Mus musculus

38 known processes

Spp1

secreted phosphoprotein 1

(Aliases: BSPI,Apl-1,ETA-1,Opnl,Bsp,Spp-1,Eta,2AR,BNSP,Opn,Ric,OP)

Spp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
detection of molecule of bacterial origin GO:0032490 2 0.836
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.808
regulation of response to wounding GO:1903034 189 0.712
induction by organism of immune response of other organism involved in symbiotic interaction GO:0052558 1 0.696
positive regulation by symbiont of defense related host nitric oxide production GO:0052347 1 0.682
modulation by symbiont of defense related host nitric oxide production GO:0052163 1 0.653
response to defense related nitric oxide production by other organism involved in symbiotic interaction GO:0052551 2 0.607
interleukin 18 mediated signaling pathway GO:0035655 2 0.606
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.587
regulation of inflammatory response GO:0050727 147 0.581
cellular amine metabolic process GO:0044106 44 0.563
cellular response to interleukin 18 GO:0071351 3 0.534
response to molecule of fungal origin GO:0002238 4 0.519
regulation of defense response GO:0031347 233 0.513
neuronal action potential GO:0019228 54 0.507
response to host immune response GO:0052572 3 0.504
response to defense related host nitric oxide production GO:0052565 2 0.470
cellular response to peptidoglycan GO:0071224 4 0.469
regulation of membrane potential GO:0042391 192 0.468
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070428 3 0.455
organic acid transport GO:0015849 101 0.431
response to bacterial lipoprotein GO:0032493 4 0.431
positive regulation of response to wounding GO:1903036 66 0.416
response to lipopolysaccharide GO:0032496 128 0.395
transmission of nerve impulse GO:0019226 76 0.394
axon ensheathment GO:0008366 76 0.394
modulation by symbiont of host immune response GO:0052553 1 0.381
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.380
regulation of nucleotide binding oligomerization domain containing signaling pathway GO:0070424 3 0.375
amine metabolic process GO:0009308 45 0.367
positive regulation of inflammatory response GO:0050729 47 0.363
peptide transport GO:0015833 133 0.362
regulation of cellular ketone metabolic process GO:0010565 66 0.359
response to molecule of bacterial origin GO:0002237 143 0.356
positive regulation of macrophage cytokine production GO:0060907 7 0.347
regulation of acute inflammatory response GO:0002673 27 0.344
interferon beta biosynthetic process GO:0045350 4 0.341
myelination GO:0042552 74 0.331
action potential GO:0001508 78 0.329
positive regulation of programmed cell death GO:0043068 218 0.329
response to immune response of other organism involved in symbiotic interaction GO:0052564 3 0.327
positive regulation of cellular amine metabolic process GO:0033240 5 0.314
response to organic cyclic compound GO:0014070 198 0.314
regulation of cellular amine metabolic process GO:0033238 20 0.312
positive regulation by symbiont of host immune response GO:0052556 1 0.312
leukocyte differentiation GO:0002521 342 0.311
negative regulation of interleukin 17 production GO:0032700 5 0.305
carboxylic acid transport GO:0046942 100 0.304
modification by symbiont of host morphology or physiology GO:0044003 4 0.301
cellular response to molecule of bacterial origin GO:0071219 83 0.295
regulation of cell activation GO:0050865 289 0.295
defense response to other organism GO:0098542 197 0.295
negative regulation of inflammatory response GO:0050728 61 0.293
cytokine mediated signaling pathway GO:0019221 115 0.290
positive regulation of interleukin 18 production GO:0032741 2 0.289
wound healing involved in inflammatory response GO:0002246 4 0.284
response to host defenses GO:0052200 3 0.283
anion transport GO:0006820 177 0.283
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.282
response to oxygen levels GO:0070482 62 0.279
cell type specific apoptotic process GO:0097285 268 0.279
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.276
regulation of ion transport GO:0043269 215 0.274
positive regulation of defense response GO:0031349 124 0.274
