Danio rerio

0 known processes

smchd1

structural maintenance of chromosomes flexible hinge domain containing 1

(Aliases: kiaa0650l,kiaao650l)

smchd1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
gene expression GO:0010467 252 0.325
Mouse
erythrocyte differentiation GO:0030218 54 0.311
hemopoiesis GO:0030097 183 0.295
primitive hemopoiesis GO:0060215 27 0.214
biosynthetic process GO:0009058 294 0.175
signal transduction GO:0007165 455 0.174
homeostasis of number of cells GO:0048872 62 0.170
organic cyclic compound biosynthetic process GO:1901362 223 0.152
regulation of stem cell differentiation GO:2000736 4 0.138
renal filtration GO:0097205 10 0.132
central nervous system development GO:0007417 387 0.127
regulation of cellular metabolic process GO:0031323 320 0.127
regulation of blood pressure GO:0008217 1 0.121
epithelial cell differentiation GO:0030855 116 0.118
regulation of neural precursor cell proliferation GO:2000177 3 0.116
glomerulus development GO:0032835 27 0.115
stem cell proliferation GO:0072089 4 0.115
hematopoietic or lymphoid organ development GO:0048534 191 0.108
renal system development GO:0072001 94 0.108
cellular nitrogen compound biosynthetic process GO:0044271 218 0.106
erythrocyte homeostasis GO:0034101 55 0.105
head development GO:0060322 303 0.103
cellular nitrogen compound metabolic process GO:0034641 290 0.093
regulation of signaling GO:0023051 235 0.089
regulation of gene expression GO:0010468 265 0.086
Mouse
nephron epithelium development GO:0072009 16 0.085
sensory organ development GO:0007423 393 0.083
rna metabolic process GO:0016070 219 0.077
nucleic acid metabolic process GO:0090304 244 0.074
homeostatic process GO:0042592 142 0.072
cell morphogenesis GO:0000902 289 0.070
aromatic compound biosynthetic process GO:0019438 217 0.068
nucleic acid templated transcription GO:0097659 181 0.063
urogenital system development GO:0001655 97 0.061
regulation of multicellular organismal process GO:0051239 277 0.060
i kappab kinase nf kappab signaling GO:0007249 4 0.060
compound eye development GO:0048749 2 0.059
larval development GO:0002164 2 0.058
kidney development GO:0001822 92 0.055
system process GO:0003008 185 0.055
muscle cell differentiation GO:0042692 139 0.054
nephron development GO:0072006 31 0.054
immune system process GO:0002376 241 0.051
erythrocyte maturation GO:0043249 8 0.050
regulation of cell differentiation GO:0045595 142 0.050
generation of neurons GO:0048699 385 0.050
cellular response to extracellular stimulus GO:0031668 2 0.048
nephron tubule morphogenesis GO:0072078 1 0.048
stem cell maintenance GO:0019827 4 0.047
regulation of systemic arterial blood pressure GO:0003073 1 0.046
regulation of cell communication GO:0010646 232 0.046
regulation of cytokine production GO:0001817 3 0.046
regulation of biological quality GO:0065008 263 0.045
aging GO:0007568 2 0.045
neuron development GO:0048666 262 0.044
negative regulation of stem cell differentiation GO:2000737 2 0.042
cellular macromolecule biosynthetic process GO:0034645 224 0.041
regulation of cellular biosynthetic process GO:0031326 245 0.040
cell projection morphogenesis GO:0048858 244 0.039
endocrine process GO:0050886 2 0.039
immune system development GO:0002520 191 0.039
carbohydrate homeostasis GO:0033500 1 0.039
regulation of metabolic process GO:0019222 359 0.038
Mouse
stem cell differentiation GO:0048863 117 0.038
nephron epithelium morphogenesis GO:0072088 1 0.037
cell migration GO:0016477 237 0.037
positive regulation of neural precursor cell proliferation GO:2000179 1 0.037
response to external stimulus GO:0009605 264 0.037
erk1 and erk2 cascade GO:0070371 4 0.037
extrinsic apoptotic signaling pathway GO:0097191 3 0.036
embryonic hemopoiesis GO:0035162 53 0.036
development of primary female sexual characteristics GO:0046545 4 0.036
cell projection organization GO:0030030 284 0.036
axonogenesis GO:0007409 152 0.036
organic substance biosynthetic process GO:1901576 289 0.035
cell morphogenesis involved in differentiation GO:0000904 195 0.035
glucose homeostasis GO:0042593 1 0.034
heterocycle metabolic process GO:0046483 290 0.034
regulation of jak stat cascade GO:0046425 3 0.034
nucleobase containing compound metabolic process GO:0006139 274 0.034
cellular biosynthetic process GO:0044249 286 0.034
female sex differentiation GO:0046660 4 0.034
glomerular filtration GO:0003094 6 0.033
negative regulation of developmental process GO:0051093 65 0.033
macromolecule biosynthetic process GO:0009059 227 0.033
striated muscle cell differentiation GO:0051146 129 0.032
maintenance of location GO:0051235 4 0.032
heterocycle biosynthetic process GO:0018130 215 0.032
positive regulation of jak stat cascade GO:0046427 2 0.032
cell differentiation involved in kidney development GO:0061005 13 0.032
regulation of nucleic acid templated transcription GO:1903506 213 0.032
locomotor rhythm GO:0045475 3 0.031
nuclear transport GO:0051169 4 0.031
sequestering of calcium ion GO:0051208 3 0.030
cellular response to chemical stimulus GO:0070887 157 0.030
cellular component movement GO:0006928 335 0.030
axon ensheathment in central nervous system GO:0032291 2 0.030
regulation of rna metabolic process GO:0051252 224 0.030
protein acylation GO:0043543 3 0.029
regulation of response to stimulus GO:0048583 269 0.029
cell motility GO:0048870 244 0.029
angiogenesis GO:0001525 158 0.029
single organism metabolic process GO:0044710 217 0.029
epithelial cell development GO:0002064 42 0.028
anterior posterior pattern specification GO:0009952 152 0.028
myeloid cell homeostasis GO:0002262 56 0.028
stem cell development GO:0048864 82 0.028
negative regulation of multicellular organismal process GO:0051241 69 0.028
tissue remodeling GO:0048771 4 0.028
multi organism process GO:0051704 134 0.027
embryonic organ development GO:0048568 381 0.027
vasculature development GO:0001944 278 0.027
cellular response to starvation GO:0009267 1 0.027
porphyrin containing compound biosynthetic process GO:0006779 8 0.026
regulation of multicellular organism growth GO:0040014 4 0.026
cellular response to external stimulus GO:0071496 2 0.026
transcription dna templated GO:0006351 181 0.026
organic cyclic compound metabolic process GO:1901360 301 0.026
peptidyl lysine acetylation GO:0018394 2 0.026
multicellular organism growth GO:0035264 4 0.026
cellular aromatic compound metabolic process GO:0006725 295 0.026
renal system process GO:0003014 14 0.026
neuron neuron synaptic transmission GO:0007270 1 0.026
female gonad development GO:0008585 4 0.026
wnt signaling pathway GO:0016055 80 0.025
renal tubule morphogenesis GO:0061333 1 0.025
morphogenesis of an epithelium GO:0002009 333 0.025
response to organic substance GO:0010033 153 0.025
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.025
positive regulation of biological process GO:0048518 253 0.025
cellular response to stress GO:0033554 62 0.025
regulation of biosynthetic process GO:0009889 250 0.024
cardiac cell fate commitment GO:0060911 1 0.024
regulation of erk1 and erk2 cascade GO:0070372 4 0.024
positive regulation of cytokine production GO:0001819 2 0.024
response to chemical GO:0042221 320 0.024
regulation of calcium ion transport GO:0051924 2 0.024
neuron differentiation GO:0030182 353 0.024
multicellular organismal homeostasis GO:0048871 29 0.024
regulation of establishment of protein localization GO:0070201 4 0.024
camera type eye development GO:0043010 222 0.023
internal peptidyl lysine acetylation GO:0018393 2 0.023
myeloid cell differentiation GO:0030099 86 0.023
cell surface receptor signaling pathway GO:0007166 325 0.023
regulation of cellular component movement GO:0051270 55 0.023
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.023
renal system process involved in regulation of blood volume GO:0001977 1 0.022
positive regulation of stem cell proliferation GO:2000648 1 0.022
positive regulation of myeloid cell differentiation GO:0045639 2 0.022
single organism nuclear import GO:1902593 3 0.022
nucleobase containing compound biosynthetic process GO:0034654 205 0.022
negative regulation of cellular process GO:0048523 283 0.022
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.022
protein secretion GO:0009306 1 0.022
nitrogen compound metabolic process GO:0006807 319 0.021
regulation of protein ubiquitination GO:0031396 3 0.021
positive regulation of jun kinase activity GO:0043507 2 0.021
cellular amino acid metabolic process GO:0006520 7 0.021
circulatory system process GO:0003013 87 0.021
negative regulation of protein transport GO:0051224 3 0.021
nuclear import GO:0051170 3 0.021
positive regulation of transport GO:0051050 2 0.021
brain development GO:0007420 293 0.021
positive regulation of secretion by cell GO:1903532 1 0.020
erythrocyte development GO:0048821 24 0.020
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.020
