Rattus norvegicus

0 known processes

Cst8

cystatin 8 (cystatin-related epididymal specific)

Cst8 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
organic acid metabolic process GO:0006082 292 0.497
carboxylic acid metabolic process GO:0019752 289 0.288
positive regulation of cellular biosynthetic process GO:0031328 295 0.235
nucleoside phosphate biosynthetic process GO:1901293 102 0.221
lipid metabolic process GO:0006629 283 0.212
single organism biosynthetic process GO:0044711 342 0.204
cellular response to peptide GO:1901653 133 0.193
forebrain development GO:0030900 98 0.163
negative regulation of cellular metabolic process GO:0031324 281 0.136
Rat
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.133
brain development GO:0007420 247 0.110
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.108
oxoacid metabolic process GO:0043436 290 0.105
response to estrogen GO:0043627 232 0.105
behavior GO:0007610 205 0.102
fatty acid metabolic process GO:0006631 99 0.099
cellular ketone metabolic process GO:0042180 51 0.098
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.098
secretion GO:0046903 307 0.097
positive regulation of transcription dna templated GO:0045893 197 0.096
cellular ion homeostasis GO:0006873 184 0.095
small molecule biosynthetic process GO:0044283 124 0.094
organic hydroxy compound metabolic process GO:1901615 115 0.092
regulation of cellular ketone metabolic process GO:0010565 27 0.090
long chain fatty acid transport GO:0015909 14 0.088
regulation of system process GO:0044057 208 0.087
multi organism reproductive process GO:0044703 262 0.085
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.085
fatty acid biosynthetic process GO:0006633 33 0.084
multi multicellular organism process GO:0044706 138 0.082
organophosphate metabolic process GO:0019637 370 0.082
defense response GO:0006952 194 0.082
organonitrogen compound biosynthetic process GO:1901566 167 0.081
negative regulation of cell proliferation GO:0008285 119 0.081
Rat
apoptotic process GO:0006915 381 0.076
central nervous system development GO:0007417 311 0.074
regulation of angiogenesis GO:0045765 39 0.073
neurological system process GO:0050877 219 0.073
regulation of cellular component organization GO:0051128 368 0.069
response to ketone GO:1901654 182 0.069
regulation of secretion GO:0051046 224 0.066
positive regulation of nucleic acid templated transcription GO:1903508 197 0.065
multicellular organism reproduction GO:0032504 233 0.065
response to inorganic substance GO:0010035 377 0.064
Rat
intracellular signal transduction GO:0035556 314 0.064
steroid metabolic process GO:0008202 73 0.063
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.063
regulation of secretion by cell GO:1903530 208 0.063
head development GO:0060322 247 0.062
carbohydrate derivative metabolic process GO:1901135 346 0.060
unsaturated fatty acid metabolic process GO:0033559 39 0.059
reproductive process GO:0022414 372 0.058
regulation of programmed cell death GO:0043067 341 0.058
positive regulation of cellular component organization GO:0051130 200 0.057
nitrogen compound transport GO:0071705 229 0.057
monocarboxylic acid metabolic process GO:0032787 152 0.056
organic acid biosynthetic process GO:0016053 83 0.055
protein phosphorylation GO:0006468 345 0.054
lipid biosynthetic process GO:0008610 128 0.053
carbohydrate derivative biosynthetic process GO:1901137 124 0.053
circulatory system process GO:0003013 183 0.053
response to decreased oxygen levels GO:0036293 237 0.052
inflammatory response GO:0006954 150 0.052
nucleotide biosynthetic process GO:0009165 98 0.051
positive regulation of rna biosynthetic process GO:1902680 197 0.050
regulation of nervous system development GO:0051960 264 0.049
regulation of response to wounding GO:1903034 69 0.049
oxidation reduction process GO:0055114 304 0.049
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.049
regulation of lipid metabolic process GO:0019216 68 0.048
positive regulation of protein metabolic process GO:0051247 178 0.048
negative regulation of cellular biosynthetic process GO:0031327 161 0.047
negative regulation of metabolic process GO:0009892 331 0.046
Rat
somatostatin receptor signaling pathway GO:0038169 4 0.046
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.045
positive regulation of cell proliferation GO:0008284 249 0.045
