Danio rerio

0 known processes

gc2

guanylyl cyclase 2

(Aliases: RETGC-2)

gc2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron differentiation GO:0030182 353 0.669
Zebrafish
heterocycle metabolic process GO:0046483 290 0.417
Zebrafish Rat
nucleotide biosynthetic process GO:0009165 21 0.395
Zebrafish Rat
purine ribonucleotide biosynthetic process GO:0009152 20 0.357
Zebrafish Rat
purine containing compound biosynthetic process GO:0072522 20 0.328
Zebrafish Rat
nucleobase containing compound metabolic process GO:0006139 274 0.306
Zebrafish Rat
cellular macromolecule metabolic process GO:0044260 391 0.276
eye development GO:0001654 277 0.266
nitrogen compound metabolic process GO:0006807 319 0.258
Zebrafish Rat
cellular nitrogen compound biosynthetic process GO:0044271 218 0.244
Zebrafish Rat
sensory organ development GO:0007423 393 0.241
g protein coupled receptor signaling pathway GO:0007186 74 0.238
organic cyclic compound metabolic process GO:1901360 301 0.217
Zebrafish Rat
biosynthetic process GO:0009058 294 0.199
Zebrafish Rat
response to light stimulus GO:0009416 46 0.195
signal transduction GO:0007165 455 0.193
cellular aromatic compound metabolic process GO:0006725 295 0.188
Zebrafish Rat
nucleoside phosphate biosynthetic process GO:1901293 21 0.187
Zebrafish Rat
organic cyclic compound biosynthetic process GO:1901362 223 0.183
Zebrafish Rat
gene expression GO:0010467 252 0.179
light absorption GO:0016037 2 0.168
response to abiotic stimulus GO:0009628 122 0.164
maintenance of location GO:0051235 4 0.164
muscle cell differentiation GO:0042692 139 0.155
organelle organization GO:0006996 227 0.149
Zebrafish
nucleic acid metabolic process GO:0090304 244 0.141
neurological system process GO:0050877 62 0.140
Zebrafish
regulation of transcription dna templated GO:0006355 213 0.134
phototransduction GO:0007602 2 0.133
cellular response to radiation GO:0071478 4 0.133
response to chemical GO:0042221 320 0.131
locomotion GO:0040011 313 0.128
photoreceptor cell differentiation GO:0046530 55 0.127
Zebrafish
cellular response to light stimulus GO:0071482 4 0.125
generation of neurons GO:0048699 385 0.124
Zebrafish
single organism organelle organization GO:1902589 199 0.119
Zebrafish
organic substance biosynthetic process GO:1901576 289 0.118
Zebrafish Rat
negative regulation of cellular process GO:0048523 283 0.118
regulation of metabolic process GO:0019222 359 0.114
rhodopsin mediated signaling pathway GO:0016056 1 0.114
neural retina development GO:0003407 49 0.111
regulation of gene expression GO:0010468 265 0.110
sequestering of calcium ion GO:0051208 3 0.108
regulation of macromolecule metabolic process GO:0060255 317 0.106
aging GO:0007568 2 0.105
neuron development GO:0048666 262 0.100
Zebrafish
ribonucleotide biosynthetic process GO:0009260 20 0.097
Zebrafish Rat
regulation of cellular metabolic process GO:0031323 320 0.096
purine nucleotide biosynthetic process GO:0006164 20 0.092
Zebrafish Rat
aromatic compound biosynthetic process GO:0019438 217 0.092
Zebrafish Rat
nucleobase containing compound biosynthetic process GO:0034654 205 0.090
Zebrafish Rat
regulation of primary metabolic process GO:0080090 311 0.090
cellular component morphogenesis GO:0032989 336 0.089
embryonic organ development GO:0048568 381 0.088
single organism biosynthetic process GO:0044711 71 0.088
Zebrafish Rat
homeostatic process GO:0042592 142 0.087
phototransduction visible light GO:0007603 2 0.087
cellular macromolecule biosynthetic process GO:0034645 224 0.087
cellular component movement GO:0006928 335 0.086
system process GO:0003008 185 0.086
Zebrafish
cyclic nucleotide biosynthetic process GO:0009190 18 0.086
