Danio rerio

24 known processes

keap1a

kelch-like ECH-associated protein 1a

(Aliases: keap1,fb36f11,MGC136521,wu:fb36f11)

keap1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleic acid metabolic process GO:0090304 244 0.382
gene expression GO:0010467 252 0.280
nucleobase containing compound metabolic process GO:0006139 274 0.272
heterocycle metabolic process GO:0046483 290 0.239
cellular nitrogen compound biosynthetic process GO:0044271 218 0.218
macromolecule biosynthetic process GO:0009059 227 0.209
regulation of gene expression GO:0010468 265 0.204
cellular biosynthetic process GO:0044249 286 0.198
organic substance biosynthetic process GO:1901576 289 0.197
heterocycle biosynthetic process GO:0018130 215 0.190
nucleobase containing compound biosynthetic process GO:0034654 205 0.185
aromatic compound biosynthetic process GO:0019438 217 0.165
organic cyclic compound biosynthetic process GO:1901362 223 0.164
cellular nitrogen compound metabolic process GO:0034641 290 0.157
nucleic acid templated transcription GO:0097659 181 0.155
response to xenobiotic stimulus GO:0009410 45 0.153
rna metabolic process GO:0016070 219 0.144
response to inorganic substance GO:0010035 38 0.143
regulation of rna biosynthetic process GO:2001141 213 0.141
organic cyclic compound metabolic process GO:1901360 301 0.138
cellular macromolecule biosynthetic process GO:0034645 224 0.125
cellular aromatic compound metabolic process GO:0006725 295 0.119
blood vessel morphogenesis GO:0048514 216 0.118
nitrogen compound metabolic process GO:0006807 319 0.117
multicellular organism growth GO:0035264 4 0.110
regulation of nitrogen compound metabolic process GO:0051171 251 0.110
regulation of cellular biosynthetic process GO:0031326 245 0.109
regulation of transcription dna templated GO:0006355 213 0.095
biosynthetic process GO:0009058 294 0.094
transcription dna templated GO:0006351 181 0.093
cellular macromolecule metabolic process GO:0044260 391 0.091
regulation of multicellular organism growth GO:0040014 4 0.083
response to chemical GO:0042221 320 0.081
establishment of localization GO:0051234 244 0.079
rna biosynthetic process GO:0032774 181 0.079
regulation of rna metabolic process GO:0051252 224 0.079
regulation of macromolecule metabolic process GO:0060255 317 0.074
regulation of response to oxidative stress GO:1902882 2 0.070
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.070
single organism transport GO:0044765 206 0.069
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.068
response to metal ion GO:0010038 34 0.068
response to fatty acid GO:0070542 5 0.067
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.066
immune system process GO:0002376 241 0.065
liver development GO:0001889 96 0.064
Zebrafish
signal transduction GO:0007165 455 0.063
vasculature development GO:0001944 278 0.061
larval development GO:0002164 2 0.061
ion transmembrane transport GO:0034220 91 0.061
response to hormone GO:0009725 48 0.060
regulation of biosynthetic process GO:0009889 250 0.060
transcription from rna polymerase ii promoter GO:0006366 80 0.059
erythrocyte homeostasis GO:0034101 55 0.058
regulation of metabolic process GO:0019222 359 0.057
cellular response to chemical stimulus GO:0070887 157 0.055
innate immune response GO:0045087 13 0.054
cellular response to xenobiotic stimulus GO:0071466 35 0.054
response to external stimulus GO:0009605 264 0.054
maintenance of location GO:0051235 4 0.053
regulation of cytokine production GO:0001817 3 0.051
response to endogenous stimulus GO:0009719 83 0.051
angiogenesis GO:0001525 158 0.051
regulation of primary metabolic process GO:0080090 311 0.050
regulation of macromolecule biosynthetic process GO:0010556 225 0.050
regulation of establishment of protein localization GO:0070201 4 0.049
positive regulation of cellular component biogenesis GO:0044089 3 0.049
regulation of protein transport GO:0051223 3 0.048
regulation of cellular metabolic process GO:0031323 320 0.048
response to glucocorticoid GO:0051384 1 0.048
regulation of cellular amine metabolic process GO:0033238 0 0.046
positive regulation of cellular process GO:0048522 201 0.046
aging GO:0007568 2 0.046
regulation of wound healing GO:0061041 2 0.046
embryonic organ development GO:0048568 381 0.045
response to stress GO:0006950 263 0.045
regulation of cellular response to oxidative stress GO:1900407 2 0.044
response to wounding GO:0009611 116 0.044
reactive oxygen species metabolic process GO:0072593 6 0.043
