IMP

Process View

Mus musculus

13 genes annotated in mouse

epithelial cell fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "epithelial cell fate commitment"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "epithelial cell fate commitment" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.999
Fgfr2	fibroblast growth factor receptor 2	0.997	Mouse
Notch1	Notch gene homolog 1 (Drosophila)	0.995
Fgfr1	fibroblast growth factor receptor 1	0.995	Mouse
Foxc1	forkhead box C1	0.994
Gata4	GATA binding protein 4	0.992
Sox9	SRY-box containing gene 9	0.989
Gli3	GLI-Kruppel family member GLI3	0.988
Otx2	orthodenticle homolog 2 (Drosophila)	0.975
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.973
Neurod1	neurogenic differentiation 1	0.973
Rarg	retinoic acid receptor, gamma	0.972	Mouse
Fgf8	fibroblast growth factor 8	0.966
Hand1	heart and neural crest derivatives expressed transcript 1	0.966	Mouse
Tcfap2a	transcription factor AP-2, alpha	0.931
Pitx2	paired-like homeodomain transcription factor 2	0.899
Hand2	heart and neural crest derivatives expressed transcript 2	0.895	Mouse
Ptf1a	pancreas specific transcription factor, 1a	0.883	Mouse
Pax3	paired box gene 3	0.882
Tbx1	T-box 1	0.856
Sox2	SRY-box containing gene 2	0.852
Lhx3	LIM homeobox protein 3	0.832
Pax6	paired box gene 6	0.809
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.805
Foxc2	forkhead box C2	0.804
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.801	Mouse
Prrx1	paired related homeobox 1	0.797
Emx1	empty spiracles homolog 1 (Drosophila)	0.772
Alx4	aristaless-like homeobox 4	0.767	Mouse
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.767
Gli2	GLI-Kruppel family member GLI2	0.766
Gata6	GATA binding protein 6	0.765	Mouse
Eya1	eyes absent 1 homolog (Drosophila)	0.749
Msx1	homeobox, msh-like 1	0.737
Isl1	ISL1 transcription factor, LIM/homeodomain	0.696
Tgfb2	transforming growth factor, beta 2	0.691
Pax2	paired box gene 2	0.685
Pax8	paired box gene 8	0.665
Dll1	delta-like 1 (Drosophila)	0.661	Mouse
Rxra	retinoid X receptor alpha	0.652
Foxg1	forkhead box G1	0.635
Pitx1	paired-like homeodomain transcription factor 1	0.605
Prrx2	paired related homeobox 2	0.597
Wnt3a	wingless-related MMTV integration site 3A	0.580
Alx3	aristaless-like homeobox 3	0.578	Mouse
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.551
Hes1	hairy and enhancer of split 1 (Drosophila)	0.550
Dlx5	distal-less homeobox 5	0.486
Gsc	goosecoid homeobox	0.459
Emx2	empty spiracles homolog 2 (Drosophila)	0.459
En1	engrailed 1	0.425
Hoxa11	homeobox A11	0.402
Tbx15	T-box 15	0.399
Hoxa1	homeobox A1	0.394
Bmp4	bone morphogenetic protein 4	0.392
Mesp1	mesoderm posterior 1	0.391
Hoxa2	homeobox A2	0.373
Jag1	jagged 1	0.343	Mouse
Vegfa	vascular endothelial growth factor A	0.333
Hes5	hairy and enhancer of split 5 (Drosophila)	0.318
Nog	noggin	0.316
Chd7	chromodomain helicase DNA binding protein 7	0.310
Dlx2	distal-less homeobox 2	0.307
Lmx1b	LIM homeobox transcription factor 1 beta	0.304
Neurog2	neurogenin 2	0.297	Mouse
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.265
Hoxa13	homeobox A13	0.265
Nhlh1	nescient helix loop helix 1	0.255	Mouse
Insm1	insulinoma-associated 1	0.253
Hmx1	H6 homeobox 1	0.242
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.234