organophosphate biosynthetic process GO:0090407 143 0.044
regulation of peptide hormone secretion GO:0090276 80 0.044
regulation of cell development GO:0060284 263 0.043
acid secretion GO:0046717 48 0.043
secretion by cell GO:0032940 248 0.043
purine ribonucleotide biosynthetic process GO:0009152 81 0.042
purine nucleotide biosynthetic process GO:0006164 83 0.042
positive regulation of long term synaptic potentiation GO:1900273 4 0.042
hormone secretion GO:0046879 115 0.042
positive regulation of hormone secretion GO:0046887 65 0.042
fatty acid derivative metabolic process GO:1901568 38 0.041
cyclic nucleotide biosynthetic process GO:0009190 63 0.041
blood circulation GO:0008015 183 0.040
regulation of phosphorus metabolic process GO:0051174 349 0.039
female pregnancy GO:0007565 122 0.039
regulation of tube size GO:0035150 89 0.039
cell cell signaling GO:0007267 335 0.039
divalent metal ion transport GO:0070838 132 0.038
telencephalon development GO:0021537 62 0.038
regulation of phosphate metabolic process GO:0019220 349 0.038
response to alkaloid GO:0043279 132 0.037
carboxylic acid biosynthetic process GO:0046394 83 0.037
cellular response to oxygen containing compound GO:1901701 386 0.037
positive regulation of transport GO:0051050 245 0.037
positive regulation of multicellular organismal process GO:0051240 387 0.037
regulation of cell proliferation GO:0042127 359 0.037
Rat
cation transport GO:0006812 382 0.036
regulation of transferase activity GO:0051338 123 0.036
cellular response to stress GO:0033554 269 0.036
cellular response to endogenous stimulus GO:0071495 377 0.036
negative regulation of cell communication GO:0010648 158 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.035
positive regulation of gene expression GO:0010628 244 0.035
cyclic nucleotide metabolic process GO:0009187 80 0.035
cellular response to organic cyclic compound GO:0071407 202 0.035
regulation of cellular amino acid metabolic process GO:0006521 2 0.035
mapk cascade GO:0000165 140 0.034
regulation of blood circulation GO:1903522 110 0.034
response to corticosteroid GO:0031960 235 0.033
organ regeneration GO:0031100 101 0.033
single organism reproductive process GO:0044702 297 0.033
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.033
protein complex subunit organization GO:0071822 302 0.033
cellular component biogenesis GO:0044085 368 0.032
amine metabolic process GO:0009308 38 0.032
cellular amine metabolic process GO:0044106 38 0.032
regulation of hormone secretion GO:0046883 106 0.032
positive regulation of rna metabolic process GO:0051254 203 0.031
positive regulation of nervous system development GO:0051962 178 0.031
t cell tolerance induction GO:0002517 3 0.031
response to oxygen levels GO:0070482 265 0.030
purine containing compound biosynthetic process GO:0072522 85 0.030
cellular homeostasis GO:0019725 252 0.030
regulation of rna biosynthetic process GO:2001141 381 0.030
organic acid transport GO:0015849 116 0.029
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.029
organic anion transport GO:0015711 132 0.029
negative regulation of phosphorus metabolic process GO:0010563 80 0.029
positive regulation of secretion by cell GO:1903532 128 0.029
regulation of phosphorylation GO:0042325 248 0.029
neuromuscular process GO:0050905 2 0.028
regulation of cellular amine metabolic process GO:0033238 8 0.028
multicellular organismal reproductive process GO:0048609 233 0.028
signal transduction by phosphorylation GO:0023014 144 0.028
positive regulation of secretion GO:0051047 140 0.028
chemosensory behavior GO:0007635 2 0.028
regulation of protein metabolic process GO:0051246 289 0.027
Rat
arachidonic acid metabolic process GO:0019369 20 0.027
response to wounding GO:0009611 254 0.027
Rat
regulation of locomotion GO:0040012 148 0.027
hormone transport GO:0009914 121 0.027
ribonucleotide biosynthetic process GO:0009260 85 0.026
positive regulation of cell differentiation GO:0045597 217 0.026
anion transport GO:0006820 178 0.026
regulation of cell growth GO:0001558 85 0.026
regulation of body fluid levels GO:0050878 90 0.026
negative regulation of macromolecule metabolic process GO:0010605 260 0.026
Rat
synaptic transmission GO:0007268 235 0.026
negative regulation of transcription dna templated GO:0045892 116 0.026
