The network for 'protein localization to endoplasmic reticulum' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein localization to endoplasmic reticulum

A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SEC63 Sec63p 1.000
KAR2 Kar2p 0.992
SEC62 Sec62p 0.989
SRP54 Srp54p 0.988
SPC1 Spc1p 0.979
GET1 Get1p 0.979
SGT2 Sgt2p 0.968
SRP14 Srp14p 0.957
SEC66 Sec66p 0.954
SPC2 Spc2p 0.946
SRP21 Srp21p 0.944
SSS1 Sss1p 0.932
ERP2 Erp2p 0.918
SBH1 Sbh1p 0.895
SEC65 Sec65p 0.817
ERV25 Erv25p 0.770
SEC61 Sec61p 0.749
SSA2 Ssa2p 0.698
LHS1 Lhs1p 0.650
GET3 Get3p 0.612
PMT1 Pmt1p 0.544
CAF130 Caf130p 0.494
SSH1 Ssh1p 0.482
ERP5 Erp5p 0.475
GET4 Get4p 0.474
SRP72 Srp72p 0.453
OST2 Ost2p 0.356
SAR1 Sar1p 0.322
SEC72 Sec72p 0.319
SCJ1 Scj1p 0.287
SEC11 Sec11p 0.261
HTA2 Hta2p 0.244
STI1 Sti1p 0.242
YDJ1 Ydj1p 0.235
GWT1 Gwt1p 0.215
JEM1 Jem1p 0.210
SIL1 Sil1p 0.198
ERJ5 Erj5p 0.186
BTN2 Btn2p 0.159
MDY2 Mdy2p 0.157
EGD2 Egd2p 0.141
EGD1 Egd1p 0.126
YPT7 Ypt7p 0.115
SSA1 Ssa1p 0.110
SVP26 Svp26p 0.101
VPS74 Vps74p 0.096
LCL2 Lcl2p 0.091
HOC1 Hoc1p 0.089
KEG1 Keg1p 0.083
YNL181W hypothetical protein 0.077
GPI2 Gpi2p 0.073
RER1 Rer1p 0.065
SRP68 Srp68p 0.064
UBC4 Ubc4p 0.064
SIS1 Sis1p 0.064
ERO1 Ero1p 0.064
ERD2 Erd2p 0.061
CUE4 Cue4p 0.061
YPT32 Ypt32p 0.059
RPL15B Rpl15bp 0.058
VMA4 Vma4p 0.057
ERP4 Erp4p 0.057
SFB2 Sfb2p 0.056
SSA4 Ssa4p 0.054
YKL063C hypothetical protein 0.051
MDM20 Mdm20p 0.050
YBT1 Ybt1p 0.050
ENA5 Ena5p 0.050
STE24 Ste24p 0.049
YLR126C hypothetical protein 0.048
YJR011C hypothetical protein 0.048
SPC3 Spc3p 0.048
GUK1 Guk1p 0.048
BAP3 Bap3p 0.047
RPB3 Rpb3p 0.045
ERP6 Erp6p 0.045
INP2 Inp2p 0.044
YLR264C-A hypothetical protein 0.043
SEC12 Sec12p 0.042
PRS2 Prs2p 0.041
MPD1 Mpd1p 0.040
CRP1 Crp1p 0.040
SRD1 Srd1p 0.040
PHO86 Pho86p 0.040
LEU2 Leu2p 0.038
ARG8 Arg8p 0.038
YIP3 Yip3p 0.038
ALG5 Alg5p 0.038
URA6 Ura6p 0.038
YRB1 Yrb1p 0.038
CUP1-1 Cup1-1p 0.037
VMA10 Vma10p 0.037
YOL038C-A hypothetical protein 0.037
YER140W hypothetical protein 0.037
YNR021W hypothetical protein 0.037
IOC3 Ioc3p 0.036
AHA1 Aha1p 0.036
YHB1 Yhb1p 0.035
SEC13 Sec13p 0.035
SED5 Sed5p 0.035
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
ahcy-1 Protein AHCY-1 0.459
pdi-1 Protein PDI-1 0.380
hsp-4 Protein HSP-4 0.296
chc-1 Protein CHC-1 0.279
ribo-1 Protein RIBO-1 0.273
CELE_Y57G11C.15 Protein Y57G11C.15 0.258
pdi-3 Protein PDI-3 0.247
ama-1 Protein AMA-1 0.237
T01G9.2 Protein T01G9.2 0.217
klp-7 Protein KLP-7 0.175
pdi-2 Protein PDI-2 0.150
stt-3 Protein STT-3 0.112
cct-7 Protein CCT-7 0.110
fkb-6 Protein FKB-6 0.110
Y25C1A.5 Protein Y25C1A.5 0.099
lron-10 Protein LRON-10 0.097
trap-1 Protein TRAP-1 0.091
T03F1.1 Protein T03F1.1 0.090
vps-32.1 Protein VPS-32.1 0.089
trap-3 Protein TRAP-3 0.083
paa-1 Protein PAA-1 0.069
pod-1 Protein POD-1 0.066
pam-1 Protein PAM-1 0.065
gck-1 Protein GCK-1 0.063
nucb-1 Protein NUCB-1 0.063
lap-2 Protein LAP-2 0.062
cct-2 Protein CCT-2 0.061
prp-8 Protein PRP-8 0.054
ima-3 Protein IMA-3 0.053
F41E6.9 Protein F41E6.9 0.051
dnj-7 Protein DNJ-7 0.049
tars-1 Protein TARS-1 0.049
ccdc-47 Protein CCDC-47 0.047
metr-1 Protein METR-1 0.046
T14G8.3 Protein T14G8.3 0.045
CELE_T03F6.3 Protein T03F6.3 0.044
tsn-1 Protein TSN-1 0.041
clic-1 Protein CLIC-1 0.041
mthf-1 Protein MTHF-1 0.040
C45G9.5 Protein C45G9.5 0.039
math-33 Protein MATH-33 0.039
eif-3.B Protein EIF-3.B 0.038
C18E9.2 Protein C18E9.2 0.038
crt-1 Protein CRT-1 0.035
snrp-200 Protein SNRP-200 0.034
trap-4 Protein TRAP-4 0.034
dnj-29 Protein DNJ-29 0.033
dao-5 Protein DAO-5 0.029
tbb-2 Protein TBB-2 0.028
CELE_C08H9.2 Protein C08H9.2 0.027
sams-4 Protein SAMS-4 0.027
uso-1 Protein USO-1 0.027
sti-1 Protein STI-1 0.026
tfg-1 Protein TFG-1 0.025
ostb-1 Protein OSTB-1 0.025
dnj-12 Protein DNJ-12 0.023
R148.3 Protein R148.3 0.023
Y71F9AL.17 Protein Y71F9AL.17 0.022
stc-1 Protein STC-1 0.022
R07H5.8 Protein R07H5.8 0.022
sec-23 Protein SEC-23 0.021
gsp-1 Protein GSP-1 0.021
dnj-16 Protein DNJ-16 0.020
CELE_ZK637.14 Protein ZK637.14 0.020
eif-3.J Protein EIF-3.J 0.019
F39G3.3 Protein F39G3.3 0.019
hsp-3 Protein HSP-3 0.018
CELE_W03F9.10 Protein W03F9.10 0.018
tag-320 Protein TAG-320 0.018
nra-4 Protein NRA-4 0.017
ostd-1 Protein OSTD-1 0.016
hsp-1 Protein HSP-1 0.016
imp-2 Protein IMP-2 0.016
sec-24.1 Protein SEC-24.1 0.015
C30C11.4 Protein C30C11.4 0.015
inf-1 Protein INF-1 0.015
cdc-37 Protein CDC-37 0.015
nmt-1 Protein NMT-1 0.015
rap-2 Protein RAP-2 0.015
lap-1 Protein LAP-1 0.014
K07H8.10 Protein K07H8.10 0.014
rpn-2 Protein RPN-2 0.013
rab-39 Protein RAB-39 0.013
hke-4.2 Protein HKE-4.2 0.013
W08E3.2 Protein W08E3.2 0.013
tkt-1 Protein TKT-1 0.013
ZK686.3 Protein ZK686.3 0.012
tag-131 Protein TAG-131 0.012
ubc-3 Protein UBC-3 0.012
dnj-13 Protein DNJ-13 0.011
nkat-3 Protein NKAT-3 0.011
mbf-1 Protein MBF-1 0.011
wip-1 Protein WIP-1 0.011
rpn-12 Protein RPN-12 0.011
CELE_C07D8.6 Protein C07D8.6 0.011
cgt-3 Protein CGT-3 0.011
npp-9 Protein NPP-9 0.011
xrn-2 Protein XRN-2 0.011
R12E2.13 Protein R12E2.13 0.010
map-2 Protein MAP-2 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Surf4 Surfeit 4 0.013
Spp Signal peptide protease 0.013
SrpRbeta Signal recognition particle receptor beta 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
HSPA1A heat shock 70kDa protein 1A 0.943
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.931
HSPA1B heat shock 70kDa protein 1B 0.894
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.791
CANX calnexin 0.774
SURF4 surfeit 4 0.452
BAG1 BCL2-associated athanogene 0.399
BAG3 BCL2-associated athanogene 3 0.369
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.351
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.337
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.332
LAPTM5 lysosomal protein transmembrane 5 0.267
TMEM173 transmembrane protein 173 0.229
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.213
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.210
PEX19 peroxisomal biogenesis factor 19 0.207
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 0.195
BAG6 BCL2-associated athanogene 6 0.187
LMAN1 lectin, mannose-binding, 1 0.173
SPTB spectrin, beta, erythrocytic 0.169
SEC61B Sec61 beta subunit 0.150
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.142
RSL24D1 ribosomal L24 domain containing 1 0.122
PPID peptidylprolyl isomerase D 0.121
DERL1 Der1-like domain family, member 1 0.121
SSR1 signal sequence receptor, alpha 0.111
PEX13 peroxisomal biogenesis factor 13 0.107
HSPH1 heat shock 105kDa/110kDa protein 1 0.104
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.096
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.093
CREB3 cAMP responsive element binding protein 3 0.090
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.090
OCRL oculocerebrorenal syndrome of Lowe 0.089
RABIF RAB interacting factor 0.086
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.085
SEC63 SEC63 homolog (S. cerevisiae) 0.081
RPN1 ribophorin I 0.077
NACA nascent polypeptide-associated complex alpha subunit 0.073
ATF7IP activating transcription factor 7 interacting protein 0.068
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.064
EHD1 EH-domain containing 1 0.063
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.061
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.058
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.057
UBQLN4 ubiquilin 4 0.057
UBL4A ubiquitin-like 4A 0.056
PPP6C protein phosphatase 6, catalytic subunit 0.055
SAV1 salvador homolog 1 (Drosophila) 0.054
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.054
USP54 ubiquitin specific peptidase 54 0.054
ROD1 ROD1 regulator of differentiation 1 (S. pombe) 0.050
OSBPL9 oxysterol binding protein-like 9 0.050
RPL36AL ribosomal protein L36a-like 0.050
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.046
RAI2 retinoic acid induced 2 0.045
