Danio rerio

0 known processes

casc3

cancer susceptibility candidate 3

(Aliases: MGC136501,mln51)

casc3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of biological process GO:0048518 253 0.434
aging GO:0007568 2 0.297
regulation of metabolic process GO:0019222 359 0.234
larval development GO:0002164 2 0.200
nitrogen compound metabolic process GO:0006807 319 0.158
regulation of macromolecule metabolic process GO:0060255 317 0.155
positive regulation of cellular process GO:0048522 201 0.154
response to stress GO:0006950 263 0.146
immune system process GO:0002376 241 0.117
cell surface receptor signaling pathway GO:0007166 325 0.113
embryonic organ development GO:0048568 381 0.107
cellular nitrogen compound metabolic process GO:0034641 290 0.106
regulation of signal transduction GO:0009966 225 0.098
regulation of primary metabolic process GO:0080090 311 0.095
response to chemical GO:0042221 320 0.091
regulation of cellular amine metabolic process GO:0033238 0 0.090
organic cyclic compound biosynthetic process GO:1901362 223 0.089
regulation of signaling GO:0023051 235 0.087
cellular response to chemical stimulus GO:0070887 157 0.084
regulation of cell communication GO:0010646 232 0.082
heterocycle metabolic process GO:0046483 290 0.079
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.078
g2 dna damage checkpoint GO:0031572 3 0.076
negative regulation of tor signaling GO:0032007 2 0.075
organelle organization GO:0006996 227 0.075
neuron development GO:0048666 262 0.073
regulation of cell shape GO:0008360 1 0.071
cellular component morphogenesis GO:0032989 336 0.071
response to other organism GO:0051707 97 0.070
regulation of cellular metabolic process GO:0031323 320 0.068
regulation of response to stimulus GO:0048583 269 0.067
embryo development ending in birth or egg hatching GO:0009792 271 0.067
establishment of localization GO:0051234 244 0.066
localization of cell GO:0051674 244 0.066
protein localization to nucleus GO:0034504 3 0.066
nucleobase containing compound metabolic process GO:0006139 274 0.064
transport GO:0006810 220 0.064
positive regulation of cellular component biogenesis GO:0044089 3 0.063
generation of neurons GO:0048699 385 0.063
response to external stimulus GO:0009605 264 0.062
response to external biotic stimulus GO:0043207 97 0.061
response to biotic stimulus GO:0009607 97 0.058
amine metabolic process GO:0009308 2 0.057
positive regulation of chromatin modification GO:1903310 1 0.057
protein targeting to nucleus GO:0044744 3 0.056
multi organism process GO:0051704 134 0.056
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.055
regulation of cellular component organization GO:0051128 86 0.055
extrinsic apoptotic signaling pathway GO:0097191 3 0.055
cell migration GO:0016477 237 0.054
regulation of mrna processing GO:0050684 3 0.054
response to drug GO:0042493 3 0.053
cellular component movement GO:0006928 335 0.053
regulation of biological quality GO:0065008 263 0.052
regulation of circadian rhythm GO:0042752 4 0.051
regulation of developmental process GO:0050793 247 0.050
cellular ketone metabolic process GO:0042180 11 0.050
protein import GO:0017038 3 0.049
internal protein amino acid acetylation GO:0006475 2 0.049
nucleic acid metabolic process GO:0090304 244 0.047
gene expression GO:0010467 252 0.045
morphogenesis of an epithelium GO:0002009 333 0.044
mitotic dna integrity checkpoint GO:0044774 4 0.044
organic cyclic compound metabolic process GO:1901360 301 0.044
nuclear import GO:0051170 3 0.044
embryonic cranial skeleton morphogenesis GO:0048701 90 0.043
organonitrogen compound metabolic process GO:1901564 74 0.043
myeloid cell homeostasis GO:0002262 56 0.043
protein import into nucleus GO:0006606 3 0.042
hemopoiesis GO:0030097 183 0.042
cellular macromolecule metabolic process GO:0044260 391 0.042
homeostasis of number of cells GO:0048872 62 0.042
regulation of meiotic cell cycle GO:0051445 1 0.042
regulation of rna metabolic process GO:0051252 224 0.042
homeostatic process GO:0042592 142 0.042
