IMP

Process View

Mus musculus

2 genes annotated in mouse

response to increased oxygen levels

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to increased oxygen levels"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to increased oxygen levels" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	0.938
Nos3	nitric oxide synthase 3, endothelial cell	0.927	Rat
Lepr	leptin receptor	0.845
Ptgs2	prostaglandin-endoperoxide synthase 2	0.743
Apoe	apolipoprotein E	0.722
Csf1	colony stimulating factor 1 (macrophage)	0.715
Cav1	caveolin 1, caveolae protein	0.712	Human
Mmp9	matrix metallopeptidase 9	0.660	Rat
Pten	phosphatase and tensin homolog	0.603
Lep	leptin	0.596
Lyz2	lysozyme 2	0.394
Col1a1	collagen, type I, alpha 1	0.384	Rat
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.334
Vegfa	vascular endothelial growth factor A	0.296
Vhl	von Hippel-Lindau tumor suppressor	0.289
Ldlr	low density lipoprotein receptor	0.282
Apc	adenomatosis polyposis coli	0.248
Vdr	vitamin D receptor	0.241
Tlr4	toll-like receptor 4	0.239
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.237
Plat	plasminogen activator, tissue	0.230
Ccl2	chemokine (C-C motif) ligand 2	0.229
Cd44	CD44 antigen	0.170
Selp	selectin, platelet	0.157
Col4a3	collagen, type IV, alpha 3	0.139
Nos2	nitric oxide synthase 2, inducible	0.124
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.120
Tgfb1	transforming growth factor, beta 1	0.119
Lmna	lamin A	0.119
Ghr	growth hormone receptor	0.115
Pparg	peroxisome proliferator activated receptor gamma	0.099	Rat
Nos1	nitric oxide synthase 1, neuronal	0.085
Ccr2	chemokine (C-C motif) receptor 2	0.081	Rat
Tgfbr2	transforming growth factor, beta receptor II	0.078
Il10	interleukin 10	0.075
Fbn1	fibrillin 1	0.070
Fos	FBJ osteosarcoma oncogene	0.066
Il6st	interleukin 6 signal transducer	0.066
Kiss1	KiSS-1 metastasis-suppressor	0.065
Notch1	Notch gene homolog 1 (Drosophila)	0.064
Spp1	secreted phosphoprotein 1	0.062
Alox5ap	arachidonate 5-lipoxygenase activating protein	0.061
Hif1a	hypoxia inducible factor 1, alpha subunit	0.058
Gja1	gap junction protein, alpha 1	0.054
Notch2	Notch gene homolog 2 (Drosophila)	0.053
Agtr2	angiotensin II receptor, type 2	0.053
Ar	androgen receptor	0.051
Ifng	interferon gamma	0.051
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.047
Ltbp3	latent transforming growth factor beta binding protein 3	0.042
Ifngr1	interferon gamma receptor 1	0.039
Esr1	estrogen receptor 1 (alpha)	0.039
Lif	leukemia inhibitory factor	0.038
Kit	kit oncogene	0.037
Ctsk	cathepsin K	0.035
Tlr2	toll-like receptor 2	0.035
Ahr	aryl-hydrocarbon receptor	0.035
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.034
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.034
Il6	interleukin 6	0.033
Prkch	protein kinase C, eta	0.033
Prx	periaxin	0.032
Agtr1a	angiotensin II receptor, type 1a	0.029
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.029
Cyr61	cysteine rich protein 61	0.029
Orai1	ORAI calcium release-activated calcium modulator 1	0.027
Fas	Fas (TNF receptor superfamily member 6)	0.027	Human
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.027
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.027
Tal1	T-cell acute lymphocytic leukemia 1	0.027
Pnpla2	patatin-like phospholipase domain containing 2	0.026
Ptrf	polymerase I and transcript release factor	0.026
Tgfb2	transforming growth factor, beta 2	0.024
Tmprss11e	transmembrane protease, serine 11e	0.023
Ctnnb1	catenin (cadherin associated protein), beta 1	0.023
Egr2	early growth response 2	0.023
Insr	insulin receptor	0.022
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.022
Tcf21	transcription factor 21	0.022
Plin1	perilipin 1	0.021
Wdfy2	WD repeat and FYVE domain containing 2	0.021
Sox13	SRY-box containing gene 13	0.021
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.021
Sele	selectin, endothelial cell	0.021
Pdgfb	platelet derived growth factor, B polypeptide	0.020
Smad3	MAD homolog 3 (Drosophila)	0.020
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.020
Ivd	isovaleryl coenzyme A dehydrogenase	0.020
Adipoq	adiponectin, C1Q and collagen domain containing	0.020
Nab2	Ngfi-A binding protein 2	0.019
Kl	klotho	0.019
Foxa2	forkhead box A2	0.019
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.018
Lama2	laminin, alpha 2	0.018
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.018
