The network for 'cell adhesion mediated by integrin' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell adhesion mediated by integrin

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.

Drosophila melanogaster
Name Description Probability Func Analog Organism
mew multiple edematous wings 0.107
LanB2 Laminin B2 0.102
myoglianin CG1838 gene product from transcript CG1838-RD 0.072
if inflated 0.071
CG31352 CG31352 gene product from transcript CG31352-RA 0.043
blot bloated tubules 0.041
Cg25C Collagen type IV 0.036
LanA Laminin A 0.034
CG8709 CG8709 gene product from transcript CG8709-RK 0.030
sr stripe 0.029
wun wunen 0.027
Fs Follistatin 0.026
pod1 CG4532 gene product from transcript CG4532-RF 0.024
Unc-76 CG3981 gene product from transcript CG3981-RB 0.021
zetaTry zetaTrypsin 0.020
lqf liquid facets 0.020
p16-ARC CG9881 gene product from transcript CG9881-RA 0.019
Mcr Macroglobulin complement-related 0.018
Ppn Papilin 0.018
pgant3 polypeptide GalNAc transferase 3 0.018
CG10777 CG10777 gene product from transcript CG10777-RB 0.018
CG32251 CG32251 gene product from transcript CG32251-RA 0.017
baz bazooka 0.017
Tsf2 Transferrin 2 0.016
wkd whacked 0.015
CG8486 CG8486 gene product from transcript CG8486-RE 0.015
htl heartless 0.015
CdsA CDP diglyceride synthetase 0.014
CG10413 CG10413 gene product from transcript CG10413-RA 0.014
Sbf SET domain binding factor 0.014
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.014
Ptp52F CG18243 gene product from transcript CG18243-RB 0.013
kon kon-tiki 0.013
NFAT NFAT homolog 0.013
Vrp1 Verprolin 1 0.013
Gsc Goosecoid 0.012
pcx pecanex 0.012
mav maverick 0.012
sev sevenless 0.012
yata CG1973 gene product from transcript CG1973-RA 0.011
CG30069 CG30069 gene product from transcript CG30069-RA 0.011
CG31731 CG31731 gene product from transcript CG31731-RB 0.011
drpr draper 0.011
sls sallimus 0.011
CG4168 CG4168 gene product from transcript CG4168-RA 0.010
LamC Lamin C 0.010
Prat2 Phosphoribosylamidotransferase 2 0.010
CG3194 CG3194 gene product from transcript CG3194-RB 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
arpc5b actin related protein 2/3 complex, subunit 5B 0.652
itgb1b.2 integrin, beta 1b.2 0.371
tgfb3 transforming growth factor, beta 3 0.367
cotl1 coactosin-like 1 (Dictyostelium) 0.247
itgb1b integrin, beta 1b 0.246
itgb1a integrin, beta 1a 0.140
arpc5a actin related protein 2/3 complex, subunit 5A 0.140
her7 hairy and enhancer of split related-7 0.139
her1 hairy-related 1 0.133
mespb mesoderm posterior b 0.110
ret1 receptor tyrosine kinase 0.099
prrx1a paired related homeobox 1a 0.092
itgb1b.1 integrin, beta 1b.1 0.085
npy8ar neuropeptide Y receptor Y8a 0.077
fn1 fibronectin 1 0.058
capza1a capping protein (actin filament) muscle Z-line, alpha 1a 0.057
msgn1 mesogenin 1 0.055
col5a2l collagen, type V, alpha 2-like 0.054
pcdh8 protocadherin 8 0.051
myf5 myogenic factor 5 0.048
dctn1a dynactin 1a 0.048
spon2a spondin 2a, extracellular matrix protein 0.048
nrp1a neuropilin 1a 0.044
zgc:110591 zgc:110591 0.043
arpc3 actin related protein 2/3 complex, subunit 3 0.043
tbx24 T-box 24 0.043
spry4 sprouty (Drosophila) homolog 4 0.042
fstl1b follistatin-like 1b 0.042
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.041
satb2 SATB homeobox 2 0.040
optc opticin 0.040
lama5 laminin, alpha 5 0.039
fgfr2 fibroblast growth factor receptor 2 0.038
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.038
src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.038
foxi1 forkhead box I1 0.037
tbx6 T-box gene 6 0.037
dynll1 dynein, light chain, LC8-type 1 0.037
xirp1 xin actin-binding repeat containing 1 0.036
cdh23 cadherin-like 23 0.036
col4a2 collagen, type IV, alpha 2 0.036
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.036
angpt1 angiopoietin 1 0.035
twf1a twinfilin, actin-binding protein, homolog 1a 0.034
fn1b fibronectin 1b 0.033
tbx18 T-box 18 0.030
hoxa1a homeo box A1a 0.030
fes feline sarcoma oncogene 0.030
smtnl smoothelin, like 0.029
lpar1 lysophosphatidic acid receptor 1 0.028
xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 0.028
sulf2l sulfatase 2, like 0.028
wt1a wilms tumor 1a 0.028
sulf1 sulfatase 1 0.027
pxn paxillin 0.026
zdhhc8b zinc finger, DHHC-type containing 8b 0.026
fgf13b fibroblast growth factor 13b 0.026
actr2 ARP2 actin-related protein 2 homolog 0.026
hmcn1 hemicentin 1 0.026
itgb4 integrin, beta 4 0.025
gpr126 G protein-coupled receptor 126 0.025
zgc:64051 zgc:64051 0.025
bactin1 bactin1 0.024
faf1 Fas associated factor 1 0.024
brd4 bromodomain containing 4 0.024
b2m beta-2-microglobulin 0.024
prickle1a prickle-like 1 (Drosophila) a 0.024
myl9l myosin, light polypeptide 9, like 0.023
foxd5 forkhead box D5 0.023
fhl four and a half LIM domains 0.022
iqgap1 IQ motif containing GTPase activating protein 1 0.022
ripply2 ripply2 0.022
wt1b wilms tumor 1b 0.021
igfbp6a insulin-like growth factor binding protein 6a 0.021
lrrc17 leucine rich repeat containing 17 0.021
jhdm1da jumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae) 0.021
abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.021
sept6 septin 6 0.021
b3gnt7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 0.020
scn8aa sodium channel, voltage-gated, type VIII, alpha a 0.020
tgfb1a transforming growth factor, beta 1a 0.020
tnfaip8l2a tumor necrosis factor, alpha-induced protein 8, like 2a 0.020
zgc:77517 zgc:77517 0.020
fbln1 fibulin 1 0.020
lasp1 LIM and SH3 protein 1 0.020
pcdh2ac protocadherin 2 alpha c 0.020
wu:fq26c12 wu:fq26c12 0.020
igfbp6b insulin-like growth factor binding protein 6b 0.020
fzd2 frizzled homolog 2 0.020
cha charon 0.020
zgc:56064 zgc:56064 0.019
zgc:112211 zgc:112211 0.019
ntn1b netrin 1b 0.019
plagl2 pleiomorphic adenoma gene-like 2 0.019
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.019
tln1 talin 1 0.019
qk quaking 0.019
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.018
smoc1 SPARC related modular calcium binding 1 0.018
nfe2 nuclear factor, erythroid-derived 2 0.018
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.991
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.925
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.915
FLNA filamin A, alpha 0.852
FN1 fibronectin 1 0.807
PLAUR plasminogen activator, urokinase receptor 0.795
FHL2 four and a half LIM domains 2 0.778
VCAM1 vascular cell adhesion molecule 1 0.768
CCL5 chemokine (C-C motif) ligand 5 0.749
PLAU plasminogen activator, urokinase 0.685
EPHA2 EPH receptor A2 0.593
PTPRC protein tyrosine phosphatase, receptor type, C 0.529
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.528
ENG endoglin 0.513
WASL Wiskott-Aldrich syndrome-like 0.477
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.414
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.343
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.296
ICAM1 intercellular adhesion molecule 1 0.286
CCL2 chemokine (C-C motif) ligand 2 0.279
MET met proto-oncogene (hepatocyte growth factor receptor) 0.275
PTK2 PTK2 protein tyrosine kinase 2 0.214
CCR5 chemokine (C-C motif) receptor 5 0.192
PDIA3 protein disulfide isomerase family A, member 3 0.171
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.171
MSN moesin 0.153
THBS1 thrombospondin 1 0.141
PXN paxillin 0.141
IL1B interleukin 1, beta 0.131
ITGA6 integrin, alpha 6 0.112
TLN1 talin 1 0.111
IL8 interleukin 8 0.105
NRP2 neuropilin 2 0.103
CXCL9 chemokine (C-X-C motif) ligand 9 0.103
PLEC plectin 0.101
CCL22 chemokine (C-C motif) ligand 22 0.098
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.092
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.087
ITGB4 integrin, beta 4 0.086
PSEN2 presenilin 2 (Alzheimer disease 4) 0.085
EPHA7 EPH receptor A7 0.076
ZNF746 zinc finger protein 746 0.072
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.071
PECAM1 platelet/endothelial cell adhesion molecule 0.069
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.068
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.066
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.062
EFNA1 ephrin-A1 0.061
RANBP9 RAN binding protein 9 0.061
IGFBP3 insulin-like growth factor binding protein 3 0.059
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.058
IL6 interleukin 6 (interferon, beta 2) 0.057
CXCL10 chemokine (C-X-C motif) ligand 10 0.056
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.056
VCL vinculin 0.056
PFN1 profilin 1 0.055
BCAR1 breast cancer anti-estrogen resistance 1 0.055
OSMR oncostatin M receptor 0.055
CCL4 chemokine (C-C motif) ligand 4 0.054
TNC tenascin C 0.054
CD44 CD44 molecule (Indian blood group) 0.053
ABI2 abl-interactor 2 0.053
ZYX zyxin 0.052
HMG20A high mobility group 20A 0.048
NCKAP1 NCK-associated protein 1 0.048
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.047
ANGPTL4 angiopoietin-like 4 0.047
CCL8 chemokine (C-C motif) ligand 8 0.045
SNX9 sorting nexin 9 0.045
CYTH1 cytohesin 1 0.044
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.044
PLAT plasminogen activator, tissue 0.043
CXCL11 chemokine (C-X-C motif) ligand 11 0.043
DLG1 discs, large homolog 1 (Drosophila) 0.043
EFNA5 ephrin-A5 0.042
HCLS1 hematopoietic cell-specific Lyn substrate 1 0.042
MYO10 myosin X 0.041
IL7R interleukin 7 receptor 0.040
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.039
CCL13 chemokine (C-C motif) ligand 13 0.038
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.038
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.037
CCL11 chemokine (C-C motif) ligand 11 0.037
GAB1 GRB2-associated binding protein 1 0.037
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.036
FXYD5 FXYD domain containing ion transport regulator 5 0.034
FYN FYN oncogene related to SRC, FGR, YES 0.034
CCL19 chemokine (C-C motif) ligand 19 0.033
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.033
IDE insulin-degrading enzyme 0.033
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.032
LGALS1 lectin, galactoside-binding, soluble, 1 0.032
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.032
INHBA inhibin, beta A 0.032
COL4A1 collagen, type IV, alpha 1 0.031
LIMS1 LIM and senescent cell antigen-like domains 1 0.031
CALD1 caldesmon 1 0.030
SELPLG selectin P ligand 0.030
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.030
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Mus musculus
Name Description Probability Func Analog Organism
Efnb2 ephrin B2 1.000
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.999
Bmp4 bone morphogenetic protein 4 0.979
Foxc2 forkhead box C2 0.974
Foxc1 forkhead box C1 0.971
Hif1a hypoxia inducible factor 1, alpha subunit 0.926
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.752
Thbs1 thrombospondin 1 0.648
Psen1 presenilin 1 0.641
Tgfb2 transforming growth factor, beta 2 0.587
Ephb2 Eph receptor B2 0.568
Epha4 Eph receptor A4 0.531
Jag1 jagged 1 0.503
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.480
Foxa2 forkhead box A2 0.441
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.417
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.383
Pitx2 paired-like homeodomain transcription factor 2 0.369
Ctnnb1 catenin (cadherin associated protein), beta 1 0.356
Itgb2 integrin beta 2 0.336
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.307
Foxe3 forkhead box E3 0.300
Gata6 GATA binding protein 6 0.265
Vav1 vav 1 oncogene 0.258
Bcar1 breast cancer anti-estrogen resistance 1 0.225
Cyr61 cysteine rich protein 61 0.224
Ephb3 Eph receptor B3 0.217
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.178
Cd44 CD44 antigen 0.176
Gata4 GATA binding protein 4 0.160
Itgb3 integrin beta 3 0.158
Lox lysyl oxidase 0.152
Flt4 FMS-like tyrosine kinase 4 0.152
Adam17 a disintegrin and metallopeptidase domain 17 0.142
Cd22 CD22 antigen 0.133
Tbx1 T-box 1 0.130
Gdnf glial cell line derived neurotrophic factor 0.125
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.124
Col4a1 collagen, type IV, alpha 1 0.119
Osmr oncostatin M receptor 0.117
Fn1 fibronectin 1 0.113
Nkx2-1 NK2 homeobox 1 0.110
Egfr epidermal growth factor receptor 0.108
Phldb2 pleckstrin homology-like domain, family B, member 2 0.106
Tgfbr2 transforming growth factor, beta receptor II 0.105
Was Wiskott-Aldrich syndrome homolog (human) 0.101
Eng endoglin 0.100
Pax2 paired box gene 2 0.099
Pax1 paired box gene 1 0.096
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.095
Hcls1 hematopoietic cell specific Lyn substrate 1 0.093
Il10ra interleukin 10 receptor, alpha 0.086
Vcl vinculin 0.082
Foxf2 forkhead box F2 0.081
Plaur plasminogen activator, urokinase receptor 0.081
Tjp1 tight junction protein 1 0.076
Hmx1 H6 homeobox 1 0.073
Ntf3 neurotrophin 3 0.072
Dock1 dedicator of cytokinesis 1 0.068
Tnc tenascin C 0.067
Myo1f myosin IF 0.067
9430031J16Rik RIKEN cDNA 9430031J16 gene 0.067
Inpp5d inositol polyphosphate-5-phosphatase D 0.066
Fas Fas (TNF receptor superfamily member 6) 0.064
Notch1 Notch gene homolog 1 (Drosophila) 0.064
Efna1 ephrin A1 0.063
Vangl2 vang-like 2 (van gogh, Drosophila) 0.062
Itga3 integrin alpha 3 0.062
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.060
Lrmp lymphoid-restricted membrane protein 0.059
Sla src-like adaptor 0.057
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.056
Nid1 nidogen 1 0.056
Arhgap9 Rho GTPase activating protein 9 0.055
Lamc1 laminin, gamma 1 0.055
Nckap1l NCK associated protein 1 like 0.054
Qsox1 quiescin Q6 sulfhydryl oxidase 1 0.053
Pxdn peroxidasin homolog (Drosophila) 0.053
Col4a2 collagen, type IV, alpha 2 0.053
Pxn paxillin 0.052
Meox2 mesenchyme homeobox 2 0.052
Flna filamin, alpha 0.051
Mmp9 matrix metallopeptidase 9 0.051
Ggta1 glycoprotein galactosyltransferase alpha 1, 3 0.051
Capn2 calpain 2 0.051
Ptk2 PTK2 protein tyrosine kinase 2 0.049
Fgfr2 fibroblast growth factor receptor 2 0.048
Epha2 Eph receptor A2 0.045
Gja1 gap junction protein, alpha 1 0.045
Ncf1 neutrophil cytosolic factor 1 0.044
Trpv2 transient receptor potential cation channel, subfamily V, member 2 0.043
Itgal integrin alpha L 0.043
Fbln2 fibulin 2 0.042
Fgfr1 fibroblast growth factor receptor 1 0.042
F12 coagulation factor XII (Hageman factor) 0.042
Dmgdh dimethylglycine dehydrogenase precursor 0.041
Adam8 a disintegrin and metallopeptidase domain 8 0.040
Vegfa vascular endothelial growth factor A 0.039
Pax6 paired box gene 6 0.039
Col12a1 collagen, type XII, alpha 1 0.039
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hck hemopoietic cell kinase 0.047
Cxcr4 chemokine (C-X-C motif) receptor 4 0.029
Ptprc protein tyrosine phosphatase, receptor type, C 0.029
Casp1 caspase 1 0.024
Ccl2 chemokine (C-C motif) ligand 2 0.023
RT1-EC2 RT1 class Ib, locus EC2 0.020
Capg capping protein (actin filament), gelsolin-like 0.019
Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.018
Iqgap1 IQ motif containing GTPase activating protein 1 0.018
Ripk3 receptor-interacting serine-threonine kinase 3 0.018
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.018
Anxa2 annexin A2 0.018
Prkcd protein kinase C, delta 0.017
Dock8 dedicator of cytokinesis 8 0.017
Plek pleckstrin 0.016
Cd151 CD151 molecule (Raph blood group) 0.016
Slfn2 schlafen 2 0.016
Laptm5 lysosomal protein transmembrane 5 0.015
Ier3 immediate early response 3 0.015
Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.015
Ctse cathepsin E 0.014
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.014
Mvp major vault protein 0.014
Adm adrenomedullin 0.014
Stk10 serine/threonine kinase 10 0.014
Vav1 vav 1 guanine nucleotide exchange factor 0.014
Bin2 bridging integrator 2 0.013
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.013
Csf1r colony stimulating factor 1 receptor 0.013
Tmem106a transmembrane protein 106A 0.012
Il1b interleukin 1 beta 0.012
Hmox1 heme oxygenase (decycling) 1 0.012
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.012
Cd37 CD37 molecule 0.012
Neurl3 neuralized homolog 3 (Drosophila) 0.012
Rhoc ras homolog gene family, member C 0.012
Skap2 src kinase associated phosphoprotein 2 0.012
Lgals3 lectin, galactoside-binding, soluble, 3 0.011
Tyrobp Tyro protein tyrosine kinase binding protein 0.011
Timp1 TIMP metallopeptidase inhibitor 1 0.011
Actg2 actin, gamma 2, smooth muscle, enteric 0.011
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.011
Wasf1 WAS protein family, member 1 0.011
Olr1307 olfactory receptor 1307 0.011
Rab13 RAB13, member RAS oncogene family 0.011
Myc myelocytomatosis oncogene 0.011
Pdpn podoplanin 0.011
Ncf4 neutrophil cytosolic factor 4 0.010
Atf3 activating transcription factor 3 0.010
Il4ra interleukin 4 receptor, alpha 0.010
Pla1a phospholipase A1 member A 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism