Danio rerio

68 known processes

dhfr

dihydrofolate reductase

(Aliases: zgc:86637,cb595)

dhfr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular aromatic compound metabolic process GO:0006725 295 0.672
biosynthetic process GO:0009058 294 0.499
organic substance biosynthetic process GO:1901576 289 0.494
cellular nitrogen compound metabolic process GO:0034641 290 0.492
sister chromatid cohesion GO:0007062 2 0.474
single organism metabolic process GO:0044710 217 0.462
nitrogen compound metabolic process GO:0006807 319 0.444
cellular macromolecule biosynthetic process GO:0034645 224 0.422
mitotic dna integrity checkpoint GO:0044774 4 0.378
multi organism process GO:0051704 134 0.359
sensory organ development GO:0007423 393 0.354
macromolecule biosynthetic process GO:0009059 227 0.353
nucleobase containing compound metabolic process GO:0006139 274 0.349
oocyte maturation GO:0001556 4 0.340
pyrimidine containing compound metabolic process GO:0072527 3 0.314
signal transduction GO:0007165 455 0.287
positive regulation of biological process GO:0048518 253 0.272
heterocycle metabolic process GO:0046483 290 0.267
cellular biosynthetic process GO:0044249 286 0.264
rna transport GO:0050658 2 0.213
dna metabolic process GO:0006259 27 0.213
deoxyribonucleotide biosynthetic process GO:0009263 1 0.201
alpha amino acid metabolic process GO:1901605 3 0.200
positive regulation of catabolic process GO:0009896 4 0.191
regulation of multicellular organismal process GO:0051239 277 0.188
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.175
rna metabolic process GO:0016070 219 0.154
positive regulation of nuclease activity GO:0032075 1 0.149
regulation of cellular biosynthetic process GO:0031326 245 0.146
organelle organization GO:0006996 227 0.140
cellular response to oxygen containing compound GO:1901701 20 0.137
organic cyclic compound metabolic process GO:1901360 301 0.135
aromatic compound biosynthetic process GO:0019438 217 0.124
cellular nitrogen compound biosynthetic process GO:0044271 218 0.119
positive regulation of cellular process GO:0048522 201 0.104
single organism transport GO:0044765 206 0.103
organic substance catabolic process GO:1901575 28 0.103
regulation of cytokine production GO:0001817 3 0.099
nucleic acid metabolic process GO:0090304 244 0.098
larval development GO:0002164 2 0.096
regulation of dna metabolic process GO:0051052 11 0.094
regulation of dna replication GO:0006275 3 0.093
response to stress GO:0006950 263 0.090
cellular amino acid biosynthetic process GO:0008652 2 0.089
immune system process GO:0002376 241 0.088
response to biotic stimulus GO:0009607 97 0.087
zymogen activation GO:0031638 3 0.085
dna catabolic process GO:0006308 1 0.084
methylation GO:0032259 22 0.082
chromosome organization GO:0051276 31 0.082
regulation of response to stimulus GO:0048583 269 0.080
response to external biotic stimulus GO:0043207 97 0.079
cell cycle g1 s phase transition GO:0044843 1 0.077
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.076
positive regulation of cellular catabolic process GO:0031331 3 0.076
organic cyclic compound biosynthetic process GO:1901362 223 0.075
response to organic substance GO:0010033 153 0.075
response to amine GO:0014075 1 0.074
regulation of primary metabolic process GO:0080090 311 0.073
rna biosynthetic process GO:0032774 181 0.071
ribonucleotide metabolic process GO:0009259 27 0.070
double strand break repair GO:0006302 3 0.069
regulation of nuclease activity GO:0032069 1 0.068
negative regulation of biological process GO:0048519 304 0.067
guanosine containing compound metabolic process GO:1901068 4 0.067
regulation of metabolic process GO:0019222 359 0.067
regulation of response to biotic stimulus GO:0002831 2 0.065
response to amphetamine GO:0001975 1 0.065
catabolic process GO:0009056 32 0.064
purine nucleoside monophosphate catabolic process GO:0009128 4 0.064
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 10 0.064
single organism biosynthetic process GO:0044711 71 0.062
spindle assembly involved in meiosis GO:0090306 1 0.061
muscle structure development GO:0061061 196 0.061
positive regulation of cellular metabolic process GO:0031325 94 0.060
regulation of rna biosynthetic process GO:2001141 213 0.059
