Rattus norvegicus

112 known processes

Cdk4

cyclin-dependent kinase 4

Cdk4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron death GO:0070997 127 0.624
response to amino acid GO:0043200 75 0.424
cellular response to organonitrogen compound GO:0071417 197 0.416
intracellular signal transduction GO:0035556 314 0.371
positive regulation of cell communication GO:0010647 271 0.363
cellular response to endogenous stimulus GO:0071495 377 0.361
regulation of neuron death GO:1901214 115 0.308
positive regulation of signaling GO:0023056 270 0.275
regulation of intracellular signal transduction GO:1902531 218 0.267
regulation of neuron apoptotic process GO:0043523 83 0.260
carbohydrate metabolic process GO:0005975 130 0.260
response to inorganic substance GO:0010035 377 0.252
response to nutrient GO:0007584 248 0.228
positive regulation of intracellular signal transduction GO:1902533 138 0.221
cellular response to peptide GO:1901653 133 0.219
cellular response to peptide hormone stimulus GO:0071375 120 0.217
response to peptide GO:1901652 292 0.199
cellular component assembly GO:0022607 360 0.198
response to ethanol GO:0045471 162 0.192
apoptotic process GO:0006915 381 0.188
negative regulation of macromolecule metabolic process GO:0010605 260 0.187
response to toxic substance GO:0009636 133 0.185
neuron apoptotic process GO:0051402 88 0.184
response to carbohydrate GO:0009743 183 0.183
single organism carbohydrate metabolic process GO:0044723 118 0.181
response to peptide hormone GO:0043434 278 0.177
response to estradiol GO:0032355 164 0.176
regulation of cellular component organization GO:0051128 368 0.175
cell cycle checkpoint GO:0000075 2 0.175
macromolecular complex assembly GO:0065003 273 0.173
protein complex biogenesis GO:0070271 263 0.169
regulation of rna biosynthetic process GO:2001141 381 0.165
protein complex assembly GO:0006461 263 0.164
negative regulation of protein metabolic process GO:0051248 114 0.162
dna metabolic process GO:0006259 96 0.161
negative regulation of cellular metabolic process GO:0031324 281 0.155
positive regulation of developmental process GO:0051094 283 0.152
aging GO:0007568 241 0.152
response to purine containing compound GO:0014074 126 0.152
regulation of viral transcription GO:0046782 2 0.151
positive regulation of response to stimulus GO:0048584 285 0.150
response to estrogen GO:0043627 232 0.145
positive regulation of cell death GO:0010942 184 0.140
response to insulin GO:0032868 133 0.134
cellular response to hormone stimulus GO:0032870 247 0.130
response to corticosteroid GO:0031960 235 0.125
response to hydrogen peroxide GO:0042542 89 0.123
programmed cell death GO:0012501 392 0.120
reproduction GO:0000003 245 0.116
response to glucocorticoid GO:0051384 223 0.116
cellular protein localization GO:0034613 122 0.116
cellular response to stress GO:0033554 269 0.113
regulation of cell migration GO:0030334 128 0.110
response to nutrient levels GO:0031667 370 0.106
cell cycle GO:0007049 101 0.105
organelle organization GO:0006996 266 0.104
regulation of catalytic activity GO:0050790 304 0.101
cellular component biogenesis GO:0044085 368 0.100
positive regulation of nucleic acid templated transcription GO:1903508 197 0.099
response to acid chemical GO:0001101 222 0.099
macromolecule localization GO:0033036 252 0.095
cellular response to insulin stimulus GO:0032869 81 0.094
cellular macromolecule localization GO:0070727 122 0.094
positive regulation of signal transduction GO:0009967 175 0.092
regulation of transcription dna templated GO:0006355 374 0.091
protein oligomerization GO:0051259 191 0.091
negative regulation of biosynthetic process GO:0009890 168 0.086
negative regulation of cell death GO:0060548 229 0.085
regulation of molecular function GO:0065009 398 0.083
regulation of cell proliferation GO:0042127 359 0.083
response to vitamin GO:0033273 131 0.083
organophosphate metabolic process GO:0019637 370 0.081
response to ketone GO:1901654 182 0.081
cellular response to oxygen containing compound GO:1901701 386 0.079
macromolecular complex subunit organization GO:0043933 339 0.079
multicellular organism reproduction GO:0032504 233 0.079
synaptic transmission GO:0007268 235 0.078
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.077
viral transcription GO:0019083 2 0.077
negative regulation of metabolic process GO:0009892 331 0.076
neuron differentiation GO:0030182 368 0.075
mapk cascade GO:0000165 140 0.074
organic substance catabolic process GO:1901575 316 0.073
positive regulation of cellular component organization GO:0051130 200 0.073
response to decreased oxygen levels GO:0036293 237 0.073
wound healing GO:0042060 122 0.073
regulation of cellular component biogenesis GO:0044087 86 0.073
single organism reproductive process GO:0044702 297 0.072
positive regulation of neuron death GO:1901216 43 0.072
regulation of protein localization GO:0032880 81 0.072
g1 s transition of mitotic cell cycle GO:0000082 12 0.070
positive regulation of transcription dna templated GO:0045893 197 0.070
nucleic acid templated transcription GO:0097659 379 0.068
localization of cell GO:0051674 202 0.067
cell cycle process GO:0022402 57 0.067
response to extracellular stimulus GO:0009991 380 0.066
nucleobase containing small molecule metabolic process GO:0055086 316 0.066
rna metabolic process GO:0016070 406 0.066
positive regulation of cellular component movement GO:0051272 102 0.066
regulation of response to stress GO:0080134 126 0.065
nucleoside phosphate metabolic process GO:0006753 283 0.065
positive regulation of nervous system development GO:0051962 178 0.064
carbohydrate derivative metabolic process GO:1901135 346 0.064
homeostatic process GO:0042592 331 0.064
response to alkaloid GO:0043279 132 0.064
response to cytokine GO:0034097 215 0.063
cellular polysaccharide metabolic process GO:0044264 23 0.061
positive regulation of gene expression GO:0010628 244 0.061
protein transport GO:0015031 132 0.061
regulation of cell cycle GO:0051726 73 0.060
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.060
catabolic process GO:0009056 351 0.060
response to transition metal nanoparticle GO:1990267 122 0.060
response to metal ion GO:0010038 253 0.059
response to reactive oxygen species GO:0000302 120 0.059
transcription from rna polymerase ii promoter GO:0006366 252 0.059
reactive oxygen species metabolic process GO:0072593 37 0.059
reproductive process GO:0022414 372 0.058
negative regulation of cellular biosynthetic process GO:0031327 161 0.058
regulation of apoptotic process GO:0042981 335 0.058
positive regulation of cell proliferation GO:0008284 249 0.058
circadian rhythm GO:0007623 88 0.058
modification dependent protein catabolic process GO:0019941 14 0.057
transcription dna templated GO:0006351 377 0.057
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.057
anatomical structure formation involved in morphogenesis GO:0048646 83 0.056
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.055
rna biosynthetic process GO:0032774 380 0.055
neuron projection morphogenesis GO:0048812 122 0.055
nuclear transport GO:0051169 49 0.054
cellular response to abiotic stimulus GO:0071214 85 0.054
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.054
cellular catabolic process GO:0044248 295 0.054
regulation of cell development GO:0060284 263 0.053
protein complex subunit organization GO:0071822 302 0.052
regulation of cellular protein metabolic process GO:0032268 267 0.050
regulation of multicellular organismal development GO:2000026 376 0.049
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.049
protein localization GO:0008104 191 0.049
viral gene expression GO:0019080 2 0.048