cellular ion homeostasis GO:0006873 165 0.267
positive regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070430 1 0.267
multicellular organismal signaling GO:0035637 91 0.266
induction by symbiont of host immune response GO:0052559 1 0.262
inflammatory response to wounding GO:0090594 4 0.261
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.254
induction by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052263 1 0.247
cellular lipid metabolic process GO:0044255 323 0.240
response to host GO:0075136 3 0.240
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.237
organic anion transport GO:0015711 137 0.237
positive regulation of leukocyte proliferation GO:0070665 73 0.237
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.234
inflammatory response GO:0006954 244 0.233
regulation of cytokine production involved in immune response GO:0002718 26 0.228
angiogenesis GO:0001525 201 0.227
leukocyte migration GO:0050900 124 0.226
cytokine production GO:0001816 319 0.220
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 5 0.215
modulation by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052302 1 0.215
nitric oxide production involved in inflammatory response GO:0002537 2 0.214
cellular response to lipid GO:0071396 145 0.213
cation homeostasis GO:0055080 212 0.208
regulation of leukocyte proliferation GO:0070663 121 0.208
positive regulation of secretion GO:0051047 130 0.208
cellular response to oxidative stress GO:0034599 76 0.205
positive regulation of apoptotic cell clearance GO:2000427 3 0.202
regulation of b cell activation GO:0050864 81 0.202
b cell proliferation GO:0042100 53 0.199
negative regulation of response to wounding GO:1903035 77 0.198
metal ion homeostasis GO:0055065 189 0.192
positive regulation of lymphocyte proliferation GO:0050671 70 0.192
cellular amino acid metabolic process GO:0006520 103 0.190
regulation of secretion GO:0051046 274 0.189
blood vessel morphogenesis GO:0048514 285 0.188
negative regulation of interleukin 6 production GO:0032715 17 0.187
regulation of mapk cascade GO:0043408 248 0.187
cellular chemical homeostasis GO:0055082 215 0.187
response to low density lipoprotein particle GO:0055098 2 0.186
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.185
positive regulation of nucleotide binding oligomerization domain containing signaling pathway GO:0070426 2 0.184
regulation of mhc class ii biosynthetic process GO:0045346 7 0.184
lipid biosynthetic process GO:0008610 179 0.184
antibiotic transport GO:0042891 1 0.183
acute inflammatory response GO:0002526 41 0.181
interleukin 18 production GO:0032621 4 0.181
regulation of cytokine production GO:0001817 266 0.180
regulation of lymphocyte activation GO:0051249 240 0.178
b cell activation GO:0042113 161 0.177
positive regulation of acute inflammatory response GO:0002675 16 0.175
fatty acid metabolic process GO:0006631 121 0.174
nitrogen compound transport GO:0071705 271 0.174
induction by organism of defense response of other organism involved in symbiotic interaction GO:0052251 1 0.174
organic hydroxy compound metabolic process GO:1901615 203 0.173
negative regulation of interferon gamma mediated signaling pathway GO:0060336 1 0.173
positive regulation of cytokine production involved in immune response GO:0002720 19 0.171
positive regulation of immune complex clearance by monocytes and macrophages GO:0090265 2 0.170
leukocyte apoptotic process GO:0071887 71 0.169
eosinophil activation involved in immune response GO:0002278 1 0.168
reactive nitrogen species metabolic process GO:2001057 0 0.167
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.165
cellular response to organonitrogen compound GO:0071417 145 0.165
cellular ketone metabolic process GO:0042180 84 0.164
response to organonitrogen compound GO:0010243 246 0.163
response to inorganic substance GO:0010035 96 0.163
ensheathment of neurons GO:0007272 76 0.161
cellular response to bacterial lipopeptide GO:0071221 3 0.159
myeloid cell differentiation GO:0030099 233 0.154
regulation of nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070432 3 0.154