sleep GO:0030431 1 0.020
wound healing GO:0042060 90 0.020
ovulation cycle GO:0042698 2 0.020
glomerular epithelium development GO:0072010 12 0.020
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.020
localization of cell GO:0051674 244 0.020
rna biosynthetic process GO:0032774 181 0.020
ovulation cycle process GO:0022602 2 0.020
positive regulation of leukocyte differentiation GO:1902107 1 0.020
regulation of synapse assembly GO:0051963 3 0.020
negative regulation of blood circulation GO:1903523 2 0.020
carboxylic acid metabolic process GO:0019752 22 0.020
epithelial cell differentiation involved in kidney development GO:0035850 13 0.020
programmed cell death GO:0012501 119 0.020
regulation of stem cell proliferation GO:0072091 2 0.020
neuronal stem cell maintenance GO:0097150 2 0.020
lipid storage GO:0019915 1 0.020
phagocytosis GO:0006909 3 0.019
positive regulation of secretion GO:0051047 1 0.019
cellular response to molecule of bacterial origin GO:0071219 3 0.019
regulation of signal transduction GO:0009966 225 0.019
regulation of locomotion GO:0040012 55 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.019
regulation of multicellular organismal development GO:2000026 223 0.019
specification of symmetry GO:0009799 204 0.019
regulation of protein transport GO:0051223 3 0.019
intracellular signal transduction GO:0035556 85 0.019
connective tissue development GO:0061448 99 0.019
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.019
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.018
anatomical structure homeostasis GO:0060249 36 0.018
nephron morphogenesis GO:0072028 2 0.018
apoptotic process GO:0006915 116 0.018
positive regulation of rho protein signal transduction GO:0035025 0 0.018
actin filament polymerization GO:0030041 2 0.018
cell part morphogenesis GO:0032990 246 0.018
regulation of nitrogen compound metabolic process GO:0051171 251 0.018
neural precursor cell proliferation GO:0061351 20 0.018
protein modification process GO:0036211 100 0.018
protein import into nucleus GO:0006606 3 0.018
cellular component assembly GO:0022607 170 0.018
cell fate commitment GO:0045165 99 0.017
regulation of metal ion transport GO:0010959 4 0.017
positive regulation of protein complex assembly GO:0031334 2 0.017
phagocytosis engulfment GO:0006911 1 0.017
epidermal cell fate specification GO:0009957 4 0.017
negative regulation of apoptotic process GO:0043066 55 0.017
neuron fate determination GO:0048664 2 0.017
autophagy GO:0006914 4 0.017
regulation of rna biosynthetic process GO:2001141 213 0.017
response to external biotic stimulus GO:0043207 97 0.017
locomotion GO:0040011 313 0.017
proximal distal pattern formation GO:0009954 1 0.017
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.017
spermatid differentiation GO:0048515 2 0.017
organonitrogen compound metabolic process GO:1901564 74 0.017
regulation of organelle assembly GO:1902115 4 0.017
collagen metabolic process GO:0032963 2 0.017
sensory perception of pain GO:0019233 1 0.017
negative regulation of gene expression GO:0010629 65 0.016
protein metabolic process GO:0019538 183 0.016
cell proliferation GO:0008283 80 0.016
cartilage development GO:0051216 96 0.016
positive regulation of gene expression GO:0010628 71 0.016
sensory organ morphogenesis GO:0090596 200 0.016
chemical homeostasis GO:0048878 49 0.016
forebrain cell migration GO:0021885 1 0.016
cellular protein catabolic process GO:0044257 4 0.016
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.016
porphyrin containing compound metabolic process GO:0006778 10 0.016
antimicrobial humoral response GO:0019730 2 0.016
macroautophagy GO:0016236 1 0.016
regulation of production of molecular mediator of immune response GO:0002700 1 0.016
regulation of transcription dna templated GO:0006355 213 0.016
myotube differentiation GO:0014902 45 0.015
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.015
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.015
regulation of wnt signaling pathway GO:0030111 53 0.015
positive regulation of blood circulation GO:1903524 2 0.015
positive regulation of cell cycle GO:0045787 3 0.015
homeostasis of number of cells within a tissue GO:0048873 4 0.015
protein polymerization GO:0051258 4 0.015
regulation of inner ear receptor cell differentiation GO:2000980 1 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.015
enzyme linked receptor protein signaling pathway GO:0007167 106 0.015
