Danio rerio

0 known processes

grn2

granulin 2

(Aliases: zgc:111860,wu:fb14a12)

grn2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular ketone metabolic process GO:0042180 11 0.286
cellular biosynthetic process GO:0044249 286 0.136
organic cyclic compound biosynthetic process GO:1901362 223 0.135
biosynthetic process GO:0009058 294 0.132
regulation of cyclic nucleotide biosynthetic process GO:0030802 15 0.122
small molecule metabolic process GO:0044281 77 0.116
alcohol biosynthetic process GO:0046165 2 0.107
single organism metabolic process GO:0044710 217 0.100
tyrosine phosphorylation of stat protein GO:0007260 1 0.093
convergent extension GO:0060026 118 0.093
localization of cell GO:0051674 244 0.076
calcium ion transport into cytosol GO:0060402 3 0.076
morphogenesis of an epithelium GO:0002009 333 0.076
regulation of cellular metabolic process GO:0031323 320 0.075
larval development GO:0002164 2 0.072
single organism biosynthetic process GO:0044711 71 0.070
organonitrogen compound metabolic process GO:1901564 74 0.066
organic cyclic compound metabolic process GO:1901360 301 0.066
hematopoietic or lymphoid organ development GO:0048534 191 0.055
cellular nitrogen compound metabolic process GO:0034641 290 0.055
cytosolic calcium ion transport GO:0060401 3 0.054
nuclear import GO:0051170 3 0.053
regulation of cytoplasmic transport GO:1903649 4 0.053
nitrogen compound metabolic process GO:0006807 319 0.052
long chain fatty acid metabolic process GO:0001676 1 0.051
cellular response to biotic stimulus GO:0071216 3 0.048
response to other organism GO:0051707 97 0.048
response to drug GO:0042493 3 0.047
striated muscle tissue development GO:0014706 110 0.047
cell surface receptor signaling pathway GO:0007166 325 0.047
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.046
amine metabolic process GO:0009308 2 0.046
regulation of cellular biosynthetic process GO:0031326 245 0.045
oxoacid metabolic process GO:0043436 31 0.044
regulation of jak stat cascade GO:0046425 3 0.044
cognition GO:0050890 1 0.043
small molecule biosynthetic process GO:0044283 16 0.041
maintenance of location GO:0051235 4 0.041
regulation of cellular amino acid metabolic process GO:0006521 0 0.040
cellular response to external stimulus GO:0071496 2 0.039
organic substance biosynthetic process GO:1901576 289 0.039
regulation of intracellular protein transport GO:0033157 3 0.038
regulation of binding GO:0051098 3 0.038
regulation of signal transduction GO:0009966 225 0.037
multicellular organism growth GO:0035264 4 0.036
neuron development GO:0048666 262 0.036
aromatic compound biosynthetic process GO:0019438 217 0.036
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.035
intracellular signal transduction GO:0035556 85 0.035
axonogenesis GO:0007409 152 0.035
negative regulation of biological process GO:0048519 304 0.035
cell migration GO:0016477 237 0.034
cellular aromatic compound metabolic process GO:0006725 295 0.034
phosphorus metabolic process GO:0006793 109 0.034
cellular response to lipopolysaccharide GO:0071222 3 0.033
cellular component movement GO:0006928 335 0.033
carboxylic acid metabolic process GO:0019752 22 0.033
hemopoiesis GO:0030097 183 0.033
cell motility GO:0048870 244 0.033
central nervous system development GO:0007417 387 0.032
ketone biosynthetic process GO:0042181 2 0.032
heterocycle biosynthetic process GO:0018130 215 0.032
protein import GO:0017038 3 0.032
regulation of protein import into nucleus GO:0042306 2 0.032
positive regulation of camp biosynthetic process GO:0030819 2 0.031
regulation of cellular amine metabolic process GO:0033238 0 0.031
positive regulation of cellular biosynthetic process GO:0031328 68 0.031
positive regulation of transport GO:0051050 2 0.031
regulation of metal ion transport GO:0010959 4 0.030
antimicrobial humoral response GO:0019730 2 0.030
single organism nuclear import GO:1902593 3 0.030
cellular amine metabolic process GO:0044106 2 0.030
nuclear transport GO:0051169 4 0.030
positive regulation of cell activation GO:0050867 1 0.029
nucleocytoplasmic transport GO:0006913 4 0.029
regulation of establishment of protein localization GO:0070201 4 0.029
regulation of developmental process GO:0050793 247 0.029
neuron differentiation GO:0030182 353 0.028
protein localization to nucleus GO:0034504 3 0.028
organic acid metabolic process GO:0006082 31 0.028
synaptic growth at neuromuscular junction GO:0051124 2 0.028
i kappab kinase nf kappab signaling GO:0007249 4 0.028
locomotion GO:0040011 313 0.028
lipid biosynthetic process GO:0008610 22 0.028
regulation of signaling GO:0023051 235 0.028
regulation of protein localization to nucleus GO:1900180 2 0.028
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.028
release of sequestered calcium ion into cytosol GO:0051209 3 0.027
