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Rattus norvegicus

0 genes annotated in rat

bone development disease

DOID:0080006

A bone disease that results in abnormal growth and development located in bone or located in cartilage.

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "bone development disease" (in gray)

Name	Description	Probability	Func Analog Organism
Col1a1	collagen, type I, alpha 1	0.985	Human
Col5a1	collagen, type V, alpha 1	0.937
Col1a2	collagen, type I, alpha 2	0.874	Human
Col3a1	collagen, type III, alpha 1	0.812
Fbn1	fibrillin 1	0.313
Lox	lysyl oxidase	0.237
Col5a2	collagen, type V, alpha 2	0.210
Glt25d1	glycosyltransferase 25 domain containing 1	0.184
Col6a2	collagen, type VI, alpha 2	0.175
Bgn	biglycan	0.165
Pcolce	procollagen C-endopeptidase enhancer	0.136
Sparc	secreted protein, acidic, cysteine-rich (osteonectin)	0.128
Ng23	Ng23 protein	0.124
Col12a1	collagen, type XII, alpha 1	0.121
Bmp1	bone morphogenetic protein 1	0.117	Human
Fstl1	follistatin-like 1	0.111
Lgals1	lectin, galactoside-binding, soluble, 1	0.108
Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	0.103	Human
Kdelr3	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3	0.101
Rcn3	reticulocalbin 3, EF-hand calcium binding domain	0.098
Acan	aggrecan	0.096
Calu	calumenin	0.091
Ggcx	gamma-glutamyl carboxylase	0.087
Loxl1	lysyl oxidase-like 1	0.082
Col18a1	collagen, type XVIII, alpha 1	0.072
Lect1	leukocyte cell derived chemotaxin 1	0.064
Ppic	peptidylprolyl isomerase C	0.064
Lum	lumican	0.061
Prelp	proline/arginine-rich end leucine-rich repeat protein	0.061
P4hb	prolyl 4-hydroxylase, beta polypeptide	0.058
Cdk4	cyclin-dependent kinase 4	0.058
Fgfr2	fibroblast growth factor receptor 2	0.054	Human
Vkorc1	vitamin K epoxide reductase complex, subunit 1	0.053
Copz2	coatomer protein complex, subunit zeta 2	0.051
Scarf2	scavenger receptor class F, member 2	0.051
Cul4a	cullin 4A	0.047
Col9a2	collagen, type IX, alpha 2	0.047	Human
Mfap4	microfibrillar-associated protein 4	0.046
Col2a1	collagen, type II, alpha 1	0.046	Human
Dpt	dermatopontin	0.046
Fgf18	fibroblast growth factor 18	0.044
Prdx4	peroxiredoxin 4	0.043
Cpz	carboxypeptidase Z	0.042
Olfml2b	olfactomedin-like 2B	0.041
Fkbp11	FK506 binding protein 11	0.040
Postn	periostin, osteoblast specific factor	0.040
Serpinf1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	0.039	Human
Myl9	myosin, light chain 9, regulatory	0.038
Acvr1	activin A receptor, type I	0.038
Eln	elastin	0.037
Mfap5	microfibrillar associated protein 5	0.036
Tnxb	tenascin XB	0.034
Rpn1	ribophorin I	0.033
B4galnt4	beta-1,4-N-acetyl-galactosaminyl transferase 4	0.032
Megf6	multiple EGF-like-domains 6	0.032
Col14a1	collagen, type XIV, alpha 1	0.032
Rarres2	retinoic acid receptor responder (tazarotene induced) 2	0.031
Col4a1	collagen, type IV, alpha 1	0.029
Akt2	v-akt murine thymoma viral oncogene homolog 2	0.029
Oaf	OAF homolog (Drosophila)	0.028
C1qtnf5	C1q and tumor necrosis factor related protein 5	0.028
Mxra8	matrix-remodelling associated 8	0.028
Hapln1	hyaluronan and proteoglycan link protein 1	0.028
Pdia4	protein disulfide isomerase family A, member 4	0.026
Glg1	golgi apparatus protein 1	0.026
Tcfe2a	transcription factor E2a	0.026
Olfml3	olfactomedin-like 3	0.026
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.025
Slc12a4	solute carrier family 12 (potassium/chloride transporters), member 4	0.025
Spag4	sperm associated antigen 4	0.024