negative regulation of biosynthetic process GO:0009890 168 0.026
limbic system development GO:0021761 38 0.026
positive regulation of biosynthetic process GO:0009891 319 0.025
carboxylic acid transport GO:0046942 115 0.025
transmembrane transport GO:0055085 412 0.025
response to glucocorticoid GO:0051384 223 0.025
camp metabolic process GO:0046058 63 0.025
signal release GO:0023061 145 0.025
cytokine mediated signaling pathway GO:0019221 43 0.024
regulation of neurogenesis GO:0050767 247 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
transcription dna templated GO:0006351 377 0.024
icosanoid biosynthetic process GO:0046456 18 0.024
icosanoid metabolic process GO:0006690 38 0.024
regeneration GO:0031099 163 0.024
growth GO:0040007 165 0.024
positive regulation of cellular protein metabolic process GO:0032270 167 0.024
g protein coupled receptor signaling pathway GO:0007186 242 0.023
cellular lipid metabolic process GO:0044255 208 0.023
somatostatin signaling pathway GO:0038170 4 0.023
positive regulation of catalytic activity GO:0043085 184 0.022
cellular component movement GO:0006928 248 0.022
nucleobase containing small molecule metabolic process GO:0055086 316 0.022
regulation of protein modification process GO:0031399 194 0.022
regulation of cellular localization GO:0060341 263 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.022
positive regulation of cell development GO:0010720 176 0.022
regulation of nucleotide biosynthetic process GO:0030808 47 0.022
dna metabolic process GO:0006259 96 0.022
cellular response to nitrogen compound GO:1901699 210 0.022
phospholipid metabolic process GO:0006644 61 0.022
regulation of response to external stimulus GO:0032101 106 0.022
locomotion GO:0040011 237 0.022
response to other organism GO:0051707 220 0.021
Rat
regulation of transcription dna templated GO:0006355 374 0.021
anterior posterior pattern specification GO:0009952 1 0.021
negative regulation of programmed cell death GO:0043069 183 0.021
rhythmic process GO:0048511 156 0.021
cellular response to hormone stimulus GO:0032870 247 0.021
monocarboxylic acid biosynthetic process GO:0072330 48 0.021
wound healing GO:0042060 122 0.021
regulation of homotypic cell cell adhesion GO:0034110 4 0.020
regulation of kinase activity GO:0043549 117 0.020
cell migration GO:0016477 197 0.020
cellular catabolic process GO:0044248 295 0.020
heart process GO:0003015 57 0.020
response to toxic substance GO:0009636 133 0.020
Rat
negative regulation of synaptic transmission dopaminergic GO:0032227 4 0.019
regulation of growth GO:0040008 105 0.019
divalent inorganic cation transport GO:0072511 134 0.019
positive regulation of signal transduction GO:0009967 175 0.019
organelle organization GO:0006996 266 0.019
positive regulation of signaling GO:0023056 270 0.019
vasculature development GO:0001944 70 0.019
response to radiation GO:0009314 137 0.019
monocarboxylic acid transport GO:0015718 52 0.019
regulation of postsynaptic membrane potential GO:0060078 25 0.019
transmission of nerve impulse GO:0019226 42 0.019
regulation of cellular component movement GO:0051270 150 0.019
positive regulation of apoptotic process GO:0043065 154 0.019
response to hexose GO:0009746 144 0.019
acute inflammatory response GO:0002526 58 0.019
positive regulation of epidermis development GO:0045684 1 0.018
negative regulation of phosphate metabolic process GO:0045936 80 0.018
purine containing compound metabolic process GO:0072521 253 0.018
cellular amino acid metabolic process GO:0006520 107 0.018
positive regulation of blood circulation GO:1903524 65 0.018
gliogenesis GO:0042063 93 0.018
single organism behavior GO:0044708 130 0.018
regulation of rna metabolic process GO:0051252 391 0.018
regulation of neuron differentiation GO:0045664 208 0.018
anatomical structure morphogenesis GO:0009653 298 0.018
regulation of peptide secretion GO:0002791 82 0.018
response to glucose GO:0009749 136 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.018
nucleotide metabolic process GO:0009117 279 0.018
amino acid transport GO:0006865 70 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.017
male sex differentiation GO:0046661 64 0.017
calcium ion transport GO:0006816 131 0.017
response to monosaccharide GO:0034284 159 0.017
response to acid chemical GO:0001101 222 0.017
leukotriene biosynthetic process GO:0019370 3 0.017