response to oxidative stress GO:0006979 123 0.153
extracellular matrix organization GO:0030198 147 0.152
negative regulation of defense response GO:0031348 77 0.151
wound healing GO:0042060 157 0.150
antibacterial peptide production GO:0002778 2 0.150
positive regulation by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052345 1 0.149
negative regulation of cytokine production GO:0001818 84 0.148
cellular response to bacterial lipoprotein GO:0071220 3 0.148
peptidyl amino acid modification GO:0018193 336 0.148
macrophage cytokine production GO:0010934 9 0.144
regulation of apoptotic signaling pathway GO:2001233 197 0.143
positive regulation by symbiont of host defense response GO:0052509 1 0.143
positive regulation of map kinase activity GO:0043406 84 0.142
regulation of membrane protein ectodomain proteolysis GO:0051043 3 0.142
positive regulation of protein modification process GO:0031401 299 0.142
response to defenses of other organism involved in symbiotic interaction GO:0052173 3 0.141
regulation of cellular amino acid metabolic process GO:0006521 5 0.141
positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070434 2 0.140
positive regulation of protein secretion GO:0050714 52 0.137
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.136
positive regulation of t cell costimulation GO:2000525 2 0.136
regulation of interleukin 18 production GO:0032661 3 0.135
extracellular structure organization GO:0043062 148 0.134
t cell extravasation GO:0072683 4 0.133
cellular response to biotic stimulus GO:0071216 92 0.132
positive regulation of apoptotic process GO:0043065 217 0.131
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.131
ossification GO:0001503 216 0.130
negative regulation of chemokine biosynthetic process GO:0045079 2 0.129
protein kinase b signaling GO:0043491 74 0.128
oxidation reduction process GO:0055114 342 0.128
modulation by organism of defense response of other organism involved in symbiotic interaction GO:0052255 1 0.127
response to vitamin a GO:0033189 1 0.124
regulation of protein localization GO:0032880 231 0.124
fever generation GO:0001660 7 0.123
transmembrane transport GO:0055085 412 0.122
negative regulation of cell proliferation GO:0008285 296 0.122
regulation of cellular response to stress GO:0080135 159 0.121
modulation by organism of immune response of other organism involved in symbiotic interaction GO:0052552 1 0.121
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.120
regulation of protein secretion GO:0050708 82 0.119
positive regulation of lymphocyte activation GO:0051251 140 0.118
peptide secretion GO:0002790 114 0.116
interleukin 10 secretion GO:0072608 4 0.116
positive regulation of interleukin 6 production GO:0032755 37 0.115
negative regulation of chemokine production GO:0032682 4 0.115
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 16 0.115
immune effector process GO:0002252 321 0.114
amide transport GO:0042886 138 0.113
positive regulation of intracellular transport GO:0032388 70 0.113
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 9 0.112
positive regulation of b cell proliferation GO:0030890 24 0.112
regulation of interleukin 6 production GO:0032675 55 0.112
positive regulation of protein phosphorylation GO:0001934 242 0.111
regulation of kinase activity GO:0043549 249 0.111
regulation of cell motility GO:2000145 236 0.110
epidermis development GO:0008544 187 0.110
protein secretion GO:0009306 111 0.108
regulation of neuron apoptotic process GO:0043523 122 0.108
neuron death GO:0070997 154 0.108
apoptotic signaling pathway GO:0097190 306 0.107
positive regulation of secretion by cell GO:1903532 114 0.106
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 2 0.105
chemokine production GO:0032602 34 0.105
immune complex clearance by monocytes and macrophages GO:0002436 2 0.104
regulation of peptide transport GO:0090087 91 0.103
positive regulation of cell migration GO:0030335 109 0.102
microglial cell activation involved in immune response GO:0002282 1 0.102
eosinophil degranulation GO:0043308 1 0.101
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.100
