IMP

Process View

Danio rerio

14 genes annotated in zebrafish

heart valve development

The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "heart valve development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "heart valve development" (in gray)

Name	Description	Probability	Func Analog Organism
tbx5a	T-box 5a	0.981
fli1a	friend leukemia integration 1a	0.603
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.589
bmp4	bone morphogenetic protein 4	0.551
tbx1	T-box 1	0.507	Zebrafish
hand2	heart and neural crest derivatives expressed transcript 2	0.471
hhex	hematopoietically expressed homeobox	0.358
tal1	T-cell acute lymphocytic leukemia 1	0.335
nkx2.5	NK2 transcription factor related 5	0.318
hnf1ba	HNF1 homeobox Ba	0.265
gata6	GATA-binding protein 6	0.254
fn1	fibronectin 1	0.226
ptch1	patched 1	0.207
tbx16	T-box gene 16	0.188	Zebrafish
dld	deltaD	0.174
dlc	deltaC	0.173
tbx20	T-box 20	0.168	Zebrafish Mouse
cdh2	cadherin 2, neuronal	0.148
wnt5b	wingless-type MMTV integration site family, member 5b	0.139
mef2cb	myocyte enhancer factor 2cb	0.136	Mouse
alcama	activated leukocyte cell adhesion molecule a	0.132
myod1	myogenic differentiation 1	0.132
runx1	runt-related transcription factor 1	0.125
vcana	versican a	0.116
wnt11r	wingless-type MMTV integration site family, member 11, related	0.112
tbx24	T-box 24	0.111	Zebrafish
fgf8a	fibroblast growth factor 8 a	0.109
myf5	myogenic factor 5	0.104
lft2	lefty2	0.103
her1	hairy-related 1	0.100
tbx18	T-box 18	0.095	Zebrafish
tbx2a	T-box gene 2a	0.089	Zebrafish
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.087	Mouse
shha	sonic hedgehog a	0.087
crip2	cysteine-rich protein 2	0.086
gsna	gelsolin a	0.079
neo1	neogenin 1	0.078
tpm4	tropomyosin 4	0.074
wnt11	wingless-type MMTV integration site family, member 11	0.071
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.069
osr2	odd-skipped related 2 (Drosophila)	0.067
bmp2b	bone morphogenetic protein 2b	0.064	Mouse
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.055
unc45b	unc-45 homolog B (C. elegans)	0.053
drl	draculin	0.052
gata2a	GATA-binding protein 2a	0.051
tbx5b	T-box 5b	0.049
notch1b	notch homolog 1b	0.048	Human Mouse
lft1	lefty1	0.046
tcf21	transcription factor 21	0.045
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.045
znfl2a	zinc finger-like gene 2a	0.042
foxi1	forkhead box I1	0.041
tgfb3	transforming growth factor, beta 3	0.041
her7	hairy and enhancer of split related-7	0.040
mib	mind bomb	0.040
acvr1l	activin A receptor, type I like	0.040
myl7	myosin, light polypeptide 7, regulatory	0.040
tnni1b	troponin I, skeletal, slow b	0.039
jag1b	jagged 1b	0.039	Human
pkd2	polycystic kidney disease 2	0.037
arhgef7b	Rho guanine nucleotide exchange factor (GEF) 7b	0.036
gli2a	GLI-Kruppel family member GLI2a	0.035
foxa3	forkhead box A3	0.035
smyd1b	SET and MYND domain containing 1b	0.035
bmp3	bone morphogenetic protein 3	0.033
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.032
zfpm1	zinc finger protein, multitype 1	0.031	Mouse
pcdh8	protocadherin 8	0.031
krt4	keratin 4	0.031
LOC566708	FL cytokine receptor-like	0.030
pdlim7	PDZ and LIM domain 7	0.030
lmo2	LIM domain only 2 (rhombotin-like 1)	0.030
foxn4	forkhead box N4	0.030