establishment of protein localization to organelle GO:0072594 4 0.027
cell projection morphogenesis GO:0048858 244 0.027
digestive tract development GO:0048565 265 0.027
immune system process GO:0002376 241 0.027
response to nutrient GO:0007584 3 0.026
response to external biotic stimulus GO:0043207 97 0.026
regulation of multicellular organism growth GO:0040014 4 0.026
positive regulation of apoptotic signaling pathway GO:2001235 1 0.026
signal transduction GO:0007165 455 0.026
response to external stimulus GO:0009605 264 0.026
chemosensory behavior GO:0007635 1 0.026
digestive tract morphogenesis GO:0048546 231 0.025
regulation of production of molecular mediator of immune response GO:0002700 1 0.025
positive regulation of cellular amine metabolic process GO:0033240 0 0.025
cation homeostasis GO:0055080 33 0.025
immune system development GO:0002520 191 0.025
regulation of cell communication GO:0010646 232 0.025
single organism localization GO:1902578 225 0.025
positive regulation of catabolic process GO:0009896 4 0.025
regulation of cellular ketone metabolic process GO:0010565 7 0.024
regulation of synapse organization GO:0050807 3 0.024
protein targeting to nucleus GO:0044744 3 0.024
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.024
regulation of cytokine production GO:0001817 3 0.024
regulation of response to stimulus GO:0048583 269 0.024
leukocyte proliferation GO:0070661 1 0.024
gastrulation GO:0007369 208 0.024
fatty acid elongation unsaturated fatty acid GO:0019368 1 0.023
nucleobase containing compound biosynthetic process GO:0034654 205 0.023
organic acid catabolic process GO:0016054 3 0.023
glucocorticoid metabolic process GO:0008211 2 0.023
regulation of multicellular organismal process GO:0051239 277 0.023
cellular nitrogen compound biosynthetic process GO:0044271 218 0.023
brain development GO:0007420 293 0.023
cell part morphogenesis GO:0032990 246 0.022
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.022
sequestering of metal ion GO:0051238 3 0.022
positive regulation of stress activated mapk cascade GO:0032874 3 0.022
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.022
regulation of nucleocytoplasmic transport GO:0046822 2 0.022
generation of neurons GO:0048699 385 0.022
organonitrogen compound biosynthetic process GO:1901566 47 0.021
cellular amino acid metabolic process GO:0006520 7 0.021
regulation of protein targeting GO:1903533 2 0.021
ubiquitin dependent protein catabolic process GO:0006511 3 0.021
regulation of inflammatory response GO:0050727 2 0.021
aging GO:0007568 2 0.021
cell projection organization GO:0030030 284 0.021
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.021
protein import into nucleus GO:0006606 3 0.021
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.021
steroid biosynthetic process GO:0006694 5 0.021
gtp metabolic process GO:0046039 4 0.021
carboxylic acid catabolic process GO:0046395 3 0.020
lipid metabolic process GO:0006629 52 0.020
head development GO:0060322 303 0.020
growth GO:0040007 174 0.020
heterocycle metabolic process GO:0046483 290 0.020
regulation of nucleoside metabolic process GO:0009118 2 0.020
regulation of programmed cell death GO:0043067 101 0.020
cellular component morphogenesis GO:0032989 336 0.019
regulation of nucleotide catabolic process GO:0030811 2 0.019
interspecies interaction between organisms GO:0044419 4 0.019
positive regulation of cellular catabolic process GO:0031331 3 0.019
cellular protein catabolic process GO:0044257 4 0.019
dorsal ventral pattern formation GO:0009953 125 0.019
intrinsic apoptotic signaling pathway GO:0097193 20 0.019
guanosine containing compound metabolic process GO:1901068 4 0.019
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.019
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.019
programmed cell death GO:0012501 119 0.019
lipid storage GO:0019915 1 0.019
neuron neuron synaptic transmission GO:0007270 1 0.019
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.019
regulation of nitrogen compound metabolic process GO:0051171 251 0.019
regulation of macromolecule metabolic process GO:0060255 317 0.019
positive regulation of biological process GO:0048518 253 0.019
immune response activating signal transduction GO:0002757 5 0.019
positive regulation of cytokine production GO:0001819 2 0.018
wnt signaling pathway GO:0016055 80 0.018
multi organism process GO:0051704 134 0.018
regulation of nervous system development GO:0051960 90 0.018
cytokinesis GO:0000910 3 0.018
morphogenesis of a branching structure GO:0001763 21 0.018
regulation of cell development GO:0060284 100 0.018
modification dependent protein catabolic process GO:0019941 3 0.018
regulation of metabolic process GO:0019222 359 0.018
regulation of biological quality GO:0065008 263 0.018
embryonic skeletal system morphogenesis GO:0048704 93 0.018
