Danio rerio

95 known processes

tal1

T-cell acute lymphocytic leukemia 1

(Aliases: tal-1,scl/tal1,scl,zgc:85605,SCL-alpha,SCL-beta)

tal1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
hemopoiesis GO:0030097 183 0.999
embryonic organ development GO:0048568 381 0.998
positive regulation of biological process GO:0048518 253 0.996
regulation of cellular metabolic process GO:0031323 320 0.996
Human Zebrafish Mouse
aorta development GO:0035904 4 0.995
central nervous system development GO:0007417 387 0.995
Zebrafish Mouse
vasculature development GO:0001944 278 0.993
heart development GO:0007507 313 0.993
regulation of erythrocyte differentiation GO:0045646 2 0.991
Human Mouse
positive regulation of neuron migration GO:2001224 2 0.988
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.988
Human Zebrafish Mouse
regulation of multicellular organismal development GO:2000026 223 0.987
negative regulation of biological process GO:0048519 304 0.987
Zebrafish Mouse
dorsal aorta morphogenesis GO:0035912 3 0.984
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.984
Human Zebrafish Mouse
tube morphogenesis GO:0035239 349 0.984
negative regulation of cellular process GO:0048523 283 0.984
Zebrafish Mouse
positive regulation of myeloid cell differentiation GO:0045639 2 0.983
Human Mouse
erythrocyte homeostasis GO:0034101 55 0.983
transcription from rna polymerase ii promoter GO:0006366 80 0.983
Human Mouse
nitrogen compound metabolic process GO:0006807 319 0.982
Human Zebrafish Mouse
atrioventricular valve formation GO:0003190 3 0.982
positive regulation of gene expression GO:0010628 71 0.981
Human Zebrafish Mouse
aorta morphogenesis GO:0035909 3 0.981
response to external biotic stimulus GO:0043207 97 0.974
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.973
Human Mouse
blood vessel development GO:0001568 246 0.972
regulation of immune system process GO:0002682 34 0.971
Human Mouse
chordate embryonic development GO:0043009 271 0.969
Zebrafish
eye development GO:0001654 277 0.969
Zebrafish
heart valve formation GO:0003188 4 0.968
heterocycle metabolic process GO:0046483 290 0.968
Human Zebrafish Mouse
head development GO:0060322 303 0.967
Zebrafish
heart morphogenesis GO:0003007 156 0.966
dorsal aorta development GO:0035907 4 0.965
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.961
Human Zebrafish Mouse
heterocycle biosynthetic process GO:0018130 215 0.958
Human Zebrafish Mouse
myeloid leukocyte differentiation GO:0002573 15 0.956
Human Mouse
localization of cell GO:0051674 244 0.955
regulation of gene expression GO:0010468 265 0.954
Human Zebrafish Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.954
Human Zebrafish Mouse
nucleic acid metabolic process GO:0090304 244 0.954
Human Zebrafish Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.953
Human Zebrafish Mouse
cellular macromolecule metabolic process GO:0044260 391 0.953
Human Zebrafish Mouse
regulation of multicellular organismal process GO:0051239 277 0.952
regulation of developmental process GO:0050793 247 0.950
cellular aromatic compound metabolic process GO:0006725 295 0.942
Human Zebrafish Mouse
organic substance biosynthetic process GO:1901576 289 0.942
Human Zebrafish Mouse
cellular component morphogenesis GO:0032989 336 0.941
Mouse
regulation of transcription dna templated GO:0006355 213 0.940
Human Zebrafish Mouse
positive regulation of metabolic process GO:0009893 108 0.939
Human Zebrafish Mouse
organelle organization GO:0006996 227 0.935
Human
cellular macromolecule biosynthetic process GO:0034645 224 0.932
Human Zebrafish Mouse
gene expression GO:0010467 252 0.931
Human Zebrafish Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.930
Human Zebrafish Mouse
digestive system development GO:0055123 289 0.922
regulation of macromolecule biosynthetic process GO:0010556 225 0.917
Human Zebrafish Mouse
organic cyclic compound metabolic process GO:1901360 301 0.909
Human Zebrafish Mouse
regulation of rna biosynthetic process GO:2001141 213 0.907
Human Zebrafish Mouse
retina development in camera type eye GO:0060041 146 0.903
Zebrafish
biosynthetic process GO:0009058 294 0.902
Human Zebrafish Mouse
regulation of neuron migration GO:2001222 2 0.899
sensory organ development GO:0007423 393 0.895
Zebrafish
epithelial tube morphogenesis GO:0060562 148 0.886
Zebrafish
response to stress GO:0006950 263 0.885
Zebrafish
nucleobase containing compound biosynthetic process GO:0034654 205 0.884
Human Zebrafish Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.884
Human Zebrafish Mouse
thyroid gland development GO:0030878 12 0.879
regulation of primary metabolic process GO:0080090 311 0.878
Human Zebrafish Mouse
ventricular cardiac muscle tissue development GO:0003229 3 0.873
regulation of metabolic process GO:0019222 359 0.871
Human Zebrafish Mouse
rna metabolic process GO:0016070 219 0.867
Human Zebrafish Mouse
positive regulation of transcription dna templated GO:0045893 57 0.867
Human Zebrafish Mouse
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.866
hindbrain development GO:0030902 91 0.865
Zebrafish
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.860
eye morphogenesis GO:0048592 144 0.858
Zebrafish
hematopoietic progenitor cell differentiation GO:0002244 23 0.855
epithelial cell differentiation GO:0030855 116 0.851
post embryonic morphogenesis GO:0009886 4 0.850
artery development GO:0060840 22 0.846
hematopoietic or lymphoid organ development GO:0048534 191 0.845
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.844
regulation of nucleic acid templated transcription GO:1903506 213 0.830
Human Zebrafish Mouse
granulocyte differentiation GO:0030851 8 0.827
Human
regulation of cell communication GO:0010646 232 0.827
organic cyclic compound biosynthetic process GO:1901362 223 0.825
Human Zebrafish Mouse
nucleic acid templated transcription GO:0097659 181 0.822
Human Zebrafish Mouse
positive regulation of rna metabolic process GO:0051254 59 0.811
Human Zebrafish Mouse
response to chemical GO:0042221 320 0.805
positive regulation of biosynthetic process GO:0009891 68 0.801
Human Zebrafish Mouse
regulation of biological quality GO:0065008 263 0.796
immune system process GO:0002376 241 0.793
regulation of signal transduction GO:0009966 225 0.789
negative regulation of cell differentiation GO:0045596 46 0.789
Zebrafish Mouse
blood vessel morphogenesis GO:0048514 216 0.784
artery morphogenesis GO:0048844 14 0.774
cellular biosynthetic process GO:0044249 286 0.773
Human Zebrafish Mouse
response to other organism GO:0051707 97 0.773
camera type eye development GO:0043010 222 0.771
Zebrafish
brain development GO:0007420 293 0.767
Zebrafish
regulation of rna metabolic process GO:0051252 224 0.763
Human Zebrafish Mouse
cell migration involved in heart formation GO:0060974 10 0.751
protein metabolic process GO:0019538 183 0.746
heart valve morphogenesis GO:0003179 8 0.746
larval development GO:0002164 2 0.742
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.739
positive regulation of cell proliferation GO:0008284 15 0.728
macromolecule biosynthetic process GO:0009059 227 0.720
Human Zebrafish Mouse
regulation of signaling GO:0023051 235 0.719
atrioventricular valve morphogenesis GO:0003181 6 0.707
cardiac muscle tissue regeneration GO:0061026 3 0.703
ear development GO:0043583 127 0.699
Zebrafish
transcription dna templated GO:0006351 181 0.698
Human Zebrafish Mouse
regulation of biosynthetic process GO:0009889 250 0.697
Human Zebrafish Mouse
megakaryocyte differentiation GO:0030219 1 0.697
Human Mouse
endocrine system development GO:0035270 65 0.697
otolith development GO:0048840 32 0.689
Zebrafish
regulation of programmed cell death GO:0043067 101 0.681
rna biosynthetic process GO:0032774 181 0.673
Human Zebrafish Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.668
Human Mouse
foregut morphogenesis GO:0007440 4 0.666
cellular amine metabolic process GO:0044106 2 0.666
primitive hemopoiesis GO:0060215 27 0.665
ventral spinal cord interneuron differentiation GO:0021514 12 0.651
single organism organelle organization GO:1902589 199 0.645
segmentation GO:0035282 97 0.645
cardiac cell fate commitment GO:0060911 1 0.642
cardioblast migration GO:0003260 7 0.638
single organism localization GO:1902578 225 0.636
positive regulation of cellular process GO:0048522 201 0.632
morphogenesis of an epithelium GO:0002009 333 0.626
Zebrafish
positive regulation of nervous system development GO:0051962 25 0.615
Zebrafish
erythrocyte development GO:0048821 24 0.615
cardiac chamber formation GO:0003207 4 0.611
positive regulation of rna biosynthetic process GO:1902680 57 0.610
Human Zebrafish Mouse
leukocyte differentiation GO:0002521 25 0.608
Human Mouse
cell surface receptor signaling pathway GO:0007166 325 0.604
microglia differentiation GO:0014004 1 0.597
actin filament based process GO:0030029 64 0.591
regulation of cytokine production GO:0001817 3 0.584
homeostasis of number of cells GO:0048872 62 0.579
gastrulation GO:0007369 208 0.575
cardioblast migration to the midline involved in heart field formation GO:0060975 7 0.564
regulation of nitrogen compound metabolic process GO:0051171 251 0.564
Human Zebrafish Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.562
Human Zebrafish Mouse
embryo development ending in birth or egg hatching GO:0009792 271 0.548
Zebrafish
kidney development GO:0001822 92 0.544
positive regulation of multicellular organismal process GO:0051240 52 0.539
Human Zebrafish Mouse
cellular response to organic substance GO:0071310 105 0.538
small molecule metabolic process GO:0044281 77 0.538
regulation of localization GO:0032879 104 0.537
regulation of cellular amino acid metabolic process GO:0006521 0 0.536
motor neuron axon guidance GO:0008045 23 0.530
regulation of myeloid leukocyte differentiation GO:0002761 5 0.528
Mouse
cell migration involved in heart development GO:0060973 22 0.522
cell migration to the midline involved in heart development GO:0003318 12 0.517
cellular ketone metabolic process GO:0042180 11 0.515
cardiac muscle tissue morphogenesis GO:0055008 7 0.515
regulation of cell differentiation GO:0045595 142 0.512
heart looping GO:0001947 94 0.509
cell morphogenesis involved in differentiation GO:0000904 195 0.508
Mouse
positive regulation of cellular amine metabolic process GO:0033240 0 0.505
myeloid cell homeostasis GO:0002262 56 0.503
atrioventricular valve development GO:0003171 11 0.501
cell differentiation in spinal cord GO:0021515 40 0.497
Mouse
embryonic hemopoiesis GO:0035162 53 0.496
growth GO:0040007 174 0.489
regulation of oligodendrocyte differentiation GO:0048713 1 0.487
positive regulation of macromolecule metabolic process GO:0010604 93 0.478
Human Zebrafish Mouse
single organism metabolic process GO:0044710 217 0.469
positive regulation of immune system process GO:0002684 17 0.469
Human Mouse
epithelial cell development GO:0002064 42 0.467
single organism transport GO:0044765 206 0.466
formation of primary germ layer GO:0001704 62 0.460
erythrocyte maturation GO:0043249 8 0.460
Mouse
digestive tract development GO:0048565 265 0.456
negative regulation of blood vessel endothelial cell migration GO:0043537 1 0.455
signal transduction GO:0007165 455 0.455
monocyte differentiation GO:0030224 2 0.454
venous blood vessel development GO:0060841 9 0.452
neuron fate commitment GO:0048663 26 0.451
Zebrafish
pancreas development GO:0031016 84 0.449
Zebrafish
organonitrogen compound metabolic process GO:1901564 74 0.446
macrophage differentiation GO:0030225 7 0.445
cardiocyte differentiation GO:0035051 44 0.442
Zebrafish
cardiac ventricle development GO:0003231 9 0.439
inner ear development GO:0048839 126 0.438
Zebrafish
striated muscle tissue development GO:0014706 110 0.437
oligopeptide transport GO:0006857 1 0.437
stem cell differentiation GO:0048863 117 0.431
muscle organ morphogenesis GO:0048644 8 0.430
heart process GO:0003015 71 0.430
Zebrafish
digestive tract morphogenesis GO:0048546 231 0.429
regulation of cellular amine metabolic process GO:0033238 0 0.429
positive regulation of developmental process GO:0051094 50 0.429
cell motility GO:0048870 244 0.427
cardiac ventricle morphogenesis GO:0003208 7 0.425
neuron migration GO:0001764 22 0.424
negative regulation of signal transduction GO:0009968 94 0.422
embryonic heart tube morphogenesis GO:0003143 108 0.422
Zebrafish
peptide transport GO:0015833 1 0.420
regulation of binding GO:0051098 3 0.419
positive regulation of macrophage chemotaxis GO:0010759 1 0.419
regulation of neurogenesis GO:0050767 87 0.418
Zebrafish
cell fate commitment GO:0045165 99 0.416
Zebrafish Mouse
establishment of localization GO:0051234 244 0.414
blood vessel endothelial cell differentiation GO:0060837 2 0.412
negative regulation of developmental process GO:0051093 65 0.410
Zebrafish Mouse
sprouting angiogenesis GO:0002040 53 0.405
convergent extension involved in organogenesis GO:0060029 10 0.402
forebrain development GO:0030900 96 0.401
Zebrafish
response to biotic stimulus GO:0009607 97 0.398
hepaticobiliary system development GO:0061008 98 0.397
mesoderm morphogenesis GO:0048332 51 0.396
angiogenesis GO:0001525 158 0.394
regulation of myeloid cell differentiation GO:0045637 8 0.391
Human Mouse
left right pattern formation GO:0060972 19 0.390
myeloid cell differentiation GO:0030099 86 0.389
diencephalon development GO:0021536 58 0.387
post embryonic foregut morphogenesis GO:0048618 3 0.383
positive regulation of transport GO:0051050 2 0.383
oxoacid metabolic process GO:0043436 31 0.383
cardiac muscle tissue development GO:0048738 48 0.366
erythrocyte differentiation GO:0030218 54 0.365
central nervous system neuron differentiation GO:0021953 74 0.363
Zebrafish Mouse
wnt signaling pathway GO:0016055 80 0.362
macromolecular complex subunit organization GO:0043933 74 0.361
Human
negative regulation of biosynthetic process GO:0009890 55 0.361
Mouse
transport GO:0006810 220 0.360
cell migration GO:0016477 237 0.359
dipeptide transport GO:0042938 1 0.355
iron ion homeostasis GO:0055072 4 0.348
response to hormone GO:0009725 48 0.341
cell fate specification GO:0001708 68 0.338
aromatic compound biosynthetic process GO:0019438 217 0.336
Human Zebrafish Mouse
liver development GO:0001889 96 0.335
heart valve development GO:0003170 14 0.335
regulation of anatomical structure morphogenesis GO:0022603 130 0.335
camera type eye morphogenesis GO:0048593 108 0.330
Zebrafish
determination of heart left right asymmetry GO:0061371 117 0.327
apoptotic process GO:0006915 116 0.327
multi organism process GO:0051704 134 0.325
cell cycle g1 s phase transition GO:0044843 1 0.325
regulation of cell motility GO:2000145 46 0.322
locomotion GO:0040011 313 0.321
convergent extension GO:0060026 118 0.321
regulation of leukocyte differentiation GO:1902105 5 0.320
Mouse
dna templated transcription initiation GO:0006352 1 0.320
neural tube development GO:0021915 62 0.320
antimicrobial humoral response GO:0019730 2 0.317
regulation of locomotion GO:0040012 55 0.315
cell cell signaling GO:0007267 52 0.309
regulation of mononuclear cell migration GO:0071675 1 0.308
negative regulation of macromolecule metabolic process GO:0010605 76 0.306
Mouse
amine metabolic process GO:0009308 2 0.306
response to abiotic stimulus GO:0009628 122 0.304
cardiac chamber development GO:0003205 19 0.303
embryonic organ morphogenesis GO:0048562 274 0.302
Zebrafish
hypochord development GO:0055016 3 0.299
multicellular organism growth GO:0035264 4 0.297
regulation of cellular ketone metabolic process GO:0010565 7 0.296
positive regulation of cellular biosynthetic process GO:0031328 68 0.294
Human Zebrafish Mouse
immune system development GO:0002520 191 0.294
semicircular canal development GO:0060872 24 0.294
axon development GO:0061564 166 0.293
Zebrafish
response to organic substance GO:0010033 153 0.292
blood vessel endothelial cell migration GO:0043534 18 0.290
negative regulation of metabolic process GO:0009892 86 0.287
Mouse
protein phosphorylation GO:0006468 47 0.286
stem cell maintenance GO:0019827 4 0.284
Mouse
cellular response to chemical stimulus GO:0070887 157 0.282
muscle structure development GO:0061061 196 0.279
response to molecule of bacterial origin GO:0002237 14 0.278
cellular amino acid metabolic process GO:0006520 7 0.277
homeostatic process GO:0042592 142 0.276
specification of symmetry GO:0009799 204 0.274
Zebrafish
regulation of macrophage differentiation GO:0045649 1 0.273
skeletal system development GO:0001501 181 0.273
Zebrafish
heart formation GO:0060914 13 0.272
cell cycle GO:0007049 93 0.269
Human Zebrafish
lymph vessel development GO:0001945 27 0.269
nuclear transport GO:0051169 4 0.269
cellular component biogenesis GO:0044085 178 0.269
Human
response to drug GO:0042493 3 0.267
neuron development GO:0048666 262 0.266
Zebrafish
astrocyte differentiation GO:0048708 1 0.265
Mouse
ameboidal type cell migration GO:0001667 143 0.265
regulation of retina development in camera type eye GO:1902866 2 0.265
response to radiation GO:0009314 51 0.262
positive regulation of cell development GO:0010720 25 0.260
Zebrafish
ventral spinal cord interneuron fate commitment GO:0060579 3 0.259
osteoclast development GO:0036035 1 0.256
negative regulation of cell death GO:0060548 60 0.255
regulation of cell development GO:0060284 100 0.249
Zebrafish Mouse
ion transport GO:0006811 114 0.246
blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 4 0.240
enzyme linked receptor protein signaling pathway GO:0007167 106 0.235
response to oxygen containing compound GO:1901700 55 0.234
organic acid metabolic process GO:0006082 31 0.233
death GO:0016265 121 0.227
lateral inhibition GO:0046331 1 0.224
carboxylic acid metabolic process GO:0019752 22 0.224
sensory organ morphogenesis GO:0090596 200 0.223
Zebrafish
generation of neurons GO:0048699 385 0.223
Zebrafish Mouse
positive regulation of leukocyte differentiation GO:1902107 1 0.223
regulation of vasculogenesis GO:2001212 1 0.220
inner ear morphogenesis GO:0042472 63 0.215
negative regulation of cellular biosynthetic process GO:0031327 55 0.210
Mouse
kupffer s vesicle development GO:0070121 50 0.207
nucleobase containing compound metabolic process GO:0006139 274 0.207
Human Zebrafish Mouse
cellular response to endogenous stimulus GO:0071495 68 0.206
ventral spinal cord development GO:0021517 35 0.206
spinal cord development GO:0021510 46 0.206
Mouse
cellular response to hormone stimulus GO:0032870 39 0.203
actin cytoskeleton organization GO:0030036 63 0.200
negative regulation of rna biosynthetic process GO:1902679 45 0.199
Mouse
immune response GO:0006955 28 0.197
mesoderm formation GO:0001707 43 0.197
muscle cell differentiation GO:0042692 139 0.196
cellular response to external stimulus GO:0071496 2 0.195
cellular localization GO:0051641 97 0.193
cation transport GO:0006812 81 0.193
positive regulation of nucleic acid templated transcription GO:1903508 57 0.192
Human Zebrafish Mouse
positive regulation of secretion by cell GO:1903532 1 0.191
chromatin organization GO:0006325 22 0.190
Human
vasculogenesis GO:0001570 41 0.189
organ formation GO:0048645 17 0.186
embryonic neurocranium morphogenesis GO:0048702 15 0.185
cell death GO:0008219 121 0.185
cell morphogenesis GO:0000902 289 0.183
Mouse
arterial endothelial cell differentiation GO:0060842 2 0.183
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.182
Human Zebrafish Mouse
response to bacterium GO:0009617 58 0.181
muscle tissue development GO:0060537 110 0.181
pharyngeal muscle development GO:0043282 4 0.181
axon guidance GO:0007411 86 0.180
regulation of response to stimulus GO:0048583 269 0.179
regionalization GO:0003002 274 0.176
axonogenesis GO:0007409 152 0.175
peptidyl serine phosphorylation GO:0018105 1 0.175
stem cell development GO:0048864 82 0.173
Mouse
regulation of protein transport GO:0051223 3 0.172
pancreatic a cell development GO:0003322 2 0.172
regulation of macromolecule metabolic process GO:0060255 317 0.169
Human Zebrafish Mouse
sodium ion transmembrane transport GO:0035725 21 0.167
wound healing GO:0042060 90 0.163
midbrain hindbrain boundary development GO:0030917 23 0.163
negative regulation of gene expression GO:0010629 65 0.162
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.160
otic vesicle formation GO:0030916 27 0.160
biological adhesion GO:0022610 40 0.158
response to external stimulus GO:0009605 264 0.158
anterior posterior pattern specification GO:0009952 152 0.157
regulation of neural retina development GO:0061074 2 0.157
cardiac atrium morphogenesis GO:0003209 2 0.156
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.156
phosphorus metabolic process GO:0006793 109 0.156
regulation of cell shape GO:0008360 1 0.154
protein modification process GO:0036211 100 0.152
epithelial cell migration GO:0010631 25 0.152
atrial ventricular junction remodeling GO:0003294 2 0.152
endosomal transport GO:0016197 2 0.151
metal ion transport GO:0030001 58 0.150
macrophage chemotaxis GO:0048246 3 0.149
cellular protein modification process GO:0006464 100 0.149
negative regulation of epithelial cell migration GO:0010633 1 0.148
regeneration GO:0031099 91 0.147
Zebrafish
otic vesicle development GO:0071599 42 0.146
tor signaling GO:0031929 7 0.145
histone modification GO:0016570 20 0.145
cardiac chamber morphogenesis GO:0003206 12 0.145
muscle organ development GO:0007517 101 0.144
protein acetylation GO:0006473 2 0.141
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.141
neuroblast fate commitment GO:0014017 1 0.141
metencephalon development GO:0022037 27 0.140
negative regulation of response to stimulus GO:0048585 104 0.139
endothelial cell migration GO:0043542 19 0.138
cellular response to oxygen containing compound GO:1901701 20 0.136
cell part morphogenesis GO:0032990 246 0.136
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.136
Mouse
regulation of vasculature development GO:1901342 33 0.135
cellular response to lipopolysaccharide GO:0071222 3 0.134
positive regulation of locomotion GO:0040017 14 0.134
defense response to fungus GO:0050832 2 0.133
system process GO:0003008 185 0.133
Zebrafish
amide transport GO:0042886 12 0.132
cranial nerve development GO:0021545 42 0.132
Zebrafish
programmed cell death GO:0012501 119 0.131
regulation of phosphorus metabolic process GO:0051174 43 0.131
negative regulation of mesodermal cell fate specification GO:0042662 3 0.131
cellular component movement GO:0006928 335 0.130
embryonic skeletal system morphogenesis GO:0048704 93 0.127
Zebrafish
negative regulation of myeloid cell differentiation GO:0045638 1 0.125
homeostasis of number of cells within a tissue GO:0048873 4 0.125
cellular response to extracellular stimulus GO:0031668 2 0.124
negative regulation of myeloid leukocyte differentiation GO:0002762 1 0.124
positive regulation of neural retina development GO:0061075 1 0.123
limbic system development GO:0021761 16 0.123
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.122
positive regulation of cell migration GO:0030335 11 0.122
nephric duct development GO:0072176 13 0.121
g1 s transition of mitotic cell cycle GO:0000082 1 0.120
membrane repolarization GO:0086009 2 0.120
striated muscle cell differentiation GO:0051146 129 0.119
neuron projection morphogenesis GO:0048812 161 0.118
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.116
regulation of ph GO:0006885 3 0.115
inner ear receptor cell development GO:0060119 20 0.114
Zebrafish
cardiac muscle cell differentiation GO:0055007 30 0.114
negative regulation of transcription dna templated GO:0045892 45 0.113
Mouse
hypothalamus cell differentiation GO:0021979 4 0.112
negative regulation of cell communication GO:0010648 96 0.112
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.110
regulation of biomineral tissue development GO:0070167 2 0.109
notochord development GO:0030903 54 0.108
regulation of mesodermal cell fate specification GO:0042661 9 0.107
regulation of heart growth GO:0060420 2 0.107
outflow tract morphogenesis GO:0003151 1 0.105
anion transport GO:0006820 38 0.104
positive regulation of cytokine production GO:0001819 2 0.104
regulation of neuron differentiation GO:0045664 56 0.102
circulatory system process GO:0003013 87 0.101
Zebrafish
protein complex biogenesis GO:0070271 30 0.101
Human
response to endogenous stimulus GO:0009719 83 0.101
tissue regeneration GO:0042246 74 0.101
regulation of homeostatic process GO:0032844 9 0.101
Human Mouse
chromosome organization GO:0051276 31 0.101
Human
regulation of dendrite development GO:0050773 3 0.100
cell proliferation GO:0008283 80 0.099
Mouse
mononuclear cell migration GO:0071674 1 0.099
endocardium morphogenesis GO:0003160 4 0.098
aging GO:0007568 2 0.098
inorganic cation transmembrane transport GO:0098662 50 0.098
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.098
positive regulation of cell cycle GO:0045787 3 0.097
Human
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.096
macromolecule modification GO:0043412 111 0.094
positive regulation of cellular component movement GO:0051272 11 0.094
regulation of organelle organization GO:0033043 29 0.094
Human
oligodendrocyte differentiation GO:0048709 23 0.093
neural retina development GO:0003407 49 0.093
Zebrafish
regulation of cell migration GO:0030334 40 0.091
positive regulation of cell motility GO:2000147 11 0.091
mesenchymal cell differentiation GO:0048762 87 0.090
regulation of protein complex assembly GO:0043254 3 0.088
Human
melanocyte apoptotic process GO:1902362 2 0.088
defense response to other organism GO:0098542 33 0.087
tissue migration GO:0090130 37 0.087
developmental maturation GO:0021700 34 0.087
Mouse
response to fungus GO:0009620 25 0.087
establishment or maintenance of cell polarity GO:0007163 29 0.086
ear morphogenesis GO:0042471 64 0.086
cellular response to organic cyclic compound GO:0071407 38 0.086
regulation of bone mineralization GO:0030500 2 0.085
regulation of cell death GO:0010941 103 0.085
compound eye development GO:0048749 2 0.084
defense response GO:0006952 47 0.083
regulation of cell activation GO:0050865 1 0.081
primitive erythrocyte differentiation GO:0060319 5 0.080
peptidyl lysine acetylation GO:0018394 2 0.080
intracellular receptor signaling pathway GO:0030522 30 0.080
positive regulation of retina development in camera type eye GO:1902868 1 0.080
mitotic cell cycle GO:0000278 64 0.079
Human
negative regulation of programmed cell death GO:0043069 58 0.079
single organismal cell cell adhesion GO:0016337 29 0.079
regulation of apoptotic process GO:0042981 98 0.078
vascular endothelial growth factor receptor signaling pathway GO:0048010 13 0.078
porphyrin containing compound metabolic process GO:0006778 10 0.078
phosphorylation GO:0016310 69 0.078
intermediate mesoderm development GO:0048389 2 0.076
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.076
tissue homeostasis GO:0001894 25 0.076
regulation of cell proliferation GO:0042127 37 0.075
Mouse
regulation of multicellular organism growth GO:0040014 4 0.074
developmental growth GO:0048589 166 0.074
body morphogenesis GO:0010171 16 0.074
otic vesicle morphogenesis GO:0071600 34 0.073
regulation of cellular component organization GO:0051128 86 0.072
Human
protein import into nucleus GO:0006606 3 0.072
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.072
stem cell fate commitment GO:0048865 1 0.072
regulation of dna metabolic process GO:0051052 11 0.072
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.072
smooth muscle contraction GO:0006939 2 0.072
neuronal stem cell maintenance GO:0097150 2 0.072
lymphocyte differentiation GO:0030098 9 0.071
hematopoietic stem cell migration GO:0035701 4 0.070
positive regulation of phosphorus metabolic process GO:0010562 21 0.070
t cell differentiation GO:0030217 6 0.070

tal1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.194
hematopoietic system disease DOID:74 0 0.176
disease of anatomical entity DOID:7 0 0.176
immune system disease DOID:2914 0 0.176
disease of cellular proliferation DOID:14566 0 0.089
cancer DOID:162 0 0.089
endocrine gland cancer DOID:170 0 0.089
organ system cancer DOID:0050686 0 0.089