response to corticosterone GO:0051412 40 0.017
regulation of wound healing GO:0061041 14 0.017
regulation of cell differentiation GO:0045595 320 0.017
regulation of nucleotide metabolic process GO:0006140 117 0.017
reproductive structure development GO:0048608 128 0.017
response to growth factor GO:0070848 189 0.017
sensory organ development GO:0007423 74 0.017
regulation of anatomical structure size GO:0090066 135 0.017
response to hypoxia GO:0001666 231 0.017
eating behavior GO:0042755 21 0.016
regulation of signal transduction GO:0009966 318 0.016
cell fate determination GO:0001709 2 0.016
reproduction GO:0000003 245 0.016
Worm
chemical homeostasis GO:0048878 292 0.016
hippocampus development GO:0021766 30 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
negative regulation of transport GO:0051051 136 0.016
multicellular organism growth GO:0035264 1 0.016
monovalent inorganic cation transport GO:0015672 172 0.016
cardiovascular system development GO:0072358 134 0.016
vasoconstriction GO:0042310 54 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
homeostatic process GO:0042592 331 0.015
glycerolipid metabolic process GO:0046486 67 0.015
gamete generation GO:0007276 124 0.015
response to extracellular stimulus GO:0009991 380 0.015
drug catabolic process GO:0042737 1 0.015
cognition GO:0050890 92 0.015
programmed cell death GO:0012501 392 0.015
fat soluble vitamin biosynthetic process GO:0042362 2 0.015
cell growth GO:0016049 104 0.015
camp biosynthetic process GO:0006171 47 0.015
response to transforming growth factor beta GO:0071559 46 0.015
macromolecular complex subunit organization GO:0043933 339 0.015
cellular component assembly GO:0022607 360 0.015
glial cell differentiation GO:0010001 65 0.015
regulation of catalytic activity GO:0050790 304 0.015
Rat
regulation of vasoconstriction GO:0019229 44 0.015
response to camp GO:0051591 91 0.015
hematopoietic progenitor cell differentiation GO:0002244 2 0.015
ribose phosphate biosynthetic process GO:0046390 87 0.015
response to food GO:0032094 27 0.015
protein complex biogenesis GO:0070271 263 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
negative regulation of molecular function GO:0044092 133 0.014
Rat
regulation of catabolic process GO:0009894 113 0.014
regulation of cellular protein metabolic process GO:0032268 267 0.014
Rat
purine ribonucleotide metabolic process GO:0009150 227 0.014
neuron neuron synaptic transmission GO:0007270 60 0.014
cell motility GO:0048870 202 0.014
spermatogenesis GO:0007283 99 0.014
peptide secretion GO:0002790 86 0.014
pallium development GO:0021543 42 0.014
response to insulin GO:0032868 133 0.014
developmental process involved in reproduction GO:0003006 159 0.014
response to bacterium GO:0009617 200 0.014
liver development GO:0001889 90 0.014
tissue development GO:0009888 252 0.014
regulation of apoptotic process GO:0042981 335 0.014
vitamin d biosynthetic process GO:0042368 2 0.014
positive regulation of cell death GO:0010942 184 0.014
hormone mediated signaling pathway GO:0009755 23 0.014
potassium ion transport GO:0006813 97 0.014
n methyl d aspartate receptor clustering GO:0097114 2 0.014
sleep GO:0030431 30 0.013
renal system process GO:0003014 40 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
cell type specific apoptotic process GO:0097285 134 0.013
regulation of hormone levels GO:0010817 187 0.013
regulation of response to stress GO:0080134 126 0.013
regulation of endocrine process GO:0044060 21 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
cellular response to insulin stimulus GO:0032869 81 0.013
response to carbohydrate GO:0009743 183 0.013
negative regulation of gene expression GO:0010629 199 0.013
Rat
fatty acid derivative biosynthetic process GO:1901570 18 0.013
regulation of platelet activation GO:0010543 2 0.013
regulation of cell migration GO:0030334 128 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
cell projection organization GO:0030030 302 0.013
regulation of nucleic acid templated transcription GO:1903506 380 0.013
circulatory system development GO:0072359 134 0.013
response to temperature stimulus GO:0009266 94 0.013
negative regulation of hormone secretion GO:0046888 46 0.013
positive regulation of protein kinase activity GO:0045860 73 0.013
positive regulation of adenylate cyclase activity GO:0045762 12 0.013
