IMP

Process View

Danio rerio

2 genes annotated in zebrafish

glucocorticoid metabolic process

The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in zebrafish Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "glucocorticoid metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "glucocorticoid metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
bmp2b	bone morphogenetic protein 2b	0.950	Human
bmp4	bone morphogenetic protein 4	0.762
dlx5a	distal-less homeobox gene 5a	0.594
atp1a1a.4	ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide	0.519	Mouse
atp1a1a.2	ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide	0.338	Mouse
slc12a2	solute carrier family 12 (potassium/chloride transporters), member 2	0.228
atp1a1a.3	ATPase, Na+/K+ transporting, alpha 1a.3 polypeptide	0.190	Mouse
gdf6a	growth differentiation factor 6a	0.165
cyp1a	cytochrome P450, family 1, subfamily A	0.152
apoa4	apolipoprotein A-IV	0.107
apobl	apolipoprotein B, like	0.103
cldn1	claudin 1	0.103
cldnh	claudin h	0.102
atp1a1a.5	ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide	0.098	Mouse
rhcgb	Rhesus blood group, C glycoprotein b	0.096
bhmt	betaine-homocysteine methyltransferase	0.091
gdnf	glial cell derived neurotrophic factor	0.089
gpr126	G protein-coupled receptor 126	0.088
mib	mind bomb	0.080
mt2	metallothionein 2	0.071
bmp7a	bone morphogenetic protein 7a	0.068
rag1	recombination activating gene 1	0.068
pvalb8	parvalbumin 8	0.066
LOC100000433	hypothetical LOC100000433	0.064
mpx	myeloid-specific peroxidase	0.064
cdh17	cadherin 17, LI cadherin (liver-intestine)	0.063
hnf1ba	HNF1 homeobox Ba	0.062
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.061
pomca	proopiomelanocortin a	0.061
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.058
agr2	anterior gradient homolog 2 (Xenopus laevis)	0.054
plcg1	phospholipase C, gamma 1	0.050
cnr1	cannabinoid receptor 1	0.049
apob	apolipoprotein B	0.048
agrp	agouti related protein homolog	0.048
atp1b1a	ATPase, Na+/K+ transporting, beta 1a polypeptide	0.047
fgf24	fibroblast growth factor 24	0.046
sst1.1	somatostatin 1, tandem duplicate 1	0.046
agt	angiotensinogen	0.046
myl7	myosin, light polypeptide 7, regulatory	0.045
spon1b	spondin 1b	0.045
gpia	glucose phosphate isomerase a	0.045
nkx2.3	NK2 transcription factor related 3	0.044
atp1b1b	ATPase, Na+/K+ transporting, beta 1b polypeptide	0.043
kal1a	Kallmann syndrome 1a sequence	0.043
ppargc1al	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like	0.041
chat	choline acetyltransferase	0.038
tp63	tumor protein p63	0.038
igfbp1a	insulin-like growth factor binding protein 1a	0.037
edn1	endothelin 1	0.035
fgb	fibrinogen, B beta polypeptide	0.035
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.034
oep	one-eyed pinhead	0.033
rrad	Ras-related associated with diabetes	0.033
dnm1l	dynamin 1-like	0.033
prox1	prospero-related homeobox gene 1	0.033
dlx4a	distal-less homeobox gene 4a	0.033
zgc:136930	zgc:136930	0.033
si:ch211-243g18.2	si:ch211-243g18.2	0.031
htr1aa	5-hydroxytryptamine (serotonin) receptor 1A a	0.031
ucp3	uncoupling protein 3	0.031
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.031
kcnj1	potassium inwardly-rectifying channel, subfamily J, member 1	0.031
LOC100003330	melanocortin-2 receptor accessory protein 2-like	0.031
st3gal2l	ST3 beta-galactoside alpha-2,3-sialyltransferase 2, like	0.031
star	steroidogenic acute regulatory protein	0.030	Mouse
fshr	follicle stimulating hormone receptor	0.030
cmlc1	cardiac myosin light chain-1	0.030
msxd	muscle segment homeobox D	0.029
ren	renin	0.029