negative regulation of cytoplasmic transport GO:1903650 2 0.018
small molecule catabolic process GO:0044282 3 0.018
regulation of biosynthetic process GO:0009889 250 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.017
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.017
positive regulation of immune effector process GO:0002699 3 0.017
regulation of sequestering of calcium ion GO:0051282 4 0.017
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.017
regulation of reproductive process GO:2000241 4 0.017
calcium ion homeostasis GO:0055074 19 0.017
regulation of cell activation GO:0050865 1 0.017
muscle tissue development GO:0060537 110 0.017
rna biosynthetic process GO:0032774 181 0.017
regulation of gtpase activity GO:0043087 2 0.017
gtp catabolic process GO:0006184 2 0.017
zymogen activation GO:0031638 3 0.016
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.016
axon development GO:0061564 166 0.016
regulation of gene expression GO:0010468 265 0.016
autophagy GO:0006914 4 0.016
proteasomal protein catabolic process GO:0010498 2 0.016
regulation of multicellular organismal development GO:2000026 223 0.016
single organism transport GO:0044765 206 0.016
ion transport GO:0006811 114 0.016
secondary metabolic process GO:0019748 3 0.016
neuron projection development GO:0031175 180 0.016
ameboidal type cell migration GO:0001667 143 0.016
response to vitamin GO:0033273 3 0.016
positive regulation of leukocyte differentiation GO:1902107 1 0.016
transcription from rna polymerase ii promoter GO:0006366 80 0.016
cellular respiration GO:0045333 3 0.016
developmental cell growth GO:0048588 52 0.016
negative regulation of multicellular organismal process GO:0051241 69 0.016
blood vessel morphogenesis GO:0048514 216 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.016
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.015
embryo development ending in birth or egg hatching GO:0009792 271 0.015
response to bacterium GO:0009617 58 0.015
cell fate commitment GO:0045165 99 0.015
cellular response to molecule of bacterial origin GO:0071219 3 0.015
homeostatic process GO:0042592 142 0.015
positive regulation of jnk cascade GO:0046330 3 0.015
extrinsic apoptotic signaling pathway GO:0097191 3 0.015
regulation of calcium ion transport GO:0051924 2 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.015
positive regulation of purine nucleotide biosynthetic process GO:1900373 8 0.015
regulation of tube size GO:0035150 2 0.015
neuron projection morphogenesis GO:0048812 161 0.015
convergent extension involved in gastrulation GO:0060027 71 0.015
smooth muscle tissue development GO:0048745 1 0.014
organic hydroxy compound biosynthetic process GO:1901617 6 0.014
response to alkaloid GO:0043279 2 0.014
gene expression GO:0010467 252 0.014
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
positive regulation of metabolic process GO:0009893 108 0.014
organic hydroxy compound metabolic process GO:1901615 16 0.014
positive regulation of jak stat cascade GO:0046427 2 0.014
tube morphogenesis GO:0035239 349 0.014
positive regulation of multicellular organismal process GO:0051240 52 0.014
b cell activation GO:0042113 2 0.014
protein homooligomerization GO:0051260 3 0.014
meiotic cell cycle process GO:1903046 3 0.014
cellular amide metabolic process GO:0043603 4 0.014
fatty acid biosynthetic process GO:0006633 4 0.014
positive regulation of cellular metabolic process GO:0031325 94 0.014
positive regulation of multi organism process GO:0043902 3 0.014
spermatid development GO:0007286 2 0.013
regulation of localization GO:0032879 104 0.013
regulation of purine nucleotide catabolic process GO:0033121 2 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
regulation of protein catabolic process GO:0042176 1 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.013
phosphatidylinositol mediated signaling GO:0048015 2 0.013
regulation of synapse assembly GO:0051963 3 0.013
cellular transition metal ion homeostasis GO:0046916 3 0.013
cellular macromolecule metabolic process GO:0044260 391 0.013
embryonic organ development GO:0048568 381 0.013
camera type eye development GO:0043010 222 0.013
determination of bilateral symmetry GO:0009855 204 0.013
positive regulation of translation GO:0045727 1 0.013
organelle fusion GO:0048284 3 0.013
spermatid differentiation GO:0048515 2 0.013
ear development GO:0043583 127 0.013
response to stress GO:0006950 263 0.013
stem cell proliferation GO:0072089 4 0.013
nucleobase containing compound metabolic process GO:0006139 274 0.013
myeloid cell differentiation GO:0030099 86 0.013
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 1 0.013
digestive system development GO:0055123 289 0.013
phagocytosis GO:0006909 3 0.012
multicellular organismal macromolecule metabolic process GO:0044259 2 0.012