nucleic acid templated transcription GO:0097659 181 0.059
gene expression GO:0010467 252 0.058
negative regulation of signal transduction GO:0009968 94 0.058
pyrimidine nucleotide metabolic process GO:0006220 1 0.058
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.058
deoxyribonucleotide metabolic process GO:0009262 1 0.057
immune system development GO:0002520 191 0.057
chordate embryonic development GO:0043009 271 0.057
negative regulation of cellular process GO:0048523 283 0.056
oxoacid metabolic process GO:0043436 31 0.055
g1 s transition of mitotic cell cycle GO:0000082 1 0.055
nucleobase containing compound biosynthetic process GO:0034654 205 0.055
cellular response to superoxide GO:0071451 2 0.055
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.054
digestive system development GO:0055123 289 0.053
organonitrogen compound biosynthetic process GO:1901566 47 0.052
response to uv GO:0009411 3 0.052
regulation of dna recombination GO:0000018 2 0.052
hematopoietic or lymphoid organ development GO:0048534 191 0.052
positive regulation of cytokine production GO:0001819 2 0.052
carbohydrate derivative metabolic process GO:1901135 61 0.052
regulation of nucleic acid templated transcription GO:1903506 213 0.051
protein metabolic process GO:0019538 183 0.050
guanosine containing compound catabolic process GO:1901069 2 0.050
regulation of apoptotic process GO:0042981 98 0.049
small molecule metabolic process GO:0044281 77 0.049
cellular macromolecule metabolic process GO:0044260 391 0.048
negative regulation of cell death GO:0060548 60 0.048
response to other organism GO:0051707 97 0.048
response to oxygen radical GO:0000305 2 0.048
organic cyclic compound catabolic process GO:1901361 15 0.048
mitochondrion organization GO:0007005 4 0.047
striated muscle tissue development GO:0014706 110 0.047
response to vitamin b3 GO:0033552 2 0.047
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.045
cellular component movement GO:0006928 335 0.045
regulation of nucleotide catabolic process GO:0030811 2 0.045
aging GO:0007568 2 0.044
ribonucleoside monophosphate catabolic process GO:0009158 4 0.044
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 1 0.044
apoptotic process GO:0006915 116 0.044
positive regulation of lipid metabolic process GO:0045834 1 0.044
establishment of rna localization GO:0051236 3 0.043
amine metabolic process GO:0009308 2 0.043
intra s dna damage checkpoint GO:0031573 1 0.043
carboxylic acid metabolic process GO:0019752 22 0.043
organonitrogen compound metabolic process GO:1901564 74 0.042
leukocyte proliferation GO:0070661 1 0.042
positive regulation of response to stimulus GO:0048584 80 0.042
regulation of dna catabolic process GO:1903624 1 0.042
regulation of reproductive process GO:2000241 4 0.041
single organism organelle organization GO:1902589 199 0.040
regulation of macromolecule metabolic process GO:0060255 317 0.039
cellular response to molecule of bacterial origin GO:0071219 3 0.038
single organism localization GO:1902578 225 0.037
regulation of macromolecule biosynthetic process GO:0010556 225 0.037
regulation of gene expression GO:0010468 265 0.036
g2 m transition of mitotic cell cycle GO:0000086 4 0.036
cellular response to stress GO:0033554 62 0.036
regulation of purine nucleotide catabolic process GO:0033121 2 0.035
nucleoside monophosphate catabolic process GO:0009125 4 0.034
growth GO:0040007 174 0.034
regulation of cellular metabolic process GO:0031323 320 0.034
immune effector process GO:0002252 23 0.034
atp catabolic process GO:0006200 4 0.034
digestive tract development GO:0048565 265 0.034
organic acid metabolic process GO:0006082 31 0.034
muscle organ development GO:0007517 101 0.033
regulation of cell communication GO:0010646 232 0.033
cellular protein catabolic process GO:0044257 4 0.032
negative regulation of dna metabolic process GO:0051053 4 0.032
nucleic acid transport GO:0050657 2 0.031
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.031
response to bacterium GO:0009617 58 0.031
hemopoiesis GO:0030097 183 0.031
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.030
cellular catabolic process GO:0044248 27 0.030
response to chemical GO:0042221 320 0.030