LOC568379	von Willebrand factor A domain-containing protein 1-like	0.028
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.028	Mouse
anxa2b	annexin A2b	0.028
igfbp2a	insulin-like growth factor binding protein 2a	0.028
pvalb9	parvalbumin 9	0.027
ugdh	UDP-glucose dehydrogenase	0.027
arntl1b	aryl hydrocarbon receptor nuclear translocator-like 1b	0.027
dlx3b	distal-less homeobox gene 3b	0.027
ccng1	cyclin G1	0.026
lama5	laminin, alpha 5	0.026
itga3b	integrin, alpha 3b	0.026
dedd1	death effector domain-containing 1	0.025
and1	actinodin1	0.025
tgfb3	transforming growth factor, beta 3	0.025
xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5	0.025
crybb1	crystallin, beta B1	0.025
prom1a	prominin 1a	0.025
lhcgr	luteinizing hormone/choriogonadotropin receptor	0.025
wu:fb15e04	wu:fb15e04	0.025
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.024
spry4	sprouty (Drosophila) homolog 4	0.024
and3	actinodin3	0.024
hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.024
ela2l	elastase 2 like	0.024
rbp4	retinol binding protein 4, plasma	0.023
grn2	granulin 2	0.023
lyz	lysozyme	0.023
si:ch211-121a2.2	si:ch211-121a2.2	0.023
rgs4	regulator of G-protein signalling 4	0.023
slc27a2	solute carrier family 27 (fatty acid transporter), member 2	0.022
zgc:136878	zgc:136878	0.022
si:dkeyp-113d7.4	si:dkeyp-113d7.4	0.022
barhl2	BarH-like 2	0.022
six2a	sine oculis-related homeobox 2a	0.022
kita	kit receptor a	0.022
acvr2a	activin receptor IIa	0.022
cldna	claudin a	0.022
apoc2	apolipoprotein C-II	0.022
rars	arginyl-tRNA synthetase	0.022
cry1a	cryptochrome 1a	0.021
rspo1	R-spondin homolog (Xenopus laevis)	0.021
foxl1	forkhead box L1	0.021
apc	adenomatosis polyposis coli	0.021
actr1	ARP1 actin-related protein 1, centractin (yeast)	0.021
LOC100537712	serine/threonine-protein kinase SIK3 homolog	0.021
pax9	paired box gene 9	0.021
atp2a2a	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a	0.021
wu:fk35f04	wu:fk35f04	0.021
rorab	RAR-related orphan receptor A, paralog b	0.021
szl	sizzled	0.021
cx43	connexin 43	0.020
zgc:193613	zgc:193613	0.020
gdi1	GDP dissociation inhibitor 1	0.020
krt15	keratin 15	0.020
fgg	fibrinogen, gamma polypeptide	0.020
clock	clock	0.020
zgc:194131	zgc:194131	0.020
sst2	somatostatin 2	0.020
si:ch211-209p5.2	si:ch211-209p5.2	0.020
bysl	bystin-like	0.020
vamp1	vesicle-associated membrane protein 1	0.019
rac3b	ras-related C3 botulinum toxin substrate 3b (rho family, small GTP binding protein Rac3)	0.019
igfbp3	insulin-like growth factor binding protein 3	0.019
ctbp2	C-terminal binding protein 2	0.019
asl	argininosuccinate lyase	0.019
im:6903943	im:6903943	0.019
lpin1	lipin 1	0.019
zgc:86773	zgc:86773	0.019
tnnt2a	troponin T2a, cardiac	0.019
acvr2b	activin receptor IIb	0.019
zgc:161979	zgc:161979	0.019
ap1m2	adaptor-related protein complex 1, mu 2 subunit	0.018
alpi	alkaline phosphatase, intestinal	0.018
LOC569583	tumor suppressor candidate 5 homolog	0.018
nt5e	5'-nucleotidase, ecto (CD73)	0.018
ces2	carboxylesterase 2 (intestine, liver)	0.018
grn1	granulin 1	0.018
inha	inhibin, alpha	0.018
si:rp71-40n14.1	si:rp71-40n14.1	0.018
itih2	inter-alpha (globulin) inhibitor H2	0.018
fetub	fetuin B	0.018
si:dkey-60b12.7	si:dkey-60b12.7	0.018
slc13a1	solute carrier family 13 (sodium/sulphate symporters), member 1	0.018
pklr	pyruvate kinase, liver and RBC	0.017
bcl2l1	bcl2-like 1	0.017
apom	apolipoprotein M	0.017
apoea	apolipoprotein Ea	0.017
mc1r	melanocortin 1 receptor	0.017
ebf3	early B-cell factor 3	0.017
col17a1b	collagen, type XVII, alpha 1b	0.017
etv5b	ets variant 5b	0.017
ptgs1	prostaglandin-endoperoxide synthase 1	0.017