Zebrafish Rat
regulation of nitrogen compound metabolic process GO:0051171 251 0.084
regulation of biosynthetic process GO:0009889 250 0.084
retina development in camera type eye GO:0060041 146 0.083
cellular biosynthetic process GO:0044249 286 0.080
Zebrafish Rat
epithelial tube morphogenesis GO:0060562 148 0.079
organonitrogen compound metabolic process GO:1901564 74 0.078
Zebrafish Rat
heterocycle biosynthetic process GO:0018130 215 0.075
Zebrafish Rat
photoreceptor cell outer segment organization GO:0035845 9 0.075
Zebrafish
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.072
response to stress GO:0006950 263 0.072
cell projection organization GO:0030030 284 0.069
Zebrafish
cyclic nucleotide metabolic process GO:0009187 18 0.066
Zebrafish Rat
regulation of behavior GO:0050795 24 0.066
head development GO:0060322 303 0.066
cell morphogenesis involved in differentiation GO:0000904 195 0.066
transcription from rna polymerase ii promoter GO:0006366 80 0.063
camera type eye development GO:0043010 222 0.063
brain development GO:0007420 293 0.061
somitogenesis GO:0001756 87 0.060
regulation of cellular biosynthetic process GO:0031326 245 0.060
eye morphogenesis GO:0048592 144 0.059
cellular nitrogen compound metabolic process GO:0034641 290 0.058
Zebrafish Rat
heart development GO:0007507 313 0.058
chordate embryonic development GO:0043009 271 0.057
single organism metabolic process GO:0044710 217 0.056
Zebrafish Rat
embryonic skeletal system morphogenesis GO:0048704 93 0.055
tube morphogenesis GO:0035239 349 0.055
embryonic skeletal system development GO:0048706 97 0.054
behavior GO:0007610 74 0.053
cyclic purine nucleotide metabolic process GO:0052652 18 0.053
Zebrafish Rat
negative regulation of sequestering of calcium ion GO:0051283 4 0.052
larval development GO:0002164 2 0.051
regulation of response to stimulus GO:0048583 269 0.051
anterior posterior pattern specification GO:0009952 152 0.050
regulation of sequestering of calcium ion GO:0051282 4 0.050
regulation of nucleic acid templated transcription GO:1903506 213 0.049
cellular component assembly GO:0022607 170 0.049
cellular component biogenesis GO:0044085 178 0.049
embryo development ending in birth or egg hatching GO:0009792 271 0.049
skeletal system development GO:0001501 181 0.049
lipid storage GO:0019915 1 0.049
growth GO:0040007 174 0.047
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.046
cell surface receptor signaling pathway GO:0007166 325 0.046
gastrulation GO:0007369 208 0.045
regulation of rna biosynthetic process GO:2001141 213 0.045
cellular ketone metabolic process GO:0042180 11 0.045
regionalization GO:0003002 274 0.044
regulation of rna metabolic process GO:0051252 224 0.044
fin morphogenesis GO:0033334 53 0.043
organelle assembly GO:0070925 110 0.041
chemosensory behavior GO:0007635 1 0.041
eye photoreceptor cell differentiation GO:0001754 45 0.040
immune system process GO:0002376 241 0.040
sequestering of metal ion GO:0051238 3 0.040
neuron projection development GO:0031175 180 0.040
developmental growth GO:0048589 166 0.039
regulation of multicellular organismal process GO:0051239 277 0.039
transmembrane transport GO:0055085 120 0.038
transcription dna templated GO:0006351 181 0.038
camera type eye morphogenesis GO:0048593 108 0.038
adult behavior GO:0030534 2 0.038
cgmp metabolic process GO:0046068 7 0.038
Zebrafish Rat
organonitrogen compound biosynthetic process GO:1901566 47 0.037
Zebrafish Rat
macromolecule biosynthetic process GO:0009059 227 0.036
morphogenesis of an epithelium GO:0002009 333 0.036
localization of cell GO:0051674 244 0.035
sensory organ morphogenesis GO:0090596 200 0.035
cell migration GO:0016477 237 0.035
response to external stimulus GO:0009605 264 0.035
regulation of developmental process GO:0050793 247 0.034
positive regulation of cellular component biogenesis GO:0044089 3 0.034
carbohydrate derivative biosynthetic process GO:1901137 43 0.034
Zebrafish Rat
regulation of system process GO:0044057 40 0.033
purine ribonucleotide metabolic process GO:0009150 27 0.032
Zebrafish Rat
translational initiation GO:0006413 3 0.032
cartilage development GO:0051216 96 0.032
cellular response to extracellular stimulus GO:0031668 2 0.031
regulation of cell communication GO:0010646 232 0.031
positive regulation of cellular process GO:0048522 201 0.031
positive regulation of cell communication GO:0010647 56 0.031
absorption of visible light GO:0016038 2 0.030
positive regulation of metabolic process GO:0009893 108 0.030
chemical homeostasis GO:0048878 49 0.030
negative regulation of biological process GO:0048519 304 0.029
negative regulation of kinase activity GO:0033673 4 0.029
central nervous system development GO:0007417 387 0.029
response to radiation GO:0009314 51 0.029
regulation of macromolecule biosynthetic process GO:0010556 225 0.028
detection of stimulus GO:0051606 29 0.028
regulation of biological quality GO:0065008 263 0.028
positive regulation of cellular biosynthetic process GO:0031328 68 0.027
multicellular organism growth GO:0035264 4 0.027
circulatory system process GO:0003013 87 0.027
axon development GO:0061564 166 0.027
striated muscle cell differentiation GO:0051146 129 0.027
positive regulation of cyclic nucleotide metabolic process GO:0030801 8 0.027
sleep GO:0030431 1 0.026
cell morphogenesis GO:0000902 289 0.026
microtubule based process GO:0007017 60 0.026
heart morphogenesis GO:0003007 156 0.026
cellular amine metabolic process GO:0044106 2 0.026
chemotaxis GO:0006935 104 0.026
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.026
positive regulation of purine nucleotide biosynthetic process GO:1900373 8 0.026
regulation of wnt signaling pathway calcium modulating pathway GO:0008591 3 0.026
skeletal system morphogenesis GO:0048705 102 0.025
detection of light stimulus GO:0009583 12 0.025
regulation of multicellular organismal development GO:2000026 223 0.025
signal transduction in absence of ligand GO:0038034 1 0.025
cellular response to nutrient levels GO:0031669 2 0.024
macromolecule modification GO:0043412 111 0.024
rna metabolic process GO:0016070 219 0.024
stem cell proliferation GO:0072089 4 0.024
digestive tract development GO:0048565 265 0.024
taxis GO:0042330 109 0.024
regulation of purine nucleotide biosynthetic process GO:1900371 15 0.023
cellular component assembly involved in morphogenesis GO:0010927 107 0.023
monovalent inorganic cation transport GO:0015672 42 0.023
determination of bilateral symmetry GO:0009855 204 0.023
neuron projection guidance GO:0097485 86 0.023
locomotory behavior GO:0007626 34 0.023
response to drug GO:0042493 3 0.022
regulation of establishment of protein localization GO:0070201 4 0.022
ion transmembrane transport GO:0034220 91 0.022
sensory perception GO:0007600 39 0.022
Zebrafish
single organism behavior GO:0044708 24 0.022
ribose phosphate biosynthetic process GO:0046390 20 0.022
Zebrafish Rat
regulation of multicellular organism growth GO:0040014 4 0.022
neuron projection morphogenesis GO:0048812 161 0.022
amine metabolic process GO:0009308 2 0.022
regulation of cell death GO:0010941 103 0.021
sensory perception of chemical stimulus GO:0007606 3 0.021
segmentation GO:0035282 97 0.021
organophosphate biosynthetic process GO:0090407 23 0.021
Zebrafish Rat
post embryonic organ development GO:0048569 4 0.021