neuron projection development GO:0031175 180 0.015
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.015
segmentation GO:0035282 97 0.015
synaptic target recognition GO:0008039 1 0.015
tyrosine phosphorylation of stat3 protein GO:0042503 1 0.015
mesoderm development GO:0007498 88 0.015
regulation of mrna processing GO:0050684 3 0.015
regulation of cell shape GO:0008360 1 0.015
regulation of protein polymerization GO:0032271 2 0.015
lymphocyte proliferation GO:0046651 1 0.015
hormone secretion GO:0046879 2 0.014
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.014
sequestering of metal ion GO:0051238 3 0.014
forebrain development GO:0030900 96 0.014
neurological system process GO:0050877 62 0.014
blood vessel development GO:0001568 246 0.014
multicellular organismal metabolic process GO:0044236 2 0.014
inositol lipid mediated signaling GO:0048017 2 0.014
negative regulation of cell death GO:0060548 60 0.014
embryonic skeletal system morphogenesis GO:0048704 93 0.014
regulation of neurological system process GO:0031644 2 0.014
regionalization GO:0003002 274 0.014
post embryonic organ development GO:0048569 4 0.014
zymogen activation GO:0031638 3 0.014
inner ear receptor cell fate commitment GO:0060120 4 0.014
protein import GO:0017038 3 0.014
b cell differentiation GO:0030183 1 0.014
germ line stem cell maintenance GO:0030718 2 0.014
translational initiation GO:0006413 3 0.014
positive regulation of cellular process GO:0048522 201 0.014
collagen biosynthetic process GO:0032964 2 0.014
regulation of sequestering of calcium ion GO:0051282 4 0.014
positive regulation of map kinase activity GO:0043406 3 0.014
regulation of circadian rhythm GO:0042752 4 0.014
tyrosine phosphorylation of stat protein GO:0007260 1 0.014
phosphatidylinositol mediated signaling GO:0048015 2 0.014
neuron projection morphogenesis GO:0048812 161 0.014
embryonic organ morphogenesis GO:0048562 274 0.014
release of sequestered calcium ion into cytosol GO:0051209 3 0.014
cellular response to organic substance GO:0071310 105 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.013
regulation of cardiac muscle tissue development GO:0055024 1 0.013
regulation of blood vessel size GO:0050880 2 0.013
positive regulation of cellular biosynthetic process GO:0031328 68 0.013
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.013
divalent inorganic cation homeostasis GO:0072507 22 0.013
protein localization to nucleus GO:0034504 3 0.013
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.013
positive regulation of catabolic process GO:0009896 4 0.013
negative regulation of sequestering of calcium ion GO:0051283 4 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
muscle structure development GO:0061061 196 0.013
epithelial cell morphogenesis GO:0003382 2 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
convergent extension GO:0060026 118 0.013
cell substrate junction assembly GO:0007044 2 0.013
cellular response to nutrient levels GO:0031669 2 0.013
cellular response to reactive oxygen species GO:0034614 2 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
auditory receptor cell fate commitment GO:0009912 4 0.013
central nervous system myelination GO:0022010 2 0.013
embryonic digestive tract development GO:0048566 4 0.013
regulation of histone methylation GO:0031060 3 0.013
circadian sleep wake cycle GO:0042745 2 0.013
endosomal transport GO:0016197 2 0.013
dna templated transcription elongation GO:0006354 3 0.012
positive regulation of chromosome organization GO:2001252 1 0.012
regulation of tube size GO:0035150 2 0.012
regulation of response to extracellular stimulus GO:0032104 1 0.012
gas transport GO:0015669 3 0.012
response to uv GO:0009411 3 0.012
negative regulation of biological process GO:0048519 304 0.012
aorta development GO:0035904 4 0.012
calcium ion transport into cytosol GO:0060402 3 0.012
positive regulation of rna biosynthetic process GO:1902680 57 0.012
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.012
regulation of synapse organization GO:0050807 3 0.012
nucleocytoplasmic transport GO:0006913 4 0.012
positive regulation of programmed cell death GO:0043068 29 0.012
cardiac atrium morphogenesis GO:0003209 2 0.012
catechol containing compound biosynthetic process GO:0009713 2 0.012
multicellular organismal macromolecule metabolic process GO:0044259 2 0.012
regulation of programmed cell death GO:0043067 101 0.012
