Mus musculus

269 known processes

Smad3

MAD homolog 3 (Drosophila)

(Aliases: Madh3,AU022421)

Smad3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of smad protein import into nucleus GO:0060390 3 1.000
Mouse
metanephric mesenchyme morphogenesis GO:0072133 4 1.000
Mouse
negative regulation of osteoblast proliferation GO:0033689 4 1.000
nephrogenic mesenchyme morphogenesis GO:0072134 2 0.999
Mouse
negative regulation of peptidyl serine phosphorylation GO:0033137 10 0.999
Mouse
cell proliferation involved in heart valve morphogenesis GO:0003249 1 0.999
Mouse
kidney mesenchyme morphogenesis GO:0072131 4 0.998
Mouse
endothelial cell activation GO:0042118 1 0.998
Mouse
epithelial tube morphogenesis GO:0060562 303 0.997
peptidyl threonine modification GO:0018210 31 0.997
Mouse
regulation of peptidyl serine phosphorylation GO:0033135 39 0.996
Mouse
peptidyl threonine phosphorylation GO:0018107 31 0.996
Mouse
negative regulation of peptidyl threonine phosphorylation GO:0010801 6 0.995
Mouse
blood vessel morphogenesis GO:0048514 285 0.995
Mouse
digestive tract development GO:0048565 190 0.995
heart morphogenesis GO:0003007 178 0.994
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.993
bmp signaling pathway GO:0030509 93 0.991
Mouse
branching morphogenesis of an epithelial tube GO:0048754 159 0.991
Mouse
negative regulation of cellular amine metabolic process GO:0033239 1 0.990
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.990
Mouse
regulation of muscle system process GO:0090257 80 0.987
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.985
Mouse
regulation of protein import into nucleus GO:0042306 52 0.985
Human Mouse
germ line stem cell division GO:0042078 2 0.984
cell fate commitment GO:0045165 210 0.982
Mouse
positive regulation of cell development GO:0010720 237 0.982
Human Mouse
negative regulation of bmp signaling pathway GO:0030514 35 0.981
Mouse
negative regulation of cell proliferation GO:0008285 296 0.981
axon guidance GO:0007411 141 0.980
Mouse
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.980
regulation of neuron differentiation GO:0045664 281 0.979
bone development GO:0060348 120 0.979
Mouse
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.978
cell adhesion GO:0007155 329 0.977
Mouse Rat
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.977
lens development in camera type eye GO:0002088 62 0.976
negative regulation of cell development GO:0010721 169 0.975
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.974
Worm
regulation of cell proliferation involved in heart valve morphogenesis GO:0003250 1 0.974
Mouse
urogenital system development GO:0001655 261 0.973
myeloid cell differentiation GO:0030099 233 0.972
Mouse
positive regulation of apoptotic process GO:0043065 217 0.972
Human Rat
activin receptor signaling pathway GO:0032924 18 0.972
Human
mesendoderm development GO:0048382 3 0.972
nephrogenic mesenchyme development GO:0072076 3 0.970
Mouse
cardiac muscle tissue development GO:0048738 130 0.970
Mouse
chemotaxis GO:0006935 247 0.969
Mouse Rat
digestive tract morphogenesis GO:0048546 147 0.969
positive regulation of nervous system development GO:0051962 221 0.969
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.969
cartilage development GO:0051216 140 0.968
connective tissue development GO:0061448 179 0.968
forebrain development GO:0030900 302 0.968
embryonic organ morphogenesis GO:0048562 276 0.968
digestive system development GO:0055123 200 0.966
cardiac endothelial cell differentiation GO:0003348 4 0.963
Mouse
mesonephric tubule development GO:0072164 94 0.962
cell proliferation involved in heart valve development GO:2000793 2 0.961
Mouse
dna metabolic process GO:0006259 303 0.960
striated muscle tissue development GO:0014706 293 0.960
positive regulation of smad protein import into nucleus GO:0060391 2 0.960
Mouse
endocardial cushion formation GO:0003272 13 0.959
Mouse
segmentation GO:0035282 93 0.959
mammary gland morphogenesis GO:0060443 54 0.959
brainstem development GO:0003360 3 0.957
Mouse
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.957
Human Mouse
regulation of cartilage development GO:0061035 44 0.954
muscle cell proliferation GO:0033002 52 0.952
Mouse
regulation of epithelial cell proliferation GO:0050678 141 0.952
regulation of protein kinase activity GO:0045859 232 0.950
angiogenesis GO:0001525 201 0.950
stem cell development GO:0048864 219 0.950
Human Mouse
leukocyte differentiation GO:0002521 342 0.949
regulation of cell adhesion GO:0030155 154 0.947
Mouse Rat
peptidyl amino acid modification GO:0018193 336 0.947
Mouse
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.945
camera type eye development GO:0043010 266 0.944
regulation of bmp signaling pathway GO:0030510 60 0.941
Mouse
regulation of osteoblast differentiation GO:0045667 67 0.939
protein localization to nucleus GO:0034504 121 0.939
Human Mouse
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.934
Mouse
regionalization GO:0003002 337 0.932
nephron tubule morphogenesis GO:0072078 68 0.932
Mouse
endoderm development GO:0007492 45 0.932
regulation of hydrolase activity GO:0051336 246 0.931
Human Rat
negative regulation of phosphorylation GO:0042326 166 0.930
Human Mouse
endocrine system development GO:0035270 98 0.930
negative regulation of nervous system development GO:0051961 156 0.929
nitrogen compound transport GO:0071705 271 0.928
Mouse
response to sterol GO:0036314 4 0.927
appendage development GO:0048736 166 0.924
muscle system process GO:0003012 141 0.924
Mouse
embryonic heart tube development GO:0035050 65 0.923
nephron epithelium morphogenesis GO:0072088 68 0.921
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.921
regulation of osteoblast proliferation GO:0033688 15 0.919
positive regulation of leukocyte differentiation GO:1902107 86 0.919
mesenchymal cell development GO:0014031 93 0.919
Human Mouse
regulation of transferase activity GO:0051338 263 0.918
positive regulation of neuron differentiation GO:0045666 141 0.917
regulation of protein serine threonine kinase activity GO:0071900 157 0.915
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.915
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.913
response to peptide hormone GO:0043434 127 0.913
hair follicle development GO:0001942 85 0.912
Mouse
mapk cascade GO:0000165 281 0.911
Mouse
osteoblast fate commitment GO:0002051 4 0.911
Mouse
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.911
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.909
response to growth factor GO:0070848 198 0.908
regulation of response to wounding GO:1903034 189 0.907
nephron tubule development GO:0072080 84 0.906
Mouse
pathway restricted smad protein phosphorylation GO:0060389 10 0.905
Mouse
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 2 0.902
neural tube development GO:0021915 160 0.901
positive regulation of apoptotic signaling pathway GO:2001235 95 0.900
Rat
positive regulation of stem cell differentiation GO:2000738 23 0.900
Human Mouse
mesodermal cell fate commitment GO:0001710 17 0.899
Mouse
negative regulation of phosphorus metabolic process GO:0010563 184 0.896
Human Mouse
peptide transport GO:0015833 133 0.896
Mouse
ossification GO:0001503 216 0.895
inflammatory response GO:0006954 244 0.891
negative regulation of phosphate metabolic process GO:0045936 184 0.888
Human Mouse
axonogenesis GO:0007409 274 0.888
Mouse
striated muscle cell proliferation GO:0014855 39 0.886
Mouse
t cell activation GO:0042110 289 0.886
wound healing GO:0042060 157 0.886
hindbrain development GO:0030902 128 0.884
Mouse
regulation of organ morphogenesis GO:2000027 144 0.883
Mouse
muscle cell development GO:0055001 133 0.882
negative regulation of cell growth GO:0030308 44 0.880
Human
negative regulation of protein phosphorylation GO:0001933 126 0.880
Human Mouse
regulation of kinase activity GO:0043549 249 0.878
morphogenesis of a branching epithelium GO:0061138 193 0.877
Mouse
female gamete generation GO:0007292 74 0.874
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 0.871
fibroblast migration GO:0010761 21 0.870
gland development GO:0048732 330 0.868