negative regulation of intracellular transport GO:0032387 3 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
regulation of primary metabolic process GO:0080090 311 0.012
response to carbohydrate GO:0009743 3 0.012
modification dependent macromolecule catabolic process GO:0043632 3 0.012
developmental growth GO:0048589 166 0.012
membrane fusion GO:0061025 2 0.012
cellular response to extracellular stimulus GO:0031668 2 0.012
cytoskeleton dependent cytokinesis GO:0061640 3 0.012
reactive oxygen species metabolic process GO:0072593 6 0.012
regulation of gtp catabolic process GO:0033124 2 0.012
axon guidance GO:0007411 86 0.012
actin polymerization or depolymerization GO:0008154 2 0.012
regulation of transcription dna templated GO:0006355 213 0.012
regulation of membrane potential GO:0042391 23 0.012
carbohydrate derivative metabolic process GO:1901135 61 0.012
protein metabolic process GO:0019538 183 0.012
regulation of protein transport GO:0051223 3 0.012
cellular response to chemical stimulus GO:0070887 157 0.012
developmental growth involved in morphogenesis GO:0060560 86 0.012
cell cycle g1 s phase transition GO:0044843 1 0.012
cell proliferation GO:0008283 80 0.012
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.012
response to uv GO:0009411 3 0.012
regulation of cellular protein catabolic process GO:1903362 1 0.012
negative regulation of protein localization to nucleus GO:1900181 2 0.011
b cell mediated immunity GO:0019724 3 0.011
long chain fatty acid biosynthetic process GO:0042759 1 0.011
cell aging GO:0007569 2 0.011
hormone secretion GO:0046879 2 0.011
regulation of blood vessel size GO:0050880 2 0.011
nucleic acid templated transcription GO:0097659 181 0.011
energy reserve metabolic process GO:0006112 2 0.011
regulation of multicellular organismal metabolic process GO:0044246 2 0.011
fatty acid elongation GO:0030497 1 0.011
guanosine containing compound catabolic process GO:1901069 2 0.011
response to monosaccharide GO:0034284 3 0.011
mononuclear cell proliferation GO:0032943 1 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.011
cellular protein metabolic process GO:0044267 129 0.011
type i interferon production GO:0032606 2 0.011
single organism membrane fusion GO:0044801 2 0.011
negative regulation of cellular process GO:0048523 283 0.011
positive regulation of signaling GO:0023056 56 0.011
skeletal muscle organ development GO:0060538 78 0.011
positive regulation of cell cycle GO:0045787 3 0.011
regulation of response to biotic stimulus GO:0002831 2 0.011
positive regulation of gtp catabolic process GO:0033126 1 0.011
cellular response to topologically incorrect protein GO:0035967 2 0.011
negative regulation of protein phosphorylation GO:0001933 4 0.011
response to unfolded protein GO:0006986 2 0.011
skeletal system development GO:0001501 181 0.011
mitochondrion organization GO:0007005 4 0.011
response to chemical GO:0042221 320 0.011
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.011
regulation of skeletal muscle tissue development GO:0048641 4 0.011
gastrulation with mouth forming second GO:0001702 44 0.011
skeletal muscle tissue development GO:0007519 67 0.011
gland development GO:0048732 143 0.010
somatic stem cell maintenance GO:0035019 1 0.010
sequestering of calcium ion GO:0051208 3 0.010
organelle assembly GO:0070925 110 0.010
negative regulation of defense response GO:0031348 2 0.010
viral process GO:0016032 1 0.010
negative regulation of multi organism process GO:0043901 3 0.010
establishment of endothelial barrier GO:0061028 3 0.010
cell substrate adhesion GO:0031589 4 0.010
positive regulation of blood circulation GO:1903524 2 0.010
tyrosine phosphorylation of stat3 protein GO:0042503 1 0.010
positive regulation of transcription dna templated GO:0045893 57 0.010
positive regulation of programmed cell death GO:0043068 29 0.010
activation of immune response GO:0002253 9 0.010
multi organism cellular process GO:0044764 2 0.010
positive regulation of nervous system development GO:0051962 25 0.010
protein localization to plasma membrane GO:0072659 1 0.010
alpha amino acid metabolic process GO:1901605 3 0.010
transcription dna templated GO:0006351 181 0.010
g1 s transition of mitotic cell cycle GO:0000082 1 0.010
regulation of dendrite development GO:0050773 3 0.010
negative regulation of sequestering of calcium ion GO:0051283 4 0.010
regulation of developmental growth GO:0048638 38 0.010
regulation of blood pressure GO:0008217 1 0.010
response to hydrogen peroxide GO:0042542 3 0.010

grn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
nervous system disease DOID:863 0 0.034
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.014
eye disease DOID:5614 0 0.014
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014
immune system disease DOID:2914 0 0.010