cellular ketone metabolic process GO:0042180 11 0.042
positive regulation of macromolecule metabolic process GO:0010604 93 0.042
regulation of nucleic acid templated transcription GO:1903506 213 0.041
ion transport GO:0006811 114 0.041
regulation of multicellular organismal process GO:0051239 277 0.041
defense response GO:0006952 47 0.040
carboxylic acid metabolic process GO:0019752 22 0.040
locomotion GO:0040011 313 0.039
superoxide metabolic process GO:0006801 2 0.039
muscle tissue development GO:0060537 110 0.039
response to nutrient GO:0007584 3 0.038
lipid storage GO:0019915 1 0.038
response to oxygen containing compound GO:1901700 55 0.037
protein secretion GO:0009306 1 0.037
positive regulation of cellular metabolic process GO:0031325 94 0.037
positive regulation of cytokine production GO:0001819 2 0.037
cation transport GO:0006812 81 0.037
extrinsic apoptotic signaling pathway GO:0097191 3 0.035
peptidyl serine phosphorylation GO:0018105 1 0.035
cellular amine metabolic process GO:0044106 2 0.035
positive regulation of transport GO:0051050 2 0.035
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.035
endoplasmic reticulum unfolded protein response GO:0030968 2 0.035
response to biotic stimulus GO:0009607 97 0.035
regulation of inflammatory response GO:0050727 2 0.034
response to alkaloid GO:0043279 2 0.034
response to other organism GO:0051707 97 0.033
tissue remodeling GO:0048771 4 0.033
inorganic ion transmembrane transport GO:0098660 57 0.033
positive regulation of cellular catabolic process GO:0031331 3 0.033
regulation of biological quality GO:0065008 263 0.033
secondary metabolic process GO:0019748 3 0.032
mitochondrion organization GO:0007005 4 0.032
regulation of developmental process GO:0050793 247 0.031
p38mapk cascade GO:0038066 1 0.031
single organism localization GO:1902578 225 0.031
lymphocyte homeostasis GO:0002260 1 0.031
positive regulation of endothelial cell proliferation GO:0001938 1 0.030
positive regulation of catabolic process GO:0009896 4 0.030
positive regulation of nucleic acid templated transcription GO:1903508 57 0.030
cellular response to hormone stimulus GO:0032870 39 0.030
cellular response to topologically incorrect protein GO:0035967 2 0.029
multi organism process GO:0051704 134 0.029
positive regulation of wound healing GO:0090303 1 0.029
blood vessel development GO:0001568 246 0.028
response to oxygen radical GO:0000305 2 0.028
chordate embryonic development GO:0043009 271 0.027
organonitrogen compound metabolic process GO:1901564 74 0.027
sensory organ morphogenesis GO:0090596 200 0.027
insulin like growth factor receptor signaling pathway GO:0048009 4 0.027
guanosine containing compound metabolic process GO:1901068 4 0.027
erythrocyte differentiation GO:0030218 54 0.027
response to bacterium GO:0009617 58 0.027
homeostatic process GO:0042592 142 0.026
cellular component morphogenesis GO:0032989 336 0.026
response to lipid GO:0033993 60 0.026
positive regulation of neuron death GO:1901216 1 0.026
somitogenesis GO:0001756 87 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.026
adult behavior GO:0030534 2 0.025
regulation of reactive oxygen species metabolic process GO:2000377 2 0.025
regulation of tube size GO:0035150 2 0.025
developmental programmed cell death GO:0010623 4 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.025
regionalization GO:0003002 274 0.025
purine ribonucleoside biosynthetic process GO:0046129 2 0.025
ovulation cycle GO:0042698 2 0.025
internal peptidyl lysine acetylation GO:0018393 2 0.025
cell death in response to oxidative stress GO:0036473 2 0.025
myeloid cell homeostasis GO:0002262 56 0.024
positive regulation of biological process GO:0048518 253 0.024
amine metabolic process GO:0009308 2 0.024
response to topologically incorrect protein GO:0035966 2 0.024
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.024
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.024
hindbrain development GO:0030902 91 0.024
apoptotic process involved in development GO:1902742 2 0.024
cellular response to prostaglandin stimulus GO:0071379 3 0.024
inorganic cation transmembrane transport GO:0098662 50 0.023
single organism metabolic process GO:0044710 217 0.023
transmembrane transport GO:0055085 120 0.023
response to copper ion GO:0046688 13 0.023
positive regulation of response to wounding GO:1903036 5 0.023
organic acid metabolic process GO:0006082 31 0.023
regulation of circadian rhythm GO:0042752 4 0.023