response to interleukin 1 GO:0070555 11 0.100
positive regulation of cell activation GO:0050867 158 0.100
induction by symbiont of defense related host nitric oxide production GO:0052063 1 0.100
cell activation involved in immune response GO:0002263 126 0.099
peptidyl serine modification GO:0018209 83 0.099
calcium ion homeostasis GO:0055074 127 0.099
response to bacterial lipopeptide GO:0070339 3 0.097
positive regulation of hemostasis GO:1900048 10 0.097
reactive oxygen species metabolic process GO:0072593 84 0.097
positive regulation of glial cell proliferation GO:0060252 4 0.097
production of molecular mediator involved in inflammatory response GO:0002532 21 0.097
leukocyte activation involved in immune response GO:0002366 126 0.097
monocarboxylic acid transport GO:0015718 44 0.096
interaction with host GO:0051701 22 0.096
purine nucleoside biosynthetic process GO:0042451 19 0.096
extrinsic apoptotic signaling pathway GO:0097191 126 0.095
dna metabolic process GO:0006259 303 0.095
monocarboxylic acid metabolic process GO:0032787 191 0.095
acylglycerol metabolic process GO:0006639 55 0.095
positive regulation of cytokine production GO:0001819 174 0.094
t cell activation GO:0042110 289 0.094
neutrophil apoptotic process GO:0001781 3 0.094
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.094
regulation of peptidase activity GO:0052547 96 0.094
positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061081 9 0.094
i kappab kinase nf kappab signaling GO:0007249 85 0.094
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.094
positive regulation of cell development GO:0010720 237 0.093
reactive oxygen species biosynthetic process GO:1903409 8 0.093
cellular divalent inorganic cation homeostasis GO:0072503 127 0.093
interleukin 5 secretion GO:0072603 2 0.093
positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 2 0.093
divalent inorganic cation homeostasis GO:0072507 138 0.092
regulation of cytokine secretion GO:0050707 61 0.092
regulation of interleukin 6 biosynthetic process GO:0045408 11 0.092
eosinophil activation GO:0043307 1 0.092
response to glucocorticoid GO:0051384 20 0.092
regulation of t cell costimulation GO:2000523 2 0.091
cellular response to cytokine stimulus GO:0071345 189 0.091
regulation of interleukin 10 secretion GO:2001179 4 0.091
chemokine mediated signaling pathway GO:0070098 17 0.091
sensory perception GO:0007600 245 0.090
lymphocyte activation involved in immune response GO:0002285 93 0.090
response to reactive oxygen species GO:0000302 56 0.090
negative regulation of secretion GO:0051048 61 0.089
response to extracellular stimulus GO:0009991 127 0.089
positive regulation of protein transport GO:0051222 93 0.089
positive regulation of phagocytosis engulfment GO:0060100 3 0.088
glial cell differentiation GO:0010001 131 0.088
adaptive immune response GO:0002250 155 0.088
regulation of establishment of protein localization GO:0070201 181 0.087
lipid homeostasis GO:0055088 63 0.087
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.086
myeloid cell homeostasis GO:0002262 114 0.086
positive regulation of t cell proliferation GO:0042102 52 0.086
regulation of protein transport GO:0051223 163 0.086
regulation of cell migration GO:0030334 219 0.084
positive regulation of interferon alpha production GO:0032727 4 0.084
nitric oxide synthase biosynthetic process GO:0051767 7 0.084
epithelial cell proliferation GO:0050673 174 0.084
positive regulation of cell motility GO:2000147 116 0.083
cytokine production involved in immune response GO:0002367 34 0.082
response to hypoxia GO:0001666 58 0.082
mapk cascade GO:0000165 281 0.082
positive regulation of cell death GO:0010942 224 0.082
glial cell apoptotic process GO:0034349 3 0.081
gliogenesis GO:0042063 141 0.081
protein catabolic process GO:0030163 221 0.079
response to growth factor GO:0070848 198 0.078
morphogenesis of a branching structure GO:0001763 203 0.078
regulation of secretion by cell GO:1903530 249 0.077
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.076
regulation of vascular endothelial growth factor production GO:0010574 13 0.076
