
hypophysis morphogenesis GO:0048850 3 0.362
anatomical structure homeostasis GO:0060249 145 0.355
atrial cardiac muscle cell development GO:0055014 2 0.353
positive regulation of protein phosphorylation GO:0001934 242 0.353
morphogenesis of a branching epithelium GO:0061138 193 0.351
Mouse
cardiocyte differentiation GO:0035051 87 0.350
hippocampus development GO:0021766 52 0.349
blood vessel morphogenesis GO:0048514 285 0.345
Mouse
ureteric bud morphogenesis GO:0060675 62 0.345
Mouse
paraxial mesodermal cell fate commitment GO:0048343 2 0.345
developmental induction GO:0031128 34 0.343
cerebellar cortex formation GO:0021697 22 0.339
membrane depolarization GO:0051899 64 0.338
purkinje myocyte differentiation GO:0003168 1 0.336
gabaergic neuron differentiation GO:0097154 11 0.334
cytokine production GO:0001816 319 0.334
tube closure GO:0060606 91 0.334
positive regulation of cellular amine metabolic process GO:0033240 5 0.331
amide transport GO:0042886 138 0.326
mesonephric tubule development GO:0072164 94 0.323
Mouse
chemotaxis GO:0006935 247 0.323
spinal cord motor neuron migration GO:0097476 4 0.320
renal system development GO:0072001 225 0.319
Mouse
regulation of asymmetric cell division GO:0009786 4 0.318
multi organism behavior GO:0051705 62 0.317
ventral spinal cord interneuron specification GO:0021521 11 0.317
neuron projection extension GO:1990138 64 0.316
cartilage development GO:0051216 140 0.316
Mouse
respiratory system development GO:0060541 190 0.314
Mouse
heart morphogenesis GO:0003007 178 0.313
Mouse
oviduct development GO:0060066 3 0.310
locomotory behavior GO:0007626 195 0.309
sensory perception GO:0007600 245 0.307
Mouse
regulation of secretion by cell GO:1903530 249 0.307
negative regulation of neuron death GO:1901215 98 0.305
Mouse
oligodendrocyte differentiation GO:0048709 53 0.304
b cell activation GO:0042113 161 0.302
axis elongation involved in somitogenesis GO:0090245 4 0.302
inorganic cation transmembrane transport GO:0098662 207 0.299
regulation of transmembrane transport GO:0034762 128 0.299
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.298
primary neural tube formation GO:0014020 95 0.298
embryonic eye morphogenesis GO:0048048 29 0.298
mesoderm development GO:0007498 100 0.298
Mouse
cardiac pacemaker cell fate commitment GO:0060927 1 0.296
sclerotome development GO:0061056 4 0.296
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.293
Mouse
gastrulation GO:0007369 116 0.293
Mouse
lymphocyte differentiation GO:0030098 242 0.292
regulation of gliogenesis GO:0014013 50 0.287
spinal cord motor neuron differentiation GO:0021522 35 0.287
neural crest cell development GO:0014032 48 0.285
multi multicellular organism process GO:0044706 109 0.284
muscle tissue development GO:0060537 308 0.283
Mouse
nephron tubule morphogenesis GO:0072078 68 0.282
Mouse
ectoderm formation GO:0001705 3 0.281
sensory perception of sound GO:0007605 97 0.280
Mouse
embryonic retina morphogenesis in camera type eye GO:0060059 7 0.277
regulation of system process GO:0044057 200 0.276
spemann organizer formation GO:0060061 2 0.274
peptide hormone secretion GO:0030072 109 0.273
positive regulation of nephron tubule epithelial cell differentiation GO:2000768 1 0.272
metanephric dct cell differentiation GO:0072240 3 0.271
gonad development GO:0008406 141 0.266
Mouse
odontogenesis GO:0042476 78 0.266
ventral spinal cord interneuron fate determination GO:0060580 1 0.265
spinal cord dorsal ventral patterning GO:0021513 23 0.265
neural tube formation GO:0001841 108 0.264
dentate gyrus development GO:0021542 14 0.263
positive regulation of cell development GO:0010720 237 0.262
interneuron migration from the subpallium to the cortex GO:0021830 7 0.255
regulation of cell projection organization GO:0031344 206 0.255
regulation of stem cell proliferation GO:0072091 78 0.255
nitrogen compound transport GO:0071705 271 0.254
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.254
bone morphogenesis GO:0060349 78 0.253
embryonic appendage morphogenesis GO:0035113 126 0.253
regulation of neural precursor cell proliferation GO:2000177 70 0.251
neural retina development GO:0003407 41 0.251
spinal cord oligodendrocyte cell differentiation GO:0021529 3 0.251