regulation of intracellular signal transduction GO:1902531 57 0.041
cell death GO:0008219 121 0.041
regulation of cellular amino acid metabolic process GO:0006521 0 0.041
cellular aromatic compound metabolic process GO:0006725 295 0.040
regulation of multicellular organism growth GO:0040014 4 0.039
peptidyl serine modification GO:0018209 2 0.039
growth GO:0040007 174 0.039
nucleocytoplasmic transport GO:0006913 4 0.038
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.038
regulation of nitrogen compound metabolic process GO:0051171 251 0.038
mitotic g2 m transition checkpoint GO:0044818 3 0.038
cellular amine metabolic process GO:0044106 2 0.037
female gonad development GO:0008585 4 0.036
neuron differentiation GO:0030182 353 0.036
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.036
positive regulation of apoptotic signaling pathway GO:2001235 1 0.036
regulation of anatomical structure morphogenesis GO:0022603 130 0.035
developmental maturation GO:0021700 34 0.034
enzyme linked receptor protein signaling pathway GO:0007167 106 0.034
tube morphogenesis GO:0035239 349 0.034
regulation of biosynthetic process GO:0009889 250 0.034
signal transduction GO:0007165 455 0.034
single organism metabolic process GO:0044710 217 0.032
phosphate containing compound metabolic process GO:0006796 108 0.032
single organism nuclear import GO:1902593 3 0.032
cytoskeleton organization GO:0007010 96 0.031
posttranscriptional gene silencing GO:0016441 3 0.031
negative regulation of signal transduction GO:0009968 94 0.031
regulation of reproductive process GO:2000241 4 0.030
mitotic g2 dna damage checkpoint GO:0007095 3 0.030
regulation of gene expression GO:0010468 265 0.030
mitotic cell cycle GO:0000278 64 0.030
cellular amino acid metabolic process GO:0006520 7 0.030
negative regulation of gene expression GO:0010629 65 0.030
alternative mrna splicing via spliceosome GO:0000380 1 0.029
response to organic substance GO:0010033 153 0.029
negative regulation of response to stimulus GO:0048585 104 0.029
peptidyl lysine acetylation GO:0018394 2 0.029
defense response GO:0006952 47 0.029
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.029
regulation of establishment of protein localization GO:0070201 4 0.028
erythrocyte differentiation GO:0030218 54 0.028
rna metabolic process GO:0016070 219 0.028
establishment of protein localization to organelle GO:0072594 4 0.028
single organism organelle organization GO:1902589 199 0.027
positive regulation of transport GO:0051050 2 0.027
regulation of rna biosynthetic process GO:2001141 213 0.027
digestive tract development GO:0048565 265 0.027
cell morphogenesis GO:0000902 289 0.027
intracellular signal transduction GO:0035556 85 0.026
positive regulation of cellular amine metabolic process GO:0033240 0 0.025
peptidyl serine phosphorylation GO:0018105 1 0.025
regulation of intracellular protein transport GO:0033157 3 0.025
regulation of bone mineralization GO:0030500 2 0.025
posttranscriptional gene silencing by rna GO:0035194 3 0.025
negative regulation of signaling GO:0023057 96 0.025
regulation of cell death GO:0010941 103 0.025
regulation of synapse organization GO:0050807 3 0.025
multicellular organism growth GO:0035264 4 0.024
negative regulation of biological process GO:0048519 304 0.024
meiotic nuclear division GO:0007126 4 0.024
compound eye development GO:0048749 2 0.024
myeloid cell differentiation GO:0030099 86 0.024
small molecule metabolic process GO:0044281 77 0.024
stem cell maintenance GO:0019827 4 0.024
cellular response to organic substance GO:0071310 105 0.024
cell cycle GO:0007049 93 0.024
mitotic dna damage checkpoint GO:0044773 4 0.024
positive regulation of catabolic process GO:0009896 4 0.023
reproduction GO:0000003 40 0.023
cytokinesis GO:0000910 3 0.023
maintenance of location GO:0051235 4 0.023
negative regulation of cell death GO:0060548 60 0.023
positive regulation of response to stimulus GO:0048584 80 0.023
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.023
