The network for 'cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
npp-1 Protein NPP-1 0.990
gpr-1 Protein GPR-1 0.988
cye-1 Protein CYE-1 0.970
goa-1 Protein GOA-1 0.959
wrm-1 Protein WRM-1 0.949
hgrs-1 Protein HGRS-1 0.942
atn-1 Protein ATN-1 0.941
gpr-2 Protein GPR-2 0.925
hcp-1 Protein HCP-1 0.917
par-5 Protein PAR-5 0.915
dao-5 Protein DAO-5 0.912
ran-1 Protein RAN-1 0.901
cyk-4 Protein CYK-4 0.900
inx-3 Protein INX-3 0.885
lin-5 Protein LIN-5 0.875
R11A8.7 Protein R11A8.7 0.875
ndc-80 Protein NDC-80 0.861
sas-5 Protein SAS-5 0.854
zyg-9 Protein ZYG-9 0.852
apr-1 Protein APR-1 0.852
elt-6 Protein ELT-6 0.849
cec-5 Protein CEC-5 0.847
knl-1 Protein KNL-1 0.844
spdl-1 Protein SPDL-1 0.837
scc-3 Protein SCC-3 0.824
skp-1 Protein SKP-1 0.823
pmk-1 Protein PMK-1 0.821
teg-4 Protein TEG-4 0.820
D1081.8 Protein D1081.8 0.820
rsa-1 Protein RSA-1 0.813
brc-1 Protein BRC-1 0.793
let-99 Protein LET-99 0.784
rpl-18 Protein RPL-18 0.779
mat-3 Protein MAT-3 0.777
CELE_D1054.14 Protein D1054.14 0.763
klp-19 Protein KLP-19 0.762
rpl-7 Protein RPL-7 0.762
mel-28 Protein MEL-28 0.759
retr-1 Protein RETR-1 0.755
rnr-1 Protein RNR-1 0.749
jmjd-1.2 Protein JMJD-1.2 0.747
cls-2 Protein CLS-2 0.744
CELE_C56A3.8 Protein C56A3.8 0.742
dna-2 Protein DNA-2 0.742
kle-2 Protein KLE-2 0.741
npp-3 Protein NPP-3 0.739
hcp-2 Protein HCP-2 0.737
mcm-5 Protein MCM-5 0.732
cgh-1 Protein CGH-1 0.732
xpo-2 Protein XPO-2 0.731
lin-12 Protein LIN-12 0.730
tbb-1 Protein TBB-1 0.723
tbg-1 Protein TBG-1 0.723
mig-5 Protein MIG-5 0.720
spt-5 Protein SPT-5 0.713
mom-2 Protein MOM-2 0.713
tam-1 Protein TAM-1 0.712
him-10 Protein HIM-10 0.710
ZK430.7 Protein ZK430.7 0.709
bub-1 Protein BUB-1 0.707
egl-18 Protein EGL-18 0.704
prp-8 Protein PRP-8 0.700
zyg-11 Protein ZYG-11 0.699
rsa-2 Protein RSA-2 0.689
mex-5 Protein MEX-5 0.688
set-2 Protein SET-2 0.688
klp-16 Protein KLP-16 0.686
rars-1 Protein RARS-1 0.679
set-1 Protein SET-1 0.677
swsn-7 Protein SWSN-7 0.676
cku-80 Protein CKU-80 0.669
adr-1 Protein ADR-1 0.668
rla-0 Protein RLA-0 0.662
Y49F6B.9 Protein Y49F6B.9 0.657
pri-1 Protein PRI-1 0.650
mix-1 Protein MIX-1 0.649
pal-1 Protein PAL-1 0.645
tim-1 Protein TIM-1 0.645
mex-3 Protein MEX-3 0.640
rpa-2 Protein RPA-2 0.639
him-1 Protein HIM-1 0.636
rpl-6 Protein RPL-6 0.635
T08A11.2 Protein T08A11.2 0.633
knl-2 Protein KNL-2 0.633
hpl-2 Protein HPL-2 0.631
smc-4 Protein SMC-4 0.630
H21P03.2 Protein H21P03.2 0.628
rskn-1 Protein RSKN-1 0.627
rpl-14 Protein RPL-14 0.625
mag-1 Protein MAG-1 0.624
rpl-4 Protein RPL-4 0.624
ZC434.8 Protein ZC434.8 0.624
attf-2 Protein ATTF-2 0.624
F22G12.5 Protein F22G12.5 0.622
hmg-4 Protein HMG-4 0.620
rps-5 Protein RPS-5 0.619
rme-2 Protein RME-2 0.619
F35F11.1 Protein F35F11.1 0.616
brd-1 Protein BRD-1 0.613
gla-3 Protein GLA-3 0.610
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Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 0.967
shha sonic hedgehog a 0.952
gdf6a growth differentiation factor 6a 0.950
efnb2a ephrin B2a 0.934
foxn4 forkhead box N4 0.910
per3 period homolog 3 (Drosophila) 0.890
bmp2b bone morphogenetic protein 2b 0.870
aurkb aurora kinase B 0.768
pax2a paired box gene 2a 0.758
wnt11r wingless-type MMTV integration site family, member 11, related 0.707
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.702
gpr126 G protein-coupled receptor 126 0.681
twist1a twist1a 0.667
gro1 groucho 1 0.662
sox3 SRY-box containing gene 3 0.661
pcna proliferating cell nuclear antigen 0.598
mmp2 matrix metalloproteinase 2 0.595
rpl19 ribosomal protein L19 0.582
tbx5a T-box 5a 0.564
pbx4 pre-B-cell leukemia transcription factor 4 0.563
cxcr4a chemokine (C-X-C motif) receptor 4a 0.559
top2a topoisomerase (DNA) II alpha 0.545
pea3 ETS-domain transcription factor pea3 0.544