cerebral cortex gabaergic interneuron development GO:0021894 6 0.251
glial cell fate commitment GO:0021781 14 0.249
cardiac muscle cell differentiation GO:0055007 69 0.247
regulation of voltage gated calcium channel activity GO:1901385 4 0.247
atrioventricular node cell development GO:0060928 2 0.246
positive regulation of voltage gated calcium channel activity GO:1901387 2 0.246
regulation of heart morphogenesis GO:2000826 22 0.246
Mouse
regulation of peptide secretion GO:0002791 77 0.245
gliogenesis GO:0042063 141 0.244
regulation of mesenchymal cell proliferation GO:0010464 37 0.243
Mouse
organonitrogen compound biosynthetic process GO:1901566 192 0.243
regulation of mast cell differentiation GO:0060375 3 0.242
cell maturation GO:0048469 127 0.241
response to growth factor GO:0070848 198 0.240
synapse organization GO:0050808 125 0.239
Mouse
muscle cell differentiation GO:0042692 261 0.238
Mouse
hindbrain morphogenesis GO:0021575 46 0.236
extracellular matrix organization GO:0030198 147 0.234
apoptotic process involved in development GO:1902742 28 0.233
neural tube closure GO:0001843 90 0.232
regulation of chondrocyte differentiation GO:0032330 33 0.232
Mouse
membrane hyperpolarization GO:0060081 21 0.228
sensory perception of light stimulus GO:0050953 54 0.226
adult behavior GO:0030534 135 0.226
hair cell differentiation GO:0035315 40 0.225
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.225
cellular response to calcium ion GO:0071277 14 0.225
retinal bipolar neuron differentiation GO:0060040 5 0.223
organ growth GO:0035265 117 0.221
developmental growth involved in morphogenesis GO:0060560 138 0.220
Mouse
determination of left right symmetry GO:0007368 80 0.220
spinal cord patterning GO:0021511 25 0.219
cell fate specification involved in pattern specification GO:0060573 11 0.219
canonical wnt signaling pathway GO:0060070 130 0.217
brain segmentation GO:0035284 3 0.214
peptide transport GO:0015833 133 0.213
closure of optic fissure GO:0061386 2 0.213
midbrain hindbrain boundary maturation GO:0021732 1 0.212
development of primary sexual characteristics GO:0045137 143 0.211
Mouse
regulation of feeding behavior GO:0060259 3 0.211
cardiac right ventricle formation GO:0003219 3 0.210
response to radiation GO:0009314 165 0.210
regulation of oxidative phosphorylation uncoupler activity GO:2000275 3 0.209
mesenchyme morphogenesis GO:0072132 32 0.209
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.207
Mouse
horizontal cell localization GO:0035852 1 0.207
cellular ketone metabolic process GO:0042180 84 0.206
regulation of cell motility GO:2000145 236 0.205
auditory receptor cell differentiation GO:0042491 37 0.205
positive regulation of peptide hormone secretion GO:0090277 31 0.205
epithelial cell development GO:0002064 159 0.203
cell fate commitment involved in pattern specification GO:0060581 14 0.202
neural crest cell migration GO:0001755 32 0.202
embryonic forelimb morphogenesis GO:0035115 32 0.201
amacrine cell differentiation GO:0035881 5 0.200
nephron epithelium development GO:0072009 92 0.200
Mouse
nephron development GO:0072006 109 0.198
Mouse
embryonic placenta development GO:0001892 98 0.196
central nervous system morphogenesis GO:0021551 2 0.196
neural tube patterning GO:0021532 43 0.195
regulation of circadian sleep wake cycle GO:0042749 3 0.194
diencephalon morphogenesis GO:0048852 6 0.194
ventricular cardiac muscle tissue development GO:0003229 38 0.194
negative regulation of cell development GO:0010721 169 0.194
regulation of cartilage development GO:0061035 44 0.193
Mouse
endocrine pancreas development GO:0031018 29 0.192
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.190
negative regulation of type b pancreatic cell apoptotic process GO:2000675 3 0.190
positive regulation of stem cell proliferation GO:2000648 59 0.188
Mouse
cation homeostasis GO:0055080 212 0.188
striated muscle cell development GO:0055002 125 0.188
Mouse
cardiac muscle tissue development GO:0048738 130 0.188
ossification GO:0001503 216 0.187
Mouse
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.187
embryonic limb morphogenesis GO:0030326 126 0.186
regulation of neural retina development GO:0061074 3 0.186
multi organism reproductive behavior GO:0044705 29 0.185
regulation of organ morphogenesis GO:2000027 144 0.185