epithelial tube morphogenesis GO:0060562 148 0.022
regulation of apoptotic process GO:0042981 98 0.022
cell cycle process GO:0022402 53 0.022
neuron remodeling GO:0016322 1 0.022
regulation of dna replication GO:0006275 3 0.022
carboxylic acid metabolic process GO:0019752 22 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.022
regulation of mitochondrion organization GO:0010821 1 0.021
regulation of macromolecule biosynthetic process GO:0010556 225 0.021
protein metabolic process GO:0019538 183 0.021
pyruvate metabolic process GO:0006090 1 0.021
synaptic growth at neuromuscular junction GO:0051124 2 0.021
regulation of multicellular organismal process GO:0051239 277 0.021
single organism localization GO:1902578 225 0.021
regulation of sequestering of calcium ion GO:0051282 4 0.021
response to wounding GO:0009611 116 0.021
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.021
intracellular estrogen receptor signaling pathway GO:0030520 3 0.021
response to monosaccharide GO:0034284 3 0.020
primary neural tube formation GO:0014020 1 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.020
system process GO:0003008 185 0.020
mitotic cell cycle process GO:1903047 48 0.020
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.020
negative regulation of metabolic process GO:0009892 86 0.020
protein acetylation GO:0006473 2 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
activation of mapkkk activity GO:0000185 1 0.020
germ cell development GO:0007281 22 0.019
regulation of cell size GO:0008361 29 0.019
sensory organ development GO:0007423 393 0.019
regulation of protein transport GO:0051223 3 0.019
regulation of protein localization to nucleus GO:1900180 2 0.019
multicellular organismal reproductive process GO:0048609 35 0.019
negative regulation of programmed cell death GO:0043069 58 0.019
centrosome cycle GO:0007098 1 0.019
gene silencing by rna GO:0031047 4 0.019
regulation of cellular response to oxidative stress GO:1900407 2 0.019
programmed cell death GO:0012501 119 0.019
hormone transport GO:0009914 2 0.019
erythrocyte homeostasis GO:0034101 55 0.019
regulation of nucleic acid templated transcription GO:1903506 213 0.019
hematopoietic or lymphoid organ development GO:0048534 191 0.019
regulation of multicellular organismal development GO:2000026 223 0.019
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.019
dna templated transcription elongation GO:0006354 3 0.019
positive regulation of cell cycle GO:0045787 3 0.019
protein secretion GO:0009306 1 0.018
response to alkaloid GO:0043279 2 0.018
regulation of synapse assembly GO:0051963 3 0.018
cellular response to dna damage stimulus GO:0006974 24 0.018
glucose homeostasis GO:0042593 1 0.018
pole plasm assembly GO:0007315 4 0.018
response to nutrient GO:0007584 3 0.018
cellular localization GO:0051641 97 0.018
positive regulation of signaling GO:0023056 56 0.018
negative regulation of dna replication GO:0008156 2 0.018
organelle fission GO:0048285 23 0.017
negative regulation of cellular catabolic process GO:0031330 3 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.017
positive regulation of cell communication GO:0010647 56 0.017
positive regulation of notch signaling pathway GO:0045747 3 0.017
locomotion GO:0040011 313 0.017
regulation of cell differentiation GO:0045595 142 0.017
positive regulation of camp biosynthetic process GO:0030819 2 0.017
modification dependent protein catabolic process GO:0019941 3 0.017
heart development GO:0007507 313 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.017
positive regulation of epithelial cell proliferation GO:0050679 1 0.017
specification of symmetry GO:0009799 204 0.017
regulation of protein import into nucleus GO:0042306 2 0.017
negative regulation of cellular metabolic process GO:0031324 77 0.017
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.017
stem cell proliferation GO:0072089 4 0.016
regulation of cytoplasmic transport GO:1903649 4 0.016
regionalization GO:0003002 274 0.016
cell motility GO:0048870 244 0.016