Nkx6-1	NK6 homeobox 1	0.225
Gbx2	gastrulation brain homeobox 2	0.222
Tbx3	T-box 3	0.221
Onecut1	one cut domain, family member 1	0.213
Pdx1	pancreatic and duodenal homeobox 1	0.211
Foxa2	forkhead box A2	0.190
Fgf10	fibroblast growth factor 10	0.188
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.179
Pitx3	paired-like homeodomain transcription factor 3	0.178
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.177
Smad6	MAD homolog 6 (Drosophila)	0.170
Lhx5	LIM homeobox protein 5	0.169
Msx2	homeobox, msh-like 2	0.163
Pbx1	pre B-cell leukemia transcription factor 1	0.163
Lhx9	LIM homeobox protein 9	0.156
Tal1	T-cell acute lymphocytic leukemia 1	0.146	Mouse
Efna2	ephrin A2	0.146
Ece1	endothelin converting enzyme 1	0.146
Smo	smoothened homolog (Drosophila)	0.145	Zebrafish
Sox3	SRY-box containing gene 3	0.142
Lhx1	LIM homeobox protein 1	0.137
Evx2	even skipped homeotic gene 2 homolog	0.137
Dlx1	distal-less homeobox 1	0.136
Hoxd13	homeobox D13	0.134	Mouse
Lmx1a	LIM homeobox transcription factor 1 alpha	0.132
Pax1	paired box gene 1	0.130
Trp63	transformation related protein 63	0.130
Myog	myogenin	0.130
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.128
Hoxd3	homeobox D3	0.128
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.127
Zfpm2	zinc finger protein, multitype 2	0.125
Fgf15	fibroblast growth factor 15	0.123
Col2a1	collagen, type II, alpha 1	0.122
Vax1	ventral anterior homeobox containing gene 1	0.109
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.108
Neurog1	neurogenin 1	0.106	Mouse
Ptch1	patched homolog 1	0.106
Psen1	presenilin 1	0.104
Gdnf	glial cell line derived neurotrophic factor	0.104
Ednra	endothelin receptor type A	0.102
Nos3	nitric oxide synthase 3, endothelial cell	0.102
Snai1	snail homolog 1 (Drosophila)	0.098
Srrm4	serine/arginine repetitive matrix 4	0.095
Notch2	Notch gene homolog 2 (Drosophila)	0.094	Mouse
Hoxd11	homeobox D11	0.091
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.091
Gata1	GATA binding protein 1	0.087	Mouse
Gata5	GATA binding protein 5	0.083	Mouse
Pou4f3	POU domain, class 4, transcription factor 3	0.082
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.080
Tcf15	transcription factor 15	0.080	Mouse
Gnrhr	gonadotropin releasing hormone receptor	0.078
Foxf1a	forkhead box F1a	0.077
Dcc	deleted in colorectal carcinoma	0.077
Runx2	runt related transcription factor 2	0.077
Neurog3	neurogenin 3	0.073	Mouse
Btbd17	BTB (POZ) domain containing 17	0.072
Hoxa10	homeobox A10	0.071
Jag2	jagged 2	0.070
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.070
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.070	Mouse
Pten	phosphatase and tensin homolog	0.070
Bmp7	bone morphogenetic protein 7	0.068
Hmx3	H6 homeobox 3	0.068
Hes3	hairy and enhancer of split 3 (Drosophila)	0.067	Mouse
Hoxd12	homeobox D12	0.067
Pax9	paired box gene 9	0.065
Gpr50	G-protein-coupled receptor 50	0.064
Hoxb1	homeobox B1	0.063
Neurod4	neurogenic differentiation 4	0.060	Mouse
Tead3	TEA domain family member 3	0.060
Fgf4	fibroblast growth factor 4	0.059
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.059
Tcf21	transcription factor 21	0.059
Tlx3	T-cell leukemia, homeobox 3	0.058
Hoxd1	homeobox D1	0.057
Sox4	SRY-box containing gene 4	0.057
Fgf3	fibroblast growth factor 3	0.056