cellular calcium ion homeostasis GO:0006874 119 0.075
b cell activation involved in immune response GO:0002312 50 0.075
negative regulation of hydrolase activity GO:0051346 71 0.075
placenta development GO:0001890 140 0.074
organ or tissue specific immune response GO:0002251 13 0.074
lymphocyte homeostasis GO:0002260 64 0.073
leukocyte mediated immunity GO:0002443 174 0.073
defense response to gram positive bacterium GO:0050830 50 0.072
positive regulation of b cell activation GO:0050871 49 0.072
purine containing compound biosynthetic process GO:0072522 70 0.072
chloramphenicol transport GO:0042892 1 0.072
cytokine secretion GO:0050663 72 0.072
cellular response to lipopolysaccharide GO:0071222 77 0.071
regulation of dendritic cell chemotaxis GO:2000508 1 0.071
cellular metal ion homeostasis GO:0006875 151 0.071
divalent metal ion transport GO:0070838 172 0.071
response to interleukin 15 GO:0070672 3 0.070
positive regulation of cytokine secretion GO:0050715 41 0.070
defense response to gram negative bacterium GO:0050829 28 0.070
positive regulation of neuron projection regeneration GO:0070572 2 0.070
response to corticosteroid GO:0031960 20 0.069
response to nutrient levels GO:0031667 109 0.069
negative regulation of interleukin 23 production GO:0032707 1 0.069
positive regulation of adaptive immune response GO:0002821 61 0.069
response to acid chemical GO:0001101 111 0.069
calcium ion transport GO:0006816 159 0.069
regulation of interleukin 8 production GO:0032677 3 0.068
response to drug GO:0042493 75 0.068
positive regulation of platelet activation GO:0010572 5 0.067
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 6 0.067
positive regulation of fatty acid oxidation GO:0046321 4 0.066
myeloid leukocyte cytokine production GO:0061082 12 0.066
cellular response to external stimulus GO:0071496 88 0.066
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.065
interleukin 6 mediated signaling pathway GO:0070102 6 0.065
negative regulation of macrophage apoptotic process GO:2000110 3 0.065
regulation of monocyte extravasation GO:2000437 2 0.065
homeostasis of number of cells GO:0048872 210 0.065
positive regulation of coagulation GO:0050820 13 0.065
response to amino acid GO:0043200 37 0.064
negative regulation of immune system process GO:0002683 209 0.064
carboxylic acid biosynthetic process GO:0046394 86 0.064
myd88 dependent toll like receptor signaling pathway GO:0002755 7 0.064
positive regulation of kinase activity GO:0033674 155 0.064
regulation of cytokine biosynthetic process GO:0042035 59 0.063
carbohydrate homeostasis GO:0033500 128 0.063
positive regulation of interferon beta biosynthetic process GO:0045359 3 0.063
oligodendrocyte differentiation GO:0048709 53 0.063
regulation of glial cell differentiation GO:0045685 41 0.063
defense response to bacterium GO:0042742 119 0.063
response to fatty acid GO:0070542 8 0.063
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.063
ion transmembrane transport GO:0034220 361 0.062
response to increased oxygen levels GO:0036296 2 0.062
macrophage activation GO:0042116 27 0.062
lymphocyte differentiation GO:0030098 242 0.061
macromolecule catabolic process GO:0009057 281 0.061
small molecule biosynthetic process GO:0044283 132 0.061
positive regulation of interleukin 12 production GO:0032735 21 0.061
regulation of chemokine secretion GO:0090196 4 0.061
interleukin 11 mediated signaling pathway GO:0038154 2 0.060
toxin transport GO:1901998 38 0.060
coagulation GO:0050817 78 0.059
intestinal epithelial structure maintenance GO:0060729 4 0.059
regulation of protein kinase activity GO:0045859 232 0.059
negative regulation of interleukin 5 secretion GO:2000663 1 0.059
myeloid leukocyte activation GO:0002274 83 0.059
regulation of type 2 immune response GO:0002828 18 0.059
neuron apoptotic process GO:0051402 142 0.058
positive regulation by organism of immune response of other organism involved in symbiotic interaction GO:0052555 1 0.058
sensory perception of pain GO:0019233 47 0.058
response to peptide hormone GO:0043434 127 0.057