mitotic dna damage checkpoint GO:0044773 4 0.030
long chain fatty acid transport GO:0015909 1 0.030
eye development GO:0001654 277 0.029
heterocycle biosynthetic process GO:0018130 215 0.029
response to external stimulus GO:0009605 264 0.029
response to drug GO:0042493 3 0.029
recombinational repair GO:0000725 1 0.029
covalent chromatin modification GO:0016569 20 0.029
centrosome organization GO:0051297 1 0.029
muscle tissue development GO:0060537 110 0.029
macromolecular complex subunit organization GO:0043933 74 0.028
defense response to virus GO:0051607 10 0.028
regulation of peptidase activity GO:0052547 23 0.028
regulation of catalytic activity GO:0050790 55 0.028
regulation of nitrogen compound metabolic process GO:0051171 251 0.028
regulation of cell death GO:0010941 103 0.028
reciprocal dna recombination GO:0035825 1 0.028
regulation of histone h3 k9 methylation GO:0051570 2 0.028
tube morphogenesis GO:0035239 349 0.028
regulation of establishment of protein localization GO:0070201 4 0.027
negative regulation of programmed cell death GO:0043069 58 0.027
negative regulation of dna replication GO:0008156 2 0.026
protein complex assembly GO:0006461 30 0.026
organophosphate metabolic process GO:0019637 37 0.026
nucleoside phosphate metabolic process GO:0006753 28 0.026
cellular response to chemical stimulus GO:0070887 157 0.026
multicellular organism growth GO:0035264 4 0.026
double strand break repair via homologous recombination GO:0000724 1 0.026
cellular response to reactive oxygen species GO:0034614 2 0.026
lymphocyte proliferation GO:0046651 1 0.025
histone h3 k4 methylation GO:0051568 2 0.025
negative regulation of response to stimulus GO:0048585 104 0.025
maintenance of dna repeat elements GO:0043570 2 0.025
cellular amine metabolic process GO:0044106 2 0.025
negative regulation of signaling GO:0023057 96 0.025
regulation of rna metabolic process GO:0051252 224 0.025
blood circulation GO:0008015 87 0.025
cellular modified amino acid metabolic process GO:0006575 3 0.025
axis specification GO:0009798 43 0.025
negative regulation of cell communication GO:0010648 96 0.024
positive regulation of signal transduction GO:0009967 56 0.024
specification of symmetry GO:0009799 204 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.024
cell aging GO:0007569 2 0.024
camera type eye development GO:0043010 222 0.024
oocyte development GO:0048599 14 0.023
regulation of biological quality GO:0065008 263 0.023
production of molecular mediator of immune response GO:0002440 2 0.023
negative regulation of metabolic process GO:0009892 86 0.023
type i interferon production GO:0032606 2 0.023
gtp catabolic process GO:0006184 2 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.023
proteasomal protein catabolic process GO:0010498 2 0.023
exocrine pancreas development GO:0031017 28 0.023
establishment of localization GO:0051234 244 0.023
transcription from rna polymerase ii promoter GO:0006366 80 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.023
determination of left right symmetry GO:0007368 179 0.022
regulation of gtp catabolic process GO:0033124 2 0.022
negative regulation of rna metabolic process GO:0051253 48 0.022
intracellular signal transduction GO:0035556 85 0.022
macromolecular complex assembly GO:0065003 35 0.022
cell death in response to oxidative stress GO:0036473 2 0.022
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.022
regulation of signal transduction GO:0009966 225 0.022
regulation of biosynthetic process GO:0009889 250 0.022
negative regulation of gene expression GO:0010629 65 0.022
pancreas development GO:0031016 84 0.022
regulation of localization GO:0032879 104 0.021
cell part morphogenesis GO:0032990 246 0.021
epithelial tube morphogenesis GO:0060562 148 0.021
rna localization GO:0006403 4 0.021
cell death GO:0008219 121 0.021
blood vessel development GO:0001568 246 0.021
regulation of protein catabolic process GO:0042176 1 0.021
dna biosynthetic process GO:0071897 3 0.021
phosphate containing compound metabolic process GO:0006796 108 0.021
response to wounding GO:0009611 116 0.021
regulation of deoxyribonuclease activity GO:0032070 1 0.021
regulation of molecular function GO:0065009 70 0.021
