Danio rerio

94 known processes

klf4

Kruppel-like factor 4

(Aliases: xx:tdsubc_1b8,zgc:109839,id:ibd5109,ik:tdsubc_1e5,ik:tdsubc_1b8,xx:tdsubc_1e5,wu:fc09b11,biklf,xx:tdsubc_1e12,ik:tdsubc_1e12)

klf4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
aromatic compound biosynthetic process GO:0019438 217 0.996
cellular nitrogen compound biosynthetic process GO:0044271 218 0.982
embryonic hemopoiesis GO:0035162 53 0.972
Zebrafish
regulation of macromolecule biosynthetic process GO:0010556 225 0.972
erythrocyte homeostasis GO:0034101 55 0.962
regulation of nucleic acid templated transcription GO:1903506 213 0.954
heterocycle biosynthetic process GO:0018130 215 0.953
regulation of primary metabolic process GO:0080090 311 0.944
erythrocyte differentiation GO:0030218 54 0.937
biosynthetic process GO:0009058 294 0.935
formation of primary germ layer GO:0001704 62 0.931
Zebrafish
heterocycle metabolic process GO:0046483 290 0.919
regulation of cellular biosynthetic process GO:0031326 245 0.913
organic substance biosynthetic process GO:1901576 289 0.905
regulation of gene expression GO:0010468 265 0.901
regulation of rna metabolic process GO:0051252 224 0.897
regulation of nitrogen compound metabolic process GO:0051171 251 0.895
central nervous system development GO:0007417 387 0.878
rna biosynthetic process GO:0032774 181 0.867
organic cyclic compound biosynthetic process GO:1901362 223 0.842
positive regulation of nucleic acid templated transcription GO:1903508 57 0.834
primitive hemopoiesis GO:0060215 27 0.824
Zebrafish
digestive tract morphogenesis GO:0048546 231 0.819
Zebrafish
regulation of rna biosynthetic process GO:2001141 213 0.815
regulation of biosynthetic process GO:0009889 250 0.812
embryonic organ development GO:0048568 381 0.806
Zebrafish
nucleobase containing compound biosynthetic process GO:0034654 205 0.801
hematopoietic or lymphoid organ development GO:0048534 191 0.796
optic placode formation involved in camera type eye formation GO:0046619 3 0.795
mesoderm formation GO:0001707 43 0.789
Zebrafish
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.777
positive regulation of metabolic process GO:0009893 108 0.775
cellular macromolecule metabolic process GO:0044260 391 0.764
cellular macromolecule biosynthetic process GO:0034645 224 0.754
regulation of transcription dna templated GO:0006355 213 0.751
nitrogen compound metabolic process GO:0006807 319 0.749
gastrulation GO:0007369 208 0.748
Zebrafish
nucleic acid metabolic process GO:0090304 244 0.741
diencephalon development GO:0021536 58 0.737
gene expression GO:0010467 252 0.733
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.700
cellular nitrogen compound metabolic process GO:0034641 290 0.698
nucleic acid templated transcription GO:0097659 181 0.695
regulation of metabolic process GO:0019222 359 0.685
carbohydrate derivative biosynthetic process GO:1901137 43 0.682
morphogenesis of an epithelium GO:0002009 333 0.677
forebrain development GO:0030900 96 0.661
positive regulation of rna biosynthetic process GO:1902680 57 0.660
rna metabolic process GO:0016070 219 0.657
regulation of cellular metabolic process GO:0031323 320 0.656
organic cyclic compound metabolic process GO:1901360 301 0.653
female sex differentiation GO:0046660 4 0.640
organonitrogen compound metabolic process GO:1901564 74 0.639
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.627
posterior lateral line neuromast development GO:0048919 20 0.625
transcription from rna polymerase ii promoter GO:0006366 80 0.613
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.609
determination of left right asymmetry in nervous system GO:0035545 4 0.600
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.597
mechanosensory lateral line system development GO:0048881 49 0.593
positive regulation of gene expression GO:0010628 71 0.577
hemopoiesis GO:0030097 183 0.562
