Danio rerio

102 known processes

piwil2

piwi-like 2 (Drosophila)

(Aliases: zili,si:dkey-88f5.1)

piwil2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
pole plasm assembly GO:0007315 4 0.975
Fly
oocyte anterior posterior axis specification GO:0007314 4 0.842
Fly
gamete generation GO:0007276 33 0.772
regulation of primary metabolic process GO:0080090 311 0.743
Mouse Fly
oocyte differentiation GO:0009994 14 0.628
Fly
cellular aromatic compound metabolic process GO:0006725 295 0.591
meiotic cell cycle process GO:1903046 3 0.589
Mouse
meiosis ii GO:0007135 1 0.579
oogenesis GO:0048477 14 0.562
Mouse Fly
meiotic nuclear division GO:0007126 4 0.551
negative regulation of feeding behavior GO:2000252 2 0.549
oocyte maturation GO:0001556 4 0.536
Fly
meiosis i GO:0007127 1 0.533
Mouse
regulation of multicellular organismal development GO:2000026 223 0.525
Fly
multicellular organism reproduction GO:0032504 35 0.506
transcription dna templated GO:0006351 181 0.492
Fly
organic cyclic compound metabolic process GO:1901360 301 0.489
regulation of cellular metabolic process GO:0031323 320 0.471
Mouse Fly
regulation of programmed cell death GO:0043067 101 0.467
meiotic chromosome segregation GO:0045132 3 0.462
oocyte development GO:0048599 14 0.461
Fly
rna biosynthetic process GO:0032774 181 0.434
Fly
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.411
Zebrafish Mouse Fly
rna metabolic process GO:0016070 219 0.374
germ cell development GO:0007281 22 0.374
Zebrafish Mouse Fly
chromosome organization involved in meiosis GO:0070192 1 0.372
regulation of biosynthetic process GO:0009889 250 0.361
Mouse Fly
multi organism reproductive process GO:0044703 36 0.339
regulation of cellular protein metabolic process GO:0032268 52 0.334
Mouse
cellular macromolecule metabolic process GO:0044260 391 0.334
cellular component movement GO:0006928 335 0.322
aromatic compound biosynthetic process GO:0019438 217 0.314
Fly
nucleobase containing compound metabolic process GO:0006139 274 0.308
spermatid development GO:0007286 2 0.305
regulation of apoptotic process GO:0042981 98 0.300
regulation of cell death GO:0010941 103 0.295
regulation of transcription dna templated GO:0006355 213 0.293
Fly
single organism reproductive process GO:0044702 40 0.282
cellular biosynthetic process GO:0044249 286 0.264
Mouse Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.258
Fly
regulation of signaling GO:0023051 235 0.257
sexual reproduction GO:0019953 36 0.246
macromolecule biosynthetic process GO:0009059 227 0.245
Mouse Fly
dorsal ventral pattern formation GO:0009953 125 0.242
regulation of rna biosynthetic process GO:2001141 213 0.241
Fly
regulation of metabolic process GO:0019222 359 0.236
multicellular organism growth GO:0035264 4 0.236
cellular nitrogen compound metabolic process GO:0034641 290 0.226
programmed cell death GO:0012501 119 0.218
negative regulation of biological process GO:0048519 304 0.208
chemical homeostasis GO:0048878 49 0.191
cell surface receptor signaling pathway GO:0007166 325 0.190
anion transport GO:0006820 38 0.188
death GO:0016265 121 0.184
regulation of biological quality GO:0065008 263 0.180
organic substance biosynthetic process GO:1901576 289 0.176
Mouse Fly
regulation of gene expression GO:0010468 265 0.175
regionalization GO:0003002 274 0.174
Fly
organelle fission GO:0048285 23 0.173
growth GO:0040007 174 0.172
multi organism process GO:0051704 134 0.170
homeostatic process GO:0042592 142 0.169
immune system process GO:0002376 241 0.168
Fly
reproductive process GO:0022414 40 0.166
neuron differentiation GO:0030182 353 0.164
negative regulation of cellular process GO:0048523 283 0.160
regulation of cellular biosynthetic process GO:0031326 245 0.157
Mouse Fly
regulation of response to stimulus GO:0048583 269 0.152
nucleic acid metabolic process GO:0090304 244 0.151
ear development GO:0043583 127 0.147
nitrogen compound metabolic process GO:0006807 319 0.146
positive regulation of cellular process GO:0048522 201 0.140
Mouse Fly
developmental maturation GO:0021700 34 0.137
Fly
positive regulation of metabolic process GO:0009893 108 0.134
female gamete generation GO:0007292 14 0.132
Mouse Fly