regulation of insulin secretion GO:0050796 65 0.013
protein dephosphorylation GO:0006470 38 0.012
regulation of systemic arterial blood pressure by norepinephrine epinephrine GO:0001993 2 0.012
sexual reproduction GO:0019953 148 0.012
immune system process GO:0002376 204 0.012
regulation of peptide transport GO:0090087 87 0.012
peptide hormone secretion GO:0030072 84 0.012
regulation of protein kinase activity GO:0045859 105 0.012
neuropeptide signaling pathway GO:0007218 29 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
negative regulation of signaling GO:0023057 157 0.012
male gamete generation GO:0048232 99 0.012
response to cold GO:0009409 29 0.012
cellular chemical homeostasis GO:0055082 247 0.012
positive regulation of cell communication GO:0010647 271 0.012
anatomical structure formation involved in morphogenesis GO:0048646 83 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.012
protein transport GO:0015031 132 0.012
regulation of muscle system process GO:0090257 79 0.012
response to lead ion GO:0010288 33 0.012
cellular protein localization GO:0034613 122 0.012
cytoplasmic transport GO:0016482 115 0.012
dephosphorylation GO:0016311 98 0.012
response to estradiol GO:0032355 164 0.012
regulation of multicellular organismal development GO:2000026 376 0.012
negative regulation of nucleotide metabolic process GO:0045980 23 0.011
response to organophosphorus GO:0046683 102 0.011
negative regulation of secretion GO:0051048 82 0.011
negative regulation of chronic inflammatory response GO:0002677 2 0.011
t cell migration GO:0072678 2 0.011
regulation of cyclase activity GO:0031279 21 0.011
rna biosynthetic process GO:0032774 380 0.011
cellular response to peptide hormone stimulus GO:0071375 120 0.011
organic hydroxy compound biosynthetic process GO:1901617 51 0.011
olfactory behavior GO:0042048 2 0.011
catabolic process GO:0009056 351 0.011
gland development GO:0048732 155 0.011
Rat
carbohydrate catabolic process GO:0016052 40 0.011
cellular glucan metabolic process GO:0006073 23 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
Rat
positive regulation of developmental process GO:0051094 283 0.011
sensory perception GO:0007600 101 0.011
glycerophospholipid metabolic process GO:0006650 47 0.011
insecticide metabolic process GO:0017143 4 0.011
response to ammonium ion GO:0060359 71 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
alcohol metabolic process GO:0006066 77 0.011
neuron projection development GO:0031175 273 0.011
positive regulation of response to stimulus GO:0048584 285 0.011
regulation of hemostasis GO:1900046 9 0.011
positive regulation of saliva secretion GO:0046878 3 0.011
smooth muscle contraction GO:0006939 37 0.011
response to progesterone GO:0032570 48 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
embryonic appendage morphogenesis GO:0035113 4 0.011
steroid biosynthetic process GO:0006694 48 0.010
negative regulation of response to external stimulus GO:0032102 37 0.010
vitamin d metabolic process GO:0042359 4 0.010
halogenated hydrocarbon metabolic process GO:0042197 4 0.010
response to purine containing compound GO:0014074 126 0.010
reproductive system development GO:0061458 128 0.010
positive regulation of peptide hormone secretion GO:0090277 50 0.010
learning or memory GO:0007611 90 0.010
ion homeostasis GO:0050801 212 0.010
synaptic transmission dopaminergic GO:0001963 11 0.010
regulation of smooth muscle contraction GO:0006940 29 0.010
regulation of cell projection organization GO:0031344 175 0.010
adenylate cyclase inhibiting serotonin receptor signaling pathway GO:0007198 1 0.010
positive regulation of protein modification process GO:0031401 142 0.010
regulation of circadian sleep wake cycle wakefulness GO:0010840 2 0.010
regulation of intracellular signal transduction GO:1902531 218 0.010
negative regulation of uterine smooth muscle contraction GO:0070473 2 0.010

Cst8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
substance related disorder DOID:303 0 0.071
disease of mental health DOID:150 0 0.071
disease of anatomical entity DOID:7 0 0.015
sensory system disease DOID:0050155 0 0.015
nervous system disease DOID:863 0 0.015
blindness DOID:1432 0 0.013
eye and adnexa disease DOID:1492 0 0.013
retinal disease DOID:5679 0 0.013
eye disease DOID:5614 0 0.013