Prdx1	peroxiredoxin 1	0.018
Cnn1	calponin 1	0.018
Amhr2	anti-Mullerian hormone type 2 receptor	0.018
Hif1an	hypoxia-inducible factor 1, alpha subunit inhibitor	0.017
Rxra	retinoid X receptor alpha	0.017
Itgb3	integrin beta 3	0.017
Bmp2	bone morphogenetic protein 2	0.017
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.017
Ltbp2	latent transforming growth factor beta binding protein 2	0.017
Sirt3	sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)	0.016
Ptgs1	prostaglandin-endoperoxide synthase 1	0.016
Runx1	runt related transcription factor 1	0.016
Ptges	prostaglandin E synthase	0.016
Icam1	intercellular adhesion molecule 1	0.016
Dpep1	dipeptidase 1 (renal)	0.016
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.016
Hspa9	heat shock protein 9	0.016
Egfr	epidermal growth factor receptor	0.016
Tenc1	tensin like C1 domain-containing phosphatase	0.016
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.016
Mmp2	matrix metallopeptidase 2	0.016	Rat
Sh3pxd2b	SH3 and PX domains 2B	0.016
Gnrh1	gonadotropin releasing hormone 1	0.016
Efnb2	ephrin B2	0.015
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.015
Ren1	renin 1 structural	0.015
Fbln1	fibulin 1	0.015
Bckdha	branched chain ketoacid dehydrogenase E1, alpha polypeptide	0.015
Hic1	hypermethylated in cancer 1	0.015
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.015
Traf3ip2	TRAF3 interacting protein 2	0.015
Ccr1	chemokine (C-C motif) receptor 1	0.015
Kdr	kinase insert domain protein receptor	0.015
Lama5	laminin, alpha 5	0.014
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.014
Gm14548	predicted gene 14548	0.014
Hlx	H2.0-like homeobox	0.014
Ripply3	ripply3 homolog (zebrafish)	0.014
Hbegf	heparin-binding EGF-like growth factor	0.014
Cycs	cytochrome c, somatic	0.014
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.013
Itga1	integrin alpha 1	0.013
Sin3a	transcriptional regulator, SIN3A (yeast)	0.013
Clec7a	C-type lectin domain family 7, member a	0.013
Igf1	insulin-like growth factor 1	0.013
Mitf	microphthalmia-associated transcription factor	0.013
Npc1	Niemann Pick type C1	0.013
Cyp2b10	cytochrome P450, family 2, subfamily b, polypeptide 10	0.013
Adcy4	adenylate cyclase 4	0.013
Fgf23	fibroblast growth factor 23	0.013
Mta2	metastasis-associated gene family, member 2	0.013
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.013
Lyz1	lysozyme 1	0.013
Gdf7	growth differentiation factor 7	0.012
Slfn4	schlafen 4	0.012
Ptger3	prostaglandin E receptor 3 (subtype EP3)	0.012
Mt1	metallothionein 1	0.012
Pgk1	phosphoglycerate kinase 1	0.012
Cd151	CD151 antigen	0.012
Hspa12b	heat shock protein 12B	0.012
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.012
Lrpprc	leucine-rich PPR-motif containing	0.012
Npr2	natriuretic peptide receptor 2	0.012
Col6a1	collagen, type VI, alpha 1	0.012
Fgfr2	fibroblast growth factor receptor 2	0.012
Casp8	caspase 8	0.012
Figf	c-fos induced growth factor	0.012
Fgfr3	fibroblast growth factor receptor 3	0.011
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.011
Psen2	presenilin 2	0.011
Fzd4	frizzled homolog 4 (Drosophila)	0.011
Tead2	TEA domain family member 2	0.011
Lox	lysyl oxidase	0.011
Mt2	metallothionein 2	0.011
Esr2	estrogen receptor 2 (beta)	0.011
Map3k6	mitogen-activated protein kinase kinase kinase 6	0.011
Slmo2	slowmo homolog 2 (Drosophila)	0.011
Irs2	insulin receptor substrate 2	0.011
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.011
Robo4	roundabout homolog 4 (Drosophila)	0.011
Lgals3	lectin, galactose binding, soluble 3	0.011
Thra	thyroid hormone receptor alpha	0.011
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.011
Trem1	triggering receptor expressed on myeloid cells 1	0.011
Bmp6	bone morphogenetic protein 6	0.011
Pld2	phospholipase D2	0.010
Tnc	tenascin C	0.010
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.010
Itga8	integrin alpha 8	0.010
B3gnt9-ps	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9, pseudogene	0.010
Eya1	eyes absent 1 homolog (Drosophila)	0.010
Foxp3	forkhead box P3	0.010
Slit3	slit homolog 3 (Drosophila)	0.010
Cox17	cytochrome c oxidase, subunit XVII assembly protein homolog (yeast)	0.010
Sertad1	SERTA domain containing 1	0.010
Tuba1b	tubulin, alpha 1B	0.010
Fmo3	flavin containing monooxygenase 3	0.010
Cd36	CD36 antigen	0.010
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.010
Pdgfa	platelet derived growth factor, alpha	0.010