Tmed3	transmembrane emp24 protein transport domain containing 3	0.024
Fn1	fibronectin 1	0.024
Aifm3	apoptosis-inducing factor, mitochondrion-associated 3	0.024
Ugt8	UDP glycosyltransferase 8	0.024
Tgfbr2	transforming growth factor, beta receptor II	0.023
Col11a2	collagen, type XI, alpha 2	0.023	Human
Sc65	synaptonemal complex protein SC65	0.023
Nt5dc2	5'-nucleotidase domain containing 2	0.023
Rpn2	ribophorin II	0.022
Znf503	zinc finger protein 503	0.022
Nek9	NIMA (never in mitosis gene a)- related kinase 9	0.022
Prkcdbp	protein kinase C, delta binding protein	0.022
Unc13c	unc-13 homolog C (C. elegans)	0.022
Adarb2	adenosine deaminase, RNA-specific, B2	0.022
Lef1	lymphoid enhancer binding factor 1	0.021
Car7	carbonic anhydrase 7	0.021
Dad1	defender against cell death 1	0.021
Htr4	5-hydroxytryptamine (serotonin) receptor 4	0.021
Arhgef19	Rho guanine nucleotide exchange factor (GEF) 19	0.021
Fkbp2	FK506 binding protein 2	0.021
Shox2	short stature homeobox 2	0.020
Gna12	guanine nucleotide binding protein (G protein) alpha 12	0.020
Notch2	Notch homolog 2 (Drosophila)	0.020
Fkbp10	FK506 binding protein 10	0.020	Human
Efemp2	EGF-containing fibulin-like extracellular matrix protein 2	0.020
Rgr	retinal G protein coupled receptor	0.020
Slc9a3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.020
Smad7	SMAD family member 7	0.020
Cpxm1	carboxypeptidase X (M14 family), member 1	0.020
Crtap	cartilage associated protein	0.019
Asmt	acetylserotonin O-methyltransferase	0.019
Tcf3	transcription factor 3	0.019
Cyp4a3	cytochrome P450, family 4, subfamily a, polypeptide 3	0.019
Cd9	CD9 molecule	0.019
Sec61a1	Sec61 alpha 1 subunit (S. cerevisiae)	0.019
Col5a3	collagen, type V, alpha 3	0.019
Fam132a	family with sequence similarity 132, member A	0.019
Ibsp	integrin-binding sialoprotein	0.019
Snrk	SNF related kinase	0.019
Tgfbi	transforming growth factor, beta induced	0.018
Galnt10	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	0.018
Ltbp4	latent transforming growth factor beta binding protein 4	0.018
Agtr1a	angiotensin II receptor, type 1a	0.018
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.018
Htra1	HtrA serine peptidase 1	0.018
Tyr	tyrosinase	0.018
Slc29a1	solute carrier family 29 (nucleoside transporters), member 1	0.017
Fgfr3	fibroblast growth factor receptor 3	0.017	Human
Gdf11	growth differentiation factor 11	0.017
Chad	chondroadherin	0.017
Scara3	scavenger receptor class A, member 3	0.017
Dlx5	distal-less homeobox 5	0.016
Angptl2	angiopoietin-like 2	0.016
Ssr4	signal sequence receptor, delta	0.016
Igf1	insulin-like growth factor 1	0.016
Ppia	peptidylprolyl isomerase A (cyclophilin A)	0.016
Gpt2	glutamic pyruvate transaminase (alanine aminotransferase) 2	0.016
Lrrc26	leucine rich repeat containing 26	0.016
Mecp2	methyl CpG binding protein 2	0.016
Defa	defensin, alpha 5, Paneth cell-specific	0.016
Pdia6	protein disulfide isomerase family A, member 6	0.016
Rplp0	ribosomal protein, large, P0	0.016
Prl2b1	Prolactin family 2, subfamily b, member 1	0.016
Flt4	fms-related tyrosine kinase 4	0.016
Leprel2	leprecan-like 2	0.015
Col15a1	collagen, type XV, alpha 1	0.015
Mmp23	matrix metallopeptidase 23	0.015
LOC686781	similar to NFkB interacting protein 1	0.015
Fkbp9	FK506 binding protein 9	0.015
St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	0.015
Hapln4	hyaluronan and proteoglycan link protein 4	0.015
Rnase4	ribonuclease, RNase A family 4	0.015
Fbln5	fibulin 5	0.015
