IMP
Process View
ruffle assembly
The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "ruffle assembly"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Pak1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.464 | ||
| Actb | actin, beta | 0.191 | ||
| Vasp | vasodilator-stimulated phosphoprotein | 0.097 | ||
| Shc1 | src homology 2 domain-containing transforming protein C1 | 0.060 | ||
| Wdr1 | WD repeat domain 1 | 0.049 | ||
| Arpc4 | actin related protein 2/3 complex, subunit 4 | 0.047 | ||
| Dnm1 | dynamin 1 | 0.022 | ||
| Rhoa | ras homolog gene family, member A | 0.021 | ||
| Rac1 | RAS-related C3 botulinum substrate 1 | 0.021 | ||
| Arhgdia | Rho GDP dissociation inhibitor (GDI) alpha | 0.017 | ||
| Enah | enabled homolog (Drosophila) | 0.015 | ||
| Sh3bgrl3 | SH3 domain binding glutamic acid-rich protein-like 3 | 0.014 | ||
| Fxyd5 | FXYD domain-containing ion transport regulator 5 | 0.014 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.014 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.013 | ||
| Actg1 | actin, gamma, cytoplasmic 1 | 0.013 | ||
| Laptm5 | lysosomal-associated protein transmembrane 5 | 0.012 | ||
| Csnk2b | casein kinase 2, beta polypeptide | 0.012 | ||
| Tyrobp | TYRO protein tyrosine kinase binding protein | 0.012 | ||
| Cd97 | CD97 antigen | 0.012 | ||
| Arhgap1 | Rho GTPase activating protein 1 | 0.012 | ||
| Myd88 | myeloid differentiation primary response gene 88 | 0.011 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.011 | ||
| Rnd3 | Rho family GTPase 3 | 0.011 | ||
| Hspb8 | heat shock protein 8 | 0.011 | ||
| Coro1a | coronin, actin binding protein 1A | 0.011 | ||
| Cd44 | CD44 antigen | 0.010 | ||
| Necap2 | NECAP endocytosis associated 2 | 0.010 |