tfap2a	transcription factor AP-2 alpha	0.030
mef2ca	myocyte enhancer factor 2ca	0.029	Mouse
kdrl	kinase insert domain receptor like	0.029
eve1	even-skipped-like1	0.028
oep	one-eyed pinhead	0.028
znf703	zinc finger protein 703	0.027
tp63	tumor protein p63	0.027
tnnc1a	troponin C type 1a (slow)	0.026
hes6	hairy and enhancer of split 6 (Drosophila)	0.026
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.026
foxh1	forkhead box H1	0.024
gja3	gap junction protein, alpha 3	0.024
nppa	natriuretic peptide precursor A	0.024
six4b	sine oculis homeobox homolog 4b	0.024
prdm1a	PR domain containing 1a, with ZNF domain	0.024
hspb1	heat shock protein, alpha-crystallin-related, 1	0.023
spaw	southpaw	0.023
has2	hyaluronan synthase 2	0.023
ndr2	nodal-related 2	0.022
sox32	SRY-box containing gene 32	0.022
wls	wntless homolog (Drosophila)	0.022
nkx3.2	NK3 homeobox 2	0.022
tmem2	transmembrane protein 2	0.022
edn1	endothelin 1	0.022
tfeb	transcription factor EB	0.021
ltbp3	latent transforming growth factor beta binding protein 3	0.021
apc	adenomatosis polyposis coli	0.021
flot2a	flotillin 2a	0.021
fgfrl1a	fibroblast growth factor receptor-like 1a	0.020
hmx3	homeo box (H6 family) 3	0.020
frem3	Fras1 related extracellular matrix 3	0.020
ttna	titin a	0.020
col8a1a	collagen, type VIII, alpha 1a	0.020
lamb1a	laminin, beta 1a	0.020
sox11b	SRY-box containing gene 11b	0.020
bmper	BMP binding endothelial regulator	0.019
flh	floating head	0.019
plagl2	pleiomorphic adenoma gene-like 2	0.019
dlb	deltaB	0.019
mmp2	matrix metalloproteinase 2	0.019
zgc:92360	zgc:92360	0.019
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.019
fzd7a	frizzled homolog 7a	0.018
col27a1a	collagen, type XXVII, alpha 1a	0.018
actn1	actinin, alpha 1	0.018
smo	smoothened homolog (Drosophila)	0.018
fbln1	fibulin 1	0.018
slc25a37	solute carrier family 25, member 37	0.018
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.018
wnt9a	wingless-type MMTV integration site family, member 9A	0.018
tbx6	T-box gene 6	0.018	Zebrafish
jam3b	junctional adhesion molecule 3b	0.017
dlx3b	distal-less homeobox gene 3b	0.017
aplnrb	apelin receptor b	0.017
fgf17	fibroblast growth factor 17	0.017
dlx2a	distal-less homeobox gene 2a	0.017
pcdh18a	protocadherin 18a	0.017
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.017
rnasel1	ribonuclease like 1	0.017
rbm24a	RNA binding motif protein 24a	0.017
jag2	jagged 2	0.016
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.016
rhoua	ras homolog gene family, member Ua	0.016
cdx4	caudal type homeo box transcription factor 4	0.016
foxa1	forkhead box A1	0.016
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.016
supt6h	suppressor of Ty 6 homolog	0.016
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.016
csnk1a1	casein kinase 1, alpha 1	0.016
fgf10a	fibroblast growth factor 10a	0.016
tnnt2a	troponin T2a, cardiac	0.015
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.015
LOC100151531	zinc finger protein Gfi-1b-like	0.015
snai1a	snail homolog 1a (Drosophila)	0.015
id1	inhibitor of DNA binding 1	0.015
gli1	GLI-Kruppel family member 1	0.015
epor	erythropoietin receptor	0.015
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.015
klf2a	Kruppel-like factor 2a	0.015