Wnt1	wingless-related MMTV integration site 1	0.055
Sox7	SRY-box containing gene 7	0.055
Tbx2	T-box 2	0.052
Tlx2	T-cell leukemia, homeobox 2	0.048
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.047
Dlx6	distal-less homeobox 6	0.046
Hr	hairless	0.045
Foxb1	forkhead box B1	0.043
Zic2	zinc finger protein of the cerebellum 2	0.043
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.043
She	src homology 2 domain-containing transforming protein E	0.042
Sall3	sal-like 3 (Drosophila)	0.041
Tcfap2c	transcription factor AP-2, gamma	0.041
Fgf17	fibroblast growth factor 17	0.040
Otp	orthopedia homolog (Drosophila)	0.040
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.039	Mouse
Foxh1	forkhead box H1	0.039
Rara	retinoic acid receptor, alpha	0.039
Wnt6	wingless-related MMTV integration site 6	0.038
Espn	espin	0.037
Hoxa5	homeobox A5	0.037
Efnb1	ephrin B1	0.037
Sim2	single-minded homolog 2 (Drosophila)	0.037
Foxn4	forkhead box N4	0.036
Uncx	UNC homeobox	0.036
Mesp2	mesoderm posterior 2	0.036
Zic1	zinc finger protein of the cerebellum 1	0.035
Utf1	undifferentiated embryonic cell transcription factor 1	0.035
Efs	embryonal Fyn-associated substrate	0.035
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.034	Mouse
Mnx1	motor neuron and pancreas homeobox 1	0.034
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.034
Dll4	delta-like 4 (Drosophila)	0.034	Mouse
Ebf3	early B-cell factor 3	0.034
Tgfbr2	transforming growth factor, beta receptor II	0.034
Foxd3	forkhead box D3	0.034
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.033
Tbx5	T-box 5	0.033
Gdf11	growth differentiation factor 11	0.033
Otx1	orthodenticle homolog 1 (Drosophila)	0.033
En2	engrailed 2	0.032
Bcl2	B-cell leukemia/lymphoma 2	0.032
Foxd2	forkhead box D2	0.031
Hes2	hairy and enhancer of split 2 (Drosophila)	0.031	Mouse
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.031
Odz2	odd Oz/ten-m homolog 2 (Drosophila)	0.031
Pou4f2	POU domain, class 4, transcription factor 2	0.030
Gli1	GLI-Kruppel family member GLI1	0.030
Efnb2	ephrin B2	0.030
Slc25a48	solute carrier family 25, member 48	0.030
Nkx2-1	NK2 homeobox 1	0.030	Mouse
Chrd	chordin	0.029
Vsx2	visual system homeobox 2	0.029	Mouse
Hoxa4	homeobox A4	0.028
Eng	endoglin	0.028
Pthlh	parathyroid hormone-like peptide	0.028
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.028
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.028
Barx1	BarH-like homeobox 1	0.027
Rarb	retinoic acid receptor, beta	0.027	Mouse
Alx1	ALX homeobox 1	0.027	Mouse
Hoxb4	homeobox B4	0.027
Sox18	SRY-box containing gene 18	0.026
T	brachyury	0.026
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.026
Hoxc6	homeobox C6	0.026
Bnc1	basonuclin 1	0.026
Lhx6	LIM homeobox protein 6	0.026
Nodal	nodal	0.025
Foxb2	forkhead box B2	0.025
Ghr	growth hormone receptor	0.025
Col22a1	collagen, type XXII, alpha 1	0.025
Ptk7	PTK7 protein tyrosine kinase 7	0.025
Hs6st3	heparan sulfate 6-O-sulfotransferase 3	0.024
Padi3	peptidyl arginine deiminase, type III	0.024
Npr3	natriuretic peptide receptor 3	0.024
Nkx3-2	NK3 homeobox 2	0.024	Mouse
Kiss1	KiSS-1 metastasis-suppressor	0.023
Ager	advanced glycosylation end product-specific receptor	0.023
Krt14	keratin 14	0.023
BC024139	cDNA sequence BC024139	0.022