kng1	kininogen 1	0.016
ch25hl1.1	cholesterol 25-hydroxylase like 1, member 1	0.016
mapk3	mitogen-activated protein kinase 3	0.016
cyp11a1	cytochrome P450, subfamily XIA, polypeptide 1	0.016	Zebrafish
mmp13a	matrix metalloproteinase 13a	0.016
gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.016
LOC100148804	mucin-2-like	0.016
grm1a	glutamate receptor, metabotropic 1a	0.016
rbp2a	retinol binding protein 2a, cellular	0.016
zgc:110788	zgc:110788	0.016
si:ch211-57g18.1	si:ch211-57g18.1	0.016
col10a1	collagen, type X, alpha 1	0.016
cry5	cryptochrome 5	0.016
cp	ceruloplasmin	0.016
ampd3	adenosine monophosphate deaminase 3	0.016
si:dkey-76b14.4	si:dkey-76b14.4	0.015
fga	fibrinogen alpha chain	0.015
arf1	ADP-ribosylation factor 1	0.015
vmhc	ventricular myosin heavy chain	0.015
mmp9	matrix metalloproteinase 9	0.015
cyp2p6	cytochrome P450, family 2, subfamily P, polypeptide 6	0.015
paqr8	progestin and adipoQ receptor family member VIII	0.015
rbpms2	RNA binding protein with multiple splicing 2	0.015
tjp3	tight junction protein 3	0.015
gc3	guanylyl cyclase 3	0.015
twist3	twist3	0.015
cldnd	claudin d	0.015
pla2g12b	phospholipase A2, group XIIB	0.015
wu:fb10g08	wu:fb10g08	0.015
rerea	arginine-glutamic acid dipeptide (RE) repeats a	0.015
nme2b.2	non-metastatic cells 2b.2, protein (NM23B) expressed in	0.014
bmp7b	bone morphogenetic protein 7b	0.014
fbp1b	fructose-1,6-bisphosphatase 1b	0.014
tm4sf4	transmembrane 4 L six family member 4	0.014
mid1ip1b	MID1 interacting protein 1b	0.014
ddc	dopa decarboxylase	0.014
si:ch211-284e13.2	si:ch211-284e13.2	0.014
sqrdl	sulfide quinone reductase-like (yeast)	0.014
nptna	neuroplastin a	0.014
slc14a2	solute carrier family 14 (urea transporter), member 2	0.014
gata1a	GATA binding protein 1a	0.014
apoeb	apolipoprotein Eb	0.014
dync1h1	dynein, cytoplasmic 1, heavy chain 1	0.014
atp6v1d	ATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D	0.014
aspn	asporin (LRR class 1)	0.014
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.014
cfhl4	complement factor H like 4	0.014
dlx2a	distal-less homeobox gene 2a	0.014
zorba	Orb/CPEB-related RNA-binding protein	0.013
ecrg4a	esophageal cancer related gene 4a	0.013
cfb	complement factor B	0.013
rhbg	Rhesus blood group, B glycoprotein	0.013
cadm3	cell adhesion molecule 3	0.013
arf1l	ADP-ribosylation factor 1 like	0.013
zgc:112964	zgc:112964	0.013
th2	tyrosine hydroxylase 2	0.013
dzip1	DAZ interacting protein 1	0.013
sepp1a	selenoprotein P, plasma, 1a	0.013
hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.013	Rat
elf3	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	0.013
rab11al	RAB11a, member RAS oncogene family, like	0.013
tdh	L-threonine dehydrogenase	0.013
LOC571837	similar to 130 kDa myosin-binding subunit of smooth muscle myosin phophatase (M130)	0.013
zgc:154045	zgc:154045	0.013
igfbp6b	insulin-like growth factor binding protein 6b	0.013
gadd45aa	growth arrest and DNA-damage-inducible, alpha, a	0.013
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.013
adipor2	adiponectin receptor 2	0.012
ip6k2	inositol hexaphosphate kinase 2	0.012
krit1	KRIT1, ankyrin repeat containing	0.012
dct	dopachrome tautomerase	0.012
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.012
adh8a	alcohol dehydrogenase 8a	0.012
tssc1	tumor suppressing subtransferable candidate 1	0.012
ptf1a	pancreas specific transcription factor, 1a	0.012
zgc:111821	zgc:111821	0.012
zgc:85682	zgc:85682	0.012
tmprss13b	transmembrane protease, serine 13b	0.012
fabp1b.1	fatty acid binding protein 1b, tandem duplicate 1	0.012
sparc	secreted acidic cysteine rich glycoprotein	0.012