wnt1 wingless-type MMTV integration site family, member 1 0.538
snrpd1 small nuclear ribonucleoprotein D1 polypeptide 0.537
myod1 myogenic differentiation 1 0.530
hoxa9b homeo box A9b 0.529
six4b sine oculis homeobox homolog 4b 0.528
snrpc small nuclear ribonucleoprotein polypeptide C 0.524
rps3a ribosomal protein S3A 0.500
sae1 SUMO1 activating enzyme subunit 1 0.497
nolc1 nucleolar and coiled-body phosphoprotein 1 0.491
rpl7 ribosomal protein L7 0.477
ccnb1 cyclin B1 0.470
piwil1 piwi-like 1 (Drosophila) 0.461
smad9 MAD homolog 9 (Drosophila) 0.444
rpl13 ribosomal protein L13 0.436
smyhc1 slow myosin heavy chain 1 0.425
tp53 tumor protein p53 0.414
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.411
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.404
mapk3 mitogen-activated protein kinase 3 0.400
snrnp70 small nuclear ribonucleoprotein 70 (U1) 0.385
ube2i ubiquitin-conjugating enzyme E2I 0.384
actn2 actinin, alpha 2 0.383
rpl6 ribosomal protein L6 0.378
hhip hedgehog interacting protein 0.378
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.377
u2af1 U2(RNU2) small nuclear RNA auxiliary factor 1 0.375
wnt4a wingless-type MMTV integration site family, member 4a 0.370
spry2 sprouty homolog 2 0.367
bcl2l1 bcl2-like 1 0.365
sass6 spindle assembly 6 homolog (C. elegans) 0.365
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.364
rps8a ribosomal protein S8a 0.362
notch3 notch homolog 3 0.362
lhx1a LIM homeobox 1a 0.354
gli1 GLI-Kruppel family member 1 0.345
rpl23a ribosomal protein L23a 0.345
eya1 eyes absent homolog 1 0.344
notch1a notch homolog 1a 0.335
rps5 ribosomal protein S5 0.335
dusp6 dual specificity phosphatase 6 0.335
smc3 structural maintenance of chromosomes 3 0.335
rpl35 ribosomal protein L35 0.334
mib mind bomb 0.332
ctnnb1 catenin (cadherin-associated protein), beta 1 0.332
map2k4a mitogen-activated protein kinase kinase 4a 0.323
cxcr4b chemokine (C-X-C motif), receptor 4b 0.320
ccna2 cyclin A2 0.317
ncapd2 non-SMC condensin I complex, subunit D2 0.315
dnmt5 DNA (cytosine-5-)-methyltransferase 5 0.311
rpl36 ribosomal protein L36 0.310
sf3b1 splicing factor 3b, subunit 1 0.308
rps18 ribosomal protein S18 0.307
dtl denticleless homolog (Drosophila) 0.307
sox4a SRY-box containing gene 4a 0.301
myf5 myogenic factor 5 0.300
foxj1a forkhead box J1a 0.298
rps11 ribosomal protein S11 0.295
tgfb3 transforming growth factor, beta 3 0.286
dag1 dystroglycan 1 0.285
pax6b paired box gene 6b 0.275
snrnp27 small nuclear ribonucleoprotein 27 (U4/U6.U5) 0.275
tal1 T-cell acute lymphocytic leukemia 1 0.269
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.267
sall4 sal-like 4 (Drosophila) 0.266
ptch2 patched 2 0.262
prkcz protein kinase C, zeta 0.261
dld deltaD 0.259
rpl4 ribosomal protein L4 0.257
fbn2b fibrillin 2b 0.253
ncapg non-SMC condensin I complex, subunit G 0.250
atoh1a atonal homolog 1a 0.247
sox11a SRY-box containing gene 11a 0.247
fbl fibrillarin 0.247
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.246
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.244
ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.243
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.238
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Pfn1 profilin 1 0.906
Arf6 ADP-ribosylation factor 6 0.782
Eif4h eukaryotic translation initiation factor 4H 0.674
Tpm3 tropomyosin 3, gamma 0.572
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.505
Fgfr1 Fibroblast growth factor receptor 1 0.470
Exoc5 exocyst complex component 5 0.469
Tpm4 tropomyosin 4 0.466
Mapk1 mitogen activated protein kinase 1 0.384
Top2a topoisomerase (DNA) II alpha 0.380
Hk1 hexokinase 1 0.372
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.365
Cdk2 cyclin dependent kinase 2 0.317
Tubb5 tubulin, beta 5 0.314
Ap2m1 adaptor-related protein complex 2, mu 1 subunit 0.298