metal ion homeostasis GO:0055065 26 0.020
positive regulation of transcription dna templated GO:0045893 57 0.020
digestive tract morphogenesis GO:0048546 231 0.020
circadian sleep wake cycle GO:0042745 2 0.020
regulation of localization GO:0032879 104 0.020
protein metabolic process GO:0019538 183 0.020
organic acid metabolic process GO:0006082 31 0.020
photoreceptor cell development GO:0042461 40 0.020
Zebrafish
regulation of cell activation GO:0050865 1 0.020
death GO:0016265 121 0.020
negative regulation of metabolic process GO:0009892 86 0.019
dorsal ventral pattern formation GO:0009953 125 0.019
negative regulation of multicellular organismal process GO:0051241 69 0.019
appendage development GO:0048736 80 0.019
regulation of membrane potential GO:0042391 23 0.019
digestive system development GO:0055123 289 0.019
regulation of programmed cell death GO:0043067 101 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.019
regulation of anatomical structure morphogenesis GO:0022603 130 0.019
regulation of growth rate GO:0040009 1 0.019
cellular lipid catabolic process GO:0044242 3 0.019
energy reserve metabolic process GO:0006112 2 0.019
regulation of phosphorus metabolic process GO:0051174 43 0.018
camera type eye photoreceptor cell differentiation GO:0060219 19 0.018
mesoderm development GO:0007498 88 0.018
connective tissue development GO:0061448 99 0.018
membrane repolarization GO:0086009 2 0.018
nucleic acid templated transcription GO:0097659 181 0.018
somite development GO:0061053 96 0.018
ear development GO:0043583 127 0.018
cell death GO:0008219 121 0.018
embryonic heart tube development GO:0035050 133 0.018
cellular response to external stimulus GO:0071496 2 0.018
gland development GO:0048732 143 0.018
regulation of apoptotic process GO:0042981 98 0.018
positive regulation of transport GO:0051050 2 0.018
regulation of cyclic nucleotide metabolic process GO:0030799 15 0.017
regulation of phosphate metabolic process GO:0019220 43 0.017
regulation of dendrite morphogenesis GO:0048814 3 0.017
meiotic nuclear division GO:0007126 4 0.017
heart looping GO:0001947 94 0.017
regulation of cellular amine metabolic process GO:0033238 0 0.017
cellular response to chemical stimulus GO:0070887 157 0.017
rna biosynthetic process GO:0032774 181 0.017
heart process GO:0003015 71 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.017
determination of heart left right asymmetry GO:0061371 117 0.017
regulation of molecular function GO:0065009 70 0.017
phosphate containing compound metabolic process GO:0006796 108 0.017
Zebrafish Rat
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.017
mononuclear cell proliferation GO:0032943 1 0.017
regulation of protein metabolic process GO:0051246 56 0.017
positive regulation of biological process GO:0048518 253 0.017
proteasomal protein catabolic process GO:0010498 2 0.017
positive regulation of biosynthetic process GO:0009891 68 0.016
cellular homeostasis GO:0019725 26 0.016
establishment of localization GO:0051234 244 0.016
embryonic organ morphogenesis GO:0048562 274 0.016
phosphorus metabolic process GO:0006793 109 0.016
Zebrafish Rat
regulation of protein complex assembly GO:0043254 3 0.016
negative regulation of protein phosphorylation GO:0001933 4 0.016
sodium ion transport GO:0006814 24 0.016
appendage morphogenesis GO:0035107 56 0.016
positive regulation of macromolecule metabolic process GO:0010604 93 0.016
negative regulation of defense response GO:0031348 2 0.016
embryonic camera type eye development GO:0031076 29 0.016
positive regulation of cell cycle GO:0045787 3 0.016
transmission of nerve impulse GO:0019226 19 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
