IMP

Process View

Homo sapiens

1 genes annotated in human

negative regulation of circadian sleep wake cycle sleep

Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of circadian sleep wake cycle sleep"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of circadian sleep wake cycle sleep" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	0.787
IGF1R	insulin-like growth factor 1 receptor	0.433	Fly
IRS1	insulin receptor substrate 1	0.384
INSR	insulin receptor	0.295	Fly
ADORA2A	adenosine A2a receptor	0.263
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.042
GRB10	growth factor receptor-bound protein 10	0.032
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.025
GHR	growth hormone receptor	0.018
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.016
IRS2	insulin receptor substrate 2	0.010