IMP
Process View
The network for 'interleukin 1 biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
interleukin 1 biosynthetic process
The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| GNLY | granulysin | 0.998 | |
| NKG7 | natural killer cell group 7 sequence | 0.849 | |
| PRF1 | perforin 1 (pore forming protein) | 0.775 | |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.686 | |
| ELANE | elastase, neutrophil expressed | 0.473 | |
| CTSG | cathepsin G | 0.299 | |
| MPO | myeloperoxidase | 0.227 | |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.162 | |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.156 | |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 0.147 | |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | 0.124 | |
| CST7 | cystatin F (leukocystatin) | 0.124 | |
| IL2RB | interleukin 2 receptor, beta | 0.105 | |
| CD8A | CD8a molecule | 0.101 | |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | 0.098 | |
| CTSW | cathepsin W | 0.087 | |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.087 | |
| CXCR6 | chemokine (C-X-C motif) receptor 6 | 0.086 | |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.086 | |
| ITK | IL2-inducible T-cell kinase | 0.081 | |
| IL18RAP | interleukin 18 receptor accessory protein | 0.062 | |
| GPR171 | G protein-coupled receptor 171 | 0.056 | |
| CD2 | CD2 molecule | 0.052 | |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.051 | |
| IFNG | interferon, gamma | 0.049 | |
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.046 | |
| SH2D1A | SH2 domain containing 1A | 0.045 | |
| HDC | histidine decarboxylase | 0.042 | |
| PGLYRP1 | peptidoglycan recognition protein 1 | 0.040 | |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.039 | |
| CAMP | cathelicidin antimicrobial peptide | 0.038 | |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 0.036 | |
| GZMM | granzyme M (lymphocyte met-ase 1) | 0.031 | |
| DEFA4 | defensin, alpha 4, corticostatin | 0.031 | |
| TARP | TCR gamma alternate reading frame protein | 0.027 | |
| TRAT1 | T cell receptor associated transmembrane adaptor 1 | 0.024 | |
| BPI | bactericidal/permeability-increasing protein | 0.021 | |
| CPA3 | carboxypeptidase A3 (mast cell) | 0.020 | |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.019 | |
| CD96 | CD96 molecule | 0.018 | |
| GFI1 | growth factor independent 1 transcription repressor | 0.017 | |
| KLRF1 | killer cell lectin-like receptor subfamily F, member 1 | 0.016 | |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.016 | |
| KLRG1 | killer cell lectin-like receptor subfamily G, member 1 | 0.014 | |
| LTF | lactotransferrin | 0.013 | |
| CD48 | CD48 molecule | 0.013 | |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.012 | |
| CLC | Charcot-Leyden crystal protein | 0.012 | |
| CLEC4G | C-type lectin domain family 4, member G | 0.012 | |
| XCL2 | chemokine (C motif) ligand 2 | 0.012 | |
| IGJ | immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides | 0.012 | |
| CD160 | CD160 molecule | 0.012 | |
| LAIR2 | leukocyte-associated immunoglobulin-like receptor 2 | 0.011 | |
| LTC4S | leukotriene C4 synthase | 0.011 | |
| ICOS | inducible T-cell co-stimulator | 0.011 | |
| SRGN | serglycin | 0.011 | |
| STAT4 | signal transducer and activator of transcription 4 | 0.011 | |
| RETN | resistin | 0.010 | |
| CLEC10A | C-type lectin domain family 10, member A | 0.010 |
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Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.883 | |