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.044
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.044
PDCD6 programmed cell death 6 0.043
BAG2 BCL2-associated athanogene 2 0.041
SERP1 stress-associated endoplasmic reticulum protein 1 0.040
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.040
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.040
SH3GL2 SH3-domain GRB2-like 2 0.038
RAB8A RAB8A, member RAS oncogene family 0.036
ERBB2IP erbb2 interacting protein 0.036
AKAP6 A kinase (PRKA) anchor protein 6 0.034
SEC62 SEC62 homolog (S. cerevisiae) 0.034
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.032
ARL1 ADP-ribosylation factor-like 1 0.032
GDI2 GDP dissociation inhibitor 2 0.031
CDK17 cyclin-dependent kinase 17 0.031
EIF3E eukaryotic translation initiation factor 3, subunit E 0.031
EPS15 epidermal growth factor receptor pathway substrate 15 0.031
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.030
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.029
USP8 ubiquitin specific peptidase 8 0.027
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) 0.027
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.026
TBK1 TANK-binding kinase 1 0.026
USO1 USO1 vesicle docking protein homolog (yeast) 0.025
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.025
LAMP1 lysosomal-associated membrane protein 1 0.025
DPP8 dipeptidyl-peptidase 8 0.025
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 0.025
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.024
SMAD2 SMAD family member 2 0.024
SEPT7 septin 7 0.023
MORF4L1 mortality factor 4 like 1 0.022
TMED9 transmembrane emp24 protein transport domain containing 9 0.021
MEOX2 mesenchyme homeobox 2 0.021
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.021
RPN2 ribophorin II 0.021
HYOU1 hypoxia up-regulated 1 0.020
STX5 syntaxin 5 0.020
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.019
ZMPSTE24 zinc metallopeptidase (STE24 homolog, S. cerevisiae) 0.019
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.018
PEX14 peroxisomal biogenesis factor 14 0.018
ANTXR2 anthrax toxin receptor 2 0.018
PTPLB protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b 0.018
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Timm13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.112
Ndufs8 NADH dehydrogenase (ubiquinone) Fe-S protein 8 0.085
Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.074
Lsmd1 LSM domain containing 1 0.064
Ndufs7 NADH dehydrogenase (ubiquinone) Fe-S protein 7 0.062
Rpl38 ribosomal protein L38 0.054
Atp5e ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 0.054
LOC499782 similar to 60S ribosomal protein L12 0.054
LOC100361944 hypothetical protein LOC100361944 0.054
Ndufb2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 0.053
Cox5b cytochrome c oxidase subunit Vb 0.053
Ndufb6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 0.052
Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.049
Atp5j2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 0.049
Tomm7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.048
Mrpl54 mitochondrial ribosomal protein L54 0.046
LOC688869 similar to cytochrome c oxidase, subunit VIb polypeptide 1 0.046
Romo1 reactive oxygen species modulator 1 0.046
Myeov2 myeloma overexpressed 2 0.045
Ndufa6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (B14) 0.042
RGD1306917 similar to RIKEN cDNA 2900010M23 0.042
Tomm6 translocase of outer mitochondrial membrane 6 homolog (yeast) 0.041
Ndufs6 NADH dehydrogenase (ubiquinone) Fe-S protein 6 0.039
Timm8b translocase of inner mitochondrial membrane 8 homolog b (yeast) 0.038
Polr2g polymerase (RNA) II (DNA directed) polypeptide G 0.035
Smek2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 0.034
Rpl19 ribosomal protein L19 0.033
Ndufc1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1 0.033
Erh enhancer of rudimentary homolog (Drosophila) 0.032