cardiac muscle tissue development GO:0048738 48 0.546
cellular aromatic compound metabolic process GO:0006725 295 0.541
negative regulation of gene expression GO:0010629 65 0.536
positive regulation of signaling GO:0023056 56 0.532
myeloid cell differentiation GO:0030099 86 0.528
regulation of macromolecule metabolic process GO:0060255 317 0.521
determination of left right asymmetry in diencephalon GO:0035462 4 0.507
regulation of epithelial cell proliferation GO:0050678 3 0.501
nephron epithelium morphogenesis GO:0072088 1 0.475
nucleobase containing compound metabolic process GO:0006139 274 0.468
erythrocyte development GO:0048821 24 0.457
myeloid cell homeostasis GO:0002262 56 0.457
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.453
cellular component movement GO:0006928 335 0.437
digestive tract development GO:0048565 265 0.425
Zebrafish
female gonad development GO:0008585 4 0.416
cell projection morphogenesis GO:0048858 244 0.407
cellular biosynthetic process GO:0044249 286 0.396
negative regulation of metabolic process GO:0009892 86 0.389
development of primary female sexual characteristics GO:0046545 4 0.383
protein metabolic process GO:0019538 183 0.379
Worm
thymus development GO:0048538 10 0.367
sensory organ development GO:0007423 393 0.367
endoderm formation GO:0001706 29 0.365
immune system process GO:0002376 241 0.359
heart field specification GO:0003128 1 0.340
cellular component assembly involved in morphogenesis GO:0010927 107 0.337
transcription dna templated GO:0006351 181 0.337
cardiac atrium morphogenesis GO:0003209 2 0.327
non canonical wnt signaling pathway involved in heart development GO:0061341 2 0.326
small molecule metabolic process GO:0044281 77 0.317
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.312
liver development GO:0001889 96 0.310
Zebrafish
response to stress GO:0006950 263 0.303
Worm
rhombomere 5 development GO:0021571 4 0.295
tube morphogenesis GO:0035239 349 0.295
Zebrafish
macromolecule modification GO:0043412 111 0.292
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.279
regulation of binding GO:0051098 3 0.278
carbohydrate derivative metabolic process GO:1901135 61 0.278
cell proliferation involved in heart morphogenesis GO:0061323 2 0.270
positive regulation of cellular process GO:0048522 201 0.264
negative regulation of cellular metabolic process GO:0031324 77 0.264
specification of symmetry GO:0009799 204 0.263
negative regulation of macromolecule metabolic process GO:0010605 76 0.262
dorsal ventral pattern formation GO:0009953 125 0.262
digestive system development GO:0055123 289 0.258
Zebrafish
negative regulation of cellular biosynthetic process GO:0031327 55 0.257
macromolecule biosynthetic process GO:0009059 227 0.256
protein modification process GO:0036211 100 0.254
signal transduction GO:0007165 455 0.252
regulation of cell death GO:0010941 103 0.246
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.242
stem cell maintenance GO:0019827 4 0.241
septum transversum development GO:0003343 4 0.234
nephron morphogenesis GO:0072028 2 0.221
cell fate commitment GO:0045165 99 0.220
Zebrafish
heart valve formation GO:0003188 4 0.218
positive regulation of biological process GO:0048518 253 0.217
regulation of cardiac muscle tissue development GO:0055024 1 0.210
positive regulation of biosynthetic process GO:0009891 68 0.201
regulation of multicellular organismal development GO:2000026 223 0.199
Zebrafish
negative regulation of biosynthetic process GO:0009890 55 0.198
cardiogenic plate morphogenesis GO:0003142 1 0.193
astrocyte differentiation GO:0048708 1 0.190
eye development GO:0001654 277 0.188
organelle organization GO:0006996 227 0.185
inner ear development GO:0048839 126 0.184
determination of bilateral symmetry GO:0009855 204 0.182
cell migration involved in gastrulation GO:0042074 79 0.180
response to wounding GO:0009611 116 0.179
determination of dorsal ventral asymmetry GO:0048262 34 0.179
posterior lateral line development GO:0048916 38 0.178
cellular protein metabolic process GO:0044267 129 0.177
lateral line development GO:0048882 66 0.177
positive regulation of cellular metabolic process GO:0031325 94 0.170
convergent extension GO:0060026 118 0.169
organonitrogen compound biosynthetic process GO:1901566 47 0.166
positive regulation of macromolecule metabolic process GO:0010604 93 0.166
cardiac chamber development GO:0003205 19 0.164
pituitary gland development GO:0021983 16 0.164
eye morphogenesis GO:0048592 144 0.164
neuromast hair cell differentiation GO:0048886 12 0.163
axonogenesis GO:0007409 152 0.158
heart development GO:0007507 313 0.156
optic placode formation GO:0001743 4 0.154
embryonic eye morphogenesis GO:0048048 30 0.152
positive regulation of cellular biosynthetic process GO:0031328 68 0.152
regulation of ectodermal cell fate specification GO:0042665 2 0.151
Zebrafish
ectodermal placode development GO:0071696 37 0.147
nuclear transport GO:0051169 4 0.146
positive regulation of signal transduction GO:0009967 56 0.145
wound healing GO:0042060 90 0.144
positive regulation of cell communication GO:0010647 56 0.144
cellular protein modification process GO:0006464 100 0.143
convergent extension involved in gastrulation GO:0060027 71 0.142
neuromast development GO:0048884 46 0.140
myeloid cell development GO:0061515 32 0.138
regulation of developmental process GO:0050793 247 0.137
Zebrafish
mitochondrion organization GO:0007005 4 0.136
cellular response to starvation GO:0009267 1 0.136
ribonucleotide metabolic process GO:0009259 27 0.135
camera type eye development GO:0043010 222 0.133
proepicardium development GO:0003342 4 0.132
phosphorus metabolic process GO:0006793 109 0.129
cell migration GO:0016477 237 0.128
left right pattern formation GO:0060972 19 0.127
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.127
positive regulation of rna metabolic process GO:0051254 59 0.126
cilium morphogenesis GO:0060271 85 0.126
phosphate containing compound metabolic process GO:0006796 108 0.126
negative regulation of developmental process GO:0051093 65 0.125
Zebrafish
mesenchyme development GO:0060485 127 0.124
death GO:0016265 121 0.123
head development GO:0060322 303 0.122
radial glial cell differentiation GO:0060019 2 0.119
regeneration GO:0031099 91 0.117
hepaticobiliary system development GO:0061008 98 0.116
Zebrafish
oxoacid metabolic process GO:0043436 31 0.116
larval development GO:0002164 2 0.115
Worm
wnt signaling pathway GO:0016055 80 0.114
olfactory placode formation GO:0030910 1 0.112
specification of organ identity GO:0010092 2 0.108
mesenchymal cell differentiation GO:0048762 87 0.107
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.107
tissue regeneration GO:0042246 74 0.106
positive regulation of epithelial cell proliferation GO:0050679 1 0.106
hair cell differentiation GO:0035315 32 0.106
negative regulation of rna biosynthetic process GO:1902679 45 0.105
regulation of phosphorus metabolic process GO:0051174 43 0.104
sensory system development GO:0048880 76 0.104
spinal cord radial glial cell differentiation GO:0021531 2 0.102
brain development GO:0007420 293 0.101
cellular response to nutrient levels GO:0031669 2 0.101
neuron differentiation GO:0030182 353 0.100
regulation of neuron migration GO:2001222 2 0.100
single organism nuclear import GO:1902593 3 0.099
negative regulation of transcription dna templated GO:0045892 45 0.098
single organism biosynthetic process GO:0044711 71 0.097
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.097
nephron tubule morphogenesis GO:0072078 1 0.096
fin regeneration GO:0031101 51 0.096
neuron projection morphogenesis GO:0048812 161 0.096
neural nucleus development GO:0048857 15 0.096
endodermal cell fate determination GO:0007493 2 0.095
adenohypophysis development GO:0021984 15 0.094
multi organism process GO:0051704 134 0.092
cardiac atrium development GO:0003230 4 0.092
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.091
peptide metabolic process GO:0006518 1 0.091
cellular amide metabolic process GO:0043603 4 0.091
defense response GO:0006952 47 0.089
Worm
vasculature development GO:0001944 278 0.088
heart formation GO:0060914 13 0.088
cellular response to extracellular stimulus GO:0031668 2 0.087
endodermal cell differentiation GO:0035987 19 0.087
negative regulation of response to stimulus GO:0048585 104 0.086
regulation of heart morphogenesis GO:2000826 17 0.085
single organism organelle organization GO:1902589 199 0.080
cell motility GO:0048870 244 0.080
proximal distal pattern formation GO:0009954 1 0.079
lateral line system development GO:0048925 76 0.078
retina development in camera type eye GO:0060041 146 0.077
cell part morphogenesis GO:0032990 246 0.076
muscle cell differentiation GO:0042692 139 0.075
positive regulation of jnk cascade GO:0046330 3 0.073
embryonic camera type eye formation GO:0060900 10 0.073
negative regulation of rna metabolic process GO:0051253 48 0.073
positive regulation of neural retina development GO:0061075 1 0.072
transport GO:0006810 220 0.072
response to chemical GO:0042221 320 0.072
negative regulation of muscle tissue development GO:1901862 2 0.071
sensory organ morphogenesis GO:0090596 200 0.071
regulation of wnt signaling pathway involved in heart development GO:0003307 2 0.071
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.070
compound eye development GO:0048749 2 0.070
gland development GO:0048732 143 0.070
protein localization to nucleus GO:0034504 3 0.070
regulation of myeloid cell differentiation GO:0045637 8 0.069
cellular ketone metabolic process GO:0042180 11 0.069
protein import into nucleus GO:0006606 3 0.068
regulation of cell proliferation GO:0042127 37 0.068
renal tubule morphogenesis GO:0061333 1 0.067
regulation of biological quality GO:0065008 263 0.067
locomotion GO:0040011 313 0.066
Worm
posterior lateral line system development GO:0048915 46 0.066
negative regulation of biological process GO:0048519 304 0.066
cartilage development GO:0051216 96 0.066
olfactory lobe development GO:0021988 4 0.066
embryonic skeletal system morphogenesis GO:0048704 93 0.066
ear morphogenesis GO:0042471 64 0.065
cellular response to chemical stimulus GO:0070887 157 0.064
cell morphogenesis GO:0000902 289 0.064
regulation of stem cell differentiation GO:2000736 4 0.064
purine containing compound metabolic process GO:0072521 29 0.064
determination of ventral identity GO:0048264 21 0.064
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.063
cellular component biogenesis GO:0044085 178 0.063
generation of neurons GO:0048699 385 0.063
positive regulation of transcription dna templated GO:0045893 57 0.063
regulation of organ morphogenesis GO:2000027 35 0.063
Zebrafish
negative regulation of wnt signaling pathway involved in heart development GO:0003308 2 0.062
endoderm development GO:0007492 49 0.061
endocardium formation GO:0060214 1 0.060
positive regulation of muscle tissue development GO:1901863 1 0.060
ectodermal placode formation GO:0060788 26 0.060
protein targeting to nucleus GO:0044744 3 0.060
heart jogging GO:0003146 40 0.059
regulation of cellular amino acid metabolic process GO:0006521 0 0.059
regulation of signaling GO:0023051 235 0.058
response to external stimulus GO:0009605 264 0.058
embryonic cranial skeleton morphogenesis GO:0048701 90 0.058
regulation of cellular ketone metabolic process GO:0010565 7 0.058
regulation of nucleoside metabolic process GO:0009118 2 0.058
cilium organization GO:0044782 71 0.058
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.057
mesoderm morphogenesis GO:0048332 51 0.057
Zebrafish
cell surface receptor signaling pathway GO:0007166 325 0.057
ectodermal cell fate specification GO:0001715 2 0.057
Zebrafish
cell projection organization GO:0030030 284 0.056
heart looping GO:0001947 94 0.056
regulation of heart growth GO:0060420 2 0.056
immune system development GO:0002520 191 0.055
muscle tissue morphogenesis GO:0060415 7 0.055
negative regulation of cellular process GO:0048523 283 0.054
Zebrafish
inner ear receptor cell differentiation GO:0060113 29 0.054
ribose phosphate metabolic process GO:0019693 27 0.053
cellular component morphogenesis GO:0032989 336 0.053
tongue morphogenesis GO:0043587 3 0.053
hematopoietic progenitor cell differentiation GO:0002244 23 0.052
angioblast cell differentiation GO:0035779 2 0.052
inner ear morphogenesis GO:0042472 63 0.052
regulation of cell communication GO:0010646 232 0.052
nuclear import GO:0051170 3 0.051
regulation of inner ear receptor cell differentiation GO:2000980 1 0.051
embryonic heart tube left right pattern formation GO:0060971 5 0.051
regulation of activin receptor signaling pathway GO:0032925 5 0.051
determination of left right symmetry GO:0007368 179 0.050
regulation of gastrulation GO:0010470 24 0.050
Zebrafish
organelle assembly GO:0070925 110 0.050
locus ceruleus development GO:0021703 3 0.050
positive regulation of phosphorus metabolic process GO:0010562 21 0.050
regulation of signal transduction GO:0009966 225 0.049
cell morphogenesis involved in differentiation GO:0000904 195 0.049
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.049
regulation of nucleocytoplasmic transport GO:0046822 2 0.048
establishment of nucleus localization GO:0040023 7 0.048
blood vessel development GO:0001568 246 0.048
positive regulation of neuron migration GO:2001224 2 0.047
determination of heart left right asymmetry GO:0061371 117 0.046
extrinsic apoptotic signaling pathway GO:0097191 3 0.045
protein import GO:0017038 3 0.045
blood circulation GO:0008015 87 0.045
cellular response to stress GO:0033554 62 0.044
regulation of skeletal muscle cell differentiation GO:2001014 1 0.044
positive regulation of developmental process GO:0051094 50 0.043
nodal signaling pathway GO:0038092 7 0.043
synaptic growth at neuromuscular junction GO:0051124 2 0.042
stem cell differentiation GO:0048863 117 0.042
response to acid chemical GO:0001101 17 0.041
regulation of tube size GO:0035150 2 0.041
positive regulation of muscle cell differentiation GO:0051149 1 0.041
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.041
negative regulation of reproductive process GO:2000242 3 0.041
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.041
fin morphogenesis GO:0033334 53 0.041
organic acid metabolic process GO:0006082 31 0.041
regulation of wnt signaling pathway GO:0030111 53 0.041
regulation of cardiac muscle cell differentiation GO:2000725 1 0.040
aging GO:0007568 2 0.040
striated muscle cell proliferation GO:0014855 7 0.040
purine nucleotide metabolic process GO:0006163 27 0.039
embryonic heart tube development GO:0035050 133 0.038
mesoderm development GO:0007498 88 0.038
Zebrafish
carboxylic acid metabolic process GO:0019752 22 0.038
positive regulation of myeloid cell differentiation GO:0045639 2 0.038
stem cell proliferation GO:0072089 4 0.038
ectodermal placode morphogenesis GO:0071697 32 0.037
regulation of multicellular organism growth GO:0040014 4 0.037
fin development GO:0033333 77 0.036
single organism membrane organization GO:0044802 20 0.036
ovarian follicle development GO:0001541 2 0.036
negative regulation of striated muscle tissue development GO:0045843 2 0.035
forebrain generation of neurons GO:0021872 14 0.035
canonical wnt signaling pathway GO:0060070 48 0.035
atrioventricular valve formation GO:0003190 3 0.035
regulation of response to stimulus GO:0048583 269 0.035
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.035
Zebrafish
purine ribonucleotide metabolic process GO:0009150 27 0.034
positive regulation of catabolic process GO:0009896 4 0.034
axon development GO:0061564 166 0.034
regulation of phosphate metabolic process GO:0019220 43 0.034
single fertilization GO:0007338 3 0.034
forebrain neuron differentiation GO:0021879 14 0.033
positive regulation of nucleoside metabolic process GO:0045979 1 0.033
epithelium regeneration GO:1990399 14 0.033
negative regulation of collateral sprouting of intact axon in response to injury GO:0048685 2 0.033
endodermal cell fate commitment GO:0001711 18 0.033
homeostasis of number of cells GO:0048872 62 0.033
regulation of cell differentiation GO:0045595 142 0.032
Zebrafish
regulation of molecular function GO:0065009 70 0.032
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.032
regulation of vitamin metabolic process GO:0030656 6 0.032
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 1 0.032
positive regulation of cell cycle GO:0045787 3 0.032
regulation of reproductive process GO:2000241 4 0.032
positive regulation of cellular catabolic process GO:0031331 3 0.032
cellular response to external stimulus GO:0071496 2 0.032
response to oxygen containing compound GO:1901700 55 0.032
ameboidal type cell migration GO:0001667 143 0.031
negative regulation of myeloid leukocyte differentiation GO:0002762 1 0.031
cardioblast migration GO:0003260 7 0.031
activin receptor signaling pathway GO:0032924 8 0.031
nuclear migration GO:0007097 3 0.031
pancreas development GO:0031016 84 0.031
Zebrafish
fibroblast growth factor receptor signaling pathway GO:0008543 22 0.030
negative regulation of gastrulation GO:2000542 11 0.030
Zebrafish
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.030
erythrocyte maturation GO:0043249 8 0.030
endodermal cell fate specification GO:0001714 17 0.029
regulation of protein complex assembly GO:0043254 3 0.029
pharyngeal muscle development GO:0043282 4 0.029
phosphorylation GO:0016310 69 0.029
hepatocyte differentiation GO:0070365 1 0.029
retina morphogenesis in camera type eye GO:0060042 79 0.029
ossification GO:0001503 23 0.029
atrioventricular valve development GO:0003171 11 0.029
response to retinoic acid GO:0032526 6 0.028
epidermis development GO:0008544 48 0.028
mechanoreceptor differentiation GO:0042490 37 0.028
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.027
negative regulation of canonical wnt signaling pathway GO:0090090 21 0.027
mesodermal cell differentiation GO:0048333 21 0.027
Zebrafish
nucleocytoplasmic transport GO:0006913 4 0.027
positive regulation of jun kinase activity GO:0043507 2 0.027
regulation of catalytic activity GO:0050790 55 0.027
regulation of cellular component organization GO:0051128 86 0.027
calcium independent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016338 1 0.027
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.027
ear development GO:0043583 127 0.027
epithelial tube morphogenesis GO:0060562 148 0.027
regulation of epithelial to mesenchymal transition GO:0010717 3 0.026
heart contraction GO:0060047 71 0.026
metencephalon development GO:0022037 27 0.026
monocyte differentiation GO:0030224 2 0.026
negative regulation of nucleic acid templated transcription GO:1903507 45 0.026
establishment of organelle localization GO:0051656 45 0.026
positive regulation of cell migration GO:0030335 11 0.026
epithelial to mesenchymal transition GO:0001837 21 0.026
regulation of developmental growth GO:0048638 38 0.025
appendage morphogenesis GO:0035107 56 0.025
somatic stem cell maintenance GO:0035019 1 0.025
extraocular skeletal muscle development GO:0002074 3 0.025
single organism metabolic process GO:0044710 217 0.025
apoptotic process GO:0006915 116 0.025
endomembrane system organization GO:0010256 13 0.025
connective tissue development GO:0061448 99 0.025
positive regulation of embryonic development GO:0040019 3 0.025
negative regulation of embryonic development GO:0045992 11 0.025
Zebrafish
regulation of nodal signaling pathway GO:1900107 4 0.025
organophosphate metabolic process GO:0019637 37 0.025
peripheral nervous system neuron differentiation GO:0048934 28 0.024
response to other organism GO:0051707 97 0.024
regulation of cellular amine metabolic process GO:0033238 0 0.024
pharyngeal system development GO:0060037 18 0.024
notochord development GO:0030903 54 0.024
regulation of muscle tissue development GO:1901861 6 0.024
antimicrobial humoral response GO:0019730 2 0.023
nucleotide metabolic process GO:0009117 28 0.023
regulation of response to cytokine stimulus GO:0060759 3 0.023
peripheral nervous system development GO:0007422 55 0.023
anterior posterior axis specification embryo GO:0008595 5 0.023
appendage development GO:0048736 80 0.023
neural retina development GO:0003407 49 0.023
ectoderm formation GO:0001705 2 0.023
Zebrafish
vestibular receptor cell differentiation GO:0060114 3 0.022
bmp signaling pathway GO:0030509 52 0.022
developmental maturation GO:0021700 34 0.022
response to axon injury GO:0048678 14 0.022
regulation of apoptotic process GO:0042981 98 0.022
regionalization GO:0003002 274 0.022
regulation of erythrocyte differentiation GO:0045646 2 0.022
response to alcohol GO:0097305 14 0.022
central nervous system formation GO:0021556 1 0.022
regulation of anatomical structure morphogenesis GO:0022603 130 0.022
Zebrafish
amine metabolic process GO:0009308 2 0.022
heart process GO:0003015 71 0.022
regulation of programmed cell death GO:0043067 101 0.022
negative regulation of nodal signaling pathway GO:1900108 4 0.022
peripheral nervous system neuron development GO:0048935 22 0.022
tetrapyrrole metabolic process GO:0033013 10 0.022
production of molecular mediator of immune response GO:0002440 2 0.022
cellular catabolic process GO:0044248 27 0.021
lymphocyte differentiation GO:0030098 9 0.021
cardioblast migration to the midline involved in heart field formation GO:0060975 7 0.021
embryonic heart tube morphogenesis GO:0003143 108 0.021
outflow tract morphogenesis GO:0003151 1 0.021
homeostatic process GO:0042592 142 0.021
amide biosynthetic process GO:0043604 1 0.021
regulation of jun kinase activity GO:0043506 3 0.021
aorta morphogenesis GO:0035909 3 0.021
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.021
cell proliferation GO:0008283 80 0.021
wnt signaling pathway involved in heart development GO:0003306 5 0.021
cofactor biosynthetic process GO:0051188 10 0.020
negative regulation of wnt signaling pathway GO:0030178 30 0.020
cardiac muscle tissue regeneration GO:0061026 3 0.020
epiboly GO:0090504 41 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
dorsal convergence GO:0060030 14 0.020
regulation of organ growth GO:0046620 3 0.020
regulation of skeletal muscle tissue development GO:0048641 4 0.020
cell cycle g2 m phase transition GO:0044839 4 0.020
regulation of synapse assembly GO:0051963 3 0.020
chordate embryonic development GO:0043009 271 0.020
apoptotic signaling pathway GO:0097190 23 0.019
negative regulation of myeloid cell differentiation GO:0045638 1 0.019
homeostasis of number of cells within a tissue GO:0048873 4 0.019
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.019
mitochondrial transport GO:0006839 2 0.019
regulation of establishment of protein localization GO:0070201 4 0.019
olfactory bulb development GO:0021772 4 0.019
embryonic pectoral fin morphogenesis GO:0035118 24 0.019
regulation of canonical wnt signaling pathway GO:0060828 34 0.019
cilium assembly GO:0042384 58 0.019

klf4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
auditory system disease DOID:2742 0 0.118
autosomal dominant nonsyndromic deafness DOID:0050564 0 0.118
nonsyndromic deafness DOID:0050563 0 0.118
sensory system disease DOID:0050155 0 0.118
disease of anatomical entity DOID:7 0 0.118
nervous system disease DOID:863 0 0.118
disease of cellular proliferation DOID:14566 0 0.033
musculoskeletal system disease DOID:17 0 0.027
cancer DOID:162 0 0.020
organ system cancer DOID:0050686 0 0.020