cellular amino acid metabolic process GO:0006520 7 0.023
female gonad development GO:0008585 4 0.023
regulation of cell activation GO:0050865 1 0.023
leukocyte homeostasis GO:0001776 2 0.022
immune system development GO:0002520 191 0.022
negative regulation of metabolic process GO:0009892 86 0.022
positive regulation of rna metabolic process GO:0051254 59 0.022
embryo development ending in birth or egg hatching GO:0009792 271 0.022
positive regulation of transcription dna templated GO:0045893 57 0.022
cellular response to biotic stimulus GO:0071216 3 0.022
hatching GO:0035188 4 0.022
removal of superoxide radicals GO:0019430 2 0.022
monovalent inorganic cation transport GO:0015672 42 0.021
response to unfolded protein GO:0006986 2 0.021
peptidyl serine modification GO:0018209 2 0.021
response to external biotic stimulus GO:0043207 97 0.021
defense response to bacterium GO:0042742 22 0.021
sensory organ development GO:0007423 393 0.021
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.021
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.021
response to transition metal nanoparticle GO:1990267 28 0.021
i kappab kinase nf kappab signaling GO:0007249 4 0.020
gland development GO:0048732 143 0.020
Zebrafish
regulation of oxidative stress induced cell death GO:1903201 2 0.020
epithelial cell differentiation GO:0030855 116 0.020
homeostasis of number of cells GO:0048872 62 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
modification dependent protein catabolic process GO:0019941 3 0.020
camera type eye development GO:0043010 222 0.020
enzyme linked receptor protein signaling pathway GO:0007167 106 0.020
regulation of protein catabolic process GO:0042176 1 0.020
positive regulation of cellular biosynthetic process GO:0031328 68 0.019
oxoacid metabolic process GO:0043436 31 0.019
regulation of p38mapk cascade GO:1900744 1 0.019
positive regulation of stem cell proliferation GO:2000648 1 0.019
single organism biosynthetic process GO:0044711 71 0.019
positive regulation of metabolic process GO:0009893 108 0.019
response to carbohydrate GO:0009743 3 0.019
protein metabolic process GO:0019538 183 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.019
modification of morphology or physiology of other organism GO:0035821 4 0.019
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.019
peptide transport GO:0015833 1 0.019
cation transmembrane transport GO:0098655 65 0.018
response to corticosteroid GO:0031960 1 0.018
ameboidal type cell migration GO:0001667 143 0.018
cellular response to oxygen containing compound GO:1901701 20 0.018
modulation by virus of host morphology or physiology GO:0019048 1 0.018
response to hexose GO:0009746 3 0.018
regulation of protein ubiquitination GO:0031396 3 0.018
cellular response to unfolded protein GO:0034620 2 0.018
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.018
cellular response to lipopolysaccharide GO:0071222 3 0.018
negative regulation of dna replication GO:0008156 2 0.018
cell surface receptor signaling pathway GO:0007166 325 0.018
hemopoiesis GO:0030097 183 0.018
response to cadmium ion GO:0046686 14 0.018
killing of cells in other organism involved in symbiotic interaction GO:0051883 1 0.018
regulation of response to stress GO:0080134 36 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.017
cellular response to stress GO:0033554 62 0.017
positive regulation of multicellular organismal process GO:0051240 52 0.017
cellular response to organic substance GO:0071310 105 0.017
regulation of response to stimulus GO:0048583 269 0.017
response to ketone GO:1901654 1 0.017
hematopoietic or lymphoid organ development GO:0048534 191 0.017
response to glucose GO:0009749 3 0.017
cellular response to estradiol stimulus GO:0071392 1 0.017
positive regulation of secretion GO:0051047 1 0.017
regulation of multicellular organismal development GO:2000026 223 0.017
brain development GO:0007420 293 0.016
leukocyte proliferation GO:0070661 1 0.016
er nucleus signaling pathway GO:0006984 2 0.016
regulation of ph GO:0006885 3 0.016
positive regulation of inflammatory response GO:0050729 1 0.016
positive regulation of jak stat cascade GO:0046427 2 0.016
female sex differentiation GO:0046660 4 0.016
intracellular signal transduction GO:0035556 85 0.016
organelle fusion GO:0048284 3 0.016
regulation of cell communication GO:0010646 232 0.016
regulation of mitochondrion organization GO:0010821 1 0.016
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.016
regulation of protein localization to nucleus GO:1900180 2 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.016
protein acetylation GO:0006473 2 0.016
cellular response to fatty acid GO:0071398 3 0.016
post embryonic organ development GO:0048569 4 0.016
striated muscle tissue development GO:0014706 110 0.016
gtp metabolic process GO:0046039 4 0.015
positive regulation of secretion by cell GO:1903532 1 0.015
small molecule metabolic process GO:0044281 77 0.015
response to amino acid GO:0043200 2 0.015
positive regulation of neuron apoptotic process GO:0043525 1 0.015
protein acylation GO:0043543 3 0.015
cell morphogenesis involved in differentiation GO:0000904 195 0.015
organelle organization GO:0006996 227 0.015
response to organic substance GO:0010033 153 0.015
positive regulation of biosynthetic process GO:0009891 68 0.015
peptidyl lysine acetylation GO:0018394 2 0.015
positive regulation of immune effector process GO:0002699 3 0.015
positive regulation of epithelial cell migration GO:0010634 2 0.015
tube morphogenesis GO:0035239 349 0.015
cellular protein catabolic process GO:0044257 4 0.015
cell matrix adhesion GO:0007160 4 0.015
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.015
neuron differentiation GO:0030182 353 0.015
regulation of cytokine mediated signaling pathway GO:0001959 3 0.015
myeloid cell differentiation GO:0030099 86 0.015
zymogen activation GO:0031638 3 0.015
single organism membrane fusion GO:0044801 2 0.015
cellular response to extracellular stimulus GO:0031668 2 0.015
negative regulation of dna metabolic process GO:0051053 4 0.015
developmental growth GO:0048589 166 0.015
wound healing GO:0042060 90 0.015
positive regulation of cell cycle GO:0045787 3 0.015
regulation of blood vessel size GO:0050880 2 0.014
response to monosaccharide GO:0034284 3 0.014
embryonic hemopoiesis GO:0035162 53 0.014
post embryonic organ morphogenesis GO:0048563 1 0.014
pyruvate metabolic process GO:0006090 1 0.014
regulation of dna replication GO:0006275 3 0.014
sensory perception GO:0007600 39 0.014
protein import GO:0017038 3 0.014
somite development GO:0061053 96 0.014
negative regulation of gene expression GO:0010629 65 0.014
pigment metabolic process GO:0042440 12 0.014
lipid catabolic process GO:0016042 4 0.014
neuromuscular process controlling balance GO:0050885 3 0.014
development of primary female sexual characteristics GO:0046545 4 0.014
carbon dioxide transport GO:0015670 3 0.014
myeloid cell development GO:0061515 32 0.014
death GO:0016265 121 0.014
cellular response to lipid GO:0071396 39 0.014
fatty acid biosynthetic process GO:0006633 4 0.014
positive regulation of cell activation GO:0050867 1 0.014
cell proliferation GO:0008283 80 0.014
cellular protein metabolic process GO:0044267 129 0.013
protein targeting to nucleus GO:0044744 3 0.013
cellular component disassembly GO:0022411 1 0.013
cellular component biogenesis GO:0044085 178 0.013
cell projection organization GO:0030030 284 0.013
positive regulation of dna metabolic process GO:0051054 1 0.013
gtp catabolic process GO:0006184 2 0.013
epithelium migration GO:0090132 25 0.013
purine nucleoside triphosphate biosynthetic process GO:0009145 2 0.013
protein localization to nucleus GO:0034504 3 0.013
cellular response to oxygen radical GO:0071450 2 0.013
negative regulation of biological process GO:0048519 304 0.013
regulation of response to cytokine stimulus GO:0060759 3 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.013
regulation of cytoplasmic transport GO:1903649 4 0.013
regulation of erk1 and erk2 cascade GO:0070372 4 0.013
positive regulation of rna biosynthetic process GO:1902680 57 0.013
positive regulation of protein complex assembly GO:0031334 2 0.013
regulation of protein complex assembly GO:0043254 3 0.013
apoptotic process involved in morphogenesis GO:0060561 2 0.013
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.013
membrane repolarization GO:0086009 2 0.013
oocyte maturation GO:0001556 4 0.013
positive regulation of neural precursor cell proliferation GO:2000179 1 0.013
positive regulation of defense response GO:0031349 9 0.013
interaction with host GO:0051701 4 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
internal protein amino acid acetylation GO:0006475 2 0.013
membrane fusion GO:0061025 2 0.012
regulation of dendrite development GO:0050773 3 0.012
oxidative demethylation GO:0070989 1 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.012
protein import into nucleus GO:0006606 3 0.012
nucleocytoplasmic transport GO:0006913 4 0.012
transport GO:0006810 220 0.012
ovulation cycle process GO:0022602 2 0.012
alcohol biosynthetic process GO:0046165 2 0.012
cell part morphogenesis GO:0032990 246 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.012
modification dependent macromolecule catabolic process GO:0043632 3 0.012
retina development in camera type eye GO:0060041 146 0.012
protein localization to plasma membrane GO:0072659 1 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.012
autophagy GO:0006914 4 0.012
positive regulation of apoptotic signaling pathway GO:2001235 1 0.012
melanin metabolic process GO:0006582 2 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.012
regulation of cell death GO:0010941 103 0.012
stem cell proliferation GO:0072089 4 0.012
type i interferon production GO:0032606 2 0.012
spermatid development GO:0007286 2 0.012
sex determination GO:0007530 1 0.012
cellular response to reactive oxygen species GO:0034614 2 0.012
response to vitamin GO:0033273 3 0.012
striated muscle cell differentiation GO:0051146 129 0.012
hydrogen peroxide metabolic process GO:0042743 2 0.012
positive regulation of gene expression GO:0010628 71 0.012
single organism organelle organization GO:1902589 199 0.012
response to uv GO:0009411 3 0.012
regulation of gtpase activity GO:0043087 2 0.012
regulation of cellular component organization GO:0051128 86 0.012
tetrapyrrole metabolic process GO:0033013 10 0.011
negative regulation of cytokine production GO:0001818 1 0.011
phagocytosis GO:0006909 3 0.011
carboxylic acid biosynthetic process GO:0046394 12 0.011
dorsal ventral pattern formation GO:0009953 125 0.011
cellular response to external stimulus GO:0071496 2 0.011
cellular response to radiation GO:0071478 4 0.011
central nervous system development GO:0007417 387 0.011
negative regulation of apoptotic process GO:0043066 55 0.011
nuclear import GO:0051170 3 0.011
regulation of lipid transport GO:0032368 4 0.011
cellular response to superoxide GO:0071451 2 0.011
response to hydrogen peroxide GO:0042542 3 0.011
inner ear development GO:0048839 126 0.011
organism emergence from protective structure GO:0071684 4 0.011
cell projection morphogenesis GO:0048858 244 0.011
response to drug GO:0042493 3 0.011
neurological system process GO:0050877 62 0.011
regulation of nucleotide catabolic process GO:0030811 2 0.011
nucleoside biosynthetic process GO:0009163 2 0.011
guanosine containing compound catabolic process GO:1901069 2 0.011
regulation of response to external stimulus GO:0032101 31 0.011
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.011
b cell activation GO:0042113 2 0.011
dicarboxylic acid transport GO:0006835 1 0.011
cell motility GO:0048870 244 0.011
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.011
b cell mediated immunity GO:0019724 3 0.010
ubiquitin dependent protein catabolic process GO:0006511 3 0.010
negative regulation of defense response GO:0031348 2 0.010
regulation of signal transduction GO:0009966 225 0.010
exocytosis GO:0006887 1 0.010
regulation of jak stat cascade GO:0046425 3 0.010
hepaticobiliary system development GO:0061008 98 0.010
Zebrafish
regulation of neural precursor cell proliferation GO:2000177 3 0.010
generation of neurons GO:0048699 385 0.010
nucleoside triphosphate biosynthetic process GO:0009142 2 0.010
negative regulation of macromolecule metabolic process GO:0010605 76 0.010
production of molecular mediator of immune response GO:0002440 2 0.010
regulation of protein targeting GO:1903533 2 0.010
regulation of cell projection organization GO:0031344 44 0.010
system process GO:0003008 185 0.010
programmed cell death GO:0012501 119 0.010
regulation of sodium ion transport GO:0002028 2 0.010

keap1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.066
nervous system disease DOID:863 0 0.049
inherited metabolic disorder DOID:655 0 0.023
disease of metabolism DOID:0014667 0 0.023
organ system cancer DOID:0050686 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
cancer DOID:162 0 0.017
neurodegenerative disease DOID:1289 0 0.016
central nervous system disease DOID:331 0 0.016
amyotrophic lateral sclerosis DOID:332 0 0.016
motor neuron disease DOID:231 0 0.016
musculoskeletal system disease DOID:17 0 0.015
lipid storage disease DOID:9455 0 0.013
lysosomal storage disease DOID:3211 0 0.013
immune system disease DOID:2914 0 0.012
connective tissue disease DOID:65 0 0.011