Art5	ADP-ribosyltransferase 5	0.021
Ebf2	early B-cell factor 2	0.021
Wnt7a	wingless-related MMTV integration site 7A	0.021
Arx	aristaless related homeobox	0.021
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.021
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.021
Pou3f4	POU domain, class 3, transcription factor 4	0.021
Gja1	gap junction protein, alpha 1	0.021
Emid2	EMI domain containing 2	0.020
Fgf18	fibroblast growth factor 18	0.020
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.020
Sox11	SRY-box containing gene 11	0.020
Sox1	SRY-box containing gene 1	0.020
Bmp2	bone morphogenetic protein 2	0.020
Adra2b	adrenergic receptor, alpha 2b	0.020
Tbx18	T-box18	0.020
Atoh7	atonal homolog 7 (Drosophila)	0.020	Mouse
Pkd1	polycystic kidney disease 1 homolog	0.019
Efna4	ephrin A4	0.019
Fbn2	fibrillin 2	0.019
Cdh15	cadherin 15	0.019
Tef	thyrotroph embryonic factor	0.019
Irx1	Iroquois related homeobox 1 (Drosophila)	0.019
Lhb	luteinizing hormone beta	0.019
Atoh1	atonal homolog 1 (Drosophila)	0.019
Cer1	cerberus 1 homolog (Xenopus laevis)	0.019
Gsx2	GS homeobox 2	0.019
Gas1	growth arrest specific 1	0.019
Mdfi	MyoD family inhibitor	0.019
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.019
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.018
Sstr5	somatostatin receptor 5	0.018
Mmp24	matrix metallopeptidase 24	0.018
Phlda2	pleckstrin homology-like domain, family A, member 2	0.018
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.018
Epor	erythropoietin receptor	0.018
Lef1	lymphoid enhancer binding factor 1	0.018
Cdh23	cadherin 23 (otocadherin)	0.018
Pou3f3	POU domain, class 3, transcription factor 3	0.018
Omp	olfactory marker protein	0.018
Sox14	SRY-box containing gene 14	0.017
Twist2	twist homolog 2 (Drosophila)	0.017	Mouse
Amh	anti-Mullerian hormone	0.017
Hist1h1t	histone cluster 1, H1t	0.017
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.017
Prox1	prospero-related homeobox 1	0.017	Human
Lhx4	LIM homeobox protein 4	0.017
Vangl2	vang-like 2 (van gogh, Drosophila)	0.016
Rb1	retinoblastoma 1	0.016
Dbp	D site albumin promoter binding protein	0.016
Meox2	mesenchyme homeobox 2	0.016
Nrk	Nik related kinase	0.016
Bcl6b	B-cell CLL/lymphoma 6, member B	0.016
Gata3	GATA binding protein 3	0.016	Mouse
Cdx1	caudal type homeobox 1	0.016
Tacr2	tachykinin receptor 2	0.016
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.016
Fgf9	fibroblast growth factor 9	0.016
Oprd1	opioid receptor, delta 1	0.016
Hif3a	hypoxia inducible factor 3, alpha subunit	0.016
Dmrtb1	DMRT-like family B with proline-rich C-terminal, 1	0.016
Tigd5	tigger transposable element derived 5	0.016
Pou2f2	POU domain, class 2, transcription factor 2	0.016
Egfl7	EGF-like domain 7	0.016
Fev	FEV (ETS oncogene family)	0.016
Isl2	insulin related protein 2 (islet 2)	0.016
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.016
Hoxa3	homeobox A3	0.016
Lama5	laminin, alpha 5	0.016
Fzd8	frizzled homolog 8 (Drosophila)	0.015
Pou3f2	POU domain, class 3, transcription factor 2	0.015
Thrb	thyroid hormone receptor beta	0.015	Mouse
Tbx20	T-box 20	0.015
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.015
Evx1	even skipped homeotic gene 1 homolog	0.015
Fshr	follicle stimulating hormone receptor	0.015