positive regulation of apoptotic process GO:0043065 154 0.048
protein phosphorylation GO:0006468 345 0.048
regulation of cell cycle g1 s phase transition GO:1902806 7 0.048
negative regulation of apoptotic process GO:0043066 181 0.048
immune system process GO:0002376 204 0.048
positive regulation of cellular component biogenesis GO:0044089 55 0.047
cellular response to cytokine stimulus GO:0071345 127 0.047
response to hexose GO:0009746 144 0.047
regulation of programmed cell death GO:0043067 341 0.047
cellular homeostasis GO:0019725 252 0.047
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.046
regulation of apoptotic signaling pathway GO:2001233 13 0.046
cell aging GO:0007569 14 0.046
negative regulation of rna metabolic process GO:0051253 123 0.046
cellular response to dna damage stimulus GO:0006974 19 0.045
cellular response to oxidative stress GO:0034599 76 0.045
negative regulation of rna biosynthetic process GO:1902679 118 0.045
energy derivation by oxidation of organic compounds GO:0015980 46 0.045
regulation of kinase activity GO:0043549 117 0.045
cytoplasmic transport GO:0016482 115 0.044
cellular response to nitrogen compound GO:1901699 210 0.044
regulation of phosphorylation GO:0042325 248 0.044
positive regulation of cellular protein metabolic process GO:0032270 167 0.044
negative regulation of cell cycle phase transition GO:1901988 4 0.043
response to growth factor GO:0070848 189 0.043
positive regulation of intracellular protein transport GO:0090316 20 0.043
positive regulation of protein transport GO:0051222 41 0.043
secretion GO:0046903 307 0.042
regulation of anatomical structure size GO:0090066 135 0.042
negative regulation of nucleic acid templated transcription GO:1903507 117 0.042
intracellular transport GO:0046907 185 0.042
regulation of cell growth GO:0001558 85 0.042
negative regulation of response to stimulus GO:0048585 155 0.041
cellular component movement GO:0006928 248 0.041
carbohydrate catabolic process GO:0016052 40 0.041
regulation of neurogenesis GO:0050767 247 0.040
response to glucose GO:0009749 136 0.040
negative regulation of neuron death GO:1901215 69 0.040
positive regulation of catalytic activity GO:0043085 184 0.039
cell type specific apoptotic process GO:0097285 134 0.039
regulation of cell motility GO:2000145 131 0.039
defense response GO:0006952 194 0.039
chromatin assembly or disassembly GO:0006333 1 0.038
regulation of mapk cascade GO:0043408 116 0.038
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.038
negative regulation of programmed cell death GO:0043069 183 0.038
negative regulation of cell proliferation GO:0008285 119 0.038
negative regulation of transcription dna templated GO:0045892 116 0.037
dna integrity checkpoint GO:0031570 2 0.037
regulation of secretion by cell GO:1903530 208 0.037
positive regulation of protein modification process GO:0031401 142 0.037
positive regulation of organelle organization GO:0010638 48 0.037
organ regeneration GO:0031100 101 0.036
regulation of cell differentiation GO:0045595 320 0.036
neuron projection development GO:0031175 273 0.036
regulation of cell projection organization GO:0031344 175 0.035
purine nucleoside triphosphate metabolic process GO:0009144 141 0.035
regulation of phosphate metabolic process GO:0019220 349 0.035
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.034
central nervous system development GO:0007417 311 0.034
cellular response to external stimulus GO:0071496 118 0.034
interleukin 1 production GO:0032612 11 0.034
sexual reproduction GO:0019953 148 0.033
amine metabolic process GO:0009308 38 0.033
regulation of secretion GO:0051046 224 0.033
multicellular organismal reproductive process GO:0048609 233 0.033
regulation of cell cycle phase transition GO:1901987 12 0.033
positive regulation of mitochondrion organization GO:0010822 4 0.032