aromatic compound biosynthetic process GO:0019438 217 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
regulation of cell cycle GO:0051726 52 0.016
embryonic heart tube morphogenesis GO:0003143 108 0.016
negative regulation of apoptotic process GO:0043066 55 0.016
adult behavior GO:0030534 2 0.016
development of primary female sexual characteristics GO:0046545 4 0.016
rna biosynthetic process GO:0032774 181 0.016
regulation of autophagy GO:0010506 3 0.016
transmembrane transport GO:0055085 120 0.016
embryonic hemopoiesis GO:0035162 53 0.016
ion homeostasis GO:0050801 41 0.016
blood vessel development GO:0001568 246 0.015
regulation of cell development GO:0060284 100 0.015
negative regulation of catabolic process GO:0009895 3 0.015
chordate embryonic development GO:0043009 271 0.015
single organism transport GO:0044765 206 0.015
positive regulation of programmed cell death GO:0043068 29 0.015
negative regulation of cell communication GO:0010648 96 0.015
negative regulation of developmental process GO:0051093 65 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
determination of left right symmetry GO:0007368 179 0.015
cellular response to stress GO:0033554 62 0.015
negative regulation of cellular process GO:0048523 283 0.015
organic acid metabolic process GO:0006082 31 0.015
eye development GO:0001654 277 0.015
positive regulation of epithelial cell migration GO:0010634 2 0.015
autophagy GO:0006914 4 0.014
female sex differentiation GO:0046660 4 0.014
biological adhesion GO:0022610 40 0.014
guanosine containing compound metabolic process GO:1901068 4 0.014
tissue remodeling GO:0048771 4 0.014
regulation of cytokine production GO:0001817 3 0.014
regulation of programmed cell death GO:0043067 101 0.014
oxoacid metabolic process GO:0043436 31 0.014
apoptotic process GO:0006915 116 0.014
regulation of translational initiation GO:0006446 1 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.014
positive regulation of chromosome organization GO:2001252 1 0.014
odontogenesis of dentin containing tooth GO:0042475 1 0.014
brain development GO:0007420 293 0.014
positive regulation of camp metabolic process GO:0030816 2 0.014
cell projection organization GO:0030030 284 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.014
nuclear transport GO:0051169 4 0.014
post embryonic organ development GO:0048569 4 0.014
embryonic organ morphogenesis GO:0048562 274 0.014
mesenchyme development GO:0060485 127 0.014
protein acylation GO:0043543 3 0.014
immune system development GO:0002520 191 0.014
amino acid transport GO:0006865 2 0.014
negative regulation of multicellular organismal process GO:0051241 69 0.014
regulation of biomineral tissue development GO:0070167 2 0.014
histone h3 k4 methylation GO:0051568 2 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
ovulation cycle GO:0042698 2 0.013
multicellular organismal metabolic process GO:0044236 2 0.013
entrainment of circadian clock by photoperiod GO:0043153 1 0.013
cell cycle arrest GO:0007050 1 0.013
positive regulation of myeloid cell differentiation GO:0045639 2 0.013
cellular response to hypoxia GO:0071456 1 0.013
digestive system development GO:0055123 289 0.013
oocyte anterior posterior axis specification GO:0007314 4 0.013
regulation of response to oxidative stress GO:1902882 2 0.013
angiogenesis GO:0001525 158 0.013
locomotor rhythm GO:0045475 3 0.013
positive regulation of secretion by cell GO:1903532 1 0.013
negative regulation of reproductive process GO:2000242 3 0.013
hormone secretion GO:0046879 2 0.013
response to hexose GO:0009746 3 0.013
nuclear division GO:0000280 23 0.013
positive regulation of cellular metabolic process GO:0031325 94 0.013
defense response to other organism GO:0098542 33 0.013
positive regulation of signal transduction GO:0009967 56 0.013
cellular nitrogen compound biosynthetic process GO:0044271 218 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.013
meiotic cell cycle process GO:1903046 3 0.013
tube closure GO:0060606 1 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