inorganic ion transmembrane transport GO:0098660 57 0.016
hematopoietic or lymphoid organ development GO:0048534 191 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.015
light induced release of internally sequestered calcium ion GO:0008377 1 0.015
regulation of reproductive process GO:2000241 4 0.015
cell part morphogenesis GO:0032990 246 0.015
tissue remodeling GO:0048771 4 0.015
muscle tissue development GO:0060537 110 0.015
hemopoiesis GO:0030097 183 0.015
small molecule metabolic process GO:0044281 77 0.015
Zebrafish Rat
cell proliferation GO:0008283 80 0.015
negative regulation of biosynthetic process GO:0009890 55 0.015
multicellular organismal homeostasis GO:0048871 29 0.015
autonomic nervous system development GO:0048483 19 0.015
cell projection morphogenesis GO:0048858 244 0.015
cellular response to starvation GO:0009267 1 0.015
pigmentation GO:0043473 85 0.015
mesenchymal cell differentiation GO:0048762 87 0.015
regulation of signal transduction GO:0009966 225 0.015
regulation of intracellular protein transport GO:0033157 3 0.014
cellular chemical homeostasis GO:0055082 17 0.014
microtubule cytoskeleton organization GO:0000226 33 0.014
female gonad development GO:0008585 4 0.014
glucose homeostasis GO:0042593 1 0.014
ion transport GO:0006811 114 0.014
regulation of blood circulation GO:1903522 32 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.014
regulation of cellular ketone metabolic process GO:0010565 7 0.014
regulation of signaling GO:0023051 235 0.014
cation transport GO:0006812 81 0.014
oxoacid metabolic process GO:0043436 31 0.014
positive regulation of response to stimulus GO:0048584 80 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.014
carbohydrate homeostasis GO:0033500 1 0.014
negative regulation of macromolecule metabolic process GO:0010605 76 0.014
response to lipid GO:0033993 60 0.014
specification of symmetry GO:0009799 204 0.014
regulation of anterior head development GO:2000742 2 0.014
protein modification process GO:0036211 100 0.014
myofibril assembly GO:0030239 48 0.014
regulation of tube size GO:0035150 2 0.013
tissue regeneration GO:0042246 74 0.013
regulation of stem cell proliferation GO:0072091 2 0.013
cellular protein catabolic process GO:0044257 4 0.013
cardiac muscle tissue development GO:0048738 48 0.013
kidney development GO:0001822 92 0.013
muscle organ development GO:0007517 101 0.013
regulation of cell differentiation GO:0045595 142 0.013
positive regulation of nucleic acid templated transcription GO:1903508 57 0.013
regulation of metal ion transport GO:0010959 4 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.013
determination of left right symmetry GO:0007368 179 0.013
anatomical structure homeostasis GO:0060249 36 0.013
detection of visible light GO:0009584 12 0.013
regulation of neurological system process GO:0031644 2 0.013
actin filament based process GO:0030029 64 0.013
visual perception GO:0007601 17 0.013
Zebrafish
regulation of hormone secretion GO:0046883 2 0.013
embryonic heart tube morphogenesis GO:0003143 108 0.013
post embryonic morphogenesis GO:0009886 4 0.013
regulation of protein catabolic process GO:0042176 1 0.013
positive regulation of cellular metabolic process GO:0031325 94 0.013
positive regulation of camp biosynthetic process GO:0030819 2 0.013
cation homeostasis GO:0055080 33 0.012
regulation of circadian rhythm GO:0042752 4 0.012
organophosphate metabolic process GO:0019637 37 0.012
Zebrafish Rat
apoptotic process GO:0006915 116 0.012
optomotor response GO:0071632 1 0.012
compound eye development GO:0048749 2 0.012
protein heterooligomerization GO:0051291 1 0.012