immune response GO:0006955 104 0.032
cellular response to reactive oxygen species GO:0034614 55 0.032
i kappab kinase nf kappab signaling GO:0007249 19 0.032
positive regulation of neurogenesis GO:0050769 165 0.032
positive regulation of apoptotic signaling pathway GO:2001235 6 0.031
response to monosaccharide GO:0034284 159 0.031
tissue development GO:0009888 252 0.031
response to lead ion GO:0010288 33 0.031
regulation of rna metabolic process GO:0051252 391 0.031
cellular amino acid metabolic process GO:0006520 107 0.031
aromatic compound catabolic process GO:0019439 168 0.031
response to endoplasmic reticulum stress GO:0034976 10 0.030
cellular glucan metabolic process GO:0006073 23 0.030
regulation of dna metabolic process GO:0051052 60 0.030
positive regulation of viral transcription GO:0050434 2 0.030
glucan metabolic process GO:0044042 23 0.030
negative regulation of cellular protein metabolic process GO:0032269 106 0.030
gamete generation GO:0007276 124 0.030
growth GO:0040007 165 0.030
carbohydrate derivative biosynthetic process GO:1901137 124 0.030
axis specification GO:0009798 4 0.030
axon development GO:0061564 96 0.029
positive regulation of biosynthetic process GO:0009891 319 0.029
response to antibiotic GO:0046677 39 0.029
oxoacid metabolic process GO:0043436 290 0.029
peptidyl amino acid modification GO:0018193 126 0.029
cellular divalent inorganic cation homeostasis GO:0072503 162 0.029
mitotic dna damage checkpoint GO:0044773 1 0.029
neurological system process GO:0050877 219 0.029
positive regulation of rna metabolic process GO:0051254 203 0.029
g protein coupled receptor signaling pathway GO:0007186 242 0.029
positive regulation of molecular function GO:0044093 230 0.029
cellular response to growth factor stimulus GO:0071363 162 0.029
intracellular protein transport GO:0006886 79 0.029
positive regulation of rna biosynthetic process GO:1902680 197 0.029
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.029
carboxylic acid metabolic process GO:0019752 289 0.028
regulation of growth GO:0040008 105 0.028
glial cell differentiation GO:0010001 65 0.028
purine ribonucleotide metabolic process GO:0009150 227 0.028
nucleotide metabolic process GO:0009117 279 0.028
polysaccharide metabolic process GO:0005976 25 0.028
nucleoside triphosphate metabolic process GO:0009141 144 0.028
developmental growth GO:0048589 100 0.028
positive regulation of cell development GO:0010720 176 0.028
regulation of cellular response to stress GO:0080135 49 0.028
positive regulation of cell projection organization GO:0031346 111 0.027
regulation of response to external stimulus GO:0032101 106 0.027
chromatin organization GO:0006325 34 0.027
regulation of cellular localization GO:0060341 263 0.027
regulation of behavior GO:0050795 61 0.027
regulation of nucleic acid templated transcription GO:1903506 380 0.027
positive regulation of i kappab kinase nf kappab signaling GO:0043123 8 0.027
regulation of tumor necrosis factor production GO:0032680 13 0.027
regulation of signal transduction GO:0009966 318 0.027
proteolysis GO:0006508 175 0.027
negative regulation of signaling GO:0023057 157 0.027
positive regulation of cell growth GO:0030307 44 0.027
response to other organism GO:0051707 220 0.026
tumor necrosis factor superfamily cytokine production GO:0071706 13 0.026
positive regulation of secretion GO:0051047 140 0.026
protein homooligomerization GO:0051260 91 0.026
response to light stimulus GO:0009416 52 0.026
regulation of organelle organization GO:0033043 80 0.026
protein targeting GO:0006605 61 0.026
regulation of nervous system development GO:0051960 264 0.026
ribonucleoside metabolic process GO:0009119 174 0.026
positive regulation of protein kinase activity GO:0045860 73 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