leukocyte homeostasis GO:0001776 2 0.012
cortical cytoskeleton organization GO:0030865 1 0.012
response to corticosteroid GO:0031960 1 0.012
negative regulation of synapse assembly GO:0051964 2 0.012
apoptotic signaling pathway GO:0097190 23 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
chemical homeostasis GO:0048878 49 0.012
transcription dna templated GO:0006351 181 0.012
erythrocyte maturation GO:0043249 8 0.012
digestive tract morphogenesis GO:0048546 231 0.012
lateral line system development GO:0048925 76 0.012
gene silencing GO:0016458 4 0.012
cellular macromolecule biosynthetic process GO:0034645 224 0.012
response to abiotic stimulus GO:0009628 122 0.012
microtubule based process GO:0007017 60 0.012
determination of bilateral symmetry GO:0009855 204 0.012
head development GO:0060322 303 0.012
cellular response to radiation GO:0071478 4 0.012
metal ion transport GO:0030001 58 0.012
developmental process involved in reproduction GO:0003006 27 0.012
positive regulation of synapse assembly GO:0051965 1 0.012
intestinal epithelial cell differentiation GO:0060575 3 0.012
positive regulation of cell death GO:0010942 29 0.012
heterocycle biosynthetic process GO:0018130 215 0.012
embryonic skeletal system morphogenesis GO:0048704 93 0.011
regulation of cell activation GO:0050865 1 0.011
sensory system development GO:0048880 76 0.011
positive regulation of metabolic process GO:0009893 108 0.011
regulation of response to nutrient levels GO:0032107 1 0.011
mitochondrion organization GO:0007005 4 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
lateral line development GO:0048882 66 0.011
carbohydrate homeostasis GO:0033500 1 0.011
response to hydrogen peroxide GO:0042542 3 0.011
regulation of protein metabolic process GO:0051246 56 0.011
developmental growth GO:0048589 166 0.011
cytokinetic process GO:0032506 2 0.011
cellular response to light stimulus GO:0071482 4 0.011
skeletal system development GO:0001501 181 0.011
cellular response to extracellular stimulus GO:0031668 2 0.011
regulation of cell proliferation GO:0042127 37 0.011
cell substrate adhesion GO:0031589 4 0.011
cellular transition metal ion homeostasis GO:0046916 3 0.011
release of sequestered calcium ion into cytosol GO:0051209 3 0.011
regulation of carbohydrate metabolic process GO:0006109 4 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.011
regulation of nervous system development GO:0051960 90 0.011
response to bacterium GO:0009617 58 0.011
cellular response to external stimulus GO:0071496 2 0.011
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.011
periodic partitioning GO:0007365 1 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.011
protein localization GO:0008104 40 0.011
cellular component biogenesis GO:0044085 178 0.011
response to oxygen levels GO:0070482 25 0.011
mesoderm development GO:0007498 88 0.010
cellular component assembly GO:0022607 170 0.010
cellular carbohydrate metabolic process GO:0044262 4 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.010
central nervous system development GO:0007417 387 0.010
death GO:0016265 121 0.010
response to carbohydrate GO:0009743 3 0.010
erythrocyte development GO:0048821 24 0.010
defense response to virus GO:0051607 10 0.010
positive regulation of apoptotic process GO:0043065 29 0.010
vasculature development GO:0001944 278 0.010
heart looping GO:0001947 94 0.010
regulation of tor signaling GO:0032006 7 0.010
gastrulation GO:0007369 208 0.010
negative regulation of multi organism process GO:0043901 3 0.010
cellular response to molecule of bacterial origin GO:0071219 3 0.010
cellular modified amino acid metabolic process GO:0006575 3 0.010
cellular protein catabolic process GO:0044257 4 0.010
regulation of gtpase activity GO:0043087 2 0.010
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.010

casc3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.018
disease of anatomical entity DOID:7 0 0.016
musculoskeletal system disease DOID:17 0 0.011
disease of metabolism DOID:0014667 0 0.010