regulation of mechanoreceptor differentiation GO:0045631 1 0.012
definitive hemopoiesis GO:0060216 18 0.012
regulation of protein metabolic process GO:0051246 56 0.012
mesenchyme development GO:0060485 127 0.012
regulation of transporter activity GO:0032409 2 0.012
regulation of muscle contraction GO:0006937 3 0.012
regulation of autophagy GO:0010506 3 0.012
forebrain regionalization GO:0021871 4 0.012
auditory receptor cell fate determination GO:0042668 2 0.012
rhombomere development GO:0021546 19 0.012
tube morphogenesis GO:0035239 349 0.012
single organism biosynthetic process GO:0044711 71 0.012
oligopeptide transport GO:0006857 1 0.012
positive regulation of translation GO:0045727 1 0.012
negative regulation of signaling GO:0023057 96 0.012
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.011
positive regulation of transcription dna templated GO:0045893 57 0.011
regulation of protein complex assembly GO:0043254 3 0.011
centrosome duplication GO:0051298 1 0.011
dorsal ventral pattern formation GO:0009953 125 0.011
cytokinesis GO:0000910 3 0.011
energy reserve metabolic process GO:0006112 2 0.011
peripheral nervous system neuron development GO:0048935 22 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
response to stress GO:0006950 263 0.011
amine metabolic process GO:0009308 2 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
mononuclear cell proliferation GO:0032943 1 0.011
reactive oxygen species metabolic process GO:0072593 6 0.011
neuroblast proliferation GO:0007405 2 0.011
mesoderm morphogenesis GO:0048332 51 0.011
response to biotic stimulus GO:0009607 97 0.011
centrosome organization GO:0051297 1 0.011
cation homeostasis GO:0055080 33 0.011
primitive erythrocyte differentiation GO:0060319 5 0.011
regulation of response to external stimulus GO:0032101 31 0.011
establishment of protein localization to organelle GO:0072594 4 0.011
cell adhesion GO:0007155 40 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
response to wounding GO:0009611 116 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
membrane invagination GO:0010324 1 0.011
mitotic dna integrity checkpoint GO:0044774 4 0.011
organic acid metabolic process GO:0006082 31 0.011
bmp signaling pathway GO:0030509 52 0.011
b cell activation GO:0042113 2 0.011
developmental growth GO:0048589 166 0.011
hematopoietic stem cell differentiation GO:0060218 20 0.011
toll like receptor signaling pathway GO:0002224 4 0.011
regulation of circadian sleep wake cycle GO:0042749 1 0.011
protein targeting to nucleus GO:0044744 3 0.011
cellular component disassembly GO:0022411 1 0.011
regulation of neuron migration GO:2001222 2 0.011
synaptic growth at neuromuscular junction GO:0051124 2 0.011
negative regulation of secretion by cell GO:1903531 2 0.011
cofactor biosynthetic process GO:0051188 10 0.011
cytosolic calcium ion transport GO:0060401 3 0.010
gastrulation GO:0007369 208 0.010
taxis GO:0042330 109 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.010
hematopoietic progenitor cell differentiation GO:0002244 23 0.010
regulation of endothelial cell differentiation GO:0045601 3 0.010
centrosome cycle GO:0007098 1 0.010
positive regulation of multi organism process GO:0043902 3 0.010
regulation of response to stress GO:0080134 36 0.010
cellular response to endogenous stimulus GO:0071495 68 0.010
pharyngeal muscle development GO:0043282 4 0.010
skeletal system development GO:0001501 181 0.010
cardiac chamber formation GO:0003207 4 0.010
gland development GO:0048732 143 0.010
regulation of dna templated transcription elongation GO:0032784 3 0.010
ovarian follicle development GO:0001541 2 0.010
positive regulation of dna templated transcription elongation GO:0032786 1 0.010
pericardium development GO:0060039 1 0.010
chemosensory behavior GO:0007635 1 0.010
regulation of reactive oxygen species metabolic process GO:2000377 2 0.010
mitotic g2 dna damage checkpoint GO:0007095 3 0.010
negative regulation of muscle tissue development GO:1901862 2 0.010
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.010
rhombomere 5 development GO:0021571 4 0.010
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.010
oxoacid metabolic process GO:0043436 31 0.010

smchd1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.015
disease of anatomical entity DOID:7 0 0.012
immune system disease DOID:2914 0 0.010
hematopoietic system disease DOID:74 0 0.010