ptgs1	prostaglandin-endoperoxide synthase 1	0.015
eif3hb	eukaryotic translation initiation factor 3, subunit H, b	0.015
matn4	matrilin 4	0.015
slc8a1a	solute carrier family 8 (sodium/calcium exchanger), member 1a	0.014
sp5l	Sp5 transcription factor-like	0.014
bambib	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b	0.014
prrx1a	paired related homeobox 1a	0.014
zgc:63523	zgc:63523	0.014
vmhc	ventricular myosin heavy chain	0.014
flot1b	flotillin 1b	0.014
sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.014
hoxb5a	homeo box B5a	0.014
qk	quaking	0.014
chd	chordin	0.014
otpb	orthopedia homolog b	0.014
sdprb	serum deprivation response b	0.014
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.013
ywhai	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide	0.013
mespa	mesoderm posterior a	0.013
gatsl2	GATS protein-like 2	0.013
lamc1	laminin, gamma 1	0.013
cdh1	cadherin 1, epithelial	0.013
dusp5	dual specificity phosphatase 5	0.013
nkx2.3	NK2 transcription factor related 3	0.013
klf2b	Kruppel-like factor 2b	0.013
dusp6	dual specificity phosphatase 6	0.013
pdlim2	PDZ and LIM domain 2 (mystique)	0.013
prrx1b	paired related homeobox 1b	0.013
anxa11a	annexin A11a	0.013
dcc	deleted in colorectal carcinoma	0.013
lama5	laminin, alpha 5	0.013
pou5f1	POU domain, class 5, transcription factor 1	0.013
twist1a	twist1a	0.013
tbx2b	T-box 2b	0.012	Zebrafish
celf1	cugbp, Elav-like family member 1	0.012
onecutl	one cut domain, family member, like	0.012
yap1	Yes-associated protein 1	0.012
disp1	dispatched homolog 1 (Drosophila)	0.012
rgma	RGM domain family, member A	0.012
wu:fv91b12	wu:fv91b12	0.012
nr2e3	nuclear receptor subfamily 2, group E, member 3	0.012
hmgn3	high mobility group nucleosomal binding domain 3	0.012
hoxa11a	homeo box A11a	0.012
her6	hairy-related 6	0.012
wwp2	WW domain containing E3 ubiquitin protein ligase 2	0.012
bcdo2l	beta-carotene 15, 15-dioxygenase 2, like	0.012
fgfr4	fibroblast growth factor receptor 4	0.012
lhx1a	LIM homeobox 1a	0.012
hspb7	heat shock protein family, alpha-crystallin-related, b7	0.012
fzd10	frizzled homolog 10	0.012
smad9	MAD homolog 9 (Drosophila)	0.011
plcg1	phospholipase C, gamma 1	0.011
atp2a2a	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a	0.011
hoxd11a	homeo box D11a	0.011
hoxa9a	homeo box A9a	0.011
traf4a	tnf receptor-associated factor 4a	0.011
sulf1	sulfatase 1	0.011
cpox	coproporphyrinogen oxidase	0.011
scn12ab	sodium channel, voltage gated, type XII, alpha b	0.011
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.011
ntla	no tail a	0.011	Zebrafish
ripply1	ripply1	0.011
popdc2	popeye domain containing 2	0.011
irx3a	iroquois homeobox protein 3a	0.011
gata1a	GATA binding protein 1a	0.011	Zebrafish
cdx1b	caudal type homeobox 1 b	0.011
myca	myelocytomatosis oncogene a	0.011
lhx1b	LIM homeobox 1b	0.011
nrp1a	neuropilin 1a	0.011
gipc2	GIPC PDZ domain containing family, member 2	0.011
sox17	SRY-box containing gene 17	0.011
perp	PERP, TP53 apoptosis effector	0.011
plxna3	plexin A3	0.011
fhla	four and a half LIM domains a	0.010
aplnra	apelin receptor a	0.010
xirp1	xin actin-binding repeat containing 1	0.010
her12	hairy-related 12	0.010
cbfb	core-binding factor, beta subunit	0.010
lmo4a	LIM domain only 4a	0.010