transmission of nerve impulse GO:0019226 42 0.026
regulation of i kappab kinase nf kappab signaling GO:0043122 13 0.026
cellular modified amino acid metabolic process GO:0006575 61 0.025
gland development GO:0048732 155 0.025
response to oxidative stress GO:0006979 186 0.025
rhythmic process GO:0048511 156 0.025
regulation of protein complex assembly GO:0043254 33 0.025
oxidation reduction process GO:0055114 304 0.025
ribose phosphate metabolic process GO:0019693 235 0.024
negative regulation of neuron apoptotic process GO:0043524 45 0.024
lipid metabolic process GO:0006629 283 0.024
cellular nitrogen compound catabolic process GO:0044270 163 0.024
arp2 3 complex mediated actin nucleation GO:0034314 2 0.024
cell part morphogenesis GO:0032990 123 0.024
heterocycle catabolic process GO:0046700 167 0.024
positive regulation of secretion by cell GO:1903532 128 0.024
exocytosis GO:0006887 60 0.024
anion transport GO:0006820 178 0.023
regulation of protein metabolic process GO:0051246 289 0.023
positive regulation of protein metabolic process GO:0051247 178 0.023
apoptotic signaling pathway GO:0097190 27 0.023
cell projection organization GO:0030030 302 0.023
cellular macromolecular complex assembly GO:0034622 58 0.023
negative regulation of signal transduction GO:0009968 83 0.023
single organism biosynthetic process GO:0044711 342 0.023
cell projection morphogenesis GO:0048858 123 0.023
negative regulation of molecular function GO:0044092 133 0.022
sensory organ development GO:0007423 74 0.022
regulation of protein heterodimerization activity GO:0043497 1 0.022
behavior GO:0007610 205 0.022
dna damage checkpoint GO:0000077 2 0.022
small gtpase mediated signal transduction GO:0007264 36 0.022
hexose metabolic process GO:0019318 58 0.022
eye morphogenesis GO:0048592 4 0.022
negative regulation of catalytic activity GO:0043086 103 0.022
nucleocytoplasmic transport GO:0006913 48 0.022
chemical homeostasis GO:0048878 292 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
heart morphogenesis GO:0003007 3 0.022
cell motility GO:0048870 202 0.021
cellular amine metabolic process GO:0044106 38 0.021
taxis GO:0042330 67 0.021
regulation of protein modification process GO:0031399 194 0.021
organic acid metabolic process GO:0006082 292 0.021
stress activated protein kinase signaling cascade GO:0031098 37 0.021
spermatogenesis GO:0007283 99 0.021
regulation of proteolysis GO:0030162 66 0.021
positive regulation of protein oligomerization GO:0032461 1 0.021
positive regulation of dna metabolic process GO:0051054 39 0.021
regulation of cytokine production GO:0001817 56 0.021
multicellular organism growth GO:0035264 1 0.021
regulation of transferase activity GO:0051338 123 0.021
positive regulation of locomotion GO:0040017 102 0.021
ion transmembrane transport GO:0034220 365 0.021
cell adhesion GO:0007155 110 0.021
mitotic cell cycle checkpoint GO:0007093 1 0.021
negative regulation of cellular component organization GO:0051129 83 0.020
regulation of cell adhesion GO:0030155 52 0.020
response to oxygen radical GO:0000305 8 0.020
multi organism reproductive process GO:0044703 262 0.020
regulation of exocytosis GO:0017157 37 0.020
cellular amide metabolic process GO:0043603 44 0.020
response to testosterone GO:0033574 55 0.020
negative regulation of stress activated mapk cascade GO:0032873 4 0.020
regulation of establishment of protein localization GO:0070201 69 0.019
nucleotide catabolic process GO:0009166 139 0.019
regulation of cellular component size GO:0032535 51 0.019
response to oxygen levels GO:0070482 265 0.019
neuronal action potential GO:0019228 35 0.019
cellular response to organic cyclic compound GO:0071407 202 0.019
organonitrogen compound catabolic process GO:1901565 179 0.019
cellular chemical homeostasis GO:0055082 247 0.019