central nervous system development GO:0007417 387 0.130
cytoplasm organization GO:0007028 4 0.127
Fly
male meiosis GO:0007140 2 0.125
response to abiotic stimulus GO:0009628 122 0.123
oocyte axis specification GO:0007309 5 0.122
Fly
immune system development GO:0002520 191 0.117
single organism transport GO:0044765 206 0.116
regulation of macromolecule metabolic process GO:0060255 317 0.115
spermatogenesis GO:0007283 7 0.113
Mouse Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.112
Mouse Fly
head development GO:0060322 303 0.111
regulation of oocyte development GO:0060281 3 0.109
Fly
convergent extension GO:0060026 118 0.109
reproduction GO:0000003 40 0.107
regulation of nitrogen compound metabolic process GO:0051171 251 0.102
Fly
cellular response to organic substance GO:0071310 105 0.101
cellular nitrogen compound biosynthetic process GO:0044271 218 0.101
Fly
endodermal cell fate determination GO:0007493 2 0.101
negative regulation of apoptotic process GO:0043066 55 0.099
negative regulation of cell death GO:0060548 60 0.099
regulation of embryonic development GO:0045995 47 0.096
Fly
embryonic organ morphogenesis GO:0048562 274 0.093
neuron projection development GO:0031175 180 0.093
digestive tract development GO:0048565 265 0.092
response to chemical GO:0042221 320 0.091
rna localization GO:0006403 4 0.089
Fly
anterior posterior axis specification GO:0009948 20 0.088
Fly
digestive system development GO:0055123 289 0.088
apoptotic process GO:0006915 116 0.087
oocyte construction GO:0007308 5 0.086
Fly
establishment of localization GO:0051234 244 0.086
negative regulation of programmed cell death GO:0043069 58 0.085
regulation of response to oxidative stress GO:1902882 2 0.085
chromosome organization GO:0051276 31 0.084
Fly
sensory organ development GO:0007423 393 0.084
ameboidal type cell migration GO:0001667 143 0.084
spermatid differentiation GO:0048515 2 0.083
embryonic pattern specification GO:0009880 44 0.083
Fly
development of primary female sexual characteristics GO:0046545 4 0.083
heterocycle metabolic process GO:0046483 290 0.081
hematopoietic or lymphoid organ development GO:0048534 191 0.080
negative regulation of cell cycle GO:0045786 14 0.080
cellular component assembly GO:0022607 170 0.079
cell motility GO:0048870 244 0.078
cell cycle GO:0007049 93 0.074
rhythmic process GO:0048511 21 0.073
organic cyclic compound biosynthetic process GO:1901362 223 0.071
Fly
regulation of reproductive process GO:2000241 4 0.070
Fly
spemann organizer formation GO:0060061 10 0.069
mitotic cell cycle GO:0000278 64 0.068
Fly
multicellular organismal reproductive process GO:0048609 35 0.067
tissue remodeling GO:0048771 4 0.067
regulation of protein metabolic process GO:0051246 56 0.066
Mouse
regulation of multicellular organismal process GO:0051239 277 0.066
Fly
maternal determination of anterior posterior axis embryo GO:0008358 4 0.065
Fly
regulation of cell communication GO:0010646 232 0.065
nucleic acid templated transcription GO:0097659 181 0.064
Fly
developmental growth GO:0048589 166 0.064
regulation of response to extracellular stimulus GO:0032104 1 0.063
larval development GO:0002164 2 0.063
negative regulation of mesodermal cell fate specification GO:0042662 3 0.063
cell projection organization GO:0030030 284 0.062
female sex differentiation GO:0046660 4 0.061
cellular macromolecule biosynthetic process GO:0034645 224 0.061
Mouse Fly
cellular response to chemical stimulus GO:0070887 157 0.059
developmental growth involved in morphogenesis GO:0060560 86 0.057
cell growth GO:0016049 57 0.057
cell maturation GO:0048469 23 0.056
Fly
segmentation GO:0035282 97 0.055
Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.053
Fly
positive regulation of cellular biosynthetic process GO:0031328 68 0.052
Mouse
response to stress GO:0006950 263 0.049
Fly
inner ear development GO:0048839 126 0.049
sister chromatid cohesion GO:0007062 2 0.048
response to endogenous stimulus GO:0009719 83 0.048
cellular response to drug GO:0035690 1 0.047
regulation of chromosome segregation GO:0051983 1 0.046
single organism organelle organization GO:1902589 199 0.046
Mouse Fly
positive regulation of cell division GO:0051781 2 0.046
Mouse
nuclear division GO:0000280 23 0.046
anterior posterior pattern specification GO:0009952 152 0.046
Fly
macromolecular complex subunit organization GO:0043933 74 0.046
cell type specific apoptotic process GO:0097285 22 0.045
smad protein complex assembly GO:0007183 1 0.045
response to organic substance GO:0010033 153 0.044
negative regulation of gene expression GO:0010629 65 0.044
Zebrafish Mouse Fly
transport GO:0006810 220 0.043
generation of neurons GO:0048699 385 0.043
heterocycle biosynthetic process GO:0018130 215 0.043
Fly
bmp signaling pathway involved in heart jogging GO:0003303 14 0.043
regulation of cell maturation GO:1903429 1 0.043
Fly
negative regulation of signal transduction GO:0009968 94 0.041
anterior posterior axis specification embryo GO:0008595 5 0.040
Fly
cell cycle process GO:0022402 53 0.040
Mouse Fly
dna metabolic process GO:0006259 27 0.040
Mouse Fly
response to nitrogen compound GO:1901698 19 0.040
regulation of dna replication GO:0006275 3 0.039
posttranscriptional gene silencing GO:0016441 3 0.039
Fly
cell death GO:0008219 121 0.039
negative regulation of mesoderm development GO:2000381 5 0.039
female meiotic division GO:0007143 2 0.038
germ line stem cell division GO:0042078 1 0.038
Fly
convergent extension involved in gastrulation GO:0060027 71 0.038
locomotion GO:0040011 313 0.038
tube morphogenesis GO:0035239 349 0.038
cell morphogenesis involved in differentiation GO:0000904 195 0.037
single organism cellular localization GO:1902580 46 0.037
Fly
mitotic cell cycle process GO:1903047 48 0.037
Fly
negative regulation of cellular metabolic process GO:0031324 77 0.037
Fly
female gonad development GO:0008585 4 0.036
cellular response to hormone stimulus GO:0032870 39 0.036
cellular response to hypoxia GO:0071456 1 0.036
regulation of autophagy GO:0010506 3 0.035
cellular localization GO:0051641 97 0.035
Fly
intracellular mrna localization GO:0008298 1 0.035
Fly
positive regulation of cell communication GO:0010647 56 0.034
regulation of cell differentiation GO:0045595 142 0.034
regulation of cell growth GO:0001558 29 0.034
negative regulation of protein complex assembly GO:0031333 1 0.033
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.033
Mouse Fly
regulation of anatomical structure size GO:0090066 33 0.032
positive regulation of map kinase activity GO:0043406 3 0.031
response to drug GO:0042493 3 0.031
synaptic transmission GO:0007268 35 0.031
positive regulation of mrna metabolic process GO:1903313 2 0.030
Fly
enzyme linked receptor protein signaling pathway GO:0007167 106 0.030
embryonic cranial skeleton morphogenesis GO:0048701 90 0.030
urogenital system development GO:0001655 97 0.029
neuron remodeling GO:0016322 1 0.029
aging GO:0007568 2 0.029
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.029
cell migration GO:0016477 237 0.028
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.028
embryonic axis specification GO:0000578 12 0.027
Fly
cell cycle g1 s phase transition GO:0044843 1 0.027
activation of mapk activity GO:0000187 3 0.027
maintenance of location GO:0051235 4 0.027
negative regulation of reproductive process GO:2000242 3 0.026
regulation of neuron differentiation GO:0045664 56 0.026
axon extension GO:0048675 45 0.026
ion homeostasis GO:0050801 41 0.026
regulation of membrane potential GO:0042391 23 0.026
neuron development GO:0048666 262 0.025
organelle organization GO:0006996 227 0.025
negative regulation of metabolic process GO:0009892 86 0.025
Zebrafish Mouse Fly
otic placode formation GO:0043049 23 0.025
response to organic cyclic compound GO:0014070 51 0.025
regulation of developmental process GO:0050793 247 0.025
gastrulation GO:0007369 208 0.025
response to hormone GO:0009725 48 0.025
determination of heart left right asymmetry GO:0061371 117 0.025
positive regulation of cell cycle GO:0045787 3 0.024
Mouse
sensory organ morphogenesis GO:0090596 200 0.024
regulation of multicellular organism growth GO:0040014 4 0.024
embryonic organ development GO:0048568 381 0.024
camera type eye development GO:0043010 222 0.024
posttranscriptional regulation of gene expression GO:0010608 14 0.024
Mouse Fly
axial mesoderm formation GO:0048320 4 0.023
cellular component biogenesis GO:0044085 178 0.023
regulation of mesoderm development GO:2000380 11 0.023
female meiosis chromosome segregation GO:0016321 1 0.023
regulation of rna metabolic process GO:0051252 224 0.023
Fly
meiotic spindle organization GO:0000212 1 0.023
cellular response to decreased oxygen levels GO:0036294 1 0.023
angiogenesis GO:0001525 158 0.023
positive regulation of cellular catabolic process GO:0031331 3 0.023
Fly
tripartite regional subdivision GO:0007351 5 0.023
Fly
fin regeneration GO:0031101 51 0.023
eye morphogenesis GO:0048592 144 0.022
cell morphogenesis GO:0000902 289 0.022
biosynthetic process GO:0009058 294 0.022
Mouse Fly
positive regulation of catabolic process GO:0009896 4 0.022
Fly
connective tissue development GO:0061448 99 0.022
bmp signaling pathway involved in heart development GO:0061312 15 0.022
developmental process involved in reproduction GO:0003006 27 0.021
Zebrafish Mouse Fly
retina homeostasis GO:0001895 12 0.021
cell projection morphogenesis GO:0048858 244 0.021
positive regulation of transport GO:0051050 2 0.021
bone remodeling GO:0046849 2 0.021
localization of cell GO:0051674 244 0.021
oligodendrocyte differentiation GO:0048709 23 0.020
dna templated transcription initiation GO:0006352 1 0.020
positive regulation of cellular protein metabolic process GO:0032270 22 0.020
Mouse
convergent extension involved in organogenesis GO:0060029 10 0.020
gliogenesis GO:0042063 45 0.020
regulation of neuron death GO:1901214 18 0.020
synapsis GO:0007129 1 0.020
regulation of developmental growth GO:0048638 38 0.020
mesenchyme development GO:0060485 127 0.019
regulation of nodal signaling pathway GO:1900107 4 0.019
specification of organ identity GO:0010092 2 0.019
regulation of mrna catabolic process GO:0061013 3 0.019
Fly
axon development GO:0061564 166 0.019
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.019
cellular component morphogenesis GO:0032989 336 0.018
Fly
negative regulation of signaling GO:0023057 96 0.018
ion transport GO:0006811 114 0.018
morphogenesis of an epithelium GO:0002009 333 0.018
cell cell signaling GO:0007267 52 0.018
developmental cell growth GO:0048588 52 0.018
bmp signaling pathway GO:0030509 52 0.018
skeletal system development GO:0001501 181 0.018
determination of bilateral symmetry GO:0009855 204 0.018
protein complex subunit organization GO:0071822 46 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.018
Fly
regulation of developmental pigmentation GO:0048070 6 0.018
negative regulation of developmental process GO:0051093 65 0.018
stem cell maintenance GO:0019827 4 0.017
macromolecule modification GO:0043412 111 0.017
Mouse
mesoderm development GO:0007498 88 0.017
regulation of cellular component organization GO:0051128 86 0.017
regulation of molecular function GO:0065009 70 0.017
protein complex assembly GO:0006461 30 0.017
determination of left right symmetry GO:0007368 179 0.017
camera type eye morphogenesis GO:0048593 108 0.017
cell proliferation GO:0008283 80 0.017
pancreas development GO:0031016 84 0.017
blastoderm segmentation GO:0007350 6 0.017
Fly
cellular protein modification process GO:0006464 100 0.017
adult behavior GO:0030534 2 0.017
heterocycle catabolic process GO:0046700 15 0.017
Fly
regulation of tube size GO:0035150 2 0.017
organ growth GO:0035265 12 0.017
response to temperature stimulus GO:0009266 15 0.016
regulation of protein phosphorylation GO:0001932 18 0.016
regulation of circadian rhythm GO:0042752 4 0.016
regulation of cell cycle GO:0051726 52 0.016
Mouse
cellular response to stress GO:0033554 62 0.016
regulation of meiotic cell cycle GO:0051445 1 0.016
Mouse
astrocyte differentiation GO:0048708 1 0.016
negative regulation of oocyte development GO:0060283 2 0.016
positive regulation of cell death GO:0010942 29 0.016
regulation of gene expression epigenetic GO:0040029 11 0.015
Mouse Fly
g1 s transition of mitotic cell cycle GO:0000082 1 0.015
cell cycle phase transition GO:0044770 9 0.015
neuron death GO:0070997 21 0.015
negative regulation of response to stimulus GO:0048585 104 0.015
positive regulation of macromolecule metabolic process GO:0010604 93 0.015
glucose homeostasis GO:0042593 1 0.014
catabolic process GO:0009056 32 0.014
Fly
gene expression GO:0010467 252 0.014
organonitrogen compound metabolic process GO:1901564 74 0.014
regulation of endodermal cell fate specification GO:0042663 15 0.014
brain development GO:0007420 293 0.014
transcription from rna polymerase ii promoter GO:0006366 80 0.014
negative regulation of cellular biosynthetic process GO:0031327 55 0.014
Fly
positive regulation of rna metabolic process GO:0051254 59 0.014
Fly
regulation of metal ion transport GO:0010959 4 0.014
regulation of signal transduction GO:0009966 225 0.014
chordate embryonic development GO:0043009 271 0.014
regulation of dna metabolic process GO:0051052 11 0.014
Fly
negative regulation of cellular protein metabolic process GO:0032269 16 0.014
regulation of mitotic cell cycle GO:0007346 25 0.014
positive regulation of biosynthetic process GO:0009891 68 0.014
Mouse
regulation of catalytic activity GO:0050790 55 0.014
positive regulation of lipid metabolic process GO:0045834 1 0.014
positive regulation of biological process GO:0048518 253 0.013
ion transmembrane transport GO:0034220 91 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.013
Fly
hemopoiesis GO:0030097 183 0.013
single organism localization GO:1902578 225 0.013
Fly
regulation of microtubule based movement GO:0060632 3 0.013
reciprocal dna recombination GO:0035825 1 0.013
regulation of protein complex assembly GO:0043254 3 0.012
protein modification process GO:0036211 100 0.012
neuron apoptotic process GO:0051402 20 0.012
peptidyl lysine methylation GO:0018022 3 0.012
determination of left right asymmetry in diencephalon GO:0035462 4 0.012
transmembrane transport GO:0055085 120 0.012
regulation of intracellular protein transport GO:0033157 3 0.012
epithelial cilium movement involved in determination of left right asymmetry GO:0060287 8 0.012
kupffer s vesicle development GO:0070121 50 0.012
regulation of synapse organization GO:0050807 3 0.012
response to hypoxia GO:0001666 25 0.012
cell migration involved in heart development GO:0060973 22 0.012
positive regulation of protein kinase b signaling GO:0051897 1 0.011
cell part morphogenesis GO:0032990 246 0.011
small molecule metabolic process GO:0044281 77 0.011
ectodermal placode morphogenesis GO:0071697 32 0.011
positive regulation of programmed cell death GO:0043068 29 0.011
specification of organ position GO:0010159 3 0.011
organelle localization GO:0051640 49 0.011
g2 m transition of mitotic cell cycle GO:0000086 4 0.011
axis specification GO:0009798 43 0.011
Fly
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.011
Fly
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
inner ear morphogenesis GO:0042472 63 0.011
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.011
alternative mrna splicing via spliceosome GO:0000380 1 0.011
cytokinesis GO:0000910 3 0.011
synaptic vesicle transport GO:0048489 1 0.011
cognition GO:0050890 1 0.011
renal system development GO:0072001 94 0.011
positive regulation of gene expression GO:0010628 71 0.011
regeneration GO:0031099 91 0.010
digestive tract morphogenesis GO:0048546 231 0.010
regulation of cellular component movement GO:0051270 55 0.010
protein metabolic process GO:0019538 183 0.010
Mouse
nucleoside monophosphate catabolic process GO:0009125 4 0.010
determination of left right asymmetry in nervous system GO:0035545 4 0.010
determination of dorsal ventral asymmetry GO:0048262 34 0.010
pronephros development GO:0048793 69 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.010
Fly
organic cyclic compound catabolic process GO:1901361 15 0.010
Fly
hard palate development GO:0060022 4 0.010
male gamete generation GO:0048232 7 0.010
Mouse Fly
glial cell differentiation GO:0010001 42 0.010
specification of symmetry GO:0009799 204 0.010

piwil2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.045
nervous system disease DOID:863 0 0.027
disease of cellular proliferation DOID:14566 0 0.022
osteochondrodysplasia DOID:2256 0 0.015
bone development disease DOID:0080006 0 0.015
bone disease DOID:0080001 0 0.015
musculoskeletal system disease DOID:17 0 0.015
connective tissue disease DOID:65 0 0.015