programmed cell death GO:0012501 119 0.021
regulation of cellular amine metabolic process GO:0033238 0 0.021
regulation of binding GO:0051098 3 0.021
maintenance of location GO:0051235 4 0.020
centrosome cycle GO:0007098 1 0.020
nucleotide metabolic process GO:0009117 28 0.020
b cell differentiation GO:0030183 1 0.020
meiosis i GO:0007127 1 0.020
protein homooligomerization GO:0051260 3 0.020
negative regulation of macromolecule metabolic process GO:0010605 76 0.019
cellular macromolecular complex assembly GO:0034622 24 0.019
positive regulation of metabolic process GO:0009893 108 0.019
estrogen metabolic process GO:0008210 2 0.019
nucleobase containing small molecule metabolic process GO:0055086 32 0.019
negative regulation of nucleic acid templated transcription GO:1903507 45 0.019
positive regulation of signaling GO:0023056 56 0.019
regulation of programmed cell death GO:0043067 101 0.019
positive regulation of defense response to virus by host GO:0002230 0 0.019
regulation of cellular response to stress GO:0080135 20 0.019
cell proliferation in forebrain GO:0021846 3 0.019
chromosome organization involved in meiosis GO:0070192 1 0.019
negative regulation of transcription dna templated GO:0045892 45 0.018
death GO:0016265 121 0.018
nucleobase containing compound catabolic process GO:0034655 15 0.018
negative regulation of cellular metabolic process GO:0031324 77 0.018
reciprocal meiotic recombination GO:0007131 1 0.018
positive regulation of multicellular organismal process GO:0051240 52 0.018
regulation of proteolysis GO:0030162 24 0.018
regulation of intracellular signal transduction GO:1902531 57 0.017
deoxyribose phosphate metabolic process GO:0019692 1 0.017
response to lipid GO:0033993 60 0.017
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.017
monovalent inorganic cation transport GO:0015672 42 0.017
skeletal system development GO:0001501 181 0.017
response to oxygen containing compound GO:1901700 55 0.017
positive regulation of chromosome segregation GO:0051984 1 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
homeostasis of number of cells GO:0048872 62 0.017
cellular localization GO:0051641 97 0.017
apoptotic signaling pathway GO:0097190 23 0.016
telomere organization GO:0032200 1 0.016
nucleobase containing compound transport GO:0015931 2 0.016
response to metal ion GO:0010038 34 0.016
negative regulation of apoptotic process GO:0043066 55 0.016
neuroblast fate commitment GO:0014017 1 0.016
mitotic metaphase plate congression GO:0007080 1 0.016
regulation of transcription dna templated GO:0006355 213 0.016
dicarboxylic acid metabolic process GO:0043648 1 0.016
cellular response to external stimulus GO:0071496 2 0.016
positive regulation of nucleoside metabolic process GO:0045979 1 0.015
modification dependent protein catabolic process GO:0019941 3 0.015
adult behavior GO:0030534 2 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
regulation of response to stress GO:0080134 36 0.015
germ line stem cell division GO:0042078 1 0.015
myeloid cell differentiation GO:0030099 86 0.015
lipid storage GO:0019915 1 0.015
transcription dna templated GO:0006351 181 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
cellular response to organic substance GO:0071310 105 0.014
erythrocyte differentiation GO:0030218 54 0.014
phosphorus metabolic process GO:0006793 109 0.014
striated muscle cell development GO:0055002 108 0.014
negative regulation of biosynthetic process GO:0009890 55 0.014
regulation of protein metabolic process GO:0051246 56 0.014
cellular response to dna damage stimulus GO:0006974 24 0.014
muscle cell cellular homeostasis GO:0046716 5 0.014
negative regulation of chromosome organization GO:2001251 1 0.014
muscle cell differentiation GO:0042692 139 0.014
protein acylation GO:0043543 3 0.014
digestive tract morphogenesis GO:0048546 231 0.013
regulation of immune response GO:0050776 14 0.013
cell morphogenesis GO:0000902 289 0.013
neuroblast differentiation GO:0014016 1 0.013
spindle assembly involved in female meiosis GO:0007056 1 0.013
striated muscle cell differentiation GO:0051146 129 0.013
regulation of multicellular organism growth GO:0040014 4 0.013
transport GO:0006810 220 0.013
regulation of cell activation GO:0050865 1 0.013