establishment of protein localization to organelle GO:0072594 118 0.866
Human Mouse
somitogenesis GO:0001756 69 0.866
neuron projection guidance GO:0097485 141 0.865
Mouse
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 0.864
peptidyl tyrosine phosphorylation GO:0018108 143 0.861
embryonic epithelial tube formation GO:0001838 130 0.861
cellular macromolecule catabolic process GO:0044265 206 0.861
positive regulation of programmed cell death GO:0043068 218 0.859
Human Rat
morphogenesis of a branching structure GO:0001763 203 0.858
Mouse
regulation of chondrocyte differentiation GO:0032330 33 0.858
kidney development GO:0001822 213 0.857
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.857
cellular amino acid metabolic process GO:0006520 103 0.855
embryonic skeletal system morphogenesis GO:0048704 91 0.855
positive regulation of cell adhesion GO:0045785 80 0.854
Mouse Rat
placenta development GO:0001890 140 0.854
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.852
mesonephric tubule morphogenesis GO:0072171 63 0.850
Mouse
endochondral bone morphogenesis GO:0060350 50 0.847
regulation of neuron projection development GO:0010975 169 0.846
regulation of vasculature development GO:1901342 88 0.845
negative regulation of angiogenesis GO:0016525 25 0.845
positive regulation of epithelial to mesenchymal transition GO:0010718 13 0.845
Human Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.843
Mouse
gastrulation GO:0007369 116 0.840
regulation of binding GO:0051098 111 0.838
regulation of myeloid cell differentiation GO:0045637 96 0.837
regulation of cell migration GO:0030334 219 0.836
Rat
regulation of cell activation GO:0050865 289 0.836
pallium development GO:0021543 120 0.835
somite development GO:0061053 81 0.835
chondrocyte differentiation GO:0002062 72 0.834
t cell differentiation GO:0030217 174 0.832
maternal process involved in female pregnancy GO:0060135 32 0.832
positive regulation of bmp signaling pathway GO:0030513 23 0.827
stem cell differentiation GO:0048863 268 0.826
Human Mouse
positive regulation of mammary gland involution GO:1903521 4 0.826
muscle tissue morphogenesis GO:0060415 53 0.825
Mouse
cytoplasmic transport GO:0016482 234 0.819
Human Mouse
nuclear transport GO:0051169 139 0.816
Human Mouse
cellular amine metabolic process GO:0044106 44 0.816
regulation of cellular amino acid metabolic process GO:0006521 5 0.814
regulation of cellular response to growth factor stimulus GO:0090287 82 0.813
positive regulation of intracellular transport GO:0032388 70 0.812
Human Mouse
peptide secretion GO:0002790 114 0.812
Mouse
limb morphogenesis GO:0035108 149 0.811
response to organic cyclic compound GO:0014070 198 0.809
Mouse
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 12 0.809
positive regulation of cell activation GO:0050867 158 0.807
stem cell maintenance GO:0019827 130 0.806
regulation of hormone levels GO:0010817 211 0.806
Mouse
branching involved in ureteric bud morphogenesis GO:0001658 56 0.805
Mouse
regulation of mapk cascade GO:0043408 248 0.805
negative regulation of protein metabolic process GO:0051248 282 0.805
Human Mouse
wnt signaling pathway GO:0016055 188 0.803
Human
telencephalon development GO:0021537 186 0.802
erythrocyte differentiation GO:0030218 88 0.801
Mouse
regulation of intracellular protein transport GO:0033157 82 0.798
Human Mouse
regulation of epithelial to mesenchymal transition GO:0010717 22 0.798
Human Mouse
response to cholesterol GO:0070723 4 0.795
nephron epithelium development GO:0072009 92 0.795
Mouse
regulation of angiogenesis GO:0045765 81 0.795
response to nutrient levels GO:0031667 109 0.791
renal tubule morphogenesis GO:0061333 72 0.788
Mouse
respiratory tube development GO:0030323 167 0.788
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.786
Human
metanephros development GO:0001656 79 0.786
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.786
response to transforming growth factor beta GO:0071559 88 0.785
amide transport GO:0042886 138 0.785
Mouse
mesenchymal cell differentiation GO:0048762 107 0.782