Mouse
heart formation GO:0060914 16 0.185
Mouse
regulation of ossification GO:0030278 112 0.185
Mouse
positive regulation of cell cycle process GO:0090068 61 0.184
cerebellum formation GO:0021588 1 0.184
mesonephric duct formation GO:0072181 2 0.183
somatotropin secreting cell development GO:0060133 2 0.183
regulation of cellular catabolic process GO:0031329 242 0.183
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.183
renal vesicle induction GO:0072034 3 0.183
positive regulation of neural precursor cell proliferation GO:2000179 42 0.183
establishment of organelle localization GO:0051656 122 0.182
glial cell development GO:0021782 54 0.181
regulation of bmp signaling pathway GO:0030510 60 0.180
organic hydroxy compound metabolic process GO:1901615 203 0.180
nephric duct elongation GO:0035849 1 0.179
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.179
epithelial cell fate commitment GO:0072148 13 0.179
regulation of cellular ketone metabolic process GO:0010565 66 0.179
negative regulation of cell fate specification GO:0009996 4 0.179
palate development GO:0060021 76 0.179
synapse assembly GO:0007416 56 0.179
Mouse
peripheral nervous system neuron axonogenesis GO:0048936 3 0.178
mitral valve development GO:0003174 4 0.178
metanephric loop of henle development GO:0072236 4 0.177
myelination GO:0042552 74 0.176
negative regulation of neuron apoptotic process GO:0043524 92 0.175
Mouse
spinal cord association neuron differentiation GO:0021527 14 0.174
cation transmembrane transport GO:0098655 266 0.174
odontogenesis of dentin containing tooth GO:0042475 66 0.174
regulation of epithelial cell proliferation GO:0050678 141 0.173
Mouse
positive regulation of mitotic cell cycle GO:0045931 41 0.173
cardioblast proliferation GO:0003263 8 0.173
Mouse
regulation of gastrulation GO:0010470 16 0.173
urogenital system development GO:0001655 261 0.172
Mouse
olfactory bulb interneuron development GO:0021891 7 0.171
pigmentation GO:0043473 71 0.171
atrioventricular node cell differentiation GO:0060922 2 0.171
mesodermal cell differentiation GO:0048333 22 0.170
Mouse
peripheral nervous system development GO:0007422 53 0.170
wnt signaling pathway GO:0016055 188 0.170
embryonic heart tube formation GO:0003144 1 0.169
organelle localization GO:0051640 179 0.168
tendon cell differentiation GO:0035990 4 0.167
forelimb morphogenesis GO:0035136 40 0.167
cellular component assembly involved in morphogenesis GO:0010927 139 0.166
Mouse
regulation of smoothened signaling pathway GO:0008589 58 0.166
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:2000764 1 0.165
muscle system process GO:0003012 141 0.164
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.164
regulation of peptide hormone secretion GO:0090276 75 0.164
regulation of hormone levels GO:0010817 211 0.163
regulation of cell cycle process GO:0010564 160 0.161
regulation of transporter activity GO:0032409 57 0.161
menarche GO:0042696 1 0.160
pancreas development GO:0031016 57 0.160
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.160
digestion GO:0007586 40 0.160
cellular chemical homeostasis GO:0055082 215 0.159
regulation of white fat cell proliferation GO:0070350 2 0.159
formation of primary germ layer GO:0001704 77 0.159
Mouse
cell differentiation in hindbrain GO:0021533 24 0.158
peripheral nervous system neuron development GO:0048935 9 0.157
organ induction GO:0001759 21 0.156
Mouse
telencephalon regionalization GO:0021978 14 0.155
hormone secretion GO:0046879 128 0.155
forebrain morphogenesis GO:0048853 17 0.155
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.155
visceral serous pericardium development GO:0061032 2 0.154
mesenchymal to epithelial transition GO:0060231 12 0.154
Mouse
deltoid tuberosity development GO:0035993 3 0.153
metanephric nephron morphogenesis GO:0072273 19 0.152
Mouse
muscle tissue morphogenesis GO:0060415 53 0.152
cerebral cortex tangential migration GO:0021800 7 0.151
regulation of axon guidance GO:1902667 13 0.150
g protein coupled receptor signaling pathway GO:0007186 243 0.150
hypothalamus cell differentiation GO:0021979 8 0.149
developmental maturation GO:0021700 193 0.148
specification of organ identity GO:0010092 30 0.147
Mouse