positive regulation of growth GO:0045927 55 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.019
regulation of developmental growth GO:0048638 45 0.019
establishment of protein localization GO:0045184 141 0.019
negative regulation of cell communication GO:0010648 158 0.019
camera type eye development GO:0043010 48 0.018
nucleoside metabolic process GO:0009116 179 0.018
cellular ion homeostasis GO:0006873 184 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
regulation of protein kinase activity GO:0045859 105 0.018
response to mechanical stimulus GO:0009612 134 0.018
axonogenesis GO:0007409 71 0.018
actin filament bundle organization GO:0061572 19 0.018
purine ribonucleoside metabolic process GO:0046128 168 0.018
muscle cell apoptotic process GO:0010657 30 0.018
somatic stem cell division GO:0048103 2 0.018
protein modification by small protein conjugation or removal GO:0070647 35 0.018
regulation of protein phosphorylation GO:0001932 183 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
developmental process involved in reproduction GO:0003006 159 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.018
single organism intracellular transport GO:1902582 166 0.018
regulation of actin nucleation GO:0051125 2 0.017
biological adhesion GO:0022610 110 0.017
protein localization to organelle GO:0033365 57 0.017
outer mitochondrial membrane organization GO:0007008 1 0.017
bmp signaling pathway GO:0030509 4 0.017
cyclic nucleotide metabolic process GO:0009187 80 0.017
regeneration GO:0031099 163 0.017
epithelium development GO:0060429 96 0.017
organic anion transport GO:0015711 132 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.017
positive regulation of mapk cascade GO:0043410 92 0.017
purine containing compound metabolic process GO:0072521 253 0.017
regulation of peptidase activity GO:0052547 55 0.017
cellular response to lipid GO:0071396 201 0.017
negative regulation of cell cycle g1 s phase transition GO:1902807 2 0.017
muscle cell proliferation GO:0033002 84 0.016
protein polymerization GO:0051258 22 0.016
protein import into nucleus GO:0006606 35 0.016
actin nucleation GO:0045010 2 0.016
regulation of protein serine threonine kinase activity GO:0071900 64 0.016
positive regulation of protein secretion GO:0050714 19 0.016
regulation of cellular amine metabolic process GO:0033238 8 0.016
organ morphogenesis GO:0009887 75 0.016
cell cycle g1 s phase transition GO:0044843 13 0.016
response to ammonium ion GO:0060359 71 0.016
protein localization to nucleus GO:0034504 39 0.016
response to organophosphorus GO:0046683 102 0.016
positive regulation of multicellular organismal process GO:0051240 387 0.016
negative regulation of phosphorus metabolic process GO:0010563 80 0.016
positive regulation of neuron differentiation GO:0045666 126 0.016
antigen receptor mediated signaling pathway GO:0050851 1 0.016
positive regulation of release of cytochrome c from mitochondria GO:0090200 3 0.016
cytokine production GO:0001816 61 0.016
mitotic cell cycle phase transition GO:0044772 20 0.016
brain development GO:0007420 247 0.016
amide transport GO:0042886 105 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
hair cycle process GO:0022405 2 0.015
regulation of cytokine biosynthetic process GO:0042035 3 0.015
regulation of phosphorus metabolic process GO:0051174 349 0.015
release of cytochrome c from mitochondria GO:0001836 8 0.015
positive regulation of neuron apoptotic process GO:0043525 33 0.015
male gamete generation GO:0048232 99 0.015
response to cold GO:0009409 29 0.015
regulation of protein polymerization GO:0032271 19 0.015
regulation of endopeptidase activity GO:0052548 51 0.015
cell cycle phase transition GO:0044770 21 0.015
response to camp GO:0051591 91 0.015
ribonucleoside catabolic process GO:0042454 126 0.015
cation homeostasis GO:0055080 195 0.015