Ndufb5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 0.032
Ndufb10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 0.031
Tceb2 transcription elongation factor B (SIII), polypeptide 2 0.029
Mrps21 mitochondrial ribosomal protein S21 0.028
Ndufs5 NADH dehydrogenase (ubiquinone) Fe-S protein 5 0.027
Cuta cutA divalent cation tolerance homolog (E. coli) 0.027
Rps2 ribosomal protein S2 0.027
Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d 0.026
Cox6a1 cytochrome c oxidase, subunit VIa, polypeptide 1 0.026
Ndufa2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 0.026
Myl6l myosin, light polypeptide 6, alkali, smooth muscle and non-muscle-like 0.026
RGD1564058 similar to cDNA sequence BC056474 0.025
Pomp proteasome maturation protein 0.025
Ndufb9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 0.024
LOC687029 similar to differentially expressed in B16F10 1 0.024
LOC100363539 mitochondrial ribosomal protein L33-like 0.024
Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.023
Ndufb7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7 0.023
Usmg5 up-regulated during skeletal muscle growth 5 homolog (mouse) 0.023
Mrpl13 mitochondrial ribosomal protein L13 0.022
Nedd8 neural precursor cell expressed, developmentally down-regulated 8 0.022
Rpl35 ribosomal protein L35 0.022
Cox7a2 cytochrome c oxidase subunit VIIa polypeptide 2 0.021
Mrps16 mitochondrial ribosomal protein S16 0.021
Btf3 basic transcription factor 3 0.021
Ndufa3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 0.020
Mrps12 mitochondrial ribosomal protein S12 0.020
Rpl41 ribosomal protein L41 0.020
LOC100359995 rCG63619-like 0.020
Cope coatomer protein complex, subunit epsilon 0.020
Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 0.020
Phpt1 phosphohistidine phosphatase 1 0.019
Ndufa13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.019
Cox7b cytochrome c oxidase subunit VIIb 0.019
Ndufs3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 0.019
Mrps23 mitochondrial ribosomal protein S23 0.019
RGD1565363 similar to RIKEN cDNA 1110025L05 0.018
Rps10 ribosomal protein S10 0.018
Cyc1 cytochrome c-1 0.018
Dynlrb1 dynein light chain roadblock-type 1 0.018
Ndufa11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11 0.018
Cox7c cytochrome c oxidase, subunit VIIc 0.017
Ndufa1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 0.017
Ppib peptidylprolyl isomerase B 0.017
Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII 0.017
Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 0.017
Mrps28 mitochondrial ribosomal protein S28 0.017
Eef1b2 eukaryotic translation elongation factor 1 beta 2 0.017
Atp5j ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 0.017
Tmed2 transmembrane emp24 domain trafficking protein 2 0.016
Sec61g SEC61, gamma subunit 0.016
Sfrs18 splicing factor, arginine/serine-rich 18 0.016
Pnn pinin, desmosome associated protein 0.016
Ndufa12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 0.016
Ndufc2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2 0.016
Gadd45gip1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.015
Hnrph1 heterogeneous nuclear ribonucleoprotein H1 0.015
Mdh2 malate dehydrogenase 2, NAD (mitochondrial) 0.015
Atp5g1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) 0.015
Rps21 ribosomal protein S21 0.015
Sec61b Sec61 beta subunit 0.015
Prpf4b PRP4 pre-mRNA processing factor 4 homolog B (yeast) 0.015
RGD1560220 similar to homolog of yeast TIM14 isoform c 0.015
Ndufa8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8 0.015
Mrps34 mitochondrial ribosomal protein S34 0.015
Rpl10a ribosomal protein L10A 0.014
LOC685322 similar to ubiquinol-cytochrome c reductase complex 7.2kDa protein isoform b 0.014
Cisd1 CDGSH iron sulfur domain 1 0.014
Chchd1 coiled-coil-helix-coiled-coil-helix domain containing 1 0.014
Rpl22 ribosomal protein L22 0.014
Tra2b transformer 2 beta homolog (Drosophila) 0.014