| Il1b | interleukin 1 beta | 0.837 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.761 | |
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.723 | |
| Cxcl2 | chemokine (C-X-C motif) ligand 2 | 0.601 | |
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.521 | |
| Il6 | interleukin 6 | 0.491 | |
| Reg3b | regenerating islet-derived 3 beta | 0.454 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.447 | |
| Cxcl1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.400 | |
| Ccl20 | chemokine (C-C motif) ligand 20 | 0.366 | |
| Neurl3 | neuralized homolog 3 (Drosophila) | 0.198 | |
| Olr1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.182 | |
| Mmp3 | matrix metallopeptidase 3 | 0.165 | |
| Mmp12 | matrix metallopeptidase 12 | 0.140 | |
| Prf1 | perforin 1 (pore forming protein) | 0.112 | |
| Nkg7 | natural killer cell group 7 sequence | 0.096 | |
| Fosl1 | fos-like antigen 1 | 0.084 | |
| Il1a | interleukin 1 alpha | 0.075 | |
| Tnf | tumor necrosis factor (TNF superfamily, member 2) | 0.071 | |
| Pdzk1ip1 | PDZK1 interacting protein 1 | 0.060 | |
| Hpgds | hematopoietic prostaglandin D synthase | 0.058 | |
| Stx11 | syntaxin 11 | 0.058 | |
| Il1r2 | interleukin 1 receptor, type II | 0.049 | |
| Plau | plasminogen activator, urokinase | 0.046 | |
| Fcer1a | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 0.044 | |
| Serpine1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.038 | |
| Fgr | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.037 | |
| Cd14 | CD14 molecule | 0.037 | |
| Serpinb2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.035 | |
| Ccl7 | chemokine (C-C motif) ligand 7 | 0.033 | |
| Il2rb | interleukin 2 receptor, beta | 0.033 | |
| Gzmk | granzyme K | 0.032 | |
| Ubd | ubiquitin D | 0.032 | |
| Arl5c | ADP-ribosylation factor-like 5C | 0.031 | |
| Rsad2 | radical S-adenosyl methionine domain containing 2 | 0.030 | |
| Gzmb | granzyme B | 0.029 | |
| Tgm1 | transglutaminase 1, K polypeptide | 0.027 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.026 | |
| Nox4 | NADPH oxidase 4 | 0.024 | |
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.023 | |
| Gzma | granzyme A | 0.022 | |
| Cxcl11 | chemokine (C-X-C motif) ligand 11 | 0.022 | |
| Gimap4 | GTPase, IMAP family member 4 | 0.021 | |
| Junb | jun B proto-oncogene | 0.021 | |
| Cdh17 | cadherin 17 | 0.020 | |
| Pla2g2a | phospholipase A2, group IIA (platelets, synovial fluid) | 0.018 | |
| Ch25h | cholesterol 25-hydroxylase | 0.018 | |
| Rgs1 | regulator of G-protein signaling 1 | 0.016 | |
| LOC689770 | similar to osteoclast inhibitory lectin | 0.015 | |
| Il7r | interleukin 7 receptor | 0.015 | |
| Cd8a | CD8a molecule | 0.014 | |
| Xcl1 | chemokine (C motif) ligand 1 | 0.014 | |
| Steap1 | six transmembrane epithelial antigen of the prostate 1 | 0.014 | |
| Tlr2 | toll-like receptor 2 | 0.014 | |
| Birc3 | baculoviral IAP repeat-containing 3 | 0.013 | |
| Slco1a5 | solute carrier organic anion transporter family, member 1a5 | 0.013 | |
| Cst7 | cystatin F (leukocystatin) | 0.012 | |
| Cldn7 | claudin 7 | 0.012 | |
| Gpx2 | glutathione peroxidase 2 | 0.012 | |
| Mcpt8 | mast cell protease 8 | 0.011 | |
| Reg3g | regenerating islet-derived 3 gamma | 0.011 | |
| Dpep1 | dipeptidase 1 (renal) | 0.011 | |
| Prl7b1 | prolactin family 7, subfamily b, member 1 | 0.011 | |
| Cela1 | chymotrypsin-like elastase family, member 1 | 0.010 | |
| Lrrc17 | leucine rich repeat containing 17 | 0.010 | |
| Fas | Fas (TNF receptor superfamily, member 6) | 0.010 |