regulation of granulocyte macrophage colony stimulating factor production GO:0032645 3 0.147
cell proliferation in hindbrain GO:0021534 10 0.146
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.146
heart contraction GO:0060047 93 0.145
lung induction GO:0060492 3 0.144
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.144
tendon formation GO:0035992 4 0.144
positive regulation of hormone secretion GO:0046887 38 0.143
potassium ion homeostasis GO:0055075 4 0.143
central nervous system vasculogenesis GO:0022009 3 0.143
epithalamus development GO:0021538 2 0.142
skin development GO:0043588 220 0.142
learning GO:0007612 98 0.142
developmental programmed cell death GO:0010623 41 0.142
multicellular organismal signaling GO:0035637 91 0.142
inner cell mass cell differentiation GO:0001826 7 0.142
hair follicle development GO:0001942 85 0.141
negative regulation of immune system process GO:0002683 209 0.141
feeding behavior GO:0007631 62 0.141
segmentation GO:0035282 93 0.140
cervix development GO:0060067 2 0.140
stem cell fate specification GO:0048866 3 0.139
fat cell differentiation GO:0045444 160 0.139
regulation of stem cell differentiation GO:2000736 50 0.139
Mouse
regulation of canonical wnt signaling pathway GO:0060828 82 0.138
mesenchymal stem cell maintenance involved in nephron morphogenesis GO:0072038 7 0.138
Mouse
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.137
regulation of reproductive process GO:2000241 66 0.137
negative regulation of synapse maturation GO:2000297 2 0.137
regulation of glial cell differentiation GO:0045685 41 0.137
endodermal cell fate specification GO:0001714 4 0.137
neuromuscular process GO:0050905 99 0.136
regulation of vesicle mediated transport GO:0060627 139 0.136
regulation of mitotic cell cycle GO:0007346 126 0.135
brain morphogenesis GO:0048854 32 0.134
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.134
head morphogenesis GO:0060323 34 0.134
dorsal ventral neural tube patterning GO:0021904 28 0.133
positive regulation of synaptic plasticity GO:0031915 4 0.132
oligodendrocyte cell fate specification GO:0021778 5 0.132
regulation of anterior head development GO:2000742 2 0.132
positive regulation of growth GO:0045927 104 0.131
positive regulation of peptide secretion GO:0002793 33 0.131
face morphogenesis GO:0060325 29 0.131
renal vesicle morphogenesis GO:0072077 15 0.130
Mouse
negative regulation of oxidative phosphorylation uncoupler activity GO:2000276 2 0.130
hindlimb morphogenesis GO:0035137 42 0.129
neuroblast differentiation GO:0014016 2 0.129
hindbrain development GO:0030902 128 0.128
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.127
regulation of osteoblast differentiation GO:0045667 67 0.127
embryonic camera type eye development GO:0031076 36 0.126
cell growth GO:0016049 130 0.126
macrophage colony stimulating factor production GO:0036301 1 0.125
rhythmic process GO:0048511 174 0.125
peptidyl tyrosine modification GO:0018212 145 0.125
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.125
regulation of nucleotide metabolic process GO:0006140 169 0.125
axon ensheathment GO:0008366 76 0.124
ectodermal placode formation GO:0060788 16 0.124
Mouse
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.124
somitogenesis GO:0001756 69 0.124
ensheathment of neurons GO:0007272 76 0.123
negative regulation of mesodermal cell fate specification GO:0042662 3 0.123
pericardium development GO:0060039 16 0.123
mesoderm morphogenesis GO:0048332 64 0.123
Mouse
regulation of cardioblast proliferation GO:0003264 9 0.122
Mouse
cardiac cell fate determination GO:0060913 2 0.122
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.122
Mouse
t cell differentiation GO:0030217 174 0.121
extracellular structure organization GO:0043062 148 0.121
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.121
regulation of peptide transport GO:0090087 91 0.121
detection of abiotic stimulus GO:0009582 60 0.121
rhodopsin mediated signaling pathway GO:0016056 4 0.119
metanephros morphogenesis GO:0003338 24 0.117
Mouse
paramesonephric duct development GO:0061205 3 0.117

Six3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.340
disease of anatomical entity DOID:7 0 0.340
eye and adnexa disease DOID:1492 0 0.340
nervous system disease DOID:863 0 0.340
eye disease DOID:5614 0 0.340