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Danio rerio

0 genes annotated in zebrafish

lysosomal storage disease

DOID:3211

An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lysosomal storage disease" (in gray)

Name	Description	Probability	Func Analog Organism
grnb	granulin b	0.953	Human
ctsl1a	cathepsin L, 1 a	0.731
ctsba	cathepsin B, a	0.554
atp6v0ca	ATPase, H+ transporting, lysosomal, V0 subunit c, a	0.444
grna	granulin a	0.429	Human
atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.379
ctsa	cathepsin A	0.375
lgmn	legumain	0.373
ctsc	cathepsin C	0.342
gdf6a	growth differentiation factor 6a	0.271
cpvl	carboxypeptidase, vitellogenic-like	0.256
zgc:92765	zgc:92765	0.207
fuca2	fucosidase, alpha-L- 2, plasma	0.178
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.154
LOC100330598	uncharacterized protein LOC389493-like	0.140
psap	prosaposin	0.136	Human
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.132
zgc:64114	zgc:64114	0.118
ctsd	cathepsin D	0.098	Human
foxi3b	forkhead box I3b	0.091
tkt	transketolase	0.083
mcoln1	mucolipin 1	0.073
cyp1a	cytochrome P450, family 1, subfamily A	0.068
atp6v1e1b	ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b	0.067
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.064
tp53	tumor protein p53	0.061
rrm2b	ribonucleotide reductase M2 b	0.060
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.058
zgc:158605	zgc:158605	0.058
zgc:110188	zgc:110188	0.054
rab22a	RAB22A, member RAS oncogene family	0.054
atp6v1c1a	ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1a	0.050
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.050
ctssb.2	cathepsin S, b.2	0.049
coro1a	coronin, actin binding protein, 1A	0.049
sdcbp	syndecan binding protein (syntenin)	0.048
slc2a10	solute carrier family 2 (facilitated glucose transporter), member 10	0.043
wu:fc18d04	wu:fc18d04	0.040
LOC795916	mucolipin-1-like	0.038
stard3	START domain containing 3	0.038
rdh10b	retinol dehydrogenase 10b	0.038
pttg1ipb	pituitary tumor-transforming 1 interacting protein b	0.036
txlng	taxilin gamma	0.034
asl	argininosuccinate lyase	0.034
brd2b	bromodomain containing 2b	0.033
zgc:92308	zgc:92308	0.033
apoeb	apolipoprotein Eb	0.033	Human
fuca1	fucosidase, alpha-L- 1, tissue	0.033	Human
cd63	Cd63 antigen	0.032
cyp3c1	cytochrome P450, family 3, subfamily c, polypeptide 1	0.032
zgc:113200	zgc:113200	0.031
faub	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed b	0.030
trpv1	transient receptor potential cation channel subfamily V member 1	0.030
arfgap2	ADP-ribosylation factor GTPase activating protein 2	0.029
mt2	metallothionein 2	0.028
dusp6	dual specificity phosphatase 6	0.028
ef1a	elongation factor 1-alpha	0.028
zgc:123333	zgc:123333	0.028
krt18	keratin 18	0.028
ptprb	protein tyrosine phosphatase, receptor type, b	0.027
fras1	Fraser syndrome 1	0.027
cdk7	cyclin-dependent kinase 7	0.027
pdcd10a	programmed cell death 10a	0.025
pafah1b1a	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a	0.024
mapk3	mitogen-activated protein kinase 3	0.024
tmem9b	TMEM9 domain family, member B	0.024
galcb	galactosylceramidase b	0.024
ass1	argininosuccinate synthetase 1	0.023
phf23a	PHD finger protein 23a	0.023
zgc:114095	zgc:114095	0.023
casp9	caspase 9, apoptosis-related cysteine protease	0.023
gpr137bb	G protein-coupled receptor 137bb	0.023
bcl2l1	bcl2-like 1	0.023
siae	sialic acid acetylesterase	0.022
adipor2	adiponectin receptor 2	0.022
cdk10	cyclin-dependent kinase 10	0.022
rargb	retinoic acid receptor, gamma b	0.021
card9	caspase recruitment domain family, member 9	0.020
cyba	cytochrome b-245, alpha polypeptide	0.020
zfand5a	zinc finger, AN1-type domain 5a	0.020
atp6v1h	ATPase, H+ transporting, lysosomal, V1 subunit H	0.020
hapln3	hyaluronan and proteoglycan link protein 3	0.019
epcam	epithelial cell adhesion molecule	0.019
gps2	G protein pathway suppressor 2	0.019
wnt9a	wingless-type MMTV integration site family, member 9A	0.019
p2rx4a	purinergic receptor P2X, ligand-gated ion channel, 4a	0.019
zgc:110815	zgc:110815	0.019
dpp7	dipeptidyl-peptidase 7	0.019
ssr3	signal sequence receptor, gamma	0.019
klf2a	Kruppel-like factor 2a	0.018
amfr	autocrine motility factor receptor	0.018
zgc:56525	zgc:56525	0.018
LOC569053	hypothetical LOC569053	0.018
frem2a	Fras1 related extracellular matrix protein 2a	0.018
fbxo25	F-box protein 25	0.017
ube2h	ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)	0.017
si:dkey-218h11.4	si:dkey-218h11.4	0.017
rnaset2	ribonuclease T2	0.017
zgc:153251	zgc:153251	0.017
opa3	optic atrophy 3	0.017
mkrn4	makorin, ring finger protein, 4	0.017
sid4	secreted immunoglobulin domain 4	0.016
wdr45	WD repeat domain 45	0.016
c1qc	complement component 1, q subcomponent, C chain	0.016
cps1	carbamoyl-phosphate synthase 1, mitochondrial	0.016
yipf3	Yip1 domain family, member 3	0.016
tm9sf3	transmembrane 9 superfamily member 3	0.016
dffb	DNA fragmentation factor, beta polypeptide (caspase-activated DNase)	0.016
ucp2	uncoupling protein 2	0.016
atp6v1ba	ATPase, H+ transporting, lysosomal, V1 subunit B, member a	0.016
tfa	transferrin-a	0.016
plekhf2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	0.016
abat	4-aminobutyrate aminotransferase	0.016
unc50	unc-50 homolog (C. elegans)	0.016
zgc:193699	zgc:193699	0.016
npc1	Niemann-Pick disease, type C1	0.016
kdsr	3-ketodihydrosphingosine reductase	0.016
cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.016
chsy1	chondroitin sulfate synthase 1	0.016
march5l	membrane-associated ring finger (C3HC4) 5, like	0.015
ppt1	palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)	0.015	Human
zgc:101000	zgc:101000	0.015
rhcgl1	Rhesus blood group, C glycoprotein, like 1	0.015
zgc:91862	zgc:91862	0.015
zgc:101744	zgc:101744	0.015
thap4	THAP domain containing 4	0.015
slc3a2	solute carrier family 3, member 2	0.015
rhoad	ras homolog gene family, member Ad	0.015
selt1a	selenoprotein T, 1a	0.015
ifi30	interferon gamma inducible protein 30	0.015
mvp	major vault protein	0.015
dao.2	D-amino-acid oxidase 2	0.014
grn1	granulin 1	0.014
aldob	aldolase b, fructose-bisphosphate	0.014
ptgds	prostaglandin D2 synthase	0.014
zbtb2a	zinc finger and BTB domain containing 2a	0.014
bhlhe41	basic helix-loop-helix family, member e41	0.014
zgc:55891	zgc:55891	0.014
zgc:198419	zgc:198419	0.014
LOC556597	similar to GCN5-like protein	0.014
apex2	APEX nuclease (apurinic/apyrimidinic endonuclease) 2	0.014
nod2	nucleotide-binding oligomerization domain containing 2	0.014
vil1l	villin 1 like	0.014
slc38a6	solute carrier family 38, member 6	0.014
tmem110l	transmembrane protein 110, like	0.014
mgp	matrix Gla protein	0.014
lndc1	ly6/neurotoxin domain containing 1	0.014
dusp22a	dual specificity phosphatase 22a	0.014
sqrdl	sulfide quinone reductase-like (yeast)	0.014
si:ch211-166a6.5	si:ch211-166a6.5	0.014
LOC100002236	brain protein I3-like	0.014
dirc2	disrupted in renal carcinoma 2	0.013
por	P450 (cytochrome) oxidoreductase	0.013
si:ch211-244b2.4	si:ch211-244b2.4	0.013
lonp2	lon peptidase 2, peroxisomal	0.013
oaz1	ornithine decarboxylase antizyme 1	0.013
ppp6r3	protein phosphatase 6, regulatory subunit 3	0.013
stat1b	signal transducer and activator of transcription 1b	0.013
alkbh3	alkB, alkylation repair homolog 3 (E. coli)	0.013
pex16	peroxisomal biogenesis factor 16	0.013
rhoab	ras homolog gene family, member Ab	0.013
lss	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	0.013
uvrag	UV radiation resistance associated gene	0.013
fam54b	family with sequence similarity 54, member B	0.013
bbc3	BCL2 binding component 3	0.013
hsp90b1	heat shock protein 90, beta (grp94), member 1	0.013
atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.013
keap1a	kelch-like ECH-associated protein 1a	0.013
LOC566020	Gig2-like protein DreO	0.013
zgc:56136	zgc:56136	0.013
slc4a4b	solute carrier family 4, sodium bicarbonate cotransporter, member 4b	0.013
zgc:110333	zgc:110333	0.013
lnx2b	ligand of numb-protein X 2b	0.013
xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5	0.012
stat3	signal transduction and activation of transcription 3	0.012
thy1	Thy-1 cell surface antigen	0.012
tbxas1	thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)	0.012
si:dkeyp-55f12.4	si:dkeyp-55f12.4	0.012
casp8	caspase 8, apoptosis-related cysteine peptidase	0.012
cast	calpastatin	0.012
zgc:55604	zgc:55604	0.012
psmf1	proteasome (prosome, macropain) inhibitor subunit 1	0.012
npepl1	aminopeptidase-like 1	0.012
gnpda1	glucosamine-6-phosphate deaminase 1	0.012
ptdss1	phosphatidylserine synthase 1	0.012
grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.012
ubxn6	UBX domain protein 6	0.012
sec14l1	SEC14-like 1 (S. cerevisiae)	0.012
slc26a11	solute carrier family 26, member 11	0.012
zgc:110591	zgc:110591	0.012
bnip3lb	BCL2/adenovirus E1B interacting protein 3-like b	0.012
zgc:123120	zgc:123120	0.012
itih2	inter-alpha (globulin) inhibitor H2	0.011
npc2	Niemann-Pick disease, type C2	0.011
tnfsf10l4	tumor necrosis factor (ligand) superfamily, member 10 like 4	0.011
cldn12	claudin 12	0.011
mmp9	matrix metalloproteinase 9	0.011
si:ch211-51n14.2	si:ch211-51n14.2	0.011
fth1a	ferritin, heavy polypeptide 1a	0.011
zgc:56719	zgc:56719	0.011
slc5a8l	solute carrier family 5 (iodide transporter), member 8-like	0.011
scyl3	SCY1-like 3 (S. cerevisiae)	0.011
ptpn11a	protein tyrosine phosphatase, non-receptor type 11, a	0.011
wu:fb66f03	wu:fb66f03	0.011
zgc:112426	zgc:112426	0.011
gatsl3	GATS protein-like 3	0.011
bglap	bone gamma-carboxyglutamate (gla) protein	0.011
slc4a1b	solute carrier family 4, anion exchanger, member 1b	0.011
vrk3	vaccinia related kinase 3	0.011
mif	macrophage migration inhibitory factor	0.011
snapc1a	small nuclear RNA activating complex, polypeptide 1a	0.011
ift81	intraflagellar transport 81 homolog	0.011
atp6v1f	ATPase, H+ transporting, V1 subunit F	0.011
scrn3	secernin 3	0.011
zgc:123177	zgc:123177	0.011
nedd1	neural precursor cell expressed, developmentally down-regulated 1	0.011
zgc:114034	zgc:114034	0.011
neil3	nei endonuclease VIII-like 3 (E. coli)	0.011
zgc:171663	zgc:171663	0.011
gldc	glycine dehydrogenase (decarboxylating)	0.011
wnt8a	wingless-type MMTV integration site family, member 8a	0.011
stk35l	serine/threonine kinase 35, like	0.010
LOC792966	similar to cathepsin A	0.010
slc12a10.2	solute carrier family 12 (sodium/potassium/chloride transporters), member 10.2	0.010
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.010
otc	ornithine carbamoyltransferase	0.010
zgc:100919	zgc:100919	0.010
erp44	endoplasmic reticulum protein 44	0.010
gmds	GDP-mannose 4,6-dehydratase	0.010
st3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	0.010
zgc:113210	zgc:113210	0.010
sumf1	sulfatase modifying factor 1	0.010
spns1	spinster homolog 1 (Drosophila)	0.010
smc1al	structural maintenance of chromosomes 1A, like	0.010
vac14	vac14 homolog (S. cerevisiae)	0.010