Sox10	SRY (sex determining region Y)-box 10	0.015
Timp2	TIMP metallopeptidase inhibitor 2	0.015
Socs6	suppressor of cytokine signaling 6	0.015
Tph2	tryptophan hydroxylase 2	0.015
Scnn1a	sodium channel, nonvoltage-gated 1 alpha	0.015
Smtn	smoothelin	0.015
Maf	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	0.015
Cyr61	cysteine-rich, angiogenic inducer, 61	0.015
Trpv6	transient receptor potential cation channel, subfamily V, member 6	0.015
Sod3	superoxide dismutase 3, extracellular	0.015
Gnb2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.015
Ext2	exostoses (multiple) 2	0.014
Alx1	ALX homeobox 1	0.014
Cldn19	claudin 19	0.014
Edn2	endothelin 2	0.014
Lipc	lipase, hepatic	0.014
Nfia	nuclear factor I/A	0.014
Ltbp3	latent transforming growth factor beta binding protein 3	0.014
Fmod	fibromodulin	0.014
Ostc	oligosaccharyltransferase complex subunit	0.014
Enpp6	ectonucleotide pyrophosphatase/phosphodiesterase 6	0.014
Barx1	BARX homeobox 1	0.014
Marveld1	MARVEL domain containing 1	0.014
Ache	acetylcholinesterase	0.014
Igfbp2	insulin-like growth factor binding protein 2	0.014
Mab21l2	mab-21-like 2 (C. elegans)	0.014
Igf2r	insulin-like growth factor 2 receptor	0.014
Bai2	brain-specific angiogenesis inhibitor 2	0.013
Fbln2	fibulin 2	0.013
Fstl3	follistatin-like 3 (secreted glycoprotein)	0.013
Gal	galanin prepropeptide	0.013
Fam101a	family with sequence similarity 101, member A	0.013
Plod1	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	0.013
Ptprs	protein tyrosine phosphatase, receptor type, S	0.013
Atp6v1c2	ATPase, H+ transporting, lysosomal V1 subunit C2	0.013
Znf692	zinc finger protein 692	0.013
Igfbp4	insulin-like growth factor binding protein 4	0.013
Col22a1	collagen, type XXII, alpha 1	0.013
Tmed10	transmembrane emp24-like trafficking protein 10 (yeast)	0.013
Fzd2	frizzled homolog 2 (Drosophila)	0.013
Klc3	kinesin light chain 3	0.013
Drd4	dopamine receptor D4	0.013
Stx2	syntaxin 2	0.013
Itpr2	inositol 1,4,5-triphosphate receptor, type 2	0.013
Itgb5	integrin, beta 5	0.013
Ccl28	chemokine (C-C motif) ligand 28	0.013
Nlrp6	NLR family, pyrin domain containing 6	0.013
LOC100188932	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4	0.013
Nid2	nidogen 2	0.013
Cercam	cerebral endothelial cell adhesion molecule	0.013
RGD1559896	similar to RIKEN cDNA 2310022B05	0.012
Eps8l2	EPS8-like 2	0.012
Mfap2	microfibrillar-associated protein 2	0.012
Rhox5	reproductive homeobox 5	0.012
Gas2l3	growth arrest-specific 2 like 3	0.012
Wnt16	wingless-type MMTV integration site family, member 16	0.012
Ptprv	protein tyrosine phosphatase, receptor type, V	0.012
Capn6	calpain 6	0.012
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.012
Aebp1	AE binding protein 1	0.012
Lamc3	laminin gamma 3	0.012
Tcfap2c	transcription factor AP-2, gamma	0.012
Mcm3ap	minichromosome maintenance complex component 3 associated protein	0.012
Dmp1	dentin matrix acidic phosphoprotein 1	0.012
Prss36	protease, serine, 36	0.012
Pax1	paired box 1	0.012
Pofut2	protein O-fucosyltransferase 2	0.012
Tmprss2	transmembrane protease, serine 2	0.012
Col9a3	procollagen, type IX, alpha 3	0.012
Galnt7	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	0.012
Ptgis	prostaglandin I2 (prostacyclin) synthase	0.012
Jub	jub, ajuba homolog (Xenopus laevis)	0.012
Arsb	arylsulfatase B	0.012
Irx4	iroquois homeobox 4	0.012
Hrasls5	HRAS-like suppressor family, member 5	0.012
Hspa2	heat shock protein 2	0.011