pharyngeal muscle development GO:0043282 4 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
regulation of synaptic plasticity GO:0048167 1 0.012
cognition GO:0050890 1 0.012
cellular response to stress GO:0033554 62 0.012
regulation of blood vessel size GO:0050880 2 0.012
embryonic cranial skeleton morphogenesis GO:0048701 90 0.012
nucleotide metabolic process GO:0009117 28 0.012
Zebrafish Rat
leukocyte proliferation GO:0070661 1 0.012
intracellular signal transduction GO:0035556 85 0.012
mechanosensory behavior GO:0007638 2 0.012
negative regulation of gene expression GO:0010629 65 0.012
muscle structure development GO:0061061 196 0.012
action potential GO:0001508 19 0.012
cellular response to unfolded protein GO:0034620 2 0.012
regulation of ion transmembrane transporter activity GO:0032412 2 0.012
cell fate specification GO:0001708 68 0.012
bmp signaling pathway GO:0030509 52 0.012
optokinetic behavior GO:0007634 9 0.012
positive regulation of leukocyte mediated immunity GO:0002705 1 0.012
response to endogenous stimulus GO:0009719 83 0.012
negative regulation of catabolic process GO:0009895 3 0.012
regulation of transporter activity GO:0032409 2 0.011
detection of external stimulus GO:0009581 24 0.011
regulation of nucleotide biosynthetic process GO:0030808 15 0.011
cell fate commitment GO:0045165 99 0.011
nuclear transport GO:0051169 4 0.011
negative regulation of blood circulation GO:1903523 2 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
carboxylic acid metabolic process GO:0019752 22 0.011
regulation of binding GO:0051098 3 0.011
cellular protein metabolic process GO:0044267 129 0.011
cellular response to hypoxia GO:0071456 1 0.011
negative regulation of programmed cell death GO:0043069 58 0.011
positive regulation of protein complex assembly GO:0031334 2 0.011
embryonic skeletal joint development GO:0072498 3 0.011
convergent extension GO:0060026 118 0.011
negative regulation of feeding behavior GO:2000252 2 0.011
positive regulation of catabolic process GO:0009896 4 0.011
cytokinesis GO:0000910 3 0.011
developmental programmed cell death GO:0010623 4 0.011
regulation of inflammatory response GO:0050727 2 0.011
regulation of ph GO:0006885 3 0.011
macromolecular complex subunit organization GO:0043933 74 0.011
sensory perception of light stimulus GO:0050953 19 0.011
Zebrafish
purine containing compound metabolic process GO:0072521 29 0.011
Zebrafish Rat
oocyte maturation GO:0001556 4 0.011
response to hexose GO:0009746 3 0.011
mitochondrion organization GO:0007005 4 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
single organism localization GO:1902578 225 0.011
response to alkaloid GO:0043279 2 0.010
circadian sleep wake cycle process GO:0022410 2 0.010
neuroblast proliferation GO:0007405 2 0.010
negative regulation of nuclear division GO:0051784 3 0.010
spemann organizer formation at the embryonic shield GO:0060063 2 0.010
positive regulation of cellular catabolic process GO:0031331 3 0.010
response to oxygen containing compound GO:1901700 55 0.010
axon guidance GO:0007411 86 0.010
cellular response to oxygen levels GO:0071453 1 0.010
meiosis ii GO:0007135 1 0.010
anterior head development GO:0097065 2 0.010
neural crest cell differentiation GO:0014033 72 0.010
hormone secretion GO:0046879 2 0.010
cellular response to decreased oxygen levels GO:0036294 1 0.010

gc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.161
eye disease DOID:5614 0 0.082
eye and adnexa disease DOID:1492 0 0.082
sensory system disease DOID:0050155 0 0.082
nervous system disease DOID:863 0 0.082
disease of metabolism DOID:0014667 0 0.019
retinal disease DOID:5679 0 0.011