Sim1	single-minded homolog 1 (Drosophila)	0.015
Gfi1b	growth factor independent 1B	0.015
Ntf3	neurotrophin 3	0.015
Foxa1	forkhead box A1	0.015
Irs2	insulin receptor substrate 2	0.015
Hoxa9	homeobox A9	0.014
Rax	retina and anterior neural fold homeobox	0.014
Magel2	melanoma antigen, family L, 2	0.014
Efna1	ephrin A1	0.014
Cilp2	cartilage intermediate layer protein 2	0.014
Pax7	paired box gene 7	0.014
Msx3	homeobox, msh-like 3	0.014
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.014
Idua	iduronidase, alpha-L-	0.014
Gja3	gap junction protein, alpha 3	0.014
Tead4	TEA domain family member 4	0.014
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.014
Odf3	outer dense fiber of sperm tails 3	0.014
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.014
Bhlhe23	basic helix-loop-helix family, member e23	0.014
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.014
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.013
Axin2	axin2	0.013
Vipr2	vasoactive intestinal peptide receptor 2	0.013
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.013
Gata2	GATA binding protein 2	0.013	Mouse
Epha8	Eph receptor A8	0.013
Mecom	MDS1 and EVI1 complex locus	0.013
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.013
Msi1	Musashi homolog 1(Drosophila)	0.013
Krtap12-1	keratin associated protein 12-1	0.013
Grem1	gremlin 1	0.013
Pou3f1	POU domain, class 3, transcription factor 1	0.013
Edn3	endothelin 3	0.013
Tbx19	T-box 19	0.013
Serpina12	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	0.013
Gjb4	gap junction protein, beta 4	0.013
Dmrt3	doublesex and mab-3 related transcription factor 3	0.012
Robo3	roundabout homolog 3 (Drosophila)	0.012
Chrna3	cholinergic receptor, nicotinic, alpha polypeptide 3	0.012
Gja5	gap junction protein, alpha 5	0.012
Mab21l2	mab-21-like 2 (C. elegans)	0.012
Wnt9b	wingless-type MMTV integration site 9B	0.012
Zic4	zinc finger protein of the cerebellum 4	0.012
Irx6	Iroquois related homeobox 6 (Drosophila)	0.012
Ush1g	Usher syndrome 1G homolog (human)	0.012
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.012
Prph2	peripherin 2	0.012
Hoxa7	homeobox A7	0.012
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.012
2310002J15Rik	RIKEN cDNA 2310002J15 gene	0.012
Flt4	FMS-like tyrosine kinase 4	0.012
Matn3	matrilin 3	0.012
Hoxb7	homeobox B7	0.012
Duox2	dual oxidase 2	0.011
Egfr	epidermal growth factor receptor	0.011
Sox13	SRY-box containing gene 13	0.011
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.011
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.011
BC057022	cDNA sequence BC057022	0.011
Trim10	tripartite motif-containing 10	0.011
Hmga2	high mobility group AT-hook 2	0.011
Gad2	glutamic acid decarboxylase 2	0.011
Rbl2	retinoblastoma-like 2	0.011
Zfp358	zinc finger protein 358	0.011
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.011
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.011
Wap	whey acidic protein	0.011
Foxe1	forkhead box E1	0.011
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.011
Cux2	cut-like homeobox 2	0.011
Sp7	Sp7 transcription factor 7	0.010
Sost	sclerostin	0.010
Klf3	Kruppel-like factor 3 (basic)	0.010
Sykb	spleen tyrosine kinase	0.010
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.010
Tcl1	T-cell lymphoma breakpoint 1	0.010