protein complex biogenesis GO:0070271 30 0.013
positive regulation of map kinase activity GO:0043406 3 0.013
response to amino acid GO:0043200 2 0.013
brain development GO:0007420 293 0.013
cellular amino acid metabolic process GO:0006520 7 0.013
chromatin organization GO:0006325 22 0.013
protein polymerization GO:0051258 4 0.013
purine containing compound metabolic process GO:0072521 29 0.013
immunoglobulin production GO:0002377 1 0.013
dna replication GO:0006260 6 0.013
positive regulation of immune effector process GO:0002699 3 0.012
erythrocyte homeostasis GO:0034101 55 0.012
signal transduction by p53 class mediator GO:0072331 13 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
immune response GO:0006955 28 0.012
regulation of nucleoside metabolic process GO:0009118 2 0.012
cell growth GO:0016049 57 0.012
immunoglobulin mediated immune response GO:0016064 3 0.012
liver development GO:0001889 96 0.012
mrna transport GO:0051028 2 0.012
regulation of endopeptidase activity GO:0052548 23 0.012
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.012
positive regulation of gliogenesis GO:0014015 2 0.012
centrosome duplication GO:0051298 1 0.012
positive regulation of cell activation GO:0050867 1 0.012
retina development in camera type eye GO:0060041 146 0.012
muscle cell development GO:0055001 115 0.012
sensory organ morphogenesis GO:0090596 200 0.012
positive regulation of muscle tissue development GO:1901863 1 0.012
response to nitrogen compound GO:1901698 19 0.012
extrinsic apoptotic signaling pathway GO:0097191 3 0.012
cellular response to oxygen levels GO:0071453 1 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
regulation of production of molecular mediator of immune response GO:0002700 1 0.011
negative regulation of meiotic cell cycle GO:0051447 1 0.011
protein complex subunit organization GO:0071822 46 0.011
nuclear division GO:0000280 23 0.011
locomotion GO:0040011 313 0.011
histone lysine methylation GO:0034968 12 0.011
cellular protein modification process GO:0006464 100 0.011
ear development GO:0043583 127 0.011
negative regulation of reproductive process GO:2000242 3 0.011
protein acetylation GO:0006473 2 0.011
antimicrobial humoral response GO:0019730 2 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 6 0.011
regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 1 0.011
cell migration GO:0016477 237 0.011
cellular protein metabolic process GO:0044267 129 0.011
regulation of cellular component movement GO:0051270 55 0.011
histone phosphorylation GO:0016572 2 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.011
lipid metabolic process GO:0006629 52 0.011
negative regulation of protein phosphorylation GO:0001933 4 0.011
regulation of gtpase activity GO:0043087 2 0.011
negative regulation of protein kinase activity GO:0006469 4 0.011
morphogenesis of an epithelial fold GO:0060571 1 0.011
intracellular steroid hormone receptor signaling pathway GO:0030518 5 0.011
signal transduction by phosphorylation GO:0023014 18 0.010
cellular response to hypoxia GO:0071456 1 0.010
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
stem cell maintenance GO:0019827 4 0.010
regulation of heart growth GO:0060420 2 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.010
response to vitamin GO:0033273 3 0.010
connective tissue development GO:0061448 99 0.010
female gamete generation GO:0007292 14 0.010
vasculature development GO:0001944 278 0.010
ribose phosphate metabolic process GO:0019693 27 0.010
cellular component assembly GO:0022607 170 0.010
peptide metabolic process GO:0006518 1 0.010
positive regulation of cell cycle GO:0045787 3 0.010

dhfr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.085
inherited metabolic disorder DOID:655 0 0.085
cancer DOID:162 0 0.036
disease of cellular proliferation DOID:14566 0 0.036
organ system cancer DOID:0050686 0 0.036
thoracic cancer DOID:5093 0 0.014
large intestine cancer DOID:5672 0 0.013
gastrointestinal system cancer DOID:3119 0 0.013
intestinal cancer DOID:10155 0 0.013
colorectal cancer DOID:9256 0 0.013
benign neoplasm DOID:0060072 0 0.012
colon carcinoma DOID:1520 0 0.012
colon cancer DOID:219 0 0.012
disease of anatomical entity DOID:7 0 0.010