Human Mouse
myeloid leukocyte differentiation GO:0002573 119 0.781
regulation of stem cell differentiation GO:2000736 50 0.780
Human Mouse
metencephalon development GO:0022037 89 0.779
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.777
Human Mouse
regulation of ossification GO:0030278 112 0.774
positive regulation of neuron projection development GO:0010976 79 0.773
epidermis development GO:0008544 187 0.769
Mouse
neural tube formation GO:0001841 108 0.768
t cell differentiation in thymus GO:0033077 77 0.766
g protein coupled receptor signaling pathway GO:0007186 243 0.764
fat cell differentiation GO:0045444 160 0.764
smad protein complex assembly GO:0007183 1 0.758
Human Rat
ureteric bud morphogenesis GO:0060675 62 0.758
Mouse
lung development GO:0030324 164 0.755
Mouse
nucleocytoplasmic transport GO:0006913 139 0.755
Human Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.755
Human Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.754
regulation of heart contraction GO:0008016 77 0.752
Mouse
regulation of pathway restricted smad protein phosphorylation GO:0060393 6 0.748
Mouse
negative regulation of protein modification process GO:0031400 163 0.746
Human Mouse
appendage morphogenesis GO:0035107 149 0.745
engulfment of apoptotic cell GO:0043652 3 0.745
regulation of wound healing GO:0061041 40 0.744
molting cycle GO:0042303 90 0.743
Mouse
negative regulation of defense response GO:0031348 77 0.741
regulation of cell growth GO:0001558 91 0.734
Human
multicellular organism growth GO:0035264 161 0.734
Worm
positive regulation of glial cell proliferation GO:0060252 4 0.730
male sex differentiation GO:0046661 109 0.729
Worm
positive regulation of map kinase activity GO:0043406 84 0.725
chondrocyte development GO:0002063 24 0.723
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.722
positive regulation of behavior GO:0048520 40 0.721
Rat
response to radiation GO:0009314 165 0.718
sebaceous gland development GO:0048733 7 0.718
Mouse
ureteric bud development GO:0001657 94 0.716
midbrain development GO:0030901 35 0.712
Mouse
amine metabolic process GO:0009308 45 0.712
cell cycle switching GO:0060184 1 0.711
Worm
hormone secretion GO:0046879 128 0.711
Mouse
positive regulation of neuron projection regeneration GO:0070572 2 0.705
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 4 0.705
positive regulation of cell death GO:0010942 224 0.702
Human Rat
negative regulation of cell cycle GO:0045786 123 0.700
Human Worm
nephron morphogenesis GO:0072028 69 0.698
Mouse
embryonic skeletal system development GO:0048706 120 0.697
neural tube closure GO:0001843 90 0.697
cytokine production GO:0001816 319 0.695
Human Rat
extracellular matrix organization GO:0030198 147 0.695
Human
positive regulation of cell proliferation involved in heart morphogenesis GO:2000138 5 0.695
Mouse
palate development GO:0060021 76 0.694
Mouse
developmental growth involved in morphogenesis GO:0060560 138 0.694
canonical wnt signaling pathway GO:0060070 130 0.689
Human
regulation of striated muscle contraction GO:0006942 25 0.688
Mouse
response to monosaccharide GO:0034284 67 0.688
Mouse
central nervous system neuron differentiation GO:0021953 162 0.688
multi multicellular organism process GO:0044706 109 0.684
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.684
skeletal system development GO:0001501 356 0.684
antral ovarian follicle growth GO:0001547 5 0.682
neural precursor cell proliferation GO:0061351 121 0.682
protein import into nucleus GO:0006606 95 0.680
Human Mouse
regulation of peptidyl threonine phosphorylation GO:0010799 12 0.680
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.680
Mouse
cardiac muscle tissue morphogenesis GO:0055008 44 0.675
Mouse
mesenchyme morphogenesis GO:0072132 32 0.673
learning or memory GO:0007611 148 0.672
peptidyl serine modification GO:0018209 83 0.668
Mouse
female sex differentiation GO:0046660 84 0.668
germ cell development GO:0007281 185 0.667
Mouse
positive regulation of notch signaling pathway GO:0045747 18 0.666