response to fatty acid GO:0070542 65 0.015
positive regulation of epithelial cell proliferation GO:0050679 32 0.015
cellular response to superoxide GO:0071451 6 0.015
energy reserve metabolic process GO:0006112 25 0.015
regulation of locomotion GO:0040012 148 0.015
generation of precursor metabolites and energy GO:0006091 62 0.015
positive regulation of cellular catabolic process GO:0031331 71 0.014
glycogen biosynthetic process GO:0005978 15 0.014
ion homeostasis GO:0050801 212 0.014
chromosome organization GO:0051276 36 0.014
cellular response to extracellular stimulus GO:0031668 73 0.014
negative regulation of cell cycle GO:0045786 21 0.014
mitotic cell cycle GO:0000278 49 0.014
regulation of synaptic plasticity GO:0048167 70 0.014
regulation of cellular ketone metabolic process GO:0010565 27 0.014
anion transmembrane transport GO:0098656 77 0.014
negative regulation of smooth muscle cell proliferation GO:0048662 21 0.014
negative regulation of protein modification process GO:0031400 52 0.014
regulation of cell cycle process GO:0010564 31 0.014
regulation of neuron differentiation GO:0045664 208 0.014
regulation of immune system process GO:0002682 123 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 31 0.014
calcium ion homeostasis GO:0055074 162 0.014
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.014
regulation of smooth muscle cell proliferation GO:0048660 75 0.014
positive regulation of kinase activity GO:0033674 77 0.014
multi multicellular organism process GO:0044706 138 0.014
vesicle localization GO:0051648 33 0.014
single organism organelle organization GO:1902589 180 0.013
negative regulation of peptidase activity GO:0010466 38 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
response to radiation GO:0009314 137 0.013
single organism catabolic process GO:0044712 283 0.013
positive regulation of cell motility GO:2000147 97 0.013
ovulation cycle GO:0042698 67 0.013
regulation of cellular component movement GO:0051270 150 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
anatomical structure morphogenesis GO:0009653 298 0.013
embryonic axis specification GO:0000578 1 0.013
regulation of vesicle mediated transport GO:0060627 81 0.013
neuron development GO:0048666 286 0.013
regulation of epithelial cell proliferation GO:0050678 49 0.013
regulation of hormone levels GO:0010817 187 0.013
sulfur compound metabolic process GO:0006790 70 0.013
glucan biosynthetic process GO:0009250 15 0.013
sensory perception GO:0007600 101 0.013
regulation of membrane potential GO:0042391 110 0.013
regulation of canonical wnt signaling pathway GO:0060828 4 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
regulation of embryonic development GO:0045995 2 0.013
smooth muscle cell migration GO:0014909 36 0.013
circadian regulation of gene expression GO:0032922 3 0.013
glycosaminoglycan biosynthetic process GO:0006024 4 0.013
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.012

Cdk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
gastrointestinal system cancer DOID:3119 0 0.356
intestinal cancer DOID:10155 0 0.356
cancer DOID:162 0 0.356
disease of cellular proliferation DOID:14566 0 0.356
organ system cancer DOID:0050686 0 0.356
large intestine cancer DOID:5672 0 0.151
colon cancer DOID:219 0 0.151
colorectal cancer DOID:9256 0 0.151
colon carcinoma DOID:1520 0 0.115
bone development disease DOID:0080006 0 0.058
bone disease DOID:0080001 0 0.058
disease of anatomical entity DOID:7 0 0.058
musculoskeletal system disease DOID:17 0 0.058
connective tissue disease DOID:65 0 0.058
osteochondrodysplasia DOID:2256 0 0.036
nervous system disease DOID:863 0 0.034
benign neoplasm DOID:0060072 0 0.033
hepatocellular carcinoma DOID:684 0 0.020
liver carcinoma DOID:686 0 0.020
liver cancer DOID:3571 0 0.020
organ system benign neoplasm DOID:0060085 0 0.017