Stip1 stress-induced phosphoprotein 1 0.296
Jak2 Janus kinase 2 0.284
Taok1 TAO kinase 1 0.273
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.268
Csnk2b casein kinase 2, beta polypeptide 0.266
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.264
Mapk3 mitogen activated protein kinase 3 0.254
Ptbp1 polypyrimidine tract binding protein 1 0.229
Impdh2 IMP (inosine monophosphate) dehydrogenase 2 0.228
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.220
Cenpi centromere protein I 0.210
Cand1 cullin-associated and neddylation-dissociated 1 0.207
Ccnd1 cyclin D1 0.198
Dnm1l dynamin 1-like 0.196
Ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.196
Id3 inhibitor of DNA binding 3 0.185
Rap1b RAP1B, member of RAS oncogene family 0.185
Ptgs2 prostaglandin-endoperoxide synthase 2 0.181
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.177
Eef2 eukaryotic translation elongation factor 2 0.177
Myh9 myosin, heavy chain 9, non-muscle 0.176
LOC100360986 mCG1035404-like 0.174
Fkbp1a FK506 binding protein 1a 0.172
Gja5 gap junction protein, alpha 5 0.167
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.165
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.164
Mdm2 Mdm2 p53 binding protein homolog (mouse) 0.164
Dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.159
Cfp complement factor properdin 0.158
Dctn4 dynactin 4 0.155
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.152
Rhoa ras homolog gene family, member A 0.152
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.150
Stxbp1 syntaxin binding protein 1 0.145
Dnm1 dynamin 1 0.144
Csnk1d casein kinase 1, delta 0.143
Btg2 BTG family, member 2 0.143
Ptma prothymosin alpha 0.142
Apba1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.139
Myo1b myosin Ib 0.138
Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 0.136
Casp2 caspase 2 0.134
Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 0.130
Arih1 ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) 0.130
Csnk1g3 casein kinase 1, gamma 3 0.129
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.128
Actb actin, beta 0.127
Myo1c myosin IC 0.124
Tspyl1 TSPY-like 1 0.124
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.124
Pcna proliferating cell nuclear antigen 0.123
Nfia nuclear factor I/A 0.121
Ccnd3 cyclin D3 0.121
Tmsb10 thymosin, beta 10 0.121
Sf3a3 splicing factor 3a, subunit 3 0.119
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.118
Akt1 v-akt murine thymoma viral oncogene homolog 1 0.117
Nap1l1 nucleosome assembly protein 1-like 1 0.114
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.112
Jun Jun oncogene 0.111
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.111
Acta2 smooth muscle alpha-actin 0.111
Rpl23 ribosomal protein L23 0.110
Ptov1 prostate tumor overexpressed 1 0.110
Hpca hippocalcin 0.109
Rps5 ribosomal protein S5 0.108
Tpm2 tropomyosin 2, beta 0.107
Phka1 phosphorylase kinase, alpha 1 0.106
Gjb3 gap junction protein, beta 3 0.106
Dynll1 dynein light chain LC8-type 1 0.106
Ubc ubiquitin C 0.105
Cdk4 cyclin-dependent kinase 4 0.105
Brsk1 BR serine/threonine kinase 1 0.104
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.104
Nup88 nucleoporin 88 0.104
Mprip myosin phosphatase Rho interacting protein 0.104
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.103
Prkar1a protein kinase, cAMP-dependent, regulatory, type I, alpha 0.103
Ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.103
Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 0.103
Cttn cortactin 0.102
Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 0.102
Smad2 SMAD family member 2 0.101
Rpl11 ribosomal protein L11 0.100
Lifr leukemia inhibitory factor receptor alpha 0.099
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism