Danio rerio

81 known processes

ptf1a

pancreas specific transcription factor, 1a

(Aliases: MGC112216,PTF1,si:zc142h2.2,zgc:112216)

ptf1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
generation of neurons GO:0048699 385 0.986
Zebrafish Mouse
posterior lateral line neuromast hair cell differentiation GO:0048923 8 0.982
Zebrafish
aromatic compound biosynthetic process GO:0019438 217 0.981
nucleic acid metabolic process GO:0090304 244 0.980
polarized epithelial cell differentiation GO:0030859 4 0.972
Zebrafish
sensory organ development GO:0007423 393 0.969
Zebrafish Mouse
regulation of rna metabolic process GO:0051252 224 0.966
endocardium morphogenesis GO:0003160 4 0.964
Zebrafish
neuron differentiation GO:0030182 353 0.963
Zebrafish Mouse
endocardium development GO:0003157 9 0.963
Zebrafish
camera type eye morphogenesis GO:0048593 108 0.961
Zebrafish Mouse
cardiogenic plate morphogenesis GO:0003142 1 0.944
Zebrafish
photoreceptor cell differentiation GO:0046530 55 0.939
auditory receptor cell fate determination GO:0042668 2 0.937
Zebrafish
gastrulation GO:0007369 208 0.936
Zebrafish
regulation of nucleic acid templated transcription GO:1903506 213 0.930
hindbrain development GO:0030902 91 0.928
Human Zebrafish Mouse
regulation of multicellular organismal process GO:0051239 277 0.927
Zebrafish Mouse
stem cell differentiation GO:0048863 117 0.926
Zebrafish
neuron fate determination GO:0048664 2 0.920
Zebrafish
cellular component morphogenesis GO:0032989 336 0.919
cellular macromolecule biosynthetic process GO:0034645 224 0.919
inner ear receptor cell development GO:0060119 20 0.919
Zebrafish
photoreceptor cell development GO:0042461 40 0.914
regionalization GO:0003002 274 0.908
regulation of developmental process GO:0050793 247 0.899
Zebrafish Mouse
negative regulation of neurogenesis GO:0050768 20 0.895
Zebrafish
positive regulation of transcription dna templated GO:0045893 57 0.893
central nervous system development GO:0007417 387 0.889
Human Zebrafish Mouse
posterior lateral line system development GO:0048915 46 0.886
Zebrafish
endocardium formation GO:0060214 1 0.886
Zebrafish
retina layer formation GO:0010842 24 0.885
Zebrafish Mouse
retina morphogenesis in camera type eye GO:0060042 79 0.885
Zebrafish Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.885
cellular aromatic compound metabolic process GO:0006725 295 0.873
regulation of cell differentiation GO:0045595 142 0.873
Zebrafish
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.871
regulation of endothelial cell differentiation GO:0045601 3 0.869
Zebrafish
retina development in camera type eye GO:0060041 146 0.864
Zebrafish Mouse
regulation of gene expression GO:0010468 265 0.864
regulation of primary metabolic process GO:0080090 311 0.859
pancreas development GO:0031016 84 0.856
heterocycle biosynthetic process GO:0018130 215 0.853
regulation of macromolecule metabolic process GO:0060255 317 0.842
regulation of rna biosynthetic process GO:2001141 213 0.841
positive regulation of epithelial cell differentiation GO:0030858 2 0.835
Zebrafish
regulation of neurogenesis GO:0050767 87 0.835
Zebrafish
eye development GO:0001654 277 0.834
Zebrafish Mouse
embryonic heart tube formation GO:0003144 1 0.831
Zebrafish
chordate embryonic development GO:0043009 271 0.811
Zebrafish
endocrine system development GO:0035270 65 0.803
Zebrafish
mechanosensory lateral line system development GO:0048881 49 0.798
Zebrafish
hindbrain morphogenesis GO:0021575 22 0.787
Zebrafish
rna biosynthetic process GO:0032774 181 0.786
camera type eye development GO:0043010 222 0.781
Zebrafish Mouse
organic cyclic compound metabolic process GO:1901360 301 0.781
digestive system development GO:0055123 289 0.776
organic substance biosynthetic process GO:1901576 289 0.774
epidermal cell differentiation GO:0009913 36 0.768
Zebrafish
organic cyclic compound biosynthetic process GO:1901362 223 0.765
tube morphogenesis GO:0035239 349 0.761
Zebrafish
response to wounding GO:0009611 116 0.757
Zebrafish
nucleic acid templated transcription GO:0097659 181 0.757
digestive tract morphogenesis GO:0048546 231 0.754
Zebrafish
head development GO:0060322 303 0.748
Human Zebrafish Mouse
posterior lateral line development GO:0048916 38 0.744
Zebrafish
determination of intestine left right asymmetry GO:0071908 2 0.729
Zebrafish
mechanoreceptor differentiation GO:0042490 37 0.726
Zebrafish
skin development GO:0043588 54 0.723
Zebrafish
positive regulation of nucleic acid templated transcription GO:1903508 57 0.712
regulation of nervous system development GO:0051960 90 0.708
Zebrafish
nucleobase containing compound biosynthetic process GO:0034654 205 0.705
neuron development GO:0048666 262 0.699
Zebrafish
cardiocyte differentiation GO:0035051 44 0.698
Zebrafish
cell morphogenesis GO:0000902 289 0.697
digestive tract development GO:0048565 265 0.695
Zebrafish
brain development GO:0007420 293 0.690
Human Zebrafish Mouse
cell projection organization GO:0030030 284 0.690
Zebrafish
axonogenesis GO:0007409 152 0.689
regulation of macromolecule biosynthetic process GO:0010556 225 0.686
pectoral fin development GO:0033339 50 0.683
Zebrafish
nerve development GO:0021675 45 0.683
Zebrafish
cellular biosynthetic process GO:0044249 286 0.682
regulation of transcription dna templated GO:0006355 213 0.662
determination of digestive tract left right asymmetry GO:0071907 10 0.661
Zebrafish
negative regulation of nervous system development GO:0051961 22 0.656
Zebrafish
inner ear development GO:0048839 126 0.655
Zebrafish
neural retina development GO:0003407 49 0.654
Zebrafish Mouse
posterior lateral line nerve development GO:0048918 8 0.650
Zebrafish
neuron projection regeneration GO:0031102 16 0.646
Zebrafish
posterior lateral line neuromast development GO:0048919 20 0.634
Zebrafish
hematopoietic stem cell differentiation GO:0060218 20 0.631
Zebrafish
biosynthetic process GO:0009058 294 0.630
regulation of anatomical structure morphogenesis GO:0022603 130 0.626
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.626
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.625
positive regulation of endothelial cell differentiation GO:0045603 2 0.618
Zebrafish
regulation of biosynthetic process GO:0009889 250 0.608
photoreceptor cell fate commitment GO:0046552 1 0.608
neuron projection development GO:0031175 180 0.606
Zebrafish
negative regulation of multicellular organismal process GO:0051241 69 0.602
Zebrafish
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.588
Mouse
locomotion GO:0040011 313 0.586
Worm
eye morphogenesis GO:0048592 144 0.582
Zebrafish Mouse
regeneration GO:0031099 91 0.575
Zebrafish
anterior lateral line system development GO:0048898 9 0.564
Zebrafish
regulation of programmed cell death GO:0043067 101 0.554
developmental programmed cell death GO:0010623 4 0.547
regulation of multicellular organismal development GO:2000026 223 0.534
Zebrafish Mouse
regulation of metabolic process GO:0019222 359 0.532
negative regulation of cellular process GO:0048523 283 0.530
Zebrafish
gene expression GO:0010467 252 0.521
regulation of cellular metabolic process GO:0031323 320 0.517
embryonic heart tube development GO:0035050 133 0.512
Zebrafish
regulation of nitrogen compound metabolic process GO:0051171 251 0.505
apoptotic process involved in development GO:1902742 2 0.501
positive regulation of nervous system development GO:0051962 25 0.499
Zebrafish
axon development GO:0061564 166 0.498
Zebrafish
cellular nitrogen compound metabolic process GO:0034641 290 0.491
transcription from rna polymerase ii promoter GO:0006366 80 0.488
Mouse
skeletal system development GO:0001501 181 0.485
Zebrafish
neuromast hair cell development GO:0035675 6 0.485
Zebrafish
olfactory bulb development GO:0021772 4 0.481
Zebrafish
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.476
regulation of cellular biosynthetic process GO:0031326 245 0.474
macromolecule biosynthetic process GO:0009059 227 0.468
eye photoreceptor cell development GO:0042462 30 0.464
auditory receptor cell fate commitment GO:0009912 4 0.455
Zebrafish
embryonic pattern specification GO:0009880 44 0.446
neuron fate commitment GO:0048663 26 0.445
Zebrafish Mouse
hematopoietic progenitor cell differentiation GO:0002244 23 0.441
Zebrafish
apoptotic process GO:0006915 116 0.435
central nervous system neuron differentiation GO:0021953 74 0.431
Zebrafish
neuron projection morphogenesis GO:0048812 161 0.428
heterocycle metabolic process GO:0046483 290 0.424
death GO:0016265 121 0.403
anterior lateral line nerve development GO:0048909 4 0.400
Zebrafish
exocrine pancreas development GO:0031017 28 0.397
positive regulation of rna biosynthetic process GO:1902680 57 0.395
glial cell migration GO:0008347 3 0.393
epithelial tube formation GO:0072175 19 0.392
Zebrafish
pharyngeal muscle development GO:0043282 4 0.388
telencephalon development GO:0021537 14 0.387
Zebrafish
heart development GO:0007507 313 0.386
Zebrafish
positive regulation of cellular biosynthetic process GO:0031328 68 0.385
lateral line nerve development GO:0048892 9 0.385
Zebrafish
hematopoietic or lymphoid organ development GO:0048534 191 0.384
Zebrafish
endothelium development GO:0003158 25 0.384
Zebrafish
regulation of cell death GO:0010941 103 0.382
mesoderm development GO:0007498 88 0.377
Zebrafish
positive regulation of rna metabolic process GO:0051254 59 0.377
neuromast development GO:0048884 46 0.371
Zebrafish
cellular macromolecule metabolic process GO:0044260 391 0.358
rna metabolic process GO:0016070 219 0.355
cell morphogenesis involved in differentiation GO:0000904 195 0.353
positive regulation of biosynthetic process GO:0009891 68 0.348
metencephalon development GO:0022037 27 0.347
Human Mouse
proepicardium development GO:0003342 4 0.346
Zebrafish
locomotory behavior GO:0007626 34 0.345
Zebrafish
positive regulation of gene expression GO:0010628 71 0.344
cell projection morphogenesis GO:0048858 244 0.322
endocrine pancreas development GO:0031018 27 0.320
Zebrafish
nitrogen compound metabolic process GO:0006807 319 0.317
positive regulation of neurogenesis GO:0050769 24 0.315
Zebrafish
negative regulation of transcription dna templated GO:0045892 45 0.307
erythrocyte development GO:0048821 24 0.301
Zebrafish
tissue regeneration GO:0042246 74 0.297
lateral line system development GO:0048925 76 0.291
Zebrafish
apoptotic process involved in morphogenesis GO:0060561 2 0.288
artery development GO:0060840 22 0.287
Zebrafish
regulation of axonogenesis GO:0050770 32 0.287
neuron projection guidance GO:0097485 86 0.281
somitogenesis GO:0001756 87 0.280
hair cell differentiation GO:0035315 32 0.274
Zebrafish
epidermis development GO:0008544 48 0.273
Zebrafish
negative regulation of developmental process GO:0051093 65 0.271
Zebrafish
positive regulation of macromolecule metabolic process GO:0010604 93 0.270
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.269
embryonic viscerocranium morphogenesis GO:0048703 52 0.267
Zebrafish
appendage development GO:0048736 80 0.267
Zebrafish
olfactory placode development GO:0071698 12 0.266
Zebrafish
behavior GO:0007610 74 0.259
Zebrafish
gland development GO:0048732 143 0.257
Zebrafish
positive regulation of metabolic process GO:0009893 108 0.256
eye photoreceptor cell differentiation GO:0001754 45 0.254
axon regeneration GO:0031103 14 0.252
Zebrafish
axon guidance GO:0007411 86 0.251
exocrine system development GO:0035272 28 0.250
negative regulation of biological process GO:0048519 304 0.250
Zebrafish
regulation of neuron differentiation GO:0045664 56 0.249
artery morphogenesis GO:0048844 14 0.242
Zebrafish
neuromast hair cell differentiation GO:0048886 12 0.240
Zebrafish
ventral spinal cord interneuron fate commitment GO:0060579 3 0.238
cellular component movement GO:0006928 335 0.237
negative regulation of nucleic acid templated transcription GO:1903507 45 0.235
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.233
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.231
ear development GO:0043583 127 0.230
Zebrafish
response to chemical GO:0042221 320 0.221
Worm
nucleobase containing compound metabolic process GO:0006139 274 0.219
negative regulation of apoptotic process GO:0043066 55 0.217
negative regulation of programmed cell death GO:0043069 58 0.216
glial cell differentiation GO:0010001 42 0.214
regulation of apoptotic process GO:0042981 98 0.212
regulation of mechanoreceptor differentiation GO:0045631 1 0.211
olfactory lobe development GO:0021988 4 0.210
Zebrafish
cell surface receptor signaling pathway GO:0007166 325 0.209
Worm
regulation of protein binding GO:0043393 3 0.202
epithelial cell differentiation GO:0030855 116 0.201
Zebrafish
hemopoiesis GO:0030097 183 0.200
Zebrafish
negative regulation of cellular biosynthetic process GO:0031327 55 0.198
morphogenesis of embryonic epithelium GO:0016331 30 0.198
Zebrafish
neuroblast differentiation GO:0014016 1 0.197
response to external stimulus GO:0009605 264 0.196
regulation of cell communication GO:0010646 232 0.194
segmentation GO:0035282 97 0.192
embryonic organ morphogenesis GO:0048562 274 0.191
Zebrafish
neurological system process GO:0050877 62 0.188
negative regulation of gene expression GO:0010629 65 0.187
formation of anatomical boundary GO:0048859 14 0.183
stem cell maintenance GO:0019827 4 0.182
rhombomere formation GO:0021594 12 0.181
negative regulation of cell development GO:0010721 26 0.180
Zebrafish
cell differentiation in spinal cord GO:0021515 40 0.180
heart morphogenesis GO:0003007 156 0.180
Zebrafish
cell part morphogenesis GO:0032990 246 0.175
cranial nerve development GO:0021545 42 0.174
Zebrafish
response to stress GO:0006950 263 0.174
Zebrafish Worm
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.172
neural tube patterning GO:0021532 33 0.170
neuron recognition GO:0008038 18 0.169
Zebrafish
positive regulation of cellular metabolic process GO:0031325 94 0.168
cell death GO:0008219 121 0.168
response to oxidative stress GO:0006979 11 0.167
Worm
myeloid cell differentiation GO:0030099 86 0.165
Zebrafish
response to axon injury GO:0048678 14 0.163
Zebrafish
programmed cell death GO:0012501 119 0.162
negative regulation of rna metabolic process GO:0051253 48 0.162
epithelial cell morphogenesis GO:0003382 2 0.162
positive regulation of cell development GO:0010720 25 0.162
Zebrafish
anion transmembrane transport GO:0098656 12 0.161
rostrocaudal neural tube patterning GO:0021903 29 0.161
neuroblast fate determination GO:0007400 1 0.160
embryo development ending in birth or egg hatching GO:0009792 271 0.158
Zebrafish Worm
pancreatic a cell development GO:0003322 2 0.157
positive regulation of cell differentiation GO:0045597 30 0.157
Zebrafish
embryonic appendage morphogenesis GO:0035113 30 0.156
Zebrafish
negative regulation of peptidase activity GO:0010466 10 0.156
sensory organ morphogenesis GO:0090596 200 0.155
Zebrafish Mouse
forebrain development GO:0030900 96 0.150
Zebrafish
midbrain hindbrain boundary development GO:0030917 23 0.150
negative regulation of rna biosynthetic process GO:1902679 45 0.150
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.150
Mouse
mesenchyme development GO:0060485 127 0.147
Zebrafish
ectodermal placode development GO:0071696 37 0.145
Zebrafish
glucose homeostasis GO:0042593 1 0.145
morphogenesis of an epithelium GO:0002009 333 0.143
Zebrafish
response to light stimulus GO:0009416 46 0.139
sensory perception of sound GO:0007605 9 0.136
blood vessel morphogenesis GO:0048514 216 0.135
Zebrafish
peripheral nervous system neuron differentiation GO:0048934 28 0.135
Zebrafish
appendage morphogenesis GO:0035107 56 0.134
Zebrafish
erythrocyte homeostasis GO:0034101 55 0.131
Zebrafish
septum transversum development GO:0003343 4 0.130
Zebrafish
intracellular estrogen receptor signaling pathway GO:0030520 3 0.129
vasculogenesis GO:0001570 41 0.129
Zebrafish
cell motility GO:0048870 244 0.128
immune system process GO:0002376 241 0.127
Zebrafish
embryonic organ development GO:0048568 381 0.126
Zebrafish
neuromuscular process controlling balance GO:0050885 3 0.126
positive regulation of neuron differentiation GO:0045666 12 0.126
response to hydrogen peroxide GO:0042542 3 0.123
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.123
neuron fate specification GO:0048665 20 0.121
transcription dna templated GO:0006351 181 0.118
negative regulation of cell death GO:0060548 60 0.117
lateral line development GO:0048882 66 0.116
Zebrafish
auditory receptor cell differentiation GO:0042491 15 0.115
Zebrafish
endothelial cell differentiation GO:0045446 20 0.115
Zebrafish
mesoderm formation GO:0001707 43 0.115
Zebrafish
cell fate commitment GO:0045165 99 0.112
Zebrafish Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.112
embryonic hemopoiesis GO:0035162 53 0.111
Zebrafish
cardiac atrium development GO:0003230 4 0.110
signal transduction GO:0007165 455 0.110
Mouse Worm
stem cell proliferation GO:0072089 4 0.110
cell fate specification GO:0001708 68 0.108
stem cell fate determination GO:0048867 1 0.107
cell migration GO:0016477 237 0.107
response to oxygen containing compound GO:1901700 55 0.106
Worm
cell recognition GO:0008037 19 0.104
Zebrafish
central nervous system neuron development GO:0021954 29 0.103
Zebrafish
positive regulation of developmental process GO:0051094 50 0.103
Zebrafish
chemotaxis GO:0006935 104 0.103
somite specification GO:0001757 12 0.102
neural tube development GO:0021915 62 0.102
negative regulation of biosynthetic process GO:0009890 55 0.102
neuroblast fate commitment GO:0014017 1 0.101
anterior posterior pattern specification GO:0009952 152 0.100
formation of primary germ layer GO:0001704 62 0.099
Zebrafish
skeletal system morphogenesis GO:0048705 102 0.099
Zebrafish
regulation of neural precursor cell proliferation GO:2000177 3 0.097
immune system development GO:0002520 191 0.097
Zebrafish
ventral spinal cord interneuron differentiation GO:0021514 12 0.096
sensory system development GO:0048880 76 0.095
Zebrafish
gliogenesis GO:0042063 45 0.094
cognition GO:0050890 1 0.092
neural crest cell migration GO:0001755 42 0.091
positive regulation of biological process GO:0048518 253 0.089
adult behavior GO:0030534 2 0.089
forebrain neuron development GO:0021884 7 0.089
Zebrafish
positive regulation of cellular process GO:0048522 201 0.088
fin development GO:0033333 77 0.087
Zebrafish
taxis GO:0042330 109 0.087
cerebellum development GO:0021549 17 0.086
Human Mouse
regulation of cell development GO:0060284 100 0.086
Zebrafish
regulation of epithelial cell differentiation GO:0030856 7 0.085
Zebrafish
embryonic skeletal system morphogenesis GO:0048704 93 0.085
Zebrafish
regulation of embryonic development GO:0045995 47 0.084
fin morphogenesis GO:0033334 53 0.084
Zebrafish
growth GO:0040007 174 0.084
carbohydrate homeostasis GO:0033500 1 0.083
wound healing GO:0042060 90 0.081
negative regulation of endothelial cell migration GO:0010596 1 0.081
response to inorganic substance GO:0010035 38 0.080
positive regulation of neural precursor cell proliferation GO:2000179 1 0.079
lateral inhibition GO:0046331 1 0.078
regulation of organ morphogenesis GO:2000027 35 0.078
detection of chemical stimulus GO:0009593 4 0.078
cellular response to stress GO:0033554 62 0.077
Zebrafish
neural plate development GO:0001840 10 0.077
Zebrafish
intracellular receptor signaling pathway GO:0030522 30 0.076
Mouse
embryonic cranial skeleton morphogenesis GO:0048701 90 0.076
Zebrafish
neuroblast proliferation GO:0007405 2 0.075
thyroid gland development GO:0030878 12 0.075
Zebrafish
negative regulation of cell differentiation GO:0045596 46 0.074
Zebrafish
apoptotic signaling pathway GO:0097190 23 0.074
axon extension GO:0048675 45 0.074
negative regulation of endopeptidase activity GO:0010951 10 0.073
localization of cell GO:0051674 244 0.073
regulation of epidermis development GO:0045682 2 0.073
definitive hemopoiesis GO:0060216 18 0.072
Zebrafish
embryonic heart tube morphogenesis GO:0003143 108 0.071
Zebrafish
inner ear receptor cell fate commitment GO:0060120 4 0.070
Zebrafish
developmental growth GO:0048589 166 0.069
cell fate specification involved in pattern specification GO:0060573 3 0.069
intracellular signal transduction GO:0035556 85 0.069
erythrocyte differentiation GO:0030218 54 0.068
Zebrafish
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.068
positive regulation of multicellular organismal process GO:0051240 52 0.068
Zebrafish
peripheral nervous system neuron development GO:0048935 22 0.067
Zebrafish
rhombomere boundary formation GO:0021654 10 0.067
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.067
cellular amine metabolic process GO:0044106 2 0.065
defense response GO:0006952 47 0.064
epithelial tube morphogenesis GO:0060562 148 0.064
Zebrafish
inner ear receptor cell differentiation GO:0060113 29 0.064
Zebrafish
motor neuron axon guidance GO:0008045 23 0.064
tissue remodeling GO:0048771 4 0.064
regulation of growth GO:0040008 42 0.063
inner ear morphogenesis GO:0042472 63 0.063
regulation of synaptic plasticity GO:0048167 1 0.063
response to radiation GO:0009314 51 0.062
glial cell fate specification GO:0021780 4 0.061
single organism behavior GO:0044708 24 0.061
rhombomere development GO:0021546 19 0.061
cardiac atrium morphogenesis GO:0003209 2 0.060
regulation of signal transduction GO:0009966 225 0.060
myeloid cell development GO:0061515 32 0.060
Zebrafish
cardiac chamber formation GO:0003207 4 0.059
regulation of signaling GO:0023051 235 0.059
stem cell fate commitment GO:0048865 1 0.059
midbrain development GO:0030901 28 0.059
fin regeneration GO:0031101 51 0.059
regulation of heart growth GO:0060420 2 0.058
negative regulation of epithelial cell migration GO:0010633 1 0.057
specification of symmetry GO:0009799 204 0.057
Zebrafish
organelle organization GO:0006996 227 0.057
canonical wnt signaling pathway GO:0060070 48 0.057
cellular response to organic substance GO:0071310 105 0.056
Worm
establishment of localization in cell GO:0051649 77 0.055
oligodendrocyte cell fate specification GO:0021778 4 0.055
specification of organ identity GO:0010092 2 0.053
regulation of inner ear receptor cell differentiation GO:2000980 1 0.053
blood circulation GO:0008015 87 0.052
Zebrafish
aging GO:0007568 2 0.052
regulation of neuron projection development GO:0010975 40 0.052
cell fate commitment involved in pattern specification GO:0060581 6 0.051
regulation of stem cell proliferation GO:0072091 2 0.051
axonal fasciculation GO:0007413 11 0.051
Zebrafish
hemangioblast cell differentiation GO:0060217 5 0.051
Zebrafish
multicellular organism growth GO:0035264 4 0.050
regulation of response to stimulus GO:0048583 269 0.050
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.050
organ formation GO:0048645 17 0.050
regulation of photoreceptor cell differentiation GO:0046532 2 0.049
glial cell development GO:0021782 20 0.048
lateral mesoderm development GO:0048368 23 0.048
Zebrafish
muscle organ development GO:0007517 101 0.047
cardioblast differentiation GO:0010002 9 0.047
Zebrafish
lipid storage GO:0019915 1 0.046
reflex GO:0060004 2 0.046
response to other organism GO:0051707 97 0.046
liver development GO:0001889 96 0.046
transport GO:0006810 220 0.046
positive regulation of synapse assembly GO:0051965 1 0.046
negative regulation of neuron projection regeneration GO:0070571 4 0.045
neural precursor cell proliferation GO:0061351 20 0.045
embryonic skeletal system development GO:0048706 97 0.045
Zebrafish
innervation GO:0060384 3 0.044
hepaticobiliary system development GO:0061008 98 0.044
sensory perception of chemical stimulus GO:0007606 3 0.043
response to biotic stimulus GO:0009607 97 0.043
negative regulation of cellular metabolic process GO:0031324 77 0.042
synaptic growth at neuromuscular junction GO:0051124 2 0.042
negative regulation of response to stimulus GO:0048585 104 0.042
mechanosensory behavior GO:0007638 2 0.041
pronephros development GO:0048793 69 0.041
cell fate determination GO:0001709 7 0.041
Zebrafish
single organism biosynthetic process GO:0044711 71 0.041
positive regulation of cell cycle GO:0045787 3 0.039
primitive hemopoiesis GO:0060215 27 0.039
Zebrafish
striated muscle cell differentiation GO:0051146 129 0.039
regulation of axon extension GO:0030516 24 0.039
heart process GO:0003015 71 0.038
Zebrafish
pectoral fin morphogenesis GO:0035138 29 0.038
Zebrafish
cardiac muscle cell differentiation GO:0055007 30 0.038
rhombomere morphogenesis GO:0021593 17 0.038
oligodendrocyte differentiation GO:0048709 23 0.038
circadian rhythm GO:0007623 19 0.037
single organism localization GO:1902578 225 0.037
lens development in camera type eye GO:0002088 22 0.037
cellular response to reactive oxygen species GO:0034614 2 0.036
regulation of neuron migration GO:2001222 2 0.036
negative regulation of macromolecule metabolic process GO:0010605 76 0.036
larval development GO:0002164 2 0.036
Worm
positive regulation of cellular component biogenesis GO:0044089 3 0.036
neuron projection extension GO:1990138 45 0.036
positive regulation of embryonic development GO:0040019 3 0.036
mesoderm morphogenesis GO:0048332 51 0.035
Zebrafish
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 7 0.035
single organism organelle organization GO:1902589 199 0.035
somatic muscle development GO:0007525 4 0.034
retinal cone cell differentiation GO:0042670 12 0.034
determination of heart left right asymmetry GO:0061371 117 0.034
anterior commissure morphogenesis GO:0021960 3 0.034
brain segmentation GO:0035284 6 0.033
developmental cell growth GO:0048588 52 0.033
somatic stem cell maintenance GO:0035019 1 0.032
cellular component assembly GO:0022607 170 0.032
positive regulation of stem cell proliferation GO:2000648 1 0.032
response to carbohydrate GO:0009743 3 0.032
positive regulation of epithelial cell proliferation GO:0050679 1 0.032
monoamine transport GO:0015844 1 0.032
regulation of cell projection organization GO:0031344 44 0.032
negative regulation of signaling GO:0023057 96 0.032
regulation of hormone secretion GO:0046883 2 0.032
regulation of neural retina development GO:0061074 2 0.032
Mouse
regulation of biological quality GO:0065008 263 0.031
Zebrafish
regulation of binding GO:0051098 3 0.031
response to reactive oxygen species GO:0000302 5 0.031
negative regulation of protein maturation GO:1903318 10 0.030
response to endogenous stimulus GO:0009719 83 0.030
Worm
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.030
enzyme linked receptor protein signaling pathway GO:0007167 106 0.030
Worm
regulation of organ growth GO:0046620 3 0.030
tube formation GO:0035148 25 0.030
Zebrafish
retinal cell programmed cell death GO:0046666 2 0.030
nitrogen compound transport GO:0071705 23 0.030
heart contraction GO:0060047 71 0.030
Zebrafish
protein metabolic process GO:0019538 183 0.030
blood vessel development GO:0001568 246 0.029
Zebrafish
actin filament based process GO:0030029 64 0.029
regulation of glial cell differentiation GO:0045685 4 0.029
keratinocyte differentiation GO:0030216 0 0.029
establishment of localization GO:0051234 244 0.029
cellular ketone metabolic process GO:0042180 11 0.029
response to hexose GO:0009746 3 0.028
negative regulation of signal transduction GO:0009968 94 0.028
developmental maturation GO:0021700 34 0.028
single organism metabolic process GO:0044710 217 0.028
cell cycle GO:0007049 93 0.028
Zebrafish
response to lipid GO:0033993 60 0.028
muscle cell differentiation GO:0042692 139 0.028
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.028
homeostasis of number of cells GO:0048872 62 0.028
Zebrafish
cerebellum formation GO:0021588 2 0.028
cell maturation GO:0048469 23 0.028
wnt signaling pathway GO:0016055 80 0.028
epithelial cell development GO:0002064 42 0.028
homeostatic process GO:0042592 142 0.027
Zebrafish
anatomical structure arrangement GO:0048532 2 0.027
regulation of cell fate commitment GO:0010453 22 0.027

ptf1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.616
sensory system disease DOID:0050155 0 0.118
eye and adnexa disease DOID:1492 0 0.118
nervous system disease DOID:863 0 0.118
retinal disease DOID:5679 0 0.054
eye disease DOID:5614 0 0.054