Snai2	snail homolog 2 (Drosophila)	0.011
RGD1306404	similar to mKIAA1402 protein	0.011
Ncam1	neural cell adhesion molecule 1	0.011
Best2	bestrophin 2	0.011
Rbp1	retinol binding protein 1, cellular	0.011
Inhbc	inhibin beta C	0.011
Zc3h7b	zinc finger CCCH-type containing 7B	0.011
Calcb	calcitonin-related polypeptide, beta	0.011
Bmp4	bone morphogenetic protein 4	0.011
Cdh15	cadherin 15	0.011
Clps	colipase, pancreatic	0.011
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.011
Nccrp1	non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)	0.011
Ppp1r3b	protein phosphatase 1, regulatory (inhibitor) subunit 3B	0.011
Dcun1d5	DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)	0.011
Accn5	amiloride-sensitive cation channel 5, intestinal	0.011
Msx1	msh homeobox 1	0.011
Ggn	gametogenetin	0.011
Slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	0.011
Prss32	protease, serine, 32	0.011
Hpn	hepsin	0.011
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.011
Srpx	sushi-repeat-containing protein, X-linked	0.011
Hoxb4	homeo box B4	0.011
Cdh23	cadherin 23 (otocadherin)	0.011
RGD1565997	similar to 4931417G12Rik protein	0.011
Tead3	TEA domain family member 3	0.011
Ucn2	urocortin 2	0.011
Hand2	heart and neural crest derivatives expressed 2	0.011
Clec3a	C-type lectin domain family 3, member a	0.011
Slc13a5	solute carrier family 13 (sodium-dependent citrate transporter), member 5	0.011
Il9	interleukin 9	0.011
Hrg	histidine-rich glycoprotein	0.011
Matn4	matrilin 4	0.011
Fgf4	fibroblast growth factor 4	0.011
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.011
Mosc1	MOCO sulphurase C-terminal domain containing 1	0.011
Clic4	chloride intracellular channel 4	0.011
Krtcap2	keratinocyte associated protein 2	0.011
Runx3	runt-related transcription factor 3	0.011
Unc5cl	unc-5 homolog C (C. elegans)-like	0.011
Pdlim7	PDZ and LIM domain 7	0.011
Sec24a	SEC24 family, member A (S. cerevisiae)	0.011
Cdh16	cadherin 16	0.010
Theg	testicular haploid expressed gene	0.010
Eef2	eukaryotic translation elongation factor 2	0.010
Tac2	tachykinin 2	0.010
Znf574	zinc finger protein 574	0.010
LOC100363145	stabilin 1	0.010
Znf394	zinc finger protein 394	0.010
Aspn	asporin	0.010
Eif2c3	eukaryotic translation initiation factor 2C, 3	0.010
Pgcp	plasma glutamate carboxypeptidase	0.010
Hk1	hexokinase 1	0.010
Fam76a	family with sequence similarity 76, member A	0.010
Apoa2	apolipoprotein A-II	0.010
Ttll3	tubulin tyrosine ligase-like family, member 3	0.010
Gja1	gap junction protein, alpha 1	0.010
Emilin1	elastin microfibril interfacer 1	0.010
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.010
Stra6	stimulated by retinoic acid gene 6	0.010
Tmprss4	transmembrane protease, serine 4	0.010
Psmb3	proteasome (prosome, macropain) subunit, beta type 3	0.010
Otp	orthopedia homeobox	0.010
Mpz	myelin protein zero	0.010
Nrg1	neuregulin 1	0.010
Fabp9	fatty acid binding protein 9, testis	0.010
Steap3	STEAP family member 3	0.010
RGD1311605	similar to apoptosis related protein APR-3; p18 protein	0.010
Cry2	cryptochrome 2 (photolyase-like)	0.010
Dmgdh	dimethylglycine dehydrogenase	0.010
Phldb1	pleckstrin homology-like domain, family B, member 1	0.010
Lppr3	lipid phosphate phosphatase-related protein type 3	0.010
Cd276	Cd276 molecule	0.010
C1ql1	complement component 1, q subcomponent-like 1	0.010
Unc5b	unc-5 homolog B (C. elegans)	0.010
Sec14l2	SEC14-like 2 (S. cerevisiae)	0.010
Tmem8a	transmembrane protein 8A	0.010