multicellular organismal macromolecule metabolic process GO:0044259 19 0.057
immune complex clearance GO:0002434 2 0.057
glucose homeostasis GO:0042593 128 0.057
regulation of transferase activity GO:0051338 263 0.056
odontogenesis GO:0042476 78 0.056
fatty acid transport GO:0015908 28 0.055
regulation of ossification GO:0030278 112 0.055
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.055
purine nucleobase metabolic process GO:0006144 4 0.055
tissue migration GO:0090130 68 0.055
muscle system process GO:0003012 141 0.055
cellular homeostasis GO:0019725 240 0.054
immunoglobulin production GO:0002377 73 0.054
response to tumor necrosis factor GO:0034612 26 0.054
regulation of cytokine secretion involved in immune response GO:0002739 4 0.054
nucleobase containing small molecule metabolic process GO:0055086 352 0.054
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.054
negative regulation of intracellular signal transduction GO:1902532 167 0.054
regulation of vitamin d biosynthetic process GO:0060556 1 0.054
vascular endothelial growth factor production GO:0010573 13 0.054
bone mineralization GO:0030282 54 0.053
cellular response to acid chemical GO:0071229 68 0.053
negative regulation of multicellular organismal metabolic process GO:0044252 1 0.053
lymphocyte migration GO:0072676 26 0.053
nucleoside metabolic process GO:0009116 246 0.053
regulation of b cell proliferation GO:0030888 39 0.053
lipid localization GO:0010876 126 0.053
ras protein signal transduction GO:0007265 77 0.053
positive regulation of nervous system development GO:0051962 221 0.053
positive regulation of homeostatic process GO:0032846 64 0.052
regulation of immunological synapse formation GO:2000520 2 0.052
b cell proliferation involved in immune response GO:0002322 5 0.052
cellular response to hexose stimulus GO:0071331 47 0.051
interleukin 6 production GO:0032635 58 0.051
interleukin 33 mediated signaling pathway GO:0038172 1 0.051
negative regulation of erk1 and erk2 cascade GO:0070373 21 0.051
regulation of neuron death GO:1901214 134 0.051
regulation of immunoglobulin secretion GO:0051023 12 0.051
regulation of macrophage cytokine production GO:0010935 8 0.050
multi multicellular organism process GO:0044706 109 0.050
anatomical structure homeostasis GO:0060249 145 0.050
regulation of wound healing GO:0061041 40 0.050
positive regulation of t cell extravasation GO:2000409 2 0.050
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.049
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.049
regulation of immunoglobulin production GO:0002637 42 0.049
activation of mapk activity GO:0000187 59 0.049
response to insulin GO:0032868 100 0.049
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.049
erk1 and erk2 cascade GO:0070371 77 0.049
detection of lipopolysaccharide GO:0032497 1 0.049
interleukin 27 mediated signaling pathway GO:0070106 1 0.049
cell cell recognition GO:0009988 44 0.049
carbohydrate derivative biosynthetic process GO:1901137 183 0.048
dna recombination GO:0006310 92 0.048
purine ribonucleoside metabolic process GO:0046128 241 0.048
glycerolipid metabolic process GO:0046486 122 0.048
regulation of lymphocyte proliferation GO:0050670 117 0.048
negative regulation of multi organism process GO:0043901 68 0.048
nuclear import GO:0051170 95 0.047
negative regulation of molecular function GO:0044092 258 0.047
acid secretion GO:0046717 33 0.047
response to monosaccharide GO:0034284 67 0.047
regulation of epithelial cell proliferation GO:0050678 141 0.047
inflammatory cell apoptotic process GO:0006925 11 0.047
organonitrogen compound biosynthetic process GO:1901566 192 0.047
purine ribonucleotide metabolic process GO:0009150 290 0.047
positive regulation of protein localization to nucleus GO:1900182 30 0.047
lymphocyte proliferation GO:0046651 164 0.046
regulation of growth of symbiont in host GO:0044126 19 0.046
peptidyl serine phosphorylation GO:0018105 74 0.046
positive regulation of chemokine production GO:0032722 22 0.046
regulation of homeostatic process GO:0032844 182 0.046
positive regulation by organism of defense response of other organism involved in symbiotic interaction GO:0052510 1 0.046