regulation of muscle tissue development GO:1901861 97 0.660
stem cell division GO:0017145 30 0.660
negative regulation of inflammatory response GO:0050728 61 0.658
regulation of mammary gland involution GO:1903519 4 0.656
mesenchyme development GO:0060485 152 0.655
negative regulation of blood vessel morphogenesis GO:2000181 25 0.652
regulation of endopeptidase activity GO:0052548 89 0.636
Human Rat
protein targeting GO:0006605 143 0.635
Human Mouse
negative regulation of osteoblast differentiation GO:0045668 30 0.635
positive regulation of cell cycle GO:0045787 92 0.634
Worm
embryonic heart tube morphogenesis GO:0003143 51 0.633
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.632
outflow tract morphogenesis GO:0003151 53 0.632
positive regulation of cell projection organization GO:0031346 95 0.623
nuclear import GO:0051170 95 0.622
Human Mouse
positive regulation of protein import into nucleus GO:0042307 26 0.621
Human Mouse
positive t cell selection GO:0043368 23 0.621
regulation of feeding behavior GO:0060259 3 0.619
apoptotic signaling pathway GO:0097190 306 0.617
Human Rat
developmental maturation GO:0021700 193 0.617
stem cell proliferation GO:0072089 117 0.617
mesonephric epithelium development GO:0072163 94 0.616
positive regulation of myeloid cell differentiation GO:0045639 43 0.616
blastoderm segmentation GO:0007350 13 0.613
organ growth GO:0035265 117 0.613
Mouse
regulation of activin receptor signaling pathway GO:0032925 10 0.609
cell fate determination GO:0001709 32 0.606
lymphocyte differentiation GO:0030098 242 0.606
membrane organization GO:0061024 245 0.605
endocardial cell differentiation GO:0060956 4 0.605
Mouse
ventricular septum development GO:0003281 42 0.605
Mouse
luteinization GO:0001553 8 0.602
mesoderm morphogenesis GO:0048332 64 0.601
positive regulation of chemotaxis GO:0050921 38 0.600
Rat
protein import GO:0017038 101 0.597
Human Mouse
cardiac chamber morphogenesis GO:0003206 93 0.597
Mouse
sensory organ morphogenesis GO:0090596 242 0.595
single organism nuclear import GO:1902593 95 0.595
Human Mouse
formation of primary germ layer GO:0001704 77 0.595
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.595
lateral mesoderm formation GO:0048370 3 0.590
regulation of cell cycle GO:0051726 281 0.586
Human Worm
renal tubule development GO:0061326 87 0.583
Mouse
carbohydrate metabolic process GO:0005975 230 0.582
ameboidal type cell migration GO:0001667 128 0.581
muscle contraction GO:0006936 101 0.578
Mouse
cardiac chamber development GO:0003205 108 0.577
Mouse
lateral mesoderm morphogenesis GO:0048369 3 0.576
morphogenesis of embryonic epithelium GO:0016331 159 0.576
response to alcohol GO:0097305 48 0.575
embryonic placenta development GO:0001892 98 0.574
regulation of myeloid leukocyte differentiation GO:0002761 58 0.572
positive regulation of protein kinase activity GO:0045860 144 0.567
positive regulation of protein modification process GO:0031401 299 0.567
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.565
cardiac muscle tissue growth GO:0055017 37 0.565
Mouse
cellular response to peptide GO:1901653 92 0.563
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.559
mesonephros development GO:0001823 97 0.558
response to granulocyte macrophage colony stimulating factor GO:0097012 3 0.558
cardiac epithelial to mesenchymal transition GO:0060317 18 0.555
Mouse
hepaticobiliary system development GO:0061008 67 0.549
tissue regeneration GO:0042246 22 0.547
bone morphogenesis GO:0060349 78 0.547
negative regulation of growth GO:0045926 99 0.546
Human
retina development in camera type eye GO:0060041 119 0.546
determination of left right symmetry GO:0007368 80 0.546
ventricular septum morphogenesis GO:0060412 27 0.545
Mouse
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.544
Mouse
organonitrogen compound catabolic process GO:1901565 264 0.541
positive regulation of cellular amine metabolic process GO:0033240 5 0.539
negative regulation of endothelial cell differentiation GO:0045602 2 0.537
regulation of cell substrate adhesion GO:0010810 73 0.536
Rat
renal system development GO:0072001 225 0.533
muscle tissue development GO:0060537 308 0.532
single organismal cell cell adhesion GO:0016337 131 0.531
Mouse
regulation of melanocyte differentiation GO:0045634 7 0.529
regulation of anti mullerian hormone signaling pathway GO:1902612 1 0.529
epithelial tube formation GO:0072175 130 0.529
cellular response to alcohol GO:0097306 23 0.529
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.528
positive regulation of cytoplasmic transport GO:1903651 40 0.526
Human Mouse
cartilage condensation GO:0001502 18 0.525
male gonad development GO:0008584 88 0.523
myeloid cell homeostasis GO:0002262 114 0.522
Mouse
regulation of rho protein signal transduction GO:0035023 71 0.522
negative regulation of wound healing GO:0061045 14 0.515
regulation of apoptotic signaling pathway GO:2001233 197 0.515
Rat
regulation of fibroblast proliferation GO:0048145 34 0.514
protein maturation GO:0051604 176 0.511
Human Rat
cell type specific apoptotic process GO:0097285 268 0.511
positive regulation of epithelial cell migration GO:0010634 19 0.510
formation of anatomical boundary GO:0048859 6 0.506
Mouse
trachea formation GO:0060440 3 0.506
regulation of axon extension GO:0030516 43 0.505
regulation of transforming growth factor beta2 production GO:0032909 2 0.504
Human
respiratory system development GO:0060541 190 0.500
Mouse
fused antrum stage GO:0048165 1 0.500
synaptic transmission GO:0007268 329 0.499
insulin secretion GO:0030073 89 0.498
Mouse
energy reserve metabolic process GO:0006112 39 0.494
regulation of protein binding GO:0043393 60 0.494
regulation of purine nucleotide metabolic process GO:1900542 169 0.494
trophectodermal cellular morphogenesis GO:0001831 3 0.493
tube formation GO:0035148 140 0.492
regulation of muscle contraction GO:0006937 49 0.490
Mouse
regulation of t cell activation GO:0050863 170 0.490
signal transduction by p53 class mediator GO:0072331 51 0.489
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.488
rho protein signal transduction GO:0007266 32 0.488
circulatory system process GO:0003013 197 0.488
Mouse
regeneration GO:0031099 38 0.487
progesterone metabolic process GO:0042448 4 0.486
development of primary female sexual characteristics GO:0046545 73 0.484
endocardium development GO:0003157 10 0.482
Mouse
regulation of nucleotide metabolic process GO:0006140 169 0.482
muscle cell differentiation GO:0042692 261 0.476
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.476
determination of heart left right asymmetry GO:0061371 48 0.475
common partner smad protein phosphorylation GO:0007182 2 0.474
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.472
ovulation cycle GO:0042698 59 0.470
cardiac septum development GO:0003279 59 0.469
Mouse
cellular homeostasis GO:0019725 240 0.468
generation of precursor metabolites and energy GO:0006091 103 0.462
regulation of protein targeting GO:1903533 61 0.461
Human Mouse
regulation of alpha beta t cell differentiation GO:0046637 35 0.461
development of primary sexual characteristics GO:0045137 143 0.460
positive regulation of activin receptor signaling pathway GO:0032927 3 0.459
regulation of protein localization to nucleus GO:1900180 60 0.459
Human Mouse
regulation of ras protein signal transduction GO:0046578 114 0.458
response to inorganic substance GO:0010035 96 0.458
atrioventricular valve morphogenesis GO:0003181 13 0.457
Mouse
maternal placenta development GO:0001893 20 0.456
peptide hormone secretion GO:0030072 109 0.455
Mouse
negative regulation of molecular function GO:0044092 258 0.455
positive regulation of cartilage development GO:0061036 18 0.455
negative regulation of glycolytic process GO:0045820 4 0.453
response to amino acid GO:0043200 37 0.453
cellular response to inorganic substance GO:0071241 37 0.453
apoptotic process involved in mammary gland involution GO:0060057 4 0.453
regulation of blood circulation GO:1903522 93 0.450
Mouse
biomineral tissue development GO:0031214 64 0.449
Rat
activation of mapk activity GO:0000187 59 0.449
heart field specification GO:0003128 6 0.449
release of cytochrome c from mitochondria GO:0001836 23 0.449
lateral mesodermal cell differentiation GO:0048371 3 0.447
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.446
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 0.444
Mouse
regulation of blood vessel endothelial cell migration GO:0043535 12 0.444
oxidation reduction process GO:0055114 342 0.443
positive regulation of t cell activation GO:0050870 101 0.443
tissue remodeling GO:0048771 102 0.442
smad protein import into nucleus GO:0007184 6 0.442
Mouse
heart valve morphogenesis GO:0003179 21 0.440
Mouse
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.439
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.439
Human Rat
reactive nitrogen species metabolic process GO:2001057 0 0.439
tolerance induction to self antigen GO:0002513 4 0.439
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 11 0.434
oogenesis GO:0048477 56 0.434
blastocyst development GO:0001824 80 0.433
osteoblast development GO:0002076 17 0.431
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.431
embryonic limb morphogenesis GO:0030326 126 0.431
intracellular receptor signaling pathway GO:0030522 74 0.431
response to peptide GO:1901652 136 0.430
gonad development GO:0008406 141 0.430
regulation of nucleocytoplasmic transport GO:0046822 73 0.430
Human Mouse
spermatid differentiation GO:0048515 115 0.428
genetic imprinting GO:0071514 27 0.427
regulation of cellular catabolic process GO:0031329 242 0.427
embryonic digit morphogenesis GO:0042733 56 0.425
endothelial cell differentiation GO:0045446 41 0.424
Mouse
regulation of reproductive process GO:2000241 66 0.422
dendrite development GO:0016358 115 0.421
energy derivation by oxidation of organic compounds GO:0015980 77 0.421
regulation of notch signaling pathway GO:0008593 35 0.421
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 2 0.419
primary neural tube formation GO:0014020 95 0.419
negative regulation of immune system process GO:0002683 209 0.419
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.418
regulation of b cell tolerance induction GO:0002661 2 0.417
regulation of meiotic cell cycle GO:0051445 34 0.417
Worm
cellular response to organonitrogen compound GO:0071417 145 0.416
development of primary male sexual characteristics GO:0046546 88 0.416
skeletal system morphogenesis GO:0048705 203 0.415
cardiac septum morphogenesis GO:0060411 46 0.411
Mouse
neuronal action potential GO:0019228 54 0.411
regulation of cellular response to stress GO:0080135 159 0.410
negative regulation of neuron migration GO:2001223 6 0.409
regulation of epidermis development GO:0045682 33 0.409
Mouse
epithelial cell proliferation GO:0050673 174 0.407
asymmetric neuroblast division GO:0055059 1 0.407
kidney morphogenesis GO:0060993 83 0.405
Mouse
regulation of map kinase activity GO:0043405 120 0.403
cellular ketone metabolic process GO:0042180 84 0.403
negative regulation of response to wounding GO:1903035 77 0.401
positive regulation of cell motility GO:2000147 116 0.400
Rat
response to inactivity GO:0014854 4 0.399
cellular divalent inorganic cation homeostasis GO:0072503 127 0.399
striated muscle cell development GO:0055002 125 0.398
positive regulation of osteoblast differentiation GO:0045669 34 0.395
Mouse
protein localization to organelle GO:0033365 185 0.394
Human Mouse
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.392
female gonad development GO:0008585 71 0.391
labyrinthine layer morphogenesis GO:0060713 21 0.390
regulation of protein stability GO:0031647 52 0.389
Human
regulation of cellular senescence GO:2000772 6 0.388
keratinocyte migration GO:0051546 3 0.387
regulation of endothelial cell differentiation GO:0045601 10 0.385
response to insulin GO:0032868 100 0.383

Smad3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.942
cancer DOID:162 0 0.735
disease of anatomical entity DOID:7 0 0.668
musculoskeletal system disease DOID:17 0 0.668
connective tissue disease DOID:65 0 0.668
organ system cancer DOID:0050686 0 0.552