wu:fc07e08	wu:fc07e08	0.012
minpp1b	multiple inositol polyphosphate histidine phosphatase, 1b	0.012
ndufa4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4	0.012
wu:fb09h07	wu:fb09h07	0.012
atp6v1b2	ATPase, H+ transporting, lysosomal V1 subunit B2	0.012
cry4	cryptochrome 4	0.012
sst3	somatostatin 3	0.012
zgc:110124	zgc:110124	0.012
bsk146	brain specific kinase 146	0.012
vasa	vasa homolog	0.012
anxa6	annexin A6	0.012
fkbp5	FK506 binding protein 5	0.012
nlgn4b	neuroligin 4b	0.012
ptger2a	prostaglandin E receptor 2a (subtype EP2)	0.012
jag1b	jagged 1b	0.012
scg3	secretogranin III	0.011
pitpnb	phosphotidylinositol transfer protein, beta	0.011
lmbr1l	limb region 1 like	0.011
itgb4	integrin, beta 4	0.011
acsbg2	acyl-CoA synthetase bubblegum family member 2	0.011
ins	preproinsulin	0.011
atp1b2b	ATPase, Na+/K+ transporting, beta 2b polypeptide	0.011
raf1a	v-raf-1 murine leukemia viral oncogene homolog 1a	0.011
gbgt1l1	globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1	0.011
zgc:91936	zgc:91936	0.011
hmgcs1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	0.011
rtn1b	reticulon 1b	0.011
gh1	growth hormone 1	0.011
c9	complement component 9	0.011
acp5a	acid phosphatase 5a, tartrate resistant	0.011
th	tyrosine hydroxylase	0.011
arg2	arginase, type II	0.011
hsf2	heat shock factor 2	0.011
frem2a	Fras1 related extracellular matrix protein 2a	0.011
eef2l2	eukaryotic translation elongation factor 2, like 2	0.011
dopey1	dopey family member 1	0.011
st14b	suppression of tumorigenicity 14 (colon carcinoma) b	0.011
cpt1b	carnitine palmitoyltransferase 1B (muscle)	0.011
gnsb	glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b	0.011
lamb1a	laminin, beta 1a	0.011
si:dkey-256h2.1	si:dkey-256h2.1	0.011
fryl	furry homolog-like (Drosophila)	0.011
mapk12	mitogen-activated protein kinase 12	0.011
ptpn11b	protein tyrosine phosphatase, non-receptor type 11, b	0.011
plg	plasminogen	0.011
and2	actinodin2	0.011
ccdc40	coiled-coil domain containing 40	0.011
hapln3	hyaluronan and proteoglycan link protein 3	0.011
nccrp1	nonspecific cytotoxic cell receptor protein 1	0.011
si:ch211-215l11.5	si:ch211-215l11.5	0.011
npepps	aminopeptidase puromycin sensitive	0.010
mpp2b	membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2b)	0.010
si:ch211-250e5.16	si:ch211-250e5.16	0.010
socs1	suppressor of cytokine signaling 1	0.010
immt	inner membrane protein, mitochondrial (mitofilin)	0.010
echdc2	enoyl CoA hydratase domain containing 2	0.010
cmyb	transcription factor cmyb	0.010
thraa	thyroid hormone receptor alpha a	0.010
prr15la	proline rich 15-like a	0.010
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.010
foxi3a	forkhead box I3a	0.010
tbx2b	T-box 2b	0.010
ache	acetylcholinesterase	0.010
siae	sialic acid acetylesterase	0.010
zgc:56538	zgc:56538	0.010
atp1b3b	ATPase, Na+/K+ transporting, beta 3b polypeptide	0.010
ptgds	prostaglandin D2 synthase	0.010
gad1b	glutamate decarboxylase 1b	0.010
lxn	latexin	0.010
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.010
bbc3	BCL2 binding component 3	0.010
hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	0.010
gip	gastric inhibitory polypeptide	0.010
zgc:63569	zgc:63569	0.010
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.010
per2	period homolog 2 (Drosophila)	0.010
elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	0.010
ndrg3a	N-myc downstream regulated family member 3a	0.010
zgc:77123	zgc:77123	0.010
pgam1b	phosphoglycerate mutase 1b	0.010
foxi1	forkhead box I1	0.010
mical2b	microtubule associated monoxygenase, calponin and LIM domain containing 2b	0.010