positive regulation of cytoplasmic transport GO:1903651 40 0.046
response to hyperoxia GO:0055093 2 0.046
regulation of interferon beta biosynthetic process GO:0045357 4 0.046
response to radiation GO:0009314 165 0.045
regulation of peptidyl serine phosphorylation GO:0033135 39 0.045
regulation of cellular catabolic process GO:0031329 242 0.045
regulation of smad protein import into nucleus GO:0060390 3 0.045
regulation of map kinase activity GO:0043405 120 0.045
negative regulation of reactive oxygen species biosynthetic process GO:1903427 0 0.045
protein maturation GO:0051604 176 0.045
production of molecular mediator of immune response GO:0002440 103 0.045
small molecule catabolic process GO:0044282 71 0.045
regulation of response to oxidative stress GO:1902882 19 0.044
cell maturation GO:0048469 127 0.044
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.044
regulation of angiogenesis GO:0045765 81 0.044
female gamete generation GO:0007292 74 0.044
cation transport GO:0006812 399 0.044
tissue homeostasis GO:0001894 115 0.044
protein localization to organelle GO:0033365 185 0.044
modulation of growth of symbiont involved in interaction with host GO:0044144 19 0.044
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.043
cytokine secretion involved in immune response GO:0002374 6 0.043
regulation of interleukin 13 secretion GO:2000665 2 0.043
interleukin 13 secretion GO:0072611 2 0.043
positive regulation of monocyte extravasation GO:2000439 1 0.043
regulation of hormone secretion GO:0046883 88 0.043
alpha amino acid metabolic process GO:1901605 59 0.043
cellular response to lipoteichoic acid GO:0071223 6 0.043
fat cell differentiation GO:0045444 160 0.042
response to nitric oxide GO:0071731 4 0.042
t cell differentiation GO:0030217 174 0.042
regulation of t cell activation GO:0050863 170 0.042
nitric oxide mediated signal transduction GO:0007263 4 0.042
positive regulation of proteolysis GO:0045862 85 0.042
ammonia assimilation cycle GO:0019676 2 0.042
regulation of mammary gland involution GO:1903519 4 0.041
regulation of reactive oxygen species metabolic process GO:2000377 40 0.041
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.041
regulation of interleukin 23 production GO:0032667 2 0.041
positive regulation of tyrosine phosphorylation of stat1 protein GO:0042511 1 0.041
regulation of transmembrane transport GO:0034762 128 0.041
regulation of nucleocytoplasmic transport GO:0046822 73 0.041
somatic diversification of immune receptors GO:0002200 53 0.041
response to metal ion GO:0010038 47 0.041
regulation of interleukin 5 secretion GO:2000662 2 0.041
negative regulation of odontogenesis of dentin containing tooth GO:0042489 1 0.040
myeloid leukocyte differentiation GO:0002573 119 0.040
epithelium migration GO:0090132 63 0.040
lipid transport GO:0006869 98 0.040
hemostasis GO:0007599 78 0.040
response to interleukin 6 GO:0070741 10 0.040
interleukin 8 production GO:0032637 4 0.040
response to light stimulus GO:0009416 135 0.040
skin development GO:0043588 220 0.039
purine nucleoside metabolic process GO:0042278 241 0.039

Spp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.437
sensory system disease DOID:0050155 0 0.437
disease of anatomical entity DOID:7 0 0.437
eye and adnexa disease DOID:1492 0 0.437
nervous system disease DOID:863 0 0.437
eye disease DOID:5614 0 0.437
retinal degeneration DOID:8466 0 0.247
disease of metabolism DOID:0014667 0 0.168
degeneration of macula and posterior pole DOID:2007 0 0.115
macular degeneration DOID:4448 0 0.115
age related macular degeneration DOID:10871 0 0.115
inflammatory bowel disease DOID:0050589 0 0.081
gastrointestinal system disease DOID:77 0 0.081
intestinal disease DOID:5295 0 0.081
carbohydrate metabolism disease DOID:0050013 0 0.062
acquired metabolic disease DOID:0060158 0 0.062
diabetes mellitus DOID:9351 0 0.044
type 2 diabetes mellitus DOID:9352 0 0.044
glucose metabolism disease DOID:4194 0 0.044
inherited metabolic disorder DOID:655 0 